Day: October 24, 2022

SDS of cas: 128071-75-0In 2018 ,《Zincation and Magnesiation of Functionalized Silylated Cyanohydrins Using TMP-Bases》 was published in Synthesis. The article was written by Castello-Mico, Alicia; Knochel, Paul. The article contains the following contents:

Polyfunctional silylated cyanohydrins are readily magnesiated or zincated with TMPMgCl·LiCl or TMP2Zn·2MgCl2·2LiCl leading to the corresponding metalated derivatives These Mg- or Zn-derivatives react with various electrophiles such as benzylic bromides, allylic bromides, acid chlorides, aldehydes, NCCO2Et, or MeSO2SMe. Subsequently, TBAF-deprotection provides the corresponding keto or 1,2-diketo derivatives2-Bromonicotinaldehyde(cas: 128071-75-0SDS of cas: 128071-75-0) was used in this study.

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. SDS of cas: 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Electrocatalytic dechlorination of chloropicolinic acid mixtures by using palladium-modified metal cathodes in aqueous solutions》 was written by Ma, Hongxing; Xu, Yinghua; Ding, Xufen; Liu, Qi; Ma, Chun-An. Formula: C6H2Cl3NO2 And the article was included in Electrochimica Acta on August 20 ,2016. The article conveys some information:

In China, chloropicolinic acid (ClPA) mixtures comprising 3,5,6-trichloropicolinic acid, 3,6-dichloropicolinic acid (3,6-D), 3-ClPA, and 6-ClPA are discharged as organic wastes at a rate of ∼300 tons per yr. The authors developed an aqueous phase electrocatalytic hydrogenation (ECH) system based on Pd catalyst to dechlorinate the ClPA mixtures into picolinic acid (PA) at room temperature Firstly, the authors evaluated the influence of cathode support and Pd loading on the catalytic performance of cathodes, as well as the effects of operating parameters on the intermediate product selectivity and dechlorination efficiency of the ECH process with 3,6-D as the target compound Secondly, the authors analyzed the ECH dechlorination mechanism of 3,6-D with regard to the surface condition of cathode and catholyte pH, and the rate-limiting step of the dechlorination process is also discussed. Finally, the authors assessed the practicability of the ECH system to dechlorinate the ClPA mixtures into PA by using a plate-and-frame cell. Pd/Ni foam cathodes with Pd loading of 2.25-3.6 mg cm-2 exhibited the optimum ECH dechlorination performance, and the basic aqueous solution and high 3,6-D concentration favored the ECH process. The ClPA mixtures with 47 g L-1 concentration (the total concentration of ClPAs was ∼250 mM) can be selectively dechlorinated into PA with 99% yield, 76.3% current efficiency, and 2.47 kW h kg-1 PA specific elec. energy consumption at a c.d. of 208 A m-2 in a 1.25 M NaOH aqueous solution In addition to this study using 3,5,6-Trichloropicolinic acid, there are many other studies that have used 3,5,6-Trichloropicolinic acid(cas: 40360-44-9Formula: C6H2Cl3NO2) was used in this study.

3,5,6-Trichloropicolinic acid(cas: 40360-44-9) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Formula: C6H2Cl3NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Rational design, synthesis and testing of novel tricyclic topoisomerase inhibitors for the treatment of bacterial infections part 1》 was written by Kirk, R.; Ratcliffe, A.; Noonan, G.; Uosis-Martin, M.; Lyth, D.; Bardell-Cox, O.; Massam, J.; Schofield, P.; Hindley, S.; Jones, D. R.; Maclean, J.; Smith, A.; Savage, V.; Mohmed, S.; Charrier, C.; Salisbury, A-M.; Moyo, E.; Metzger, R.; Chalam-Judge, N.; Cheung, J.; Stokes, N. R.; Best, S.; Craighead, M.; Armer, R.; Huxley, A.. Recommanded Product: 6-Bromopyridin-3-amineThis research focused ontricyclic topoisomerase inhibitor bacterial infection treatment. The article conveys some information:

The alarming reduction in drug effectiveness against bacterial infections has created an urgent need for the development of new antibacterial agents that circumvent bacterial resistance mechanisms. We report here a series of DNA gyrase and topoisomerase IV inhibitors that demonstrate potent activity against a range of Gram-pos. and selected Gram-neg. organisms, including clin.-relevant and drug-resistant strains. In part 1, we present a detailed structure activity relationship (SAR) anal. that led to the discovery of our previously disclosed compound, REDX05931, which has a min. inhibitory concentration (MIC) of 0.06 μg mL-1 against fluoroquinolone-resistant Staphylococcus aureus. Although in vitro hERG and CYP inhibition precluded further development, it validates a rational design approach to address this urgent unmet medical need and provides a scaffold for further optimization, which is presented in part 2. The experimental part of the paper was very detailed, including the reaction process of 6-Bromopyridin-3-amine(cas: 13534-97-9Recommanded Product: 6-Bromopyridin-3-amine)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Recommanded Product: 6-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Selective C-H trifluoromethoxylation of (hetero)arenes as limiting reagent》 was written by Deng, Zhijie; Zhao, Mingxin; Wang, Feng; Tang, Pingping. Reference of 4-CyanopyridineThis research focused ontrifluoromethoxylated compound preparation regioselective; arene heteroarene trifluoromethyl arylsulfonate trifluoromethoxylation. The article conveys some information:

A general late-stage C-H trifluoromethoxylation of arenes and heteroarenes RH (R = 4-methoxypyridin-2-yl, 4-t-butylphenyl, 3-acetylbenzothien-2-yl, etc.) as limiting reagent with trifluoromethoxide anion was described. The reaction is mediated by silver salts under mild reaction conditions, exhibiting broad substrate scope and wide functional-group compatibility. In addition, ortho-position selective C-H trifluoromethoxylation of pyridines is observed The method is not only applicable to the gram-scale synthesis of trifluoromethoxylated products ROCF3 but also allows efficient late-stage C-H trifluoromethoxylation of marketed small-mol. drugs, common pharmacophores and natural products. In the experimental materials used by the author, we found 4-Cyanopyridine(cas: 100-48-1Reference of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Reference of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acidOn March 31, 1995, Monge, A.; Martinez-Merino, V.; Simon, M. A.; Sanmartin, C. published an article in Arzneimittel-Forschung. The article was 《New 5H-[1,3]thiazolo[3,2-a]pyrido[3,2-e]pyrimidin-5-one derivatives as diuretics》. The article mentions the following:

A series of new 5H-[1,3]thiazolo[3,2-a]pyrido[3.2-3]pyrimidin-5-ones 3-substituted and/or 8,9-hydrogenated was prepared and tested for their diuretic, natriuretic and kaliuretic activities on male Wistar rats at a dosage of 25 mg/kg or less. Diuretic and saliuretic activities were strongly influenced by substituents in 3-position. Quant. structure-activity relationships show that electron withdrawn substituents in 3-position enhance both diuretic and saliuretic activities at 25 mg/kg. Global anal. of the variations introduced on pyridine, pyrimidine and thiazole rings of this tricyclic system showed an increases of diuretic and natriuretic activities when the formal charge on N9a and C9b increases. Potassium ion excretion also increases, although not as drastically a in the earlier cases. Regression equations were calculated by partial least squares method (PLS) and validated by the cross-validation (leave-one-out) technique. The results came from multiple reactions, including the reaction of 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid(cas: 10177-08-9Safety of 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid)

2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid(cas: 10177-08-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Safety of 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acidThe lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of C12H10Cl2N2On September 19, 2000 ,《Synthesis of Thermochromic Iron(II) Tris(bipyridine)-Centered Star-Shaped Polyoxazolines and Their Bipyridine-Centered Macroligand Counterparts》 was published in Macromolecules. The article was written by McAlvin, John E.; Scott, Sarah B.; Fraser, Cassandra L.. The article contains the following contents:

Iron tris(bipyridine) complexes [Fe{4,4′-bis(chloromethyl)-2,2′-bipyridine}3], I, and the corresponding iodide analog generated in situ using NaI, II, were used as initiators for the polymerization of a series of 2-R-2-oxazoline monomers (R = Et, EtOX; Me, MeOX; Ph, PhOX; and undecyl, UnOX). The resulting labile core, red-violet Fe-centered star polymers fragment during mol. weight anal. by gel permeation chromatog. (GPC). Thus, samples were subjected to chem. cleavage in aqueous K2CO3 to generate metal-free bipyridine-centered polyoxazolines, bpyPROX2. When combined with ferrous ammonium sulfate, these bpyPROX2 macroligands chelate to Fe(II), regenerating the [Fe(bipyridine)3]2+ chromophores. Both preparative and anal. kinetics experiments generally produce polymers with reasonably narrow mol. weight distribution (∼1.1 – 1.5). Mol. weight vs. percent monomer conversion plots with either the iodide or chloride initiating system were nearly linear for all monomers ; however, only PEOX and PUOX products show good correlation with Mn(calculated) based on monomer/initiator loading. For most monomers, reactions with iodide initiators are faster than the chlorides, and linear first-order kinetics plots were observed Polymerization of oxazolines with 4,4′-bis(halomethyl)-2,2′-bipyridines produced polymers with narrow mol. weight distribution but with mol. weight higher than targeted based on monomer loading. The 1H NMR data indicate that termination with dipropylamine is efficient for EtOX polymerizations Thermal anal. by DSC and TGA reveal few differences between Fe-centered stars and their bpy-centered PROX macroligand counterparts. Variable-temperature UV/vis data of Fe-centered PEOX thin film illustrate the bleaching of the metal to ligand charge transfer band at about 535 nm of an Fe-centered PEOX film heated under N; cooling and reheating revealed that this process is at least partially reversible for all [Fe-(bpyPROX2)3]2+. In the experiment, the researchers used 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Synthetic Route of C12H10Cl2N2)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Synthetic Route of C12H10Cl2N2 Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dogan, Sengul Dilem; Demirpolat, Eren; Yerer Aycan, Mukerrem Betul; Balci, Metin published an article on January 14 ,2015. The article was titled 《Synthesis of new 4-aza-indoles via acyl azides》, and you may find the article in Tetrahedron.COA of Formula: C9H12N2O2 The information in the text is summarized as follows:

The authors hereby report the preparation of new azaindole derivatives starting from 2-(2-ethoxy-2-oxoethyl)nicotinic acid. Conversion of a half ester into acyl azide followed by Curtius rearrangement gave the corresponding isocyanate. Trapping of the isocyanate with different nucleophiles produced urea and urethane derivatives Intramol. cyclization reactions gave the target compounds In addition to this study using Ethyl 2-(3-aminopyridin-2-yl)acetate, there are many other studies that have used Ethyl 2-(3-aminopyridin-2-yl)acetate(cas: 295327-27-4COA of Formula: C9H12N2O2) was used in this study.

Ethyl 2-(3-aminopyridin-2-yl)acetate(cas: 295327-27-4) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.COA of Formula: C9H12N2O2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Li, Zhao; Gelbaum, Carol; Campbell, Zachary S.; Gould, Paul C.; Fisk, Jason S.; Holden, Bruce; Jaganathan, Arvind; Whiteker, Gregory T.; Pollet, Pamela; Liotta, Charles L. published 《Pd-Catalyzed Suzuki coupling reactions of aryl halides containing basic nitrogen centers with arylboronic acids in water in the absence of added base》.New Journal of Chemistry published the findings.Synthetic Route of C5H5BrN2 The information in the text is summarized as follows:

The Pd-catalyzed Suzuki coupling reactions of a series of aryl chlorides and aryl bromides containing basic nitrogen centers with arylboronic acids in water in the absence of added base were reported. The reactions proceeded either partially or entirely under acidic conditions. After surveying twenty-two phosphorus ligands, high yields of products were obtained with aryl chlorides only when a bulky ligand, 2-(di-tert-butyl-phosphino)-1-phenyl-1H-pyrrole (cataCXiumPtB) was used. In contrast, aryl bromides produced high yields of products in the absence of both added base and added ligand. In order to explore the Suzuki coupling process entirely under acidic conditions, a series of reactions were conducted in buffered acidic media using several model substrates. 4-Chlorobenzylamine, in the presence of cataCXiumPtB, produced high yields of product at buffered pH 6.0; the yields dropped off precipitously at buffered pH 5.0 and lower. The fall-off in yield was attributed to the decomposition of the Pd-ligand complex due to the protonation of the ligand in the more acidic aqueous media. In contrast, in the absence of an added ligand, 4-amino-2-chloropyridine produced quant. yields at buffered pH 3.5 and 4.5 while 4-amino-2-bromopyridine produced quant. yields in a series of buffered media ranging from pH 4.5 to 1.5. These substrates were only partially protonated in acidic media and could behave as active Pd ligands in the Suzuki catalytic cycle.6-Bromopyridin-3-amine(cas: 13534-97-9Synthetic Route of C5H5BrN2) was used in this study.

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Synthetic Route of C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Hayashi, Minoru; Nishimura, Yasunobu; Watanabe, Yutaka published 《Syntheses of 3-oxo-λ5-benzophospholes by an intramolecular cyclization of phosphorus-ylide》.Chemistry Letters published the findings.Product Details of 31106-82-8 The information in the text is summarized as follows:

Three synthetic procedures were developed for a new class of P ylide containing conjugate heterocycles, 3-oxo-λ5-benzophospholes. The key to the formation of the heterocycle is unusual intramol. acylation of a P ylide forming an endocyclic ylide. Several types of 2-substituted benzophospholes were synthesized, some of which show fluorescence. After reading the article, we found that the author used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Product Details of 31106-82-8)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Product Details of 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Yuan, Yan-Qiu; Yuan, Feng-Ling; Li, Fei-Long; Hao, Zhi-Min; Guo, Jun; Young, David J.; Zhang, Wen-Hua; Lang, Jian-Ping published 《A cuboidal [Ni4O4] cluster as a precursor for recyclable, carbon-supported nickel nanoparticle reduction catalysts》.Dalton Transactions published the findings.SDS of cas: 29682-15-3 The information in the text is summarized as follows:

Cuboidal [Ni4O4] clusters supported by a pyridine alkoxide ligand have been developed. One of these clusters was selected as a precursor for carbon-hosted Ni nanoparticles (NiNPs/C) which were efficient catalysts for the conversion of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) at room temperature In the experiment, the researchers used many compounds, for example, Methyl 5-bromopicolinate(cas: 29682-15-3SDS of cas: 29682-15-3)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. SDS of cas: 29682-15-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem