Day: October 19, 2022

In 2019,Angewandte Chemie, International Edition included an article by Bao, Xu; Wang, Qian; Zhu, Jieping. Product Details of 94928-86-6. The article was titled 《Dual Photoredox/Copper Catalysis for the Remote C(sp3)-H Functionalization of Alcohols and Alkyl Halides by N-Alkoxypyridinium Salts》. The information in the text is summarized as follows:

Under mild dual photoredox/copper catalysis, the reaction of N-alkoxypyridinium salts with readily available silyl reagents (TMSN3, TMSCN, TMSNCS) afforded δ-azido, δ-cyano, and δ-thiocyanato alcs. HOCH(R)(CH2)2C(R1)(R2)(R3) [R = H, Me, Et; R1 = n-Bu, Ph, (CH2)2OBn, etc.; R2 = H, Me; R1R2 = (CH2)4, (CH2)5; R3 = N3, CN, SCN] in high yields. The reaction proceeded through a domino process involving alkoxy radical generation, 1,5-hydrogen atom transfer (1,5-HAT) and copper-catalyzed functionalization of the resulting C-centered radical. Conditions for catalytic enantioselective δ-C(sp3)-H cyanation were also documented. In the experiment, the researchers used fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Product Details of 94928-86-6)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Product Details of 94928-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Drug and Chemical Toxicology (1977) included an article by Varol, Mehmet; Benkli, Kadriye; Koparal, Ayse T.; Bostancioglu, Rakibe B.. Name: 4,4′-Dimethyl-2,2′-bipyridine. The article was titled 《Design and synthesis of novel organometallic complexes using boronated phenylalanine derivatives as potential anticancer agents》. The information in the text is summarized as follows:

Drug design and discovery studies are important because of the prevalence of diseases without available medical cures. New anticancer agents are particularly urgent because of the high mortality rate associated with cancer. A series of mononuclear gold (III) and platinum (II) complexes based on boronated phenylalanine (BPA) were designed and synthesized using 4,4′-dimethyl-2,2′-dipyridyl (L1) or 1,10-phenanthroline-5,6-dion (L2) ligands to obtain promising anticancer drug candidates. Proton NMR, IR, mass spectrometry, and elemental analyses were utilized for chem. characterizations. Cell viability, cancer cell colony formation, endothelial tube formation, and cytoskeleton staining assays were performed using A549 lung adenocarcinoma and human umbilical vein endothelial cells (HUVECs) to investigate preliminary pharmacol. activities. L1-based platinum (II) complex (BPA-L1-Pt) was the most promising complex, and has similar activity with the approved chemotherapy drug cis-platinum. Half maximal inhibitory concentration values for BPA-L1-Pt were 9.15 μM on A549s and 16.61 μM on HUVECs; the values for cis-platinum were 5.24 μM on A549s and 23.14 μM on HUVECs. Consequently, further synthesis studies should be performed to boost the cancer cell selectivity feature of BPA by varying metal and ligand types. The experimental part of the paper was very detailed, including the reaction process of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Name: 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Name: 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Journal of Molecular Structure included an article by Ben Moussa, Oumaima; Chebbi, Hammouda; Zid, Mohamed Faouzi. Application of 141-86-6. The article was titled 《Synthesis, crystal structure, vibrational study, optical properties and Hirshfeld surface analysis of bis(2,6-diaminopyridinium) tetrachloridocobaltate(II) monohydrate》. The information in the text is summarized as follows:

The title organic-inorganic hybrid compound, (C5H8N3)2 [CoCl4]·H2O, was synthesized by slow evaporation at room temperature Single-crystal x-ray diffraction anal. indicates that the asym. unit in this compound consists of one tetrahedral geometry [CoCl4]2-, two protonated organic cations (C5H8N3)+ and one water mol. of crystallization, all of which lie in general positions. In the crystal structure, the inorganic layers are built from tetrachloridocobaltate anions [CoCl4]2- and free water mols., linked together by O-H···Cl hydrogen bonds. The organic cations are intercalated between the inorganic layers via N-H···Cl hydrogen bonds and form chains through aromatic donor-acceptor interactions. Crystal cohesion is achieved through N-H···Cl, O-H···Cl, N-H···O and C-H···Cl hydrogen bonds between organic cations, inorganic anions and the water mols. building up a three-dimensional network. The functional groups present in the crystal were studied by FTIR spectroscopy. Investigation of the optical properties of the compound confirmed its semiconducting properties by revealing a direct optical band gap at 1.67 eV. Photoluminescence proprieties are also reported. The three-dimensional Hirshfeld surface (3-dimensional-HS) anal. and the two-dimensional fingerprint plots (2-dimensional-FP) reveal that the structure is dominated by H···Cl/Cl···H and H···H contacts. After reading the article, we found that the author used 2,6-Diaminopyridine(cas: 141-86-6Application of 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Application of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Composites, Part B: Engineering included an article by Mohamadi, Mohadese; Kowsari, Elaheh; Haddadi-Asl, Vahid; Yousefzadeh, Maryam. Formula: C5H7N3. The article was titled 《Fabrication, characterization and electromagnetic wave absorption properties of covalently modified reduced graphene oxide based on dinuclear cobalt complex》. The information in the text is summarized as follows:

We are reporting on well-designed single-layered and gradient concentration triple-layered microwave-absorbing composites based on functionalized reduced graphene oxide (FRGO). The RGO-[Co2L2Cl3]Cl, called FRGO, was fabricated through systematic exptl. efforts by the covalent attachment of the 2,6-diamino-3-[(2-carboxylicacid) phenylazo]-pyridine (L)/Cobalt (Co) complex with graphene oxide (GO) functionalities. The formation of FRGO was proven by a series of characterization techniques, such as XPS, FTIR, XRD, Raman spectroscopy, FESEM, and TEM. The consideration of RGO-[Co2L2Cl3]Cl as a highly efficient microwave-absorbing material is a result of its magnetoelec. synergistic effect, impedance match, and multiple scattering. The maximum reflection loss (RL) of single-layered an RGO-[Co2L2Cl3]Cl/epoxy resin composite can reach -16.32 dB at 8.69 GHz, which corresponds to a composite with 30 wt % absorber loading and a thickness of 4.5 mm. For the triple-layered composite with increasing mass percentage (10-20-30 wt %) of RGO-[Co2L2Cl3]Cl in the direction of microwave propagation, the maximum reflection loss value of -34.9 dB can be achieved at 10.69 GHz, with a coating layer thickness of 4.5 mm. The result demonstrates that the RGO-[Co2L2Cl3]Cl/epoxy resin composites of both models can be ideal microwave-absorbing candidates for application in the X-band. In the part of experimental materials, we found many familiar compounds, such as 2,6-Diaminopyridine(cas: 141-86-6Formula: C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Formula: C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Journal of the Indian Chemical Society included an article by Sridevi, B.; Venkatesh, D.; Chitra, M.. Recommanded Product: 141-86-6. The article was titled 《Calculation of activation energy for unsaturated polyamide using fumaric acid and 2,6-diaminopyridine by modified Higashi-Yamazaki phosphorylation method》. The information in the text is summarized as follows:

With a view to examine the modification of polymer characteristics by the introduction of heterocyclic units in the polymer backbone it was proposed to synthesize and characterize unsaturated polyamides involving 2,6-diaminiopyridine and fumaric acid. Though the synthesis of these polyamide has been reported earlier by interfacial method, there is no systematic study seems to have been done to evaluate the kinetic parameters and biol. activity. In the present paper phosphorylation technique was employed to prepare the unsaturated polyamide and the results compared with the maleic acid to show the effect of cis-trans isomerism in thermal studies. After reading the article, we found that the author used 2,6-Diaminopyridine(cas: 141-86-6Recommanded Product: 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Recommanded Product: 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Selective high capacity adsorption of Au(III) from aqueous solution by poly(glycidyl methacrylate) functionalized with 2,6-diaminopyridine》 were Zhang, Bing; Wang, Shixing; Fu, Likang; Zhang, Libo; Zhao, Jiling; Wang, Chen. And the article was published in Polymer Bulletin (Heidelberg, Germany) in 2019. Safety of 2,6-Diaminopyridine The author mentioned the following in the article:

A new adsorbent was synthesized by functionalizing poly(glycidyl methacrylate) with 2,6-diaminopyridine for the selective adsorption of Au(III) from aqueous solution The fourier transform IR spectrometer, XPS and scanning electron microscope demonstrated that 2,6-diaminopyridine was successfully grafted onto poly(glycidyl methacrylate). The batch adsorption experiments were conducted to evaluate the adsorption abilities of the adsorbent. The results show that the adsorbent exhibits high adsorption capacity (459.29 mg/g) for Au(III) at pH 4. The adsorption process of Au(III) are well described by pseudo-second-order kinetic model. The adsorption isotherm is well-obeyed Langmuir and D-R models. The calculated thermodn. parameters of the adsorption process are: ΔG0 = – 24.2 kJ/mol; ΔH0 = 37.0 kJ/mol; ΔS0 = 205.4 J/mol K. The adsorbent is interacted with Au(III) through chelation and ion exchange between the amines groups and Au(III). Moreover, the adsorbent shows good selectivity from the interfering ions and can be reused at least five times. The experimental part of the paper was very detailed, including the reaction process of 2,6-Diaminopyridine(cas: 141-86-6Safety of 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Safety of 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Efficacy and tolerability of a nutraceutical combination of red yeast rice, guggulipid, and chromium picolinate evaluated in a randomized, placebo-controlled, double-blind study.》 were Iskandar, Irene; Harahap, Yahdiana; Wijayanti, Tri Rahayu; Sandra, Monika; Prasaja, Budi; Cahyaningsih, Prawitasari. And the article was published in Complementary therapies in medicine in 2019. Recommanded Product: Picolinic acid The author mentioned the following in the article:

Hypercholesterolemia is the major risk factor in the development of coronary heart disease. Coronary heart disease is a leading cause of morbidity and mortality in many countries worldwide. An increasing attention is now paid to nutraceuticals development for prevention and cure of dyslipidemia, especially for patients who do not wish to use chemical statins. The cholesterol lowering effect and the tolerability of NutraforChol®, a nutraceutical product containing red yeast rice extract, guggulipid extract and chromium picolinate, was evaluated on subjects who had total cholesterol level 200-239 mg/dL and LDL cholesterol level 100-159 mg/dL. In this study, a randomized, placebo-controlled, double-blind study which consisted of 4 weeks run-in period and 8 weeks treatment period was performed. Based on the study results, NutraforChol® effectively decreased total cholesterol (-15.9 %) and LDL level (-19.9 %) after two weeks consumption. The total cholesterol and LDL reduction were maintained during 8 weeks study period. At study termination (week 8), there was a significant difference between total cholesterol level of NutraforChol® treated group (173.5 ± 21.7 mg/dL) and placebo-treated group (204.5 ± 22.8 mg/dL) (p < 0.05). In addition, there was a significant difference between LDL level at week 8 in NutraforChol® group (115.5 ± 22.2 mg/dL) and placebo-treated group (145.1 ± 23.7 mg/dL) (p < 0.05). The tolerability of NutraforChol® was also evaluated. There were no significant changes (p > 0.05) on renal and liver function parameters between baseline and study termination. Thus, NutraforChol® may be considered as a complementary or alternative safe nutraceuticals for the treatment of mild dyslipidemic subjects. The experimental part of the paper was very detailed, including the reaction process of Picolinic acid(cas: 98-98-6Recommanded Product: Picolinic acid)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Recommanded Product: Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Direct access to 2-difluoromethyl indoles via photoredox catalysis》 were Rubinski, Miles A.; Lopez, Simon E.; Dolbier, William R. Jr.. And the article was published in Journal of Fluorine Chemistry in 2019. Reference of fac-Tris(2-phenylpyridine)iridium The author mentioned the following in the article:

A visible-light mediated approach to radical difluoromethylation of 3- and 3,5-substituted indoles was investigated using a readily synthesized difluoromethyl source, CF2HPPh3Br. Direct difluoromethylation of indoles in the two position is a rare feat in the literature. The reactions were conducted at room temperature, using Ir(ppy)3 as photocatalyst in acetone, afforded the 2-difluoromethyl indoles in relatively low to moderate yields. The experimental part of the paper was very detailed, including the reaction process of fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Reference of fac-Tris(2-phenylpyridine)iridium)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Reference of fac-Tris(2-phenylpyridine)iridium

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《pH-Switchable Coordinative Micelles for Enhancing Cellular Transfection of Biocompatible Polycations》 were Zhang, Qingyan; Zhou, Zhanwei; Li, Chenzi; Wu, Pengkai; Sun, Minjie. And the article was published in ACS Applied Materials & Interfaces in 2019. Category: pyridine-derivatives The author mentioned the following in the article:

Inefficient transfection of biocompatible low-mol.-weight (LMW) polycations, such as 1.8k polyethylenimine (PEI), is a major challenge for successful nucleic acid delivery. Current strategies to improve transfection efficiency are bottlenecked by maintaining the balance between efficient gene encapsulation and on-demand cargo release. Here, we developed a new class of Zn(II)-coordinated micelles, which showed tight small interfering RNA (siRNA) binding and pH-switchable release. The dipicolylamine-modified PEI 1.8k (PD) and dopamine-conjugated cholesterol (Chol-Dopa) assemble into coordinative micelles (Zn-PD/Chol-Dopa) via the coordination of 2,2′-dipicolylamine (DPA) and Dopa through Zn(II) as a bridge. The high phosphate-binding affinity of Zn-DPA enhanced the siRNA packaging and the interaction between cholesterol and cell membranes enhanced cellular uptake. Moreover, the coordination effect weakened in the acidic environment of lyso/endosome, triggering the disassembly of micelles and siRNA release. These properties of the micelles resulted in strong siRNA transfection efficiencies in various cell lines. Our strategy of constructing coordinative micelles improves the transfection efficiency of LMW PEI and holds tremendous potential to develop the endogenous responsive gene delivery systems. After reading the article, we found that the author used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Category: pyridine-derivatives)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Fluorescent enhancement sensing of cadmium (II) ion based on a perylene bisimide derivative》 were Xiong, Jiu-Kai; Wang, Ke-Rang; Wang, Kai-Xin; Han, Tian-Lei; Zhu, Hong-Yu; Rong, Rui-Xue; Cao, Zhi-Ran; Li, Xiao-Liu. And the article was published in Sensors and Actuators, B: Chemical in 2019. Category: pyridine-derivatives The author mentioned the following in the article:

A perylene bisimide derivative (PBI-Lac-DPA) with lactose and DPA moiety conjugates was synthesized, and this compound exhibited fluorescence turn-on sensing for Cd2+ ions in an aqueous solution with a binding constant of (6.0 ± 0.3) × 104 M-1, and detection limit of 5.2 ± 10-7 M. PBI-Lac-DPA exhibited high selectivity for the Cd2+ ion with a 2:1 binding stoichiometry between PBI-Lac-DPA and Cd2+ ions due to the addnl. coordinating sites in the self-assembly process of PBI-Lac-DPA itself. Furthermore, PBI-Lac-DPA exhibited fluorescence enhancement upon complexation with the Cd2+ ion in living cells. This work explored a new method for increasing the selectivity for Cd2+ ions via the enhanced addnl. complex sites of the DPA moiety from self-assembly process. In addition to this study using Bis(pyridin-2-ylmethyl)amine, there are many other studies that have used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Category: pyridine-derivatives) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem