Day: October 21, 2022

Demonti, Luca; Saffon-Merceron, Nathalie; Mezailles, Nicolas; Nebra, Noel published the artcile< Cross-Coupling through Ag(I)/Ag(III) Redox Manifold>, HPLC of Formula: 3796-23-4, the main research area is silver trifluoromethyl tervalent argentate preparation reductive elimination arylboronate; trifluoromethyl arene preparation coupling arylboronate trifluoromethylargentate reductive elimination; crystal mol optimized electronic structure tervalent trifluoromethyl argentate complex; AgIII chemistry; cross-coupling; fluorine; high-valent species; trifluoromethylation.

Trifluoromethyl argentates(III) undergo reductive elimination with arylboronic acids, yielding trifluoromethylarenes. In ample variety of transformations, the presence of silver as an additive or co-catalyst is believed to be innocuous for the efficiency of the operating metal catalyst. Even though Ag additives are required often as coupling partners, oxidants or halide scavengers, its role as a catalytically competent species is widely neglected in cross-coupling reactions. Most likely, this is due to the erroneously assumed incapacity of Ag to undergo 2e- redox steps. Definite proof is herein provided for the required elementary steps to accomplish the oxidative trifluoromethylation of arenes through AgI/AgIII redox catalysis (i. e. CEL coupling), namely: (i) easy AgI/AgIII 2e- oxidation mediated by air; (ii) bpy/phen ligation to AgIII; (iii) boron-to-AgIII aryl transfer; and (iv) ulterior reductive elimination of benzotrifluorides from an [aryl-AgIII-CF3] fragment. More precisely, an ultimate entry and full characterization of organosilver(III) compounds [K]+[AgIII(CF3)4]- (K-1), [(bpy)AgIII(CF3)3] (2) and [(phen)AgIII(CF3)3] (3), is described. The utility of 3 in cross-coupling has been showcased unambiguously, and a large variety of arylboron compounds was trifluoromethylated via [AgIII(aryl)(CF3)3]- intermediates. This work breaks with old stereotypes and misconceptions regarding the inability of Ag to undergo cross-coupling by itself.

Chemistry – A European Journal published new progress about Boronic acids, esters Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (arylboronates). 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, HPLC of Formula: 3796-23-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Funk, Bernhard; Kirmayer, David; Sahar-Heft, Sharonit; Gati, Irith; Friedman, Michael; Steinberg, Doron published the artcile< Efficacy and potential use of novel sustained release fillers as intracanal medicaments against Enterococcus faecalis biofilm in vitro>, HPLC of Formula: 123-03-5, the main research area is Enterococcus cetylpyridinium chloride vancomycin biofilm solidification; Cetylpyridinium chloride; E. faecalis biofilm; Intracanal medication; Sustained release.

Enterococcus faecalis is a bacterium frequently isolated after failed root canal therapy. First, the solidification capability was tested by introducing liquid SRF into phosphate buffered saline, followed by 30 s of vortexing. The antimicrobial effects of SRF-CPC against static monospecies biofilms were analyzed with a metabolic assay. Inhibition of biofilm formation was tested by exposing daily refreshed E. faecalis suspensions to SRF-CPC for 9 wk. To evaluate the effects of SRF-CPC against preformed biofilms, biofilms were grown for 1, 3 and 7 days, and then treated with SRF-CPC for 24 h. Biofilm kill time was tested by applying SRF-CPC to a 3-day-old biofilm and measuring its viability at different time points. All experiments were compared to Placebo SRFs and to untreated control biofilms. Data were analyzed with two-way ANOVA followed by Tukey’s test. Results were considered significant at P < 0.05. The liquid SRF solidified within seconds and no structural changes were observed after 30 s of vortexing at maximum speed. SRF-CPC inhibited E. faecalis biofilm formation for 7 wk and significantly reduced its viability in weeks 8 and 9. Mature biofilms grown for 1, 3 and 7 days were destructed by SRF-CPC in less than 24 h. Fifty percent of a 3-day-old biofilm was destructed in 2 h and complete destruction occurred in less than 12 h. SRF-CPC's phys. properties and long-lasting anti-biofilm effects make it a promising coadjuvant medication for endodontic therapy. BMC Oral Health published new progress about Biofilms (microbial), schmutzdecke. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, HPLC of Formula: 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kuehn, Laura; Jammal, Dominik G.; Lubitz, Katharina; Marder, Todd B.; Radius, Udo published the artcile< Stoichiometric and Catalytic Aryl-Cl Activation and Borylation using NHC-stabilized Nickel(0) Complexes>, Related Products of 329214-79-1, the main research area is bond activation aryl chloride borylation nickel NHC complex catalyst; crystal structure mol nickel heterocyclic carbene complex preparation; bond activation; boronates; borylation; carbene ligands; homogeneous catalysis; nickel.

NHC-nickel (NHC = N-heterocyclic carbene) complexes are efficient catalysts for the C-Cl bond borylation of aryl chlorides using NaOAc as a base and B2pin2 (pin = pinacolato) as the boron source. The catalysts [Ni2(ICy)4(μ-(η2:η2)-COD)] (1, ICy = 1,3-dicyclohexylimidazolin-2-ylidene; COD = 1,5-cyclooctadiene), [Ni(ICy)2(η2-C2H4)] (2), and [Ni(ICy)2(η2-COE)] (3, COE = cyclooctene) compare well with other nickel catalysts reported previously for aryl-chloride borylation with the advantage that no further ligands had to be added to the reaction. Borylation also proceeded with B2neop2 (neop = neopentylglycolato) as the boron source. Stoichiometric oxidative addition of different aryl chlorides to complex 1 was highly selective affording trans-[Ni(ICy)2(Cl)(Ar)] (Ar = 4-(F3C)C6H4, 11; 4-(MeO)C6H4, 12; C6H5, 13; 3,5-F2C6H3, 14).

Chemistry – A European Journal published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Related Products of 329214-79-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Saeidikhoo, Sara; Ezi, Samira; Khatmi, Aysan; Aghajanpour, Fakhroddin; Soltani, Reza; Abdollahifar, Mohammad Amin; Jahanian, Ali; Aliaghaei, Abbas published the artcile< Effect of Sertoli Cell Transplantation on Reducing Neuroinflammation-Induced Necroptosis and Improving Motor Coordination in the Rat Model of Cerebellar Ataxia Induced by 3-Acetylpyridine>, Quality Control of 350-03-8, the main research area is acetylpyridine antiinflammatory agent neuroinflammation cerebellar ataxia; Cell transplantation; Cerebellar ataxia; Neurodegeneration; Sertoli cells.

To date, no certain cure has been found for patients with degenerative cerebellar disease. In this trial, we examined the in vivo and in vitro neuroprotective effects of Sertoli cells (SCs) on alleviating the symptoms of cerebellar ataxia. Testicular cells from an immature male rat were isolated and characterized by immunocytochem. anal. for somatic cell markers (anti-Mullerian hormone, vimentin). The protein assessment had already confirmed the expression of neurotrophic factors of glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial factor (VEGF). In vitro neuroprotective impact of SCs was determined after exposing PC12 cells to Sertoli cell-conditioned media (SC-CM) and H2O2, simultaneously. Afterwards, ataxia rat models were induced by a single dose of 3-AP (3-acetylpyridin), and 3 days later, SCs were bilaterally implanted. Motor and neuromuscular activity test were conducted following SC transplantation. Finally, immunohistochem. against RIPK3 and Iba-1 was done in our generation. The in vivo results revealed substantial improvement in neuromuscular response, while ataxia group exhibited aggravated condition over a 28-day period. Our results suggested enhanced motor function and behavioral characteristics due to the ability of SCs to suppress necroptosis and consequently extend cell survival. Nevertheless, more studies are required to affirm the therapeutic impacts of SC transplantation in human cerebellar ataxia. In vitro data indicated cell viability was increased as a result of SC-CM with a significant reduction in ROS.

Journal of Molecular Neuroscience published new progress about Cell morphology. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Quality Control of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chebotarev, Alexander N.; Pliuta, Konstantin V.; Snigur, Denys V. published the artcile< Determination of Carmoisine onto Carbon-Paste Electrode Modified by Silica Impregnated with Cetylpyridinium Chloride>, Safety of 1-Hexadecylpyridin-1-ium chloride, the main research area is carmoisine carbon electrode silica cetylpyridinium chloride soft drinks analysis.

In this paper a simple, cheap and sensitive electrochem. sensor for determination of Carmoisine in soft drinks was developed. Carmoisine is a synthetic azo dye which is used in food products. In this work effective voltammetric sensor based on carbon-paste electrode modified by silica impregnated with cetylpyridinium chloride to increase the sensitivity of Carmoisine detection was proposed. The voltammetric behavior of Carmoisine, the number of protons and electrons involved in the oxidation process were studied. The probable mechanism of Carmoisine oxidation on the developed sensor was suggested. The optimal conditions for the square-wave voltammetric determination of Carmoisine onto developed sensor were found to be: pH=2; Eads=400 mV; tads=300s; A=50 mV; ν=25 Hz, υ=100 mV/s. The calibration curve was linear in the range of Carmoisine concentrations 0,08-1μM. The proposed method was successfully tested in the anal. of Carmoisine in soft drinks with RSD not more than 5%.

ChemistrySelect published new progress about Carbonated beverages. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Safety of 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gao, Xu-Sheng; Dai, Hai-Jie; Tang, Yuerou; Ding, Mei-Juan; Pei, Wen-Bo; Ren, Xiao-Ming published the artcile< Crystal Structures, Photoluminescence, and Magnetism of Two Novel Transition-Metal Complex Cocrystals with Three-Dimensional H-Bonding Organic Framework or Alternating Noncovalent Anionic and Cationic Layers>, Category: pyridine-derivatives, the main research area is copper zinc bipyridine benzenedicarboxylate cocrystal photoluminescence magnetism crystal structure; transition metal complex cocrystal hydrogen bonding organic framework.

Cocrystn. may alter material physicochem. properties; thus, the strategy of forming a cocrystal is generally used to improve the material performance for practical applications. In this study, two transition-metal complex cocrystals [Zn(bpy)3]H0.5BDC·H1.5BDC·0.5bpy·3H2O (1) and [Cu2(BDC)(bpy)4]BDC·bpy·2H2O (2) have been achieved using a hydrothermal reaction, where bpy and H2BDC represent 2,2′-bipyridine and benzene-1,3-dicarboxylic acid, resp. Cocrystals were characterized by microanal., IR spectroscopy, and UV-visible spectroscopy. Cocrystal 1 contains five components and crystallizes in a monoclinic space group P21/n. The H0.5BDC1.5-, H1.5BDC0.5-, and H2O mols. construct three-dimensional H-bonding organic framework; the [Zn(bpy)3]2+ coordination cations and uncoordinated bpy mols. reside in channels, where two coordinated bpy ligands in [Zn(bpy)3]2+ and one uncoordinated bpy adopt sandwich-type alignment via π···π stacking interactions. Cocrystal 2 with four components crystallizes in a triclinic space group P-1 to form alternating layers; the binuclear [Cu2(bpy)4(BDC)]2+ cations and uncoordinated bpy mols. build the cationic layers, and the BDC2- species with disordered lattice water mols. form the anionic layers. Cocrystal 1 shows intense photoluminescence at an ambient condition with a quantum yield of 14.96% and decay time of 0.48 ns, attributed to the π* → π electron transition within phenyl/pyridyl rings, and 2 exhibits magnetic behavior of an almost isolated spin system with rather weak antiferromagnetic coupling in the [Cu2(bpy)4(BDC)]2+ cation.

ACS Omega published new progress about Antiferromagnetic exchange. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dong, Guoqiang; Chen, Wei; Wang, Xia; Yang, Xinglin; Xu, Tianying; Wang, Pei; Zhang, Wannian; Rao, Yu; Miao, Chaoyu; Sheng, Chunquan published the artcile< Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors>, Synthetic Route of 56622-54-9, the main research area is preparation NAMPT HDAC dual inhibitor cancer; antitumor preparation nicotinamide phosphoribosyltransferase histone deacetylase inhibitor.

Cancer metabolism and epigenetics are among the most intensely pursued research areas in anticancer drug discovery. Here we report the first small mols. that simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT)and histone deacetylase (HDAC), two important targets of cancer metabolism and epigenetics, resp. Through iterative structure-based drug design, chem. synthesis, and biol. assays, a highly potent dual NAMPT and HDAC inhibitor was successfully identified. Compound 35 possessed excellent and balanced activities against both NAMPT (IC50 = 31 nM) and HDAC1 (IC50 = 55 nM). It could effectively induce cell apoptosis and autophagy and ultimately led to cell death. Importantly, compound 35 showed excellent in vivo antitumor efficacy in the HCT116 xenograft model. This proof-of-concept study demonstrates the feasibility of discovering an inhibitor targeting cancer metabolism and epigenetics and provides an efficient strategy for multitarget antitumor drug discovery.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 56622-54-9 belongs to class pyridine-derivatives, and the molecular formula is C7H10N2, Synthetic Route of 56622-54-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Ze-Kun; Lin, Jia-Le; Zhang, Yun-Chang; Yang, Chen-Wu; Zhao, Ya-Kun; Leng, Zheng-Wei; Wang, Hui; Zhang, Dan-Wei; Zhu, Jiang; Li, Zhan-Ting published the artcile< Synthesis and short DNA in situ loading and delivery of 4 nm-aperture flexible organic frameworks>, Related Products of 55279-29-3, the main research area is flexible organic framework short DNA loading delivery synthesis.

Five water-soluble flexible organic frameworks have been synthesized from a pyridinium-derived tetracationic tetraaldehyde and five diacylhydrazines (1 : 2) through the quant. formation of a hydrazone bond in water at ambient temperature Dynamic light scattering experiments reveal that the homogeneous frameworks display hydrodynamic diameters ranging from 68 nm to 167 nm, which can be tuned by changing the concentration of the components. Mol. modeling shows that, when adopting an ideal, extended conformation, the frameworks form an aperture of 4 nm diameter The new flexible frameworks are generally of low cytotoxicity. Fluorescence imaging and flow cytometric anal. demonstrate that the new flexible porous frameworks can quickly include single and double stranded DNA of 21 nucleotides and deliver the included DNA into both normal and cancer cells, with the percentage of delivered cells reaching up to 99.5%.

Materials Chemistry Frontiers published new progress about Bioconcentration. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, Related Products of 55279-29-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chitti, Surendar; Pulya, Sravani; Nandikolla, Adinarayana; Patel, Tarun Kumar; Banoth, Karan Kumar; Murugesan, Sankaranarayanan; Ghosh, Balaram; Chandra Sekhar Kondapalli, Venkata Gowri published the artcile< Design, synthesis and structure-activity relationship studies of novel spirochromanone hydrochloride analogs as anticancer agents>, Recommanded Product: Pyridin-4-ylmethanamine, the main research area is aminomethylphenyl spirochromanepiperidineone preparation anticancer mol docking SAR cytotoxicity; anticancer; apoptosis; cytotoxicity; molecular docking; spiro-[chromane-2,4′-piperidine]-4-one.

The authors designed and synthesized 18 spirochromanone derivs I [R = isopropylamino, cyclopentylamino, 4-methoxycyclohexylamino etc.]. The compounds I were characterized and evaluated for anticancer activity against human breast cancer (MCF-7) and murine melanoma (B16F10) cell lines. The anticancer activity ranged from 4.34 to 29.31 μm. The most potent compounds, I [R = dimethylamino, benzylamino] were less toxic against the human embryonic kidney (HEK-293) cell line and ∼ two/∼fourfold selective toward MCF-7 than B16F10 in comparison to the reference, BG-45. Compound , I [R = benzylamino] caused 28.6% total apoptosis, leading to significant cytotoxicity, and arrested the G2 phase of the cell cycle in B16F10 cells. A mol. docking study of compound , I [R = benzylamino] exhibited effective binding at the active site of the epidermal growth factor receptor kinase domain. This study highlights the importance of spirochromanones as anticancer agents.

Future Medicinal Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Recommanded Product: Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hooda, Anjli; Nehra, Kapeesha; Dalal, Anuj; Singh, Sitender; Kumar Saini, Raman; Kumar, Sanjay; Singh, Devender published the artcile< Terbium complexes of an asymmetric β-diketone: Preparation, photophysical and thermal investigation>, Formula: C10H8N2, the main research area is preparation terbium asym beta diketonate substituted bipyridin complex; thermal decomposition terbium asym beta diketonate substituted bipyridin complex; luminescence terbium asym beta diketonate substituted bipyridin complex; emission spectra terbium asym beta diketonate substituted bipyridin complex; band gap terbium asym beta diketonate substituted bipyridin complex; cyclic voltammetry terbium asym beta diketonate substituted bipyridin complex; chromaticity terbium asym beta diketonate substituted bipyridin complex.

Chromophoric 1,3-diketone ligand was used to prepare novel ternary complexes of terbium with differently substituted 2,2′-bipyridines as auxiliary ligands. These prepared complexes were thoroughly studied with the help of numerous spectroscopic techniques. IR spectral anal. suggested the coordination of diketone and ancillary ligand to the Tb(III) ion through oxygen and nitrogen atom, resp. Photoluminescence emission spectra of complexes have displayed only characteristic peaks of Tb3+ ion suggesting the efficient sensitization of metal ion by chromophoric ligands. Emission spectra of all complexes have displayed the ligand sensitized green emission due to the 5D4→7F5 transition situated at ∼548 nm. Colorimetric study and color purity of complexes reveal the green luminous character of synthesized complexes. Thermogravimetric measurements revealed the thermal stability of the complexes. Optical and electronic band gaps are in good agreement with each other that shows their importance as semiconductor material. These trivalent complexes of terbium could be used as the green component in displays and light emissive materials.

Inorganica Chimica Acta published new progress about Absorption spectra. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Formula: C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem