Day: October 17, 2022

《Studies on anticoccidial agents. 11. Synthesis and anticoccidial activity of nitropyridinecarboxamides and derivatives》 was published in Journal of Medicinal Chemistry in 1977. These research results belong to Morisawa, Yasuhiro; Kataoka, Mitsuru; Kitano, Noritoshi. Electric Literature of C6H4N2O4 The article mentions the following:

Of 56 title compounds prepared, optimal in vivo activity against Eimeria tenella was shown by 2-nitroisonicotinamide (I, R1 = R2 = H) [60780-17-8] and 11 derivatives (I: R1 = H, Me; R2 = Me, CH2OH, alkanoyl, aryl acyl, heterocyclic acyl). Activity was shown by 2-, 3-, 5-, and 6-nitro-, but not by 4-nitropyridinecarboxamides. Substitution on the amide N of the various positional isomers affected their activity differently. In the part of experimental materials, we found many familiar compounds, such as 3-Nitroisonicotinic acid(cas: 59290-82-3Electric Literature of C6H4N2O4)

3-Nitroisonicotinic acid(cas: 59290-82-3) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Electric Literature of C6H4N2O4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis and characterization of fluorescent Schiff bases and their metal complexes from 9-anthracenecarboxaldehy》 was written by Ibrahim, Inam Hassim; Hasan, Hasan A.. Formula: C5H7N3This research focused ontransition metal complex fluorescent Schiff base analysis. The article conveys some information:

Synthesis and characterization two Schiff bases[L1] (N2Z,N6Z)-N2,N6-bis(4-((E)-anthracen-9-ylmethyleneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-ylidene)pyridine-2,6-diamine Synthesis via reaction of 2,6-diaminopyridine, 4-aminoantipyrine and 9-anthracenecarboxaldehyde with mole ratio (1:2:2) resp. two steps. And [L2] (N1Z,N2Z)-N1,N2-bis(4-((E)-anthracen-9-ylmethyleneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-ylidene)-4-methylbenzene-1,2-diamine Synthesis from reaction of o-phenylendiamine, 4-aminoantipyrine and 9-anthracenecarboxaldehyde with mole ratio (1:2:2) resp. two steps. A new series of transition metal complexes of Mn(II), Co(II), Ca(II), Cd(II), Zn(II) and pd(II) were synthesized. The structural features were derived from their elemental analyses, IR, UV-visible spectroscopy, 1HNMR, 13CNMR spectroscopy, thermal gravimetric analyses spectral, magnetic susceptibility measurement, chloride content and conductivity measurements. The electronic spectral data and magnetic measurements indicate that the complexes exhibit octahedral geometry around Ca(II), Mn(II), Cd(II), Co(II), Zn(II) while Square planer geometry around Pd(II). In addition to this study using 2,6-Diaminopyridine, there are many other studies that have used 2,6-Diaminopyridine(cas: 141-86-6Formula: C5H7N3) was used in this study.

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Formula: C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1179360-43-0On May 1, 2013 ,《Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1》 appeared in Bioorganic & Medicinal Chemistry. The author of the article were Zhang, Pengtao; Yang, Xinye; Zhang, Feiran; Gabelli, Sandra B.; Wang, Renxiao; Zhang, Yihua; Bhat, Shridhar; Chen, Xiaochun; Furlani, Manuel; Amzel, L. Mario; Liu, Jun O.; Ma, Dawei. The article conveys some information:

Cellular protein synthesis is initiated with methionine in eukaryotes with few exceptions. Methionine aminopeptidases (MetAPs) which catalyze the process of N-terminal methionine excision are essential for all organisms. In mammals, type 2 MetAP (MetAP2) is known to be important for angiogenesis, while type 1 MetAP (MetAP1) has been shown to play a pivotal role in cell proliferation. Authors’ previous high-throughput screening of a com. compound library uncovered a novel class of inhibitors for both human MetAP1 (HsMetAP1) and human MetAP2 (HsMetAP2). This class of inhibitors contains a pyridinylpyrimidine core. To understand the structure-activity relationship (SAR) and to search for analogs of 2 with greater potency and higher HsMetAP1-selectivity, a total of 58 analogs were acquired through either com. source or by inhouse synthesis and their inhibitory activities against HsMetAP1 and HsMetAP2 were determined Through this systematic medicinal chem. anal., the authors have identified: (1) 5-chloro-6-methyl-2-pyridin-2-ylpyrimidine as the min. element for the inhibition of HsMetAP1; (2) 5′-chloro as the favored substituent on the pyridine ring for the enhanced potency against HsMetAP1; and (3) long C4 side chains as the essentials for higher HsMetAP1-selectivity. As a result of the SAR campaign, six compounds were found to be among the most selective and potent inhibitors of purified HsMetAP1 reported to date. In addition, crystallog. anal. of one representative inhibitor (I) in complex with N-terminally truncated HsMetAP1 was also performed. Map gene.3-Chloropicolinimidamide hydrochloride(cas: 1179360-43-0Related Products of 1179360-43-0) was used in this study.

3-Chloropicolinimidamide hydrochloride(cas: 1179360-43-0) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Related Products of 1179360-43-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 1206978-15-5On November 30, 2017 ,《Tri- and difluoromethoxylated N-based heterocycles – Synthesis and insecticidal activity of novel F3CO- and F2HCO-analogues of Imidacloprid and Thiacloprid》 appeared in Journal of Fluorine Chemistry. The author of the article were Landelle, Gregory; Schmitt, Etienne; Panossian, Armen; Vors, Jean-Pierre; Pazenok, Sergiy; Jeschke, Peter; Gutbrod, Oliver; Leroux, Frederic R.. The article conveys some information:

The preparation of F3CO- and F2HCO-analogs of Imidacloprid and Thiacloprid, I (R = CF3, CHF2) and II, resp., and the evaluation of their biol. activity have been performed. For this purpose, a first synthetic approach allowed the preparation of a desired F3CO-containing key intermediate, 3-(chloromethyl)-6-(trifluoromethoxy)pyridine. To allow facile access to the corresponding F2HCO-containing key intermediate, the difluoromethylation of hydroxylated N-based heterocycles has been developed using difluoromethyl triflate (a liquid non-ODS reagent) under air in aqueous conditions and with very short reaction time. The broad diversity of compatible heterocycles includes a large series of substituted hydroxy-pyridines, but also -pyrazoles, -pyrazine, -pyridazine, and -quinolines. The couplings of both key intermediates with the required 4,5-dihydro-N-nitro-1H-imidazol-2-amine and [N(Z)]-N-2-thiazolidinylidene-cyanamide were successfully achieved using literature conditions. This work enables the preparation of valuable building blocks, which could lead to the discovery of new bioactive entities. In the part of experimental materials, we found many familiar compounds, such as 2-Chloro-4-(difluoromethoxy)pyridine(cas: 1206978-15-5Recommanded Product: 1206978-15-5)

2-Chloro-4-(difluoromethoxy)pyridine(cas: 1206978-15-5) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Recommanded Product: 1206978-15-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formula: C9H11BrClNOOn September 8, 2016 ,《Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors》 was published in Journal of Medicinal Chemistry. The article was written by DiMauro, Erin F.; Altmann, Stephen; Berry, Loren M.; Bregman, Howard; Chakka, Nagasree; Chu-Moyer, Margaret; Bojic, Elma Feric; Foti, Robert S.; Fremeau, Robert; Gao, Hua; Gunaydin, Hakan; Guzman-Perez, Angel; Hall, Brian E.; Huang, Hongbing; Jarosh, Michael; Kornecook, Thomas; Lee, Josie; Ligutti, Joseph; Liu, Dong; Moyer, Bryan D.; Ortuno, Daniel; Rose, Paul E.; Schenkel, Laurie B.; Taborn, Kristin; Wang, Jean; Wang, Yan; Yu, Violeta; Weiss, Matthew M.. The article contains the following contents:

The majority of potent and selective hNaV1.7 inhibitors possess common pharmacophoric features that include a heteroaryl sulfonamide headgroup and a lipophilic aromatic tail group. Recently, reports of similar aromatic tail groups in combination with an acyl sulfonamide headgroup have emerged, with the acyl sulfonamide bestowing levels of selectivity over hNaV1.5 comparable to the heteroaryl sulfonamide. Beginning with com. available carboxylic acids that met selected pharmacophoric requirements in the lipophilic tail, a parallel synthetic approach was applied to rapidly generate the derived acyl sulfonamides. A biaryl acyl sulfonamide hit from this library was elaborated, optimizing for potency and selectivity with attention to physicochem. properties. The resulting novel leads are potent, ligand and lipophilic efficient, and selective over hNaV1.5. Representative lead I demonstrates selectivity over other human NaV isoforms and good pharmacokinetics in rodents. The biaryl acyl sulfonamides reported herein may also offer ADME advantages over known heteroaryl sulfonamide inhibitors. In the experiment, the researchers used 5-Bromo-3-chloro-2-isobutoxypyridine(cas: 1289093-31-7Formula: C9H11BrClNO)

5-Bromo-3-chloro-2-isobutoxypyridine(cas: 1289093-31-7) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Formula: C9H11BrClNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 18437-58-6On October 17, 2020 ,《Zinc-Catalyzed N-Alkylation of Aromatic Amines with Alcohols: A Ligand-Free Approach》 was published in Advanced Synthesis & Catalysis. The article was written by Sankar, Velayudham; Kathiresan, Murugavel; Sivakumar, Bitragunta; Mannathan, Subramaniyan. The article contains the following contents:

An efficient zinc-catalyzed N-alkylation reaction of aromatic amines was achieved using aliphatic, aromatic and heteroaromatic alcs. as the alkylating reagent. A variety of aniline derivatives, including heteroaromatic amines, underwent the N-alkylation reaction and furnished N-alkyl amines in good to excellent yields. The application of reaction was also further demonstrated by the synthesis of 2-phenylquinoline from acetophenone and 2-aminobenzyl alc. Deuterium labeling experiments showed that the reaction proceeded via a borrowing hydrogen process. The experimental part of the paper was very detailed, including the reaction process of 4-Amino-2-picoline(cas: 18437-58-6Related Products of 18437-58-6)

4-Amino-2-picoline(cas: 18437-58-6) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Related Products of 18437-58-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Barsanti, Paul A.; Pan, Yue; Lu, Yipin; Jain, Rama; Cox, Matthew; Aversa, Robert J.; Dillon, Michael P.; Elling, Robert; Hu, Cheng; Jin, Xianming; Knapp, Mark; Lan, Jiong; Ramurthy, Savithri; Rudewicz, Patrick; Setti, Lina; Subramanian, Sharadha; Mathur, Michelle; Taricani, Lorena; Thomas, George; Xiao, Linda; Yue, Qin published an article on January 8 ,2015. The article was titled 《Structure-Based Drug Design of Novel, Potent, and Selective Azabenzimidazoles (ABI) as ATR Inhibitors》, and you may find the article in ACS Medicinal Chemistry Letters.Quality Control of 2-Bromo-5-nitropyridin-4-amine The information in the text is summarized as follows:

Compound I was discovered through morphing of the ATR biochem. HTS hit I. The ABI series was potent and selective for ATR. Incorporation of a 6-azaindole afforded a marked increase in cellular potency but was associated with poor PK and hERG ion channel inhibition. DMPK experiments established that CYP P 450 and AO metabolism in conjunction with Pgp and BCRP efflux were major causative mechanisms for the observed PK. The series also harbored the CYP3A4 TDI liability driven by the presence of both a morpholine and an indole moiety. Incorporation of an adjacent fluorine or nitrogen into the 6-azaindole addressed many of the various medicinal chem. issues encountered. In addition to this study using 2-Bromo-5-nitropyridin-4-amine, there are many other studies that have used 2-Bromo-5-nitropyridin-4-amine(cas: 84487-15-0Quality Control of 2-Bromo-5-nitropyridin-4-amine) was used in this study.

2-Bromo-5-nitropyridin-4-amine(cas: 84487-15-0) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Quality Control of 2-Bromo-5-nitropyridin-4-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Duan, Yu-Hao; Zhu, Xiao-Zhao; Zhang, Qian; Yang, Yang published an article in Inorganic Chemistry Communications. The title of the article was 《Molecular enantiopure homometallic Zn14L24 cubic cages with luminescence properties》.Product Details of 1214363-66-2 The author mentioned the following in the article:

Chiral homometallic high-nuclearity cages are rare and of synthetic challenge. Herein, the authors report the syntheses and structures of a pair of enantiopure homometallic high-nuclearity [Zn14L24]28+ cages. The mol. cage has a cubic framework with pseudo-O symmetry and encloses a large void inside. The chirality of the framework is directed by the point chirality of the chiral amine applied, which is verified by the crystal structure and CD studies. The formation processes are probed by NMR and CD studies. The cage complexes also possess blue luminescence properties. They represent the first enantiopure homometallic cubic cages and rare examples of high-nuclearity enantiopure cages. In the experimental materials used by the author, we found [3,4′-Bipyridine]-6-carboxylic acid(cas: 1214363-66-2Product Details of 1214363-66-2)

[3,4′-Bipyridine]-6-carboxylic acid(cas: 1214363-66-2) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Product Details of 1214363-66-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kirilov, Plamen; Matondo, Hubert; Vicendo, Patricia; Garrigues, Jean-Christophe; Baboulene, Michel; Nguyen, Hoang-Phuong; Rico-Lattes, Isabelle published an article on February 28 ,2006. The article was titled 《Synthesis and photophysical properties of novel amphiphilic ruthenium(II) complexes containing 4,4′-dialkyl-aminomethyl-2,2′-bipyridyl ligands》, and you may find the article in Applied Organometallic Chemistry.HPLC of Formula: 138219-98-4 The information in the text is summarized as follows:

The synthesis of new 2,2′-bipyridine ligands (L = 4,4′-dialkyl-aminomethyl-2,2′-bipyridine; alkyl = octyl, dodecyl, octadodecyl) functionalized with bulky amino side groups is reported. Three homoleptic polypyridyl ruthenium(II) complexes [Ru(L)3]2+(PF6-)2 have been synthesized. These compounds were characterized and their photophys. properties examined The electronic spectra of three complexes show pyridyl π → π* transitions in the UV region and metal-to-ligand charge transfer bands in the visible region. In the experiment, the researchers used 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4HPLC of Formula: 138219-98-4)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. HPLC of Formula: 138219-98-4The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tripathi, Suparna; Hossain, Anowar; Seth, Saikat Kumar; Mukhopadhyay, Subrata published an article on February 15 ,2021. The article was titled 《Supramolecular association and quantification of intermolecular interactions of 4′-functionalized 2,2′:6′,2”-terpyridines: Experimental observation and theoretical studies》, and you may find the article in Journal of Molecular Structure.Synthetic Route of C20H14N4 The information in the text is summarized as follows:

Three versatile 4′-substituted 2,2′:6′,2”-terpyridine compounds (1-3) having different substitutions (4-ethoxyphenyl, 4-methoxyphenyl and pyridyl) at 4′-position of the central pyridine ring have been synthesized and structurally characterized. Three representative crystal structures have been determined through single crystal X-ray diffraction anal. X-ray crystallog. revels that the structures are stabilized through C-H···π and π-π stacking interactions. In the solid-state, the supramol. assemblies of the title compounds have been explored in detail. Compounds (1) and (3) exhibits both C-H···π and π-π interactions in building supramol. assemblies whereas compound (2) exhibit π-π interaction only. All the intermol. interactions that are involved within the structures are quantified through Hirshfeld surface analyses. The weak noncovalent interactions that played significant role in building supramol. assemblies are further characterized by Bader’s theory of ‘atoms-in-mols.’ (AIM). Finally, the supramol. networks are characterized by theor. ‘Noncovalent Interaction’ (NCI) plot index. The supramol. solid-state frameworks of three 4′-functionalized 2,2′:6′,2”-terpyridine derivatives have been quantified which are further characterized theor. by the Bader’s theory of ‘atoms-in-mols.'(AIM) and ‘noncovalent interaction’ (NCI) plot index. In the part of experimental materials, we found many familiar compounds, such as 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3Synthetic Route of C20H14N4)

4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Synthetic Route of C20H14N4 Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem