Day: October 21, 2022

Biehl, Zulfe Urbano published the artcile< Review of the scientific and technological literature of fungicides in tannery industry: reducing the use and increasing the efficiency of fungicides in the leather industry>, Product Details of C5H4NNaOS, the main research area is fungicide biocide phylogenetics biodeterioration ergosterol azoles microbial fungi.

One of the main challenges of the tannery industry chain is to reduce the use of biocides and restricted substances and at the same time increase efficiency with the available products. Such conduct must permeate suppliers and the tanneries in order to obtain better results, diminish the biocide resistance dissemination, optimize costs and be ecol. friendly. In this sense, we present herein an updated review and discussion of the scientific and technol. literature on the aspects involving the action of fungicides in tannery industry and how the application of this knowledge can reduce application of biocides and restricted substances in the tanning process. We have organized a review by consulting the databases PUBMED, Web of Science, Science direct, and all literature with excellence scientific support available. The review focused on: (i) Fungal diversity involved in wet-blue biodeterioration; (ii) Mechanisms of action of fungicides; (iii) Fungicide combinations to enhance activity; (iv) Fungal mechanisms of resistance and the known causes of resistance emergence. As a result of this study we are able to track the fungal phylogenetics (and relationship) responsible for leather biodeterioration enabling a guiding strategy for fungal biocide application. Moreover, understanding of the mechanisms of action and interaction between mols. can determines the extent of the biocides inhibitory effect in different fungal species. Fungicide effect could vary, and such information corroborates with the idea that even in the same species the interaction of the different mols. may vary, possibly due to variation in cytochrome protein. For example, the most accepted mechanism of action of azoles is the inhibition of synthesis of or direct interaction with ergosterol (present in all fungi). Considering that the target is always the same, a question arise, how do the distinct azoles present different activities upon fungal strains. As result of this study we show that structural differences will influence the higher or lower interaction of the azole functional group and consequently the activity. The appropriated knowledge of the mechanisms by which microbial cells might develop resistance, highlights the need for an improved understanding of the reasons for their emergence and greater attention to methods that can be used to prevent and control them. In this sense, a successful combination of biocide mols. enhances a synergetic effect, avoiding fungal mechanisms of resistance and reduces dosage of each compound, being effective against a variety of fungi.

Journal of AQEIC published new progress about Alternaria. 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Product Details of C5H4NNaOS.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wandas, M.; Talik, Z. published the artcile< Theoretical and experimental NMR data of 3,5-dinitro-2-(2-phenylhydrazinyl)pyridine and of its 4- and 6-methyl derivatives>, Synthetic Route of 21901-29-1, the main research area is methyldinitrophenylhydrazinylpyridine dinitrophenylhydrazinylpyridine NMR mol structure.

3,5-Dinitro-2-(2-phenylhydrazinyl)pyridine and its Me derivatives: 4-methyl-3,5-dinitro-2-(2-phenylhydrazinyl)pyridine and 6-methyl-3,5-dinitro-2-(2-phenylhydrazinyl)pyridine were synthesized and characterized by 1H NMR and 13C NMR. Calculations were also performed where the above mols. were optimized using the methods of d. functional theory (DFT) with 6-31G(d,p) and 6-311G(d,p) basis sets. For all mols. studied, the lowest energy was obtained using the 6-311G(d,p) basis set. The GIAO/DFT (Gauge Invariant AOs/D. Functional Theory) calculations on the 6-311G and 6-311++G and 6-311G** basis sets were carried out to determine proton and carbon chem. shifts and to find they were close to the exptl. values. It has been also found that intramol. hydrogen bonding exists between hydrogen atom (in 2-NH group) and oxygen atom (pyridine-3-NO2). Moreover, resonances between pyridine ring and electron withdrawing 3-nitro group as well between that ring and the lone electron pair of NH group favor a co-planarity of the structure; this means a chelate ring created by above-mentioned intramol. hydrogen bond is almost co-planar with pyridine ring.

Journal of Molecular Structure published new progress about Atomic charge. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Synthetic Route of 21901-29-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lengacher, Raphael; Wang, Youchao; Braband, Henrik; Blacque, Olivier; Gasser, Gilles; Alberto, Roger published the artcile< Organometallic small molecule kinase inhibitors - direct incorporation of Re and 99mTc into Opaganib>, Quality Control of 3731-53-1, the main research area is prostate cancer opaganib bioorganometallic complex anticancer mol theranostics.

[(η5-Cp)ReI(CO)3] was incorporated into the kinase inhibitor Opaganib. The resulting bioorganometallic complex showed a similar anti-cancer activity to Opaganib against PC-3 cancer cells. The IC50 value for the kinase SK2 is 30x higher than that of Opaganib. The 99mTc homolog was synthesized, completing a matched-pair for mol. theranostics.

Chemical Communications (Cambridge, United Kingdom) published new progress about Antitumor agents. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Quality Control of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Vasbinder, Melissa M.; Alimzhanov, Marat; Augustin, Martin; Bebernitz, Geraldine; Bell, Kirsten; Chuaqui, Claudio; Deegan, Tracy; Ferguson, Andrew D.; Goodwin, Kelly; Huszar, Dennis; Kawatkar, Aarti; Kawatkar, Sameer; Read, Jon; Shi, Jie; Steinbacher, Stefan; Steuber, Holger; Su, Qibin; Toader, Dorin; Wang, Haixia; Woessner, Richard; Wu, Allan; Ye, Minwei; Zinda, Michael published the artcile< Identification of azabenzimidazoles as potent JAK1 selective inhibitors>, Recommanded Product: 4,5-Dichloropyridin-2-amine, the main research area is azabenzimidazoles screening JAK1 selective inhibitor STAT3; Azabenzimidazoles; JAK selectivity; JAK1; JAK1 inhibitors.

We have identified a class of azabenzimidazoles as potent and selective JAK1 inhibitors. Investigations into the SAR are presented along with the structural features required to achieve selectivity for JAK1 vs. other JAK family members. An example from the series demonstrated highly selective inhibition of JAK1 vs. JAK2 and JAK3, along with inhibition of pSTAT3 in vivo, enabling it to serve as a JAK1 selective tool compound to further probe the biol. of JAK1 selective inhibitors.

Bioorganic & Medicinal Chemistry Letters published new progress about Drug screening. 188577-68-6 belongs to class pyridine-derivatives, and the molecular formula is C5H4Cl2N2, Recommanded Product: 4,5-Dichloropyridin-2-amine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Haratipour, Pouya; Minard, Corinne; Nakhjiri, Maryam; Negahbani, Amirsoheil; Kashemirov, Boris A.; McKenna, Charles E. published the artcile< New chirally modified bisphosphonates for synthesis of individual beta,gamma-CHX-deoxynucleotide diastereomers>, Quality Control of 2127-03-9, the main research area is Mitsunobu condensation phosphonate methylmandelate ester cytosine ethylbenzylamide preparation; nucleotide ethylbenzylamine phenylglycine hydrogenolysis phosphonate protecting group nitrobenzyl; synthon deoxynucleotide polymerase kinase enzyme active site; chiral bisphosphonates; dNTP probes; polymerase mechanism.

Individual diastereomers of CXY bisphosphonate analogs of dNTPs or NTPs are useful chem. stereoprobes to investigate interactions within the chiral active site environment of enzymes such as polymerases and kinases. We previously reported synthetic access to β,γ-CHX-dGTPs (X = F or Cl) via a bisphosphonate synthon with an (R)-Me mandelate auxiliary and have extended this approach to dTTP and dATP analogs. As removal of the chiral auxiliary by (Pd/C) hydrogenolysis is incompatible with the cytosine heterocycle and also with X = Br, we have now designed bisphosphonate synthons using (R)-(+)-α-ethylbenzylamine or Me (R)-(-)-phenylglycine auxiliaries and equipped with an o-nitrobenzyl ester protecting group allowing photochem. deprotection. These new synthons have made possible the first syntheses of individual dCTP and mono-bromo-substituted dNTP β,γ-CHX diastereomers.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about Condensation reaction. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Quality Control of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jackson, Matthew Irick published the artcile< Macronutrient Proportions and Fat Type Impact Ketogenicity and Shape the Circulating Lipidome in Dogs>, Application In Synthesis of 93-60-7, the main research area is macronutrient fat ketogenicity lipidome circulation dog; canine; ketosis; lipidome; macronutrients; metabolome.

Many physiol. processes including ketogenesis are similar in dogs and humans, but there is little information available on the effect of carbohydrate restriction in dogs. Here, the ketogenicity and serum metabolic profiles of dogs were assessed after they had consumed high carbohydrate (HiCHO); high protein, low carbohydrate (PROT_LoCHO); or high fat, low carbohydrate (FAT_LoCHO) foods. Thirty-six dogs were fed HiCHO for 4 wk, then randomized to PROT_LoCHO or FAT_LoCHO for 5 wk. Dogs then crossed over to the other food for an addnl. 5 wk. Generally, reduction of dietary carbohydrate by replacement with either protein or fat increased the energy required to maintain body weight, and fat had a greater effect. Postabsorptive energy availability derived mainly from glucose and triglycerides with HiCHO, from gluconeogenic amino acids and fatty acids with PROT_LoCHO, and from fatty acids and β-hydroxybutyrate with FAT_LoCHO. This study demonstrated that the reduction of carbohydrate in canine foods is potentially beneficial to dogs based on improvements in metabolism and supports the use of low-carbohydrate foods as safe and effective for healthy adult dogs.

Metabolites published new progress about Absorption. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Application In Synthesis of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cai, Pengfei; Gao, Zhan; Yin, Xinchi; Luo, Yuanqing; Zhao, Xiaoyong; Pan, Yuanjiang published the artcile< facile enantioseparation and recognition of mandelic acid and its derivatives in self-assembly interaction with chiral ionic liquids>, Synthetic Route of 3796-23-4, the main research area is enantioseparation mandelic acid derivatives self assembly chiral ionic liquids; chiral separation; coprecipitation; ionic liquids; mandelic acid.

Mandelic acid and its derivatives are important medical intermediates in the pharmaceutical industry. Different stereoisomers exhibited distinct biol. properties to human bodies. Given that, enantioselective recognition and separation of mandelic acid are of great importance. In this study, four novel different types of chiral ionic liquids bearing designed functional groups were synthesized and successful enantioselective precipitation with mandelic acid and its derivatives That is, (R, R)-chiral ionic liquid 1 can coprecipitated with S-mandelic acid and its derivatives was observed In addition, good correlation coefficient is achieved by using electrospray mass spectrum at neg. ion pattern for quick anal. of the enantioselective precipitation, which could be served as a method of enantioselective recognition. The possible intermol. interactions are established after systematical studies by NMR spectroscopy and DFT calculations

Journal of Separation Science published new progress about Chiral resolution. 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Synthetic Route of 3796-23-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Grongsaard, Pintipa; Bulger, Paul G.; Wallace, Debra J.; Tan, Lushi; Chen, Qinghao; Dolman, Sarah J.; Nyrop, Jason; Hoerrner, R. Scott; Weisel, Mark; Arredondo, Juan; Itoh, Takahiro; Xie, Chengfu; Wen, Xianghui; Zhao, Dalian; Muzzio, Daniel J.; Bassan, Ephraim M.; Shultz, C. Scott published the artcile< Convergent, Kilogram Scale Synthesis of an Akt Kinase Inhibitor>, Synthetic Route of 1050501-88-6, the main research area is convergent synthesis AKT kinase inhibitor.

The development of a convergent, chromatog.-free synthesis of an allosteric Akt kinase inhibitor is described. The route comprised 17 total steps and was used to produce kilogram quantities of the target mol. A key early transformation, for which both batch and flow protocols were developed, was formylation of a dianion derived by deprotonation and subsequent lithium-halogen exchange from a 2-bromo-3-aminopyridine precursor. Improved reaction yield and practicality were achieved in the continuous processing mode. Further significant process developments included the safe execution of a high temperature and pressure hydrazine displacement, separation of substituted cyclobutane diastereomers by means of chemoselective ester hydrolysis, and a late-stage Suzuki fragment coupling under mild conditions.

Organic Process Research & Development published new progress about Formylation. 1050501-88-6 belongs to class pyridine-derivatives, and the molecular formula is C5H4BrClN2, Synthetic Route of 1050501-88-6.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liang, Lijuan; Wu, Xiaoyun; Shi, Chuanling; Wen, Haoyu; Wu, Shouhai; Chen, Jing; Huang, Chunxia; Wang, Yi; Liu, Yunjun published the artcile< Synthesis and characterization of polypyridine ruthenium(II) complexes and anticancer efficacy studies in vivo and in vitro>, Application of C10H8N2, the main research area is Apoptosis; Cell cytotoxicity; Mitochondria; Ruthenium(II) complexes; Toxic activity in vivo.

In this article, ligand IPP (IPP = 4-(1H-imidazo[4,5-f][1,10]phenanthrolin-2-yl)-N,N-diphenylaniline) and its three Ru(II) complexes: [Ru(bpy)2(IPP)](ClO4)2 (1) (bpy = 2,2′-bipyridine), [Ru(dmbpy)2(IPP)](ClO4)2 (2) (dmbpy = 4,4′-dimethyl-2,2′-bipyridine), and [Ru(phen)2(IPP)](ClO4)2 (3) (phen = 1,10-phenanthroline) were synthesized and characterized. The anticancer activity in vitro of the complexes was investigated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. The scratching and colony-forming experiments confirmed the complexes 1, 2, 3 interfered with the proliferation and migration ability of cells. The accumulation of the complexes in cells was researched and we found that these complexes directly accumulated in mitochondria, then the complexes cause a decline of the mitochondrial membrane potential and induce an increase of intracellular reactive oxygen species (ROS) levels. The growth of B16 cells were inhibited by 1, 2 and 3 at G0/G1 phase. Apoptosis was induced through mitochondrial pathway and the expression of apoptosis-related factors was regulated. In addition, the complexes promoted the transition of poly(ADP-ribose)polymerase (PARP) into the cleaved form (Cleaved PARP), downregulated the anti-apoptotic proteins, and upregulated the pro-apoptotic proteins. Consequently, complexes 1, 2 and 3 exerted their anticancer activity by regulating B-cell lymphoma-2 (Bcl-2) family proteins. Complex 2 showed excellent antitumor effects with a high inhibitory rate of 65.95% in vivo. Taken together, the complexes cause apoptosis in B16 cells through a ROS-mediated mitochondrial dysfunction pathway.

Journal of Inorganic Biochemistry published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yue, Cheng-Yang; Yue, Yun-Di; Sun, Hai-Xiao; Li, Dong-Yang; Lin, Na; Wang, Xin-Ming; Jin, Ying-Xue; Dong, Yu-Han; Jing, Zhi-Hong; Lei, Xiao-Wu published the artcile< Transition metal complex dye-sensitized 3D iodoplumbates: syntheses, structures and photoelectric properties>, Electric Literature of 366-18-7, the main research area is bipyridine iron cobalt nickel manganese iodoplumbate preparation crystal structure; photoelec property dye sensitized iodoplumbate.

Here, authors prepared the first series of 3D hybrid iodoplumbates with novel porous frameworks of [Pb8I21]5- directed by transition metal complex (TMC) cationic dyes of [TM(2.2-bipy)3]2+. The microporous materials exhibit outstanding visible light-driven photoelec. properties due to the effective photosensitization of the TMC dyes. The coexistence of stronger face- and weaker corner-shared connecting manners affords the feasibility of tailoring the 3D framework into low-dimensional skeletons, which provide a new structural prototype to modify the semiconducting properties similar to those of classic perovskites.

Chemical Communications (Cambridge, United Kingdom) published new progress about Cationic dyes. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Electric Literature of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem