Day: October 24, 2022

Name: Picolinic acidIn 2020 ,《The multiple faces of tryptophan in bone biology》 appeared in Experimental Gerontology. The author of the article were Al Saedi, Ahmed; Sharma, Shilpa; Summers, Matthew A.; Nurgali, Kulmira; Duque, Gustavo. The article conveys some information:

A review. Osteoporosis is highly prevalent in older persons. While many advances have been made in the field of osteoporosis, current treatments have been affected by unexpected side effects and limited efficacy; therefore, new approaches to identify disease mechanisms and pathways are required. This review focuses on the influence of tryptophan metabolites, particularly kynurenines and serotonin on bone. The kynurenine (KYN) pathway is associated with osteoblastogenesis and can be linked to the pathophysiol. of osteoporosis. The activity of osteoblasts is reduced by 3-hydroxykynurenine (3-HKYN), a product of KYN. In addition, decreasing concentrations of 3-hydroxyanthranilic acid with aging can be one of the causes of bone loss. In contrast, picolinic acid, an end-product of the KYN pathway, acts as a bone anabolic. On the other hand, gut-derived serotonin (GDS) inhibits bone formation, whereas brain-derived serotonin enhances bone formation and decreases bone resorption. Overall, understanding the exact mechanisms of action of tryptophan metabolites on bone could have great potential to develop effective treatments for osteoporosis and other bone diseases. The experimental process involved the reaction of Picolinic acid(cas: 98-98-6Name: Picolinic acid)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Name: Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 4-CyanopyridineIn 2020 ,《P-cymene complexes of ruthenium(II) as antitumor agents》 was published in Molecules. The article was written by Pujante-Galian, Maria Angeles; Perez, Sergio A.; Montalban, Mercedes G.; Carissimi, Guzman; Fuster, Marta G.; Villora, Gloria; Garcia, Gabriel. The article contains the following contents:

In this work, the cytotoxic behavior of six ruthenium(II) complexes of stoichiometry [(η6-p-cymene)RuCl2L] (I-VI), L = 4-cyanopyridine (I), 2-aminophenol (II), 4-aminophenol (III), pyridazine (IV), and [(η6-p-cymene)RuClL2]PF6; L = cyanopyridine (V), L = 2-aminophenol(VI) towards three cell lines was studied. Two of them, HeLa and MCF-7, are human carcinogenic cells from cervical carcinoma and human breast cancer, resp. A comparison with healthy cells was carried out with BGM cells which are monkey epithelial cells of renal origin. The behavior of complex II exhibits selectivity towards healthy cells, which is a promising feature for use in cancer treatment since it might reduce the side effects of most current therapies. The experimental part of the paper was very detailed, including the reaction process of 4-Cyanopyridine(cas: 100-48-1Application In Synthesis of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Application In Synthesis of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesIn 2020 ,《Efficient trinuclear Ru(II)-Re(I) supramolecular photocatalysts for CO2 reduction based on a new tris-chelating bridging ligand built around a central aromatic ring》 was published in Chemical Science. The article was written by Cancelliere, Ambra M.; Puntoriero, Fausto; Serroni, Scolastica; Campagna, Sebastiano; Tamaki, Yusuke; Saito, Daiki; Ishitani, Osamu. The article contains the following contents:

We have designed and synthesized a new tris-chelating polypyridine ligand (bpy3Ph) suitable to be used as a bridging ligand (BL) for constructing various supramol. photocatalysts. The ligand bpy3Ph has been used to prepare, according to a multi-step synthetic protocol, trinuclear supramol. photocatalysts containing different metal subunits. In particular, the compounds Ru2Re and RuRe2 have been prepared, containing different ratios of components based on Ru(dmb)32+-type and Re(dmb)(CO)3Cl-type units (dmb = 4,4′-dimethyl-2,2′-bipyridine), which can play the roles of photosensitizers and catalyst units for photocatalytic CO2 reduction, resp. The trinuclear model Ru3 and mononuclear and dinuclear Ru and Ru2 precursor metal complexes, containing free chelating sites, have also been synthesized using the same bridging ligand. The absence of negligible accumulation of the mono-reduced form of the photosensitizer indicates fast electron transfer to the catalyst unit(s) through the relatively large bridging ligand and is proposed to contribute to the outstanding photocatalytic properties of the new species, including their durability. The relevant photocatalytic behavior of the new systems indicates new avenues for the design of extended bridging ligands capable of efficiently and functionally integrating photosensitizers and catalysts towards the preparation of new, larger supramol. photocatalysts for selective CO2 reduction In the experimental materials used by the author, we found 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Category: pyridine-derivatives)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Category: pyridine-derivatives Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesIn 2020 ,《Mild and selective hydrogenation of nitriles into primary amines over a supported Ni catalyst》 was published in New Journal of Chemistry. The article was written by Wang, Jianjian; Tang, Qingjie; Jin, Shiwei; Wang, Yanxin; Yuan, Ziliang; Chi, Quan; Zhang, Zehui. The article contains the following contents:

The development of new heterogeneous non-noble catalytic systems for the selective hydrogenation of nitriles into primary amines is a challenging task. In this study, a mesoporous Al2O3-supported Ni catalyst (denoted as Ni/Al2O3-600, where 600 represents the reduction temperature) demonstrated a high catalytic activity for the hydrogenation of nitriles under mild conditions (60-80°C and 2.5 bar H2) with ammonia as the additive. This catalytic system has a wide substrate range; and the Ni/Al2O3 catalyst demonstrated a good tolerance to other functional groups, which was possibly due to its high catalytic activity under mild conditions. A plausible reaction pathway was proposed for the hydrogenation of nitriles into primary amines, and it was found that ammonia played a great role in the enhancement of the selectivity of primary amines by the inhibition of the side reaction to generate secondary amines. In addition, the Ni/Al2O3-600 catalyst could be reused five times without activity loss through convenient magnetic recovery. In the experimental materials used by the author, we found 4-Cyanopyridine(cas: 100-48-1Category: pyridine-derivatives)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: Methyl 5-bromopicolinateIn 2014 ,《An environmentally-friendly one-pot synthesis of 4-sulfonyl benzoic acids》 was published in Tetrahedron Letters. The article was written by Frieman, Bryan A.. The article contains the following contents:

This Letter reported an environmentally-friendly one-pot SNAr reaction of thiols to 4-halobenzoic acid Me esters to provide 4-substituted sulfone benzoic acids and picolinic acids after bleach-mediated oxidative workup. These acid intermediates were synthesized on gram scale, are perfect partners for library synthesis, and have good phys. chem. properties useful for drug discovery. In the experimental materials used by the author, we found Methyl 5-bromopicolinate(cas: 29682-15-3Name: Methyl 5-bromopicolinate)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Name: Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 98-98-6In 2020 ,《Spectroscopic and Theoretical Investigation of Color Tuning in Deep-Red Luminescent Iridium(III) Complexes》 was published in Inorganic Chemistry. The article was written by Stonelake, Thomas M.; Phillips, Kaitlin A.; Otaif, Haleema Y.; Edwardson, Zachary C.; Horton, Peter N.; Coles, Simon J.; Beames, Joseph M.; Pope, Simon J. A.. The article contains the following contents:

A series of heteroleptic, neutral iridium(III) complexes of the form [Ir(L)2(N^O)] (where L = cyclometalated 2,3-disubstituted quinoxaline and N^O = ancillary picolinate or pyrazinoate) are described in terms of their synthesis and spectroscopic properties, with supporting computational analyses providing addnl. insight into the electronic properties. The 10 [Ir(L)2(N^O)] complexes were characterized using a range of anal. techniques (including 1H, 13C, and 19F NMR and IR spectroscopies and mass spectrometry). One of the examples was structurally characterized using X-ray diffraction. The redox properties were determined using cyclic voltammetry, and the electronic properties were investigated using UV-vis, time-resolved luminescence, and transient absorption spectroscopies. The complexes are phosphorescent in the red region of the visible spectrum (λem = 633-680 nm), with lifetimes typically of hundreds of nanoseconds and quantum yields ca. 5% in aerated chloroform. A combination of spectroscopic and computational analyses suggests that the long-wavelength absorption and emission properties of these complexes are strongly characterized by a combination of spin-forbidden metal-to-ligand charge-transfer and quinoxaline-centered transitions. The emission wavelength in these complexes can thus be controlled in two ways: first, substitution of the cyclometalating quinoxaline ligand can perturb both the HOMO and LUMO levels (Cl atoms on the ligand induce the largest bathochromic shift), and second, the choice of the ancillary ligand can influence the HOMO energy (pyrazinoate stabilizes the HOMO, inducing hypsochromic shifts). Heteroleptic neutral iridium(III) complexes [Ir(L)2(N^O)] (where N^O = picolinate or pyrazinoate) that incorporate cyclometalated quinoxaline ligands demonstrate tunable emission in the red region of the visible spectrum. In the experiment, the researchers used Picolinic acid(cas: 98-98-6HPLC of Formula: 98-98-6)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.HPLC of Formula: 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: 4-CyanopyridineIn 2021 ,《Metal-Free Hydropyridylation of Thioester-Activated Alkenes via Electroreductive Radical Coupling》 was published in Journal of Organic Chemistry. The article was written by Xu, Hehuan; Liu, Jiayu; Nie, Feiyun; Zhao, Xiaowei; Jiang, Zhiyong. The article contains the following contents:

An electrochem. hydropyridylation of thioester-activated alkenes R1R2C:CHC(O)SEt (R1 = Ph, 2-MeOC6H4, 3-BrC6H4, 1-naphthyl, N-Boc-indol-3-yl, etc.; R2 = H, Me, n-Bu) with 4-cyanopyridines has been developed. The reactions proceed via tandem electroreduction of both substrates on the cathode surface, protonation and radical cross-coupling processes, resulting in a variety of valuable pyridine variants, which contain a tertiary and even a quaternary carbon at the α-position of pyridines in high yields. These reactions require no catalyst or high temperature representing a highly sustainable synthetic method. In the experimental materials used by the author, we found 4-Cyanopyridine(cas: 100-48-1Name: 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Name: 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Preparation of azaindolines and benzoyl substituted azaindolines: precursors of triazabenzo[cd]azulen-9-one PDE4 inhibitors》 was published in Tetrahedron Letters in 2011. These research results belong to Badland, Matthew; Devillers, Ingrid; Durand, Corinne; Fasquelle, Veronique; Gaudilliere, Bernard; Jacobelli, Henry; Manage, Ajith C.; Pevet, Isabelle; Puaud, Jocelyne; Shorter, Anthony J.; Wrigglesworth, Roger. Electric Literature of C9H12N2O2 The article mentions the following:

The syntheses of various substituted azaindolines are described. Azaindolines were identified as potential key intermediates towards new PDE4 inhibitors. The experimental process involved the reaction of Ethyl 2-(3-aminopyridin-2-yl)acetate(cas: 295327-27-4Electric Literature of C9H12N2O2)

Ethyl 2-(3-aminopyridin-2-yl)acetate(cas: 295327-27-4) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Electric Literature of C9H12N2O2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Zinc mediated azide-alkyne ligation to 1,5- and 1,4,5-substituted 1,2,3-triazoles》 was written by Smith, Christopher D.; Greaney, Michael F.. Synthetic Route of C5H5BrN2This research focused ontriazole preparation; azide alkyne zinc dipolar cycloaddition. The article conveys some information:

A mild method for regioselective formation of 1,5-substituted 1,2,3-triazoles is described. The zinc-mediated reaction works at room temperature and is successful across a wide range of azido/alkynyl substrates. Addnl., the triazole 4-position can be further functionalized through the intermediate aryl-zinc to accommodate a diverse three-component coupling strategy. In the part of experimental materials, we found many familiar compounds, such as 6-Bromopyridin-3-amine(cas: 13534-97-9Synthetic Route of C5H5BrN2)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Synthetic Route of C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 138219-98-4On November 30, 2018 ,《Interfacial self-assembly of bipyridyl-functionalized nanoSiO2-BPy@Ln(β-diketone)n composites and their luminescent properties》 appeared in Journal of Luminescence. The author of the article were Ma, Yue-Yang; Huang, Hong-Xiang; Chen, Meng; Qian, Dong-Jin. The article conveys some information:

Interfacial self-assembly provides an effective route to design and construct various metal-organic hybrid and composite materials with interesting optical and electroactive properties. Here, we reported the interfacial self-assembly of luminescent nano-composites through the coordination reaction of lanthanide salts of Ln(CF3SO3)3 (Ln = Eu and Tb) with the 2,2′-bipyridyl (BPy)-functionalized silica nano-linkers (nanoSiO2-BPy) and several β-diketone ligands. The assembling processes and the nano-materials as-prepared were characterized by using thermogravimetry, IR, UV-vis absorption and XPS, as well as field emission transmission electron microscopy (FE-TEM). The luminescent properties from both nanoSiO2-BPy linkers and lanthanide nano-composites were investigated in the solutions and solid powders, which revealed not only the broad emissions of nanoSiO2-BPy linkers between 400 and 520 nm, but also the sharp emissions between 480 and 750 nm, designated to the 4f-4f electron transitions of 5D4 → 7Fn (n = 3,4,5,6) and 5D0 → 7Fn (n = 0,1,2,3,4) of the Tb3+ and Eu3+ ions, resp. The relative emission intensity of the Ln3+ ions in the nano-composites has been found to be closely dependent on the compositions of the nano-composites, structure of the β-diketone ligands, and the excited wavelengths. Finally, the energy transfer process in the nano-composites was discussed. In the part of experimental materials, we found many familiar compounds, such as 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Product Details of 138219-98-4)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Product Details of 138219-98-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem