Day: October 21, 2022

Nallagonda, Rajender; Musaev, Djamaladdin G.; Karimov, Rashad R. published the artcile< Light-Promoted Dearomative Cross-Coupling of Heteroarenium Salts and Aryl Iodides via Nickel Catalysis>, Computed Properties of 93-60-7, the main research area is dihydropyridine aryl preparation regioselective; aryl iodide pyridinium dearomative cross coupling nickel iridium photocatalyst.

Herein, the coupling of aryl iodides, e.g., Ph iodide with pyridinium and related heteroarenium salts, e.g., I catalyzed by Ni/bpp and an Ir photocatalyst using Zn as a terminal reductant was reported. This methodol. tolerates a wide range of functional groups and allows the coupling of aryl and heteroaryl iodides, thus significantly expanding the scope of nitrogen heterocycle scaffolds, e.g., II that could be prepared through dearomatization of heteroarenes. The reaction products have been further functionalized to prepare various nitrogen heterocycles. Initial mechanistic studies indicate that the reaction described herein goes through a unique mechanism involving dimers of dihydroheteroarenes.

ACS Catalysis published new progress about Aryl iodides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Computed Properties of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Qing-Dong; Zhang, Si-Xuan; Zhang, Zhuo-Wen; Wang, Ying; Ma, Mengtao; Chu, Xue-Qiang; Shen, Zhi-Liang published the artcile< Palladium-Catalyzed Sonogashira Coupling of a Heterocyclic Phosphonium Salt with a Terminal Alkyne>, Safety of 3-(Methoxycarbonyl)pyridine, the main research area is palladium copper catalyst Sonogashira coupling heterocyclic phosphonium terminal alkyne; pyridine quinoline pyrazine quinoxaline alkynyl preparation functionalized.

An efficient Sonogashira coupling of a heterocyclic phosphonium salt with a terminal alkyne via C-P bond cleavage was developed. The reactions proceeded smoothly in the presence of palladium catalyst, copper(I) iodide, and N,N-diisopropylethylamine (DIPEA) in N-methyl-2-pyrrolidone (NMP) at 100°C for 12 h, producing the corresponding alkynyl-substituted pyridine, quinoline, pyrazine, and quinoxaline in moderate to good yields with wide substrate scope and broad functional group tolerance. In addition, gram-scale synthesis could also be achieved, and the reaction could be applied to the functionalization of alkyne-containing complex mols. derived from sugars and pharmaceutical and naturally occurring products (e.g., estrone, D-galactopyranose, menthol, and ibuprofen).

Organic Letters published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Safety of 3-(Methoxycarbonyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Doan, Viet Sang; Saingam, Prakit; Yan, Tao; Shin, Sangwoo published the artcile< A Trace Amount of Surfactants Enables Diffusiophoretic Swimming of Bacteria>, Name: 1-Hexadecylpyridin-1-ium chloride, the main research area is surfactant bacteria diffusionphoresis; bacteria; biofilms; diffusiophoresis; surface charge; surfactants.

From birth to health, surfactants play an essential role in the authors’ lives. Due to the importance, their environmental impacts are well understood. One of the aspects that has been extensively studied is their impact on bacteria, particularly on their motility. Here, the authors uncover an alternate chemotactic strategy triggered by surfactants-diffusiophoresis. Even a trace amount of ionic surfactants, down to a single ppm level, can promote the bacterial diffusiophoresis by boosting the surface charge of the cells. Because diffusiophoresis is driven by the surface-solute interactions, surfactant-enhanced diffusiophoresis is observed regardless of the types of bacteria. Whether Gram-pos. or -neg., flagellated or nonflagellated, the surfactants enable fast migration of freely suspended bacteria, suggesting a ubiquitous locomotion mechanism that has been largely overlooked. The authors also demonstrate the implication of surfactant-enhanced bacterial diffusiophoresis on the rapid formation of biofilms in flow networks, suggesting environmental and biomedical implications.

ACS Nano published new progress about Bacteria. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Name: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chutvirasakul, Boonta; Nuchtavorn, Nantana; Macka, Mirek; Suntornsuk, Leena published the artcile< Distance-based paper device using polydiacetylene liposome as a chromogenic substance for rapid and in-field analysis of quaternary ammonium compounds>, Formula: C21H38ClN, the main research area is paper device polydiacetylene liposome chromogenic substance quaternary ammonium compound; Distance-based microfluidic paper-based device; In-field analysis; Polydiacetylene; Quaternary ammonium compounds.

This work presents an affordable distance-based microfluidic paper-based device (μPAD), using polydiacetylene (PDA) liposome as a chromogenic substance with a smartphone-based photo editor, for rapid and in-field anal. of quaternary ammonium compounds (QACs) (e.g., didecyldimethylammonium chloride (DDAC), benzyldimethyltetradecyl ammonium chloride (BAC), and cetylpyridinium chloride (CPC)). In-field anal. of these compounds is important to ensure their antimicrobial activity and user safety since they are widely used as disinfectants in households and hospitals. The μPAD featured a thermometer-like shape consisting of a sample reservoir and a microchannel as the detection zone, which was pre-deposited with PDA liposome. The color change from blue to red appeared in the presence of QACs and the color bar lengths were proportional to the QAC concentrations Reactions of QACs with the PDA required a specific pH range (from pH 4.0 to 10.0) and a readout time of 7 min. Anal. performance characteristics of the device were tested with DDAC, BAC, and CPC showing acceptable specificity, accuracy (96.1-109.4%), and precision (%RSDs ≤ 9.3%). Limits of detection and quantitation were at 20-80 and 70 to 250μM, resp. Feasibility of the newly developed device was demonstrated for in-field anal. of QACs in fumigation solution providing comparable results with those obtained from a colorimetric assay (P > 0.05). The proposed device shows potentials for further applications of other analytes since it offers speed, simplicity, and affordability for in-field anal., especially in remote areas where expertise, resources, and infrastructures are limited.

Analytical and Bioanalytical Chemistry published new progress about Colorimetry. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Formula: C21H38ClN.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nagata, Kojiro; Otsuji, Naoko; Akagi, Soichiro; Fujii, Sho; Kitamura, Noboru; Yoshimura, Takashi published the artcile< Synthesis, Structures, and Photoluminescent Properties of Tricyanidonitridorhenium(V) Complexes with Bipyridine-Type Ligands>, Application of C10H6Cl2N2, the main research area is crystal structure rhenium nitrido cyano substituted bipyridine; rhenium tricyanidonitrido bipyridine preparation electrochem redox luminescence charge transfer.

Tricyanidonitridorhenium(V) complexes with 2,2′-bipyridine (bpy) derivatives in which the 4 and 4′ positions were substituted by X, [ReN(CN)3(X2bpy)]- (X = NMe2, NH2, OMe, Me, Cl, and Br), were newly synthesized and characterized. The structures of the new complexes were determined by single-crystal x-ray anal. UV-visible spectra of the complexes in DMSO showed that the peak maximum wavelengths of Re-to-π* bpy-type-ligand charge transfer were at 474-542 nm. Cyclic voltammograms in Bu4NPF6-DMSO showed 1-electron oxidation and reduction waves corresponding to the Re(VI/V) and X2bpy0/- processes, resp. The new complexes and [ReN(CN)3bpy]- showed photoluminescence in the crystalline phase at 295 and 80 K and in DMSO at 295 K. The origin of the emission in DMSO was attributed to the triplet nature of the Re-to-π* bpy-type-ligand charge-transfer transition. D. functional theory calculations showed that the highest occupied and lowest unoccupied MOs were primarily localized on the dxy orbital of the Re and π* orbitals of the bpy-type ligand, resp. Tricyanidonitridorhenium(V) complexes with 2,2′-bipyridine (bpy) derivatives were newly synthesized and characterized. The new complexes and [ReN(CN)3bpy]- showed photoluminescence. The origin of the emission was attributed to the triplet nature of the Re-to-π* bpy-derivative charge-transfer transition.

Inorganic Chemistry published new progress about Charge transfer transition. 1762-41-0 belongs to class pyridine-derivatives, and the molecular formula is C10H6Cl2N2, Application of C10H6Cl2N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Connon, Stephen J.; Hegarty, Anthony F. published the artcile< Substituted 3,4-pyridynes: clean cycloadditions>, Category: pyridine-derivatives, the main research area is alkoxypyridine regioselective lithiation elimination; pyridyne regioselective preparation Diels Alder furan; epoxydihydroisoquinoline preparation; isoquinoline epoxydihydro preparation.

The stabilization of 3,4-pyridyne by an alkoxy group adjacent to the ring nitrogen is reported. The regioselective lithiation of 2-ethoxy-, 2-methoxy-, 2-isopropoxy- and 6-isopropoxy-, -3-chloropyridines with tert-butyllithium at low temperatures, followed by elimination of lithium chloride affords 2- and 6-alkoxy-3,4-pyridynes. These species are trapped in situ with furan in a Diels-Alder reaction to give epoxydihydroisoquinolines, e.g. I, in 66-89% yield, and do not give products typical of polymerization or nucleophilic addition to the 3,4-pyridyne intermediates. As a comparison treatment of 3-chloropyridine with furan and LDA gives only 19% of adduct I. The novel use of the isopropoxy group in these systems enhanced regioselectivity by sterically inhibiting α-lithiation by tert-butyllithium.

Perkin 1 published new progress about Diels-Alder reaction. 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Oftadeh, Mohsen; Barfarakh, Zahra; Ravari, Fatemeh published the artcile< Luminescent excited-state intramolecular proton-transfer dyes based on 4-functionalized 6,6′-dimethyl-3,3′-dihydroxy-2,2′-bipyridine (BP(OH)2-Rs); DFT simulation study>, Application of C10H8N2, the main research area is ESIPT process; Excited state; Functionalized bipyridine dyes; Luminescence; Simulation.

The 4-functionalized 6,6′-dimethyl-3,3′-dihydroxy-2,2′-bipyridine dyes (BP(OH)2-Rs) have exhibited dienol and diketo emissions. The optimum geometrical structures for ground, singlet and triplet excited states are computed by DFT/B3LYP/6-31++G that showed the planarity of BP(OH)2-Rs structure. The emission spectra of the mols. are determined in the gas-phase at singlet and triplet excited states using CIS/6-31++G. The theor. calculations are carried out for BP(OH)2-Rs to understand the impact of different substituents (R = -H (I), -Br (II), -TMS (III), -C2H (IV), -terpyridine (V) and -bodipy (diazaboraindacene) (VI)) on excited-state intramol. proton transfer (ESIPT) in singlet and triplet excited states. Based on the calculations, the concerted diproton transfer proceeds in the triplet excited state, in which nπ* state has a significant participation in ESIPT. The spectral variation at ESIPT emission of BP(OH)2-Rs is influenced by the electron-acceptor ability of the substituents. The compound V revealed a higher spectral intensity compared to the others. From the comparison with the exptl. data, the mol. V is almost planar agreed with the X-ray structure and trend variation of wavelengths. The mol. VI contains bodipy chromophore that excitation energy transfers completely from BP(OH)2 core to a bodipy substituent, leading to emission from the lowest-lying bodipy substituent, and consequently, ESIPT does not occur for this dye.

Journal of Molecular Graphics & Modelling published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fu, Zhengqiang; Wang, Xinghua; Tao, Sheng; Bu, Qingqing; Wei, Donghui; Liu, Ning published the artcile< Manganese Catalyzed Direct Amidation of Esters with Amines>, HPLC of Formula: 93-60-7, the main research area is amide preparation; ester amine amidation manganese catalyst.

The transition metal catalyzed amide bond forming reaction of esters with amines has been developed as an advanced approach for overcoming the shortcomings of traditional methods. The broad scope of substrates in transition metal catalyzed amidations remains a challenge. Here, a manganese(I)-catalyzed method for the direct synthesis of amides from a various number of esters and amines is reported with unprecedented substrate scope using a low catalyst loading. A wide range of aromatic, aliphatic, and heterocyclic esters, even in fatty acid esters, reacted with a diverse range of primary aryl amines, primary alkyl amines, and secondary alkyl amines to form amides. It is noteworthy that this approach provides the first example of the transition metal catalyzed amide bond forming reaction from fatty acid esters and amines. The acid-base mechanism for the manganese(I)-catalyzed direct amidation of esters with amines was elucidated by DFT calculations

Journal of Organic Chemistry published new progress about Amidation. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, HPLC of Formula: 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hara, Naofumi; Uemura, Nao; Nakao, Yoshiaki published the artcile< C2-Selective silylation of pyridines by a rhodium-aluminum complex>, Related Products of 581-47-5, the main research area is dehydrogenative silylation CH activation pyridine rhodium aluminum heterobimetallic catalyst; Lewis acid rhodium aluminum heterobimetallic complex dehydrogenative silylation catalyst; crystal mol structure rhodium aluminum heterobimetallic complex.

We have developed a C2-selective dehydrogenative mono-silylation of a variety of pyridines using a Rh-Al complex [(R2PCH2N-1,2-C6H4NMe-1,2-C6H4NCH2PR2)AlClRhCl(L)]n (R = Ph, iPr; n = 1, L = nbd; n = 2, L void). Both the site- and mono-selectivity are controlled via the pyridine coordination to the Lewis-acidic Al center prior to the activation of the pyridine C(2)-H bond at the proximal Rh center. A reaction mechanism is proposed based on several mechanistic studies, including the isolation of a (2-pyridyl)silylrhodium intermediate.

Chemical Communications (Cambridge, United Kingdom) published new progress about C-H bond activation. 581-47-5 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Related Products of 581-47-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Raut, Prakash; Weller, Sasha R.; Obeng, Bright; Soos, Brandy L.; West, Bailey E.; Potts, Christian M.; Sangroula, Suraj; Kinney, Marissa S.; Burnell, John E.; King, Benjamin L.; Gosse, Julie A.; Hess, Samuel T. published the artcile< Cetylpyridinium chloride (CPC) reduces zebrafish mortality from influenza infection: Super-resolution microscopy reveals CPC interference with multiple protein interactions with phosphatidylinositol 4,5-bisphosphate in immune function>, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride, the main research area is cetylpyridinium chloride antiviral agent PIP2 influenza virus infection zebrafish; Cetylpyridinium chloride; Influenza; Phosphatidylinositol 4,5-bisphosphate; Quaternary ammonium compound; Super-resolution microscopy; Zebrafish.

The COVID-19 pandemic raises significance for a potential influenza therapeutic compound, cetylpyridinium chloride (CPC), which has been extensively used in personal care products as a pos.-charged quaternary ammonium antibacterial agent. CPC is currently in clin. trials to assess its effects on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) morbidity. Two published studies have provided mouse and human data indicating that CPC may alleviate influenza infection, and here we show that CPC (0.1 μM, 1 h) reduces zebrafish mortality and viral load following influenza infection. However, CPC mechanisms of action upon viral-host cell interaction are currently unknown. We have utilized super-resolution fluorescence photoactivation localization microscopy to probe the mode of CPC action. Reduction in d. of influenza viral protein hemagglutinin (HA) clusters is known to reduce influenza infectivity: here, we show that CPC (at non-cytotoxic doses, 5-10 μM) reduces HA d. and number of HA mols. per cluster within the plasma membrane of NIH-3T3 mouse fibroblasts. HA is known to colocalize with the neg.-charged mammalian lipid phosphatidylinositol 4,5-bisphosphate (PIP2); here, we show that nanoscale co-localization of HA with the PIP2-binding Pleckstrin homol. (PH) reporter in the plasma membrane is diminished by CPC. CPC also dramatically displaces the PIP2-binding protein myristoylated alanine-rich C-kinase substrate (MARCKS) from the plasma membrane of rat RBL-2H3 mast cells; this disruption of PIP2 is correlated with inhibition of mast cell degranulation. Together, these findings offer a PIP2-focused mechanism underlying CPC disruption of influenza and suggest potential pharmacol. use of this drug as an influenza therapeutic to reduce global deaths from viral disease.

Toxicology and Applied Pharmacology published new progress about Antiviral agents. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem