Day: October 21, 2022

Cheng, Xiayun; Taylor, Alexandria P.; Zhu, Kaicheng published the artcile< Synthesis of Substituted 2-Pyridones via 6π-Electrocyclization of Dienyl Isocyanates>, Name: Methyl 3-bromo-2-pyridinecarboxylate, the main research area is substituted pyridone preparation; dienyl isocyanate pi electrocyclization Curtius.

A one-pot Curtius rearrangement of dienyl carboxylic acids followed by a 6π-electrocyclization process to form substituted 2-pyridone products was developed. Dienyl isocyanates generated from aliphatic acids were more reactive than their aromatic counterparts. Addnl., substitution patterns of the carboxylic acids had an impact on the efficiency of the cyclization.

Journal of Organic Chemistry published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 53636-56-9 belongs to class pyridine-derivatives, and the molecular formula is C7H6BrNO2, Name: Methyl 3-bromo-2-pyridinecarboxylate.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shi, Buyin; Xu, Yang; Wang, Tianqi; Gao, Shengguang; Meng, Guojie; Huang, Kun published the artcile< Ag nanoparticles encapsulated in carboxyl-functionalized hollow microporous organic nanospheres for highly efficient catalysis applications>, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane, the main research area is carboxyl functionalized hollow microporous organic nanosphere silver nanoparticle; catalysis application.

In this work, we present a novel synthesis of Ag nanoparticles encapsulated in carboxyl-functionalized hollow microporous organic nanospheres (Ag@COOH-HMONs) by a combination of hyper-crosslinking mediated self-assembly and simply impregnation method, in which the COOH-HMONs supports were prepared via a Friedel-Crafts alkylation reaction by using polylactide-b-poly(tertbutyl acrylate)-b-polystyrene (PLA-b-PtBA-b-PS) triblock copolymer as precursors. Owing to the abundant carboxyl groups in the cavity of COOH-HMONs, highly dispersed silver nanoparticles can be successfully anchored into COOH-HMONs to produce Ag@COOH-HMONs via an ion exchange with AgNO3 following by an in-situ reduction of sodium borohydride (NaBH4). The obtained Ag@COOH-HMONs exhibit the high catalytic activities for the reduction of MB and nitroarom. compounds as well as selective oxidation of thiol and styrene due to their high surface area, hierarchical porosity and yolk-shell nanostructure. This approach of constructing novel metal@porous organic polymers is expected to open doors for new types of yolk-shell structural catalysts for practical applications.

Applied Catalysis, A: General published new progress about Aromatic nitro compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sung, Hui-Ling; Hu, Zhi-Jia; Chen, Chong-You; Wu, Jing-Yun published the artcile< Thermally stable dinuclear Co(II) and Zn(II) complexes of tetra-phosphonate and 2,2'-bipyridine>, Quality Control of 366-18-7, the main research area is tetrakis phosphorylmethyl benzene dinuclear cobalt zinc bipyridine preparation structure; crystal mol structure dinuclear cobalt zinc bipyridine tetra phosphonate.

Two dinuclear phosphonate-based transition metal complexes, [Co2(H6tpmb)2(2,2′-bipy)2(H2O)2] (1) and [Zn2(H6tpmb)2(2,2′-bipy)2] (2), have been synthesized at 60° by the reactions of 1,2,4,5-tetrakis(phosphorylmethyl)benzene (H8tpmb) and 2,2′-bipyridine (2,2′-bipy) ligands, with CoCl2·6H2O and Zn(NO3)2·6H2O, resp. These two complexes are characterized by single-crystal x-ray diffraction, XRD, IR and elemental anal. Complexes 1 and 2 both adopt dinuclear macrocycle structures in which the Co(II) center in the former has an octahedral coordination geometry of {CoN2O4} while the Zn(II) center in the latter shows a square pyramidal coordination geometry of {ZnN2O3} with a τ value of 0.01. The H8tpmb ligand adopting the cis,trans,cis,trans conformation was partially deprotonated to be the H6tpmb2- dianion in both complexes 1 and 2. TG anal. shows that complexes 1 and 2 both are thermally stable upon heating to 250°.

Inorganica Chimica Acta published new progress about Coordination sphere. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Quality Control of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jin, Songyang; Geng, Xinxin; Li, Yujun; Zheng, Ke published the artcile< Phosphoric Acid Mediated Light-Induced Minisci C-H Alkylation of N-Heteroarenes>, Recommanded Product: 3-(Methoxycarbonyl)pyridine, the main research area is green phosphate catalyst Minisci alkylation heteroarene redox active ester.

Herein, we report an environmentally-friendly light-induced Minisci alkylation of N-heteroarenes with a broad substrate scope using di-Ph phosphate as catalyst under metal- and photocatalyst-free conditions. The radical precursor redox-active esters (RAEs) were introduced as alkylating reagents for the functionalization of N-heteroarene derivatives including pyridine, quinoline, and isoquinoline. Mechanistic studies suggested that di-Ph phosphate played a key role via hydrogen bonding in the catalytic cycle.

European Journal of Organic Chemistry published new progress about Alkylation (Minisci). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Recommanded Product: 3-(Methoxycarbonyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ritter, Helmut; Kaiser, M. published the artcile< Proton NMR spectra of nitrated aminopyridines>, Recommanded Product: 6-Amino-3-nitro-2-picoline, the main research area is NMR nitrated aminopyridine hydrogen bond; pyridine aminonitro NMR; steric hindrance hydrogen bond aminonitropyridine.

The 1H NMR spectra of 26 nitrated aminopyridines were measured and interpreted. Chem. shift assignments were based on existing chem. shift rules for substituted pyridines and spectral comparison with compounds of similar structure. Some o-aminonitropyridines were found to give a splitting of the amino signals due to intermol. hydrogen bonding; steric hindrance is shown to influence this bonding.

Magnetic Resonance in Chemistry published new progress about Intramolecular hydrogen bond. 22280-62-2 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Recommanded Product: 6-Amino-3-nitro-2-picoline.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pierre, Fabrice; Chua, Peter C.; O’Brien, Sean E.; Siddiqui-Jain, Adam; Bourbon, Pauline; Haddach, Mustapha; Michaux, Jerome; Nagasawa, Johnny; Schwaebe, Michael K.; Stefan, Eric; Vialettes, Anne; Whitten, Jeffrey P.; Chen, Ta Kung; Darjania, Levan; Stansfield, Ryan; Anderes, Kenna; Bliesath, Josh; Drygin, Denis; Ho, Caroline; Omori, May; Proffitt, Chris; Streiner, Nicole; Trent, Katy; Rice, William G.; Ryckman, David M. published the artcile< Discovery and SAR of 5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic Acid (CX-4945), the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancer>, Reference of 53636-56-9, the main research area is naphthyridinecarboxylic acid derivative CX4945 preparation antitumor structure activity; protein kinase CK2 target antitumor CX 4945 preparation.

Herein we chronicle the discovery of CX-4945 (I), a first-in-class, orally bioavailable ATP-competitive inhibitor of protein kinase CK2 in clin. trials for cancer. CK2 has long been considered a prime cancer drug target because of the roles of deregulated and overexpressed CK2 in cancer-promoting pro-survival and antiapoptotic pathways. These biol. properties as well as the suitability of CK2’s small ATP binding site for the design of selective inhibitors, led us to fashion novel therapeutic agents for cancer. The optimization leading to I (Ki = 0.38 nM) was guided by mol. modeling, suggesting a strong binding of I resulting from a combination of hydrophobic interactions, an ionic bridge with Lys68, and hydrogen bonding with the hinge region. I was highly selective, orally bioavailable across species (20-51%) and efficacious in xenograft models. The discovery of I will allow the therapeutic targeting of CK2 in humans for the first time.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 53636-56-9 belongs to class pyridine-derivatives, and the molecular formula is C7H6BrNO2, Reference of 53636-56-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Potapov, V. A.; Ishigeev, R. S.; Shkurchenko, I. V.; Amosova, S. V. published the artcile< Assembling of Thiazolo[3,2-a]pyridinium Salts via the Reaction of 2-Pyridinesulfenyl Halides with Vinyl Ethyl Ether>, Category: pyridine-derivatives, the main research area is pyridinesulfenyl halide vinyl ethyl ether regioselective heterocyclization; ethoxy thiazolopyridinum halide preparation.

The regio- and stereoselective synthesis of 3-ethoxy-2H,3H-[1,3]thiazolo[3,2-a]pyridin-4-ium halides via the reaction of 2-pyridinesulfenyl halides with vinyl Et ether was elaborated.

Russian Journal of General Chemistry published new progress about Ethers Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Ruiting; Tzounopoulos, Thanos; Wipf, Peter published the artcile< Synthesis and Optimization of Kv7 (KCNQ) Potassium Channel Agonists: The Role of Fluorines in Potency and Selectivity>, Formula: C7H7F3N2, the main research area is KCNQ potassium channel agonist preparation structure.

Based on the potent Kv7 agonist RL-81, we prepared new lead structures with greatly improved selectivity for Kv7.2/Kv7.3 over related potassium channels, i.e., Kv7.3/Kv7.5, Kv7.4, and Kv7.4/7.5. RL-36 and RL-12 maintain an agonist EC2x of ca. 1 μM on Kv7.2/Kv7.3 in a high-throughput assay on an automated electrophysiol. platform in HEK293 cells but lack activity on Kv7.3/Kv7.5, Kv7.4, and Kv7.4/7.5, resulting in a selectivity index SI > 10. RL-56 is remarkably potent, EC2x 0.11 ± 0.02 μM, and still shows an SI = 2.5. We also identified analogs with significant selectivity for Kv7.4/Kv7.5 over Kv7.2/Kv7.3. The extensive use of fluorine in iterative core structure modifications highlights the versatility of these substituents, including F, CF3, and SF5, to span orders of magnitude of potency and selectivity in medicinal chem. lead optimizations.

ACS Medicinal Chemistry Letters published new progress about Homo sapiens. 387350-39-2 belongs to class pyridine-derivatives, and the molecular formula is C7H7F3N2, Formula: C7H7F3N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Keping; Ding, Chengqiang; Liu, Xiaolin; Gao, Jun; Wu, Datong; Qin, Yong; Kong, Yong published the artcile< A redox and pH dual-triggered drug delivery platform based on chitosan grafted tubular mesoporous silica>, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane, the main research area is chitosan tubular mesoporous silica hydrogen ion concentration drug delivery.

Tubular mesoporous silica (T-mSiO2) was facilely synthesized through a co-template method by using cetyltrimethylammonium bromide and α-Fe2O3 as the dual templates, and then disulfide (-SS-) bonds and carboxyl groups (-COOH) were introduced to the resultant T-mSiO2 via the reaction with 2-carboxyethyl 2-pyridyl disulfide. The obtained -SS- grafted T-mSiO2 (SS-T-mSiO2) was then grafted with chitosan (CS) via the amidation reaction between the -COOH groups on SS-T-mSiO2 and the -NH2 groups on CS. The CS grafted SS-T-mSiO2 (CS-SS-T-mSiO2) was fully characterized by various technologies such as transmission electron microscopy, energy dispersive X-ray spectroscopy and Fourier transform IR spectroscopy. Finally, the as-synthesized CS-SS-T-mSiO2 was used as the carrier for redox and pH dual-triggered delivery of 5-fluorouracil (5-FU), an anti-cancer drug, and the results indicate that the developed CS-SS-T-mSiO2 might be a potential responsive carrier for redox and pH dual-triggered drug delivery.

Ceramics International published new progress about Amidation. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wan, Yupeng; Lyu, Heng; Du, Hengyi; Wang, Dunjia; Yin, Guodong published the artcile< Synthesis and photophysical properties of europium pentafluorinated β-diketonate complexes>, Product Details of C10H8N2, the main research area is preparation europium pentafluorinated beta diketonate dipyridine phenanthroline complex; photoluminescence europium pentafluorinated beta diketonate dipyridine phenanthroline complex; thermal decomposition europium pentafluorinated beta diketonate dipyridine phenanthroline complex.

Two pentafluorinated β-diketone ligands, 4,4,5,5,5-pentafluoro-1-(4-methoxyphenyl)pentane-1,3-dione (PFMP) and 4,4,5,5,5-pentafluoro-1-(4-dimethyl amino-phenyl)pentane-1,3-dione (PFAP), had been employed to synthesize six novel europium(III) complexes with ancillary ligands 2,2-dipyridine, 1,10-phenanthroline and 4,7-diphenyl-1,10-phenanthroline. The synthesized europium(III) complexes were characterized by FTIR, 1H NMR, UV-visible, luminescence spectroscopy, elemental anal. and TGA. The photoluminescence spectra of these complexes showed the typical europium(III) red emissions in solid state and chloroform solution, assigned to 5D0 → 7Fj (j = 0-4) transitions. The higher values of intensity parameter Ω2 indicated that the europium ion was in a highly polarizable ligand field in these complexes. Europium(III) complexes with the β-diketone PFMP exhibited much better photoluminescence properties than complexes with the β-diketone PFAP. Especially, the europium(III) complex of the β-diketone PFMP with the auxiliary ligand 2,2-dipyridine displayed the longest lifetime value, the highest quantum yield and good CIE color coordinates matching the pure red color (x = 0.67, y = 0.33) in these complexes. In addition, the proposed energy transfer mechanisms and the thermal stability of these complexes were also studied and analyzed.

Research on Chemical Intermediates published new progress about Emission spectra. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Product Details of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem