Day: October 28, 2022

The critical parameters of pyridine are pressure 6.70 MPa, temperature 620 K and volume 229 cm3·mol−1. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. In the temperature range 340–426 °C its vapor pressure p can be described with the Antoine equation.. Product Details of C6H4BrNO.

Seo, Junseok;Park, So-Ra;Kim, Mina;Suh, Min Chul;Lee, Jihoon research published 《 The role of electron-transporting Benzo[f]quinoline unit as an electron acceptor of new bipolar hosts for green PHOLEDs》, the research content is summarized as follows. We prepared three new compounds [3,6-di(9H-carbazol-9-yl)phenanthrene (3,6-DCP), 2,9-di(9H-carbazol-9-yl)benzo[f]quinoline (2,9-DCBQ), and 3,9-di(9H-carbazol-9-yl)benzo[f]-quinoline (3,9-DCBQ)] containing phenanthrene or benzo[f]quinoline as an electron-withdrawing moiety and a carbazole as electron-donating moiety, resp., as bipolar hosts for green phosphorescent organic light emitting diodes (PHOLEDs). We intentionally substituted nitrogen atom to the C-3 position of phenanthrene moiety to prepare benzo[f]quinolinegroup. And, we found that it allowed better electron transporting behavior than the phenanthrene moiety. Meanwhile, the benzo[f]quinoline/phenanthrene core moieties significantly improved the thermal stability of those host materials, which exhibited glass transition and decomposition temperatures of 132-139 and 395-427 °C, resp. The green PHOLEDs which were fabricated with those host materials showed the lowest operating voltage of 4.7 V at 1000 cd/m² when we used 3,9-DCBQ. Very interestingly, it has an asym. structure with completely separated HOMO and LUMO in space. In contrast, 3,6-DCP having phenanthrene and carbazole moieties showed much higher operating voltage of 6.1 V which imply that replacing nitrogen at the C-3 position of phenanthrene improves carrier transport, i.e., electron transporting behavior. As a result, the 3,9-DCBQ-based PHOLED showed the best overall performance, exhibiting current and power efficiencies of 48.5 cd/A and 20.6 lm/W, resp.

Product Details of C6H4BrNO, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., 31181-90-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The critical parameters of pyridine are pressure 6.70 MPa, temperature 620 K and volume 229 cm3·mol−1. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. In the temperature range 340–426 °C its vapor pressure p can be described with the Antoine equation.. Recommanded Product: Pyridine-3-sulfonyl chloride.

Sedenkova, Kseniya N.;Andriasov, Kristian S.;Eremenko, Marina G.;Grishin, Yuri K.;Alferova, Vera A.;Baranova, Anna A.;Zefirov, Nikolay A.;Zefirova, Olga N.;Zarubaev, Vladimir V.;Gracheva, Yulia A.;Milaeva, Elena R.;Averina, Elena B. research published 《 Bicyclic Isoxazoline Derivatives: Synthesis and Evaluation of Biological Activity》, the research content is summarized as follows. Among the works of the last decade, a literature search revealed spirothiazamenthane, which has served as a lead in the development of derivatives active against resistant viral strains. In this work, the novel mol. scaffold, which resembles spirothiazamenthane, but combines isoxazoline as a heterocycle and cyclooctane ring as a hydrophobic part of the structure is reported. The synthesis of new 3-nitro- and 3-aminoisoxazolines containing spiro-fused or 1,2-annelated cyclooctane fragments was achieved by employing 1,3-dipolar cycloaddition of 3-nitro-4,5-dihydroisoxazol-4-ol 2-oxide or tetranitromethane-derived alkyl nitronates with non-activated alkenes. A series of spiro-sulfonamides was obtained by the reaction of 3-aminoisoxazoline containing a spiro-fused cyclooctane residue with sulfonyl chlorides. Preliminary screening of the compounds for antiviral, antibacterial, antifungal and antiproliferative properties in vitro revealed 1-oxa-2-azaspiro[4.7]dodec-2-en-3-amine and 3a,4,5,6,7,8,9,9a-octahydrocycloocta[d]isoxazol-3-amine with activity against the influenza A/Puerto Rico/8/34 (H1N1) virus in the submicromolar range, and high values of selectivity index. Further study of the mechanism of the antiviral action of these compounds, and the synthesis of their analogs, is likely to identify new agents against resistant viral strains.

Recommanded Product: Pyridine-3-sulfonyl chloride, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., 16133-25-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is colorless, but older or impure samples can appear yellow. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. Computed Properties of 31181-90-5.

Scott, James S.;Moss, Thomas A.;Balazs, Amber;Barlaam, Bernard;Breed, Jason;Carbajo, Rodrigo J.;Chiarparin, Elisabetta;Davey, Paul R. J.;Delpuech, Oona;Fawell, Stephen;Fisher, David I.;Gagrica, Sladjana;Gangl, Eric T.;Grebe, Tyler;Greenwood, Ryan D.;Hande, Sudhir;Hatoum-Mokdad, Holia;Herlihy, Kara;Hughes, Samantha;Hunt, Thomas A.;Huynh, Hoan;Janbon, Sophie L. M.;Johnson, Tony;Kavanagh, Stefan;Klinowska, Teresa;Lawson, Mandy;Lister, Andrew S.;Marden, Stacey;McGinnity, Dermot F.;Morrow, Christopher J.;Nissink, J. Willem M.;O’Donovan, Daniel H.;Peng, Bo;Polanski, Radoslaw;Stead, Darren S.;Stokes, Stephen;Thakur, Kumar;Throner, Scott R.;Tucker, Michael J.;Varnes, Jeffrey;Wang, Haixia;Wilson, David M.;Wu, Dedong;Wu, Ye;Yang, Bin;Yang, Wenzhan research published 《 Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist》, the research content is summarized as follows. Herein we report the optimization of a series of tricyclic indazoles as selective estrogen receptor degraders (SERD) and antagonists for the treatment of ER⁺ breast cancer. Structure based design together with systematic investigation of each region of the mol. architecture led to the identification of N-[1-(3-fluoropropyl)azetidin-3-yl]-6-[(6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl]pyridin-3-amine (I). This compound was demonstrated to be a highly potent SERD that showed a pharmacol. profile comparable to fulvestrant in its ability to degrade ERα in both MCF-7 and CAMA-1 cell lines. A stringent control of lipophilicity ensured that I had favorable physicochem. and preclin. pharmacokinetic properties for oral administration. This, combined with demonstration of potent in vivo activity in mouse xenograft models, resulted in progression of this compound, also known as AZD9833, into clin. trials.

Computed Properties of 31181-90-5, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., 31181-90-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. For this reason, pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Category: pyridine-derivatives.

Scott, James S.;Moss, Thomas A.;Barlaam, Bernard;Davey, Paul R. J.;Fairley, Gary;Gangl, Eric T.;Greenwood, Ryan D. R.;Hatoum-Mokdad, Holia;Lister, Andrew S.;Longmire, David;Polanski, Radoslaw;Stokes, Stephen;Tucker, Michael J.;Varnes, Jeffrey G.;Yang, Bin research published 《 Addition of Fluorine and a Late-Stage Functionalization (LSF) of the Oral SERD AZD9833》, the research content is summarized as follows. Herein we describe our efforts using a late stage functionalization together with more traditional synthetic approaches to generate fluorinated analogs of the clin. candidate AZD9833. The effects of the addition of fluorine on the lipophilicity, permeability, and metabolism are discussed. Many of these changes were tolerated in terms of pharmacol. and resulted in high quality mols. which reached advanced stages of profiling in the testing cascade.

31181-90-5, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. TThe standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. COA of Formula: C6H6BrN.

Schwartz, Leyah A.;Spielmann, Kim;Swyka, Robert A.;Xiang, Ming;Krische, Michael J. research published 《 Formate-Mediated Cross-Electrophile Reductive Coupling of Aryl Iodides and Bromopyridines》, the research content is summarized as follows. Two catalytic systems for the formate-mediated cross-electrophile reductive coupling of aryl iodides with 6-bromopyridines were described. Using homogenous rhodium or heterogeneous palladium catalysts, the products of reductive biaryl cross-coupling could be formed in moderate yield with excellent levels of chemoselectivity.

COA of Formula: C6H6BrN, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., 5315-25-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. Electric Literature of 766-11-0.

Schimler, Sydonie D.;Ryan, Sarah J.;Bland, Douglas C.;Anderson, John E.;Sanford, Melanie S. research published 《 Anhydrous Tetramethylammonium Fluoride for Room-Temperature S_NAr Fluorination》, the research content is summarized as follows. This paper describes the room-temperature S_NAr fluorination of aryl halides and nitroarenes using anhydrous tetramethylammonium fluoride (NMe₄F). This reagent effectively converts aryl-X (X = Cl, Br, I, NO₂, OTf) to aryl-F under mild conditions (often room temperature). Substrates for this reaction include electron-deficient heteroaromatics (22 examples) and arenes (5 examples). The relative rates of the reactions vary with X as well as with the structure of the substrate. However, in general, substrates bearing X = NO₂ or Br react fastest. In all cases examined, the yields of these reactions are comparable to or better than those obtained with CsF at elevated temperatures (i.e., more traditional halex fluorination conditions). The reactions also afford comparable yields on scales ranging from 100 mg to 10 g. A cost anal. is presented, which shows that fluorination with NMe₄F is generally more cost-effective than fluorination with CsF.

766-11-0, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , Electric Literature of 766-11-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. For this reason, pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Reference of 5315-25-3.

Santoro, Antonio;Holub, Jan;Fik-Jaskolka, Marta A.;Vantomme, Ghislaine;Lehn, Jean-Marie research published 《 Dynamic Helicates Self-Assembly from Homo- and Heterotopic Dynamic Covalent Ligand Strands》, the research content is summarized as follows. The understanding and the application of reversible covalent reactions and coordination chem. together with the proper design of the mol. frameworks, allow to achieve not only well-defined output architectures but also different grades of complex behavior. In this work, the dynamic nature of the helical systems offers an addnl. level of complexity by combining self-sorting on two levels: (1) the build-up of the ligand strand constituents from their components through dynamic covalent chem.; (2) the assembly of the helicates from the ligands and the metal cations through dynamic metallo-supramol. chem. The information encoded in the ligands constituent mol. was read differently (and accurately at the same time) by metal cations that varied in the coordination algorithms. It enabled the selective formation of a specific type of helicates from a wide library of helicates formed by the possible combination of subcomponents. Ligands containing dynamic tridentate and/or bidentate binding motifs in the same strand were studied to explore the helicates self-assembly with appropriate metal cations.

Reference of 5315-25-3, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., 5315-25-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Name: 5-Bromo-2-fluoropyridine.

Sander, Kerstin;Gendron, Thibault;Yiannaki, Elena;Cybulska, Klaudia;Kalber, Tammy L.;Lythgoe, Mark F.;Arstad, Erik research published 《 Sulfonium Salts as Leaving Groups for Aromatic Labelling of Drug-like Small Molecules with Fluorine-18》, the research content is summarized as follows. Positron emission tomog. (PET) is unique in that it allows quantification of biochem. processes in vivo, but difficulties with preparing suitably labeled radiotracers limit its scientific and diagnostic applications. Aromatic [¹⁸F]fluorination of drug-like small mols. is particularly challenging as their functional group compositions often impair the labeling efficiency. Herein, we report a new strategy for incorporation of ¹⁸F into highly functionalized aromatic compounds using sulfonium salts as leaving groups. The method is compatible with pharmacol. relevant functional groups, including aliphatic amines and basic heterocycles. Activated substrates react with [¹⁸F]fluoride at room temperature, and with heating the reaction proceeds in the presence of hydrogen bond donors. Furthermore, the use of electron rich spectator ligands allows efficient and regioselective [¹⁸F]fluorination of non-activated aromatic moieties. The method provides a broadly applicable route for ¹⁸F labeling of biol. active small mols., and offers immediate practical benefits for drug discovery and imaging with PET.

766-11-0, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , Name: 5-Bromo-2-fluoropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is colorless, but older or impure samples can appear yellow. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. Related Products of 5315-25-3.

Sailaja, E.;Bhavani, S.;Rambabu, D.;Basaveswara Rao, M. V.;Pal, Manojit research published 《 A greener approach toward N-1 heteroarylation of indoles: Synthesis and in vitro evaluation of potential anti-proliferative agents》, the research content is summarized as follows. A greener approach was developed to synthesize N-pyridyl indoles e.g., I [R¹ = R² = H, R³ = 2-pyridyl] and N-pyrimidinyl indoles e.g., I [R¹ = R² = H, R³ = 2-pyrimidinyl] via an ultrasound assisted selective N-1 heteroarylation of indoles. This methodol. involved reaction of indoles with heteroaryl halides in PEG-400 under ultrasound irradiation Compound I [R¹ = R² = H, R³ = 2-pyrimidinyl] was benzoylated at C-2 position via palladium-mediated C-H bond activation. All the synthesized N-1 heteroarylindoles were tested for their in vitro anti-proliferative properties against cancer (leukemia) and non-cancerous cell lines. Among the tested compounds, compounds I [R¹ = H; R² = 5-OMe; R³ = 2-pyridyl, 5-Me-2-pyridyl, 2-pyrimidinyl] showed promising activity against K562 leukemia cells whereas compound I [R¹ = H, R² = 5-OMe, R³ = 2-pyrimidinyl] showed significant activity against Colo-205 cells. Addnl., none of these N-heteroaryl indoles showed any effect against noncancerous HEK293 cell lines, indicating their selectivity toward cancer cells specifically leukemia.

Related Products of 5315-25-3, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., 5315-25-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. TThe standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. COA of Formula: C6H8N2.

Sagar, Sneha R.;Singh, Devendra Pratap;Das, Rajesh D.;Panchal, Nirupa B.;Sudarsanam, Vasudevan;Nivsarkar, Manish;Vasu, Kamala K. research published 《 Investigations on substituted (2-aminothiazol-5-yl)(imidazo[1,2-a]pyridin-3-yl)methanones for the treatment of Alzheimer’s disease》, the research content is summarized as follows. Herein authors report of a new series of substituted (2-aminothiazol-5-yl)(imidazo[1,2-a]pyridin-3-yl)methanones I (R¹ = H, Me; R² = H, Me, Ph, NMe₂). The designed compounds were synthesized and characterized by spectral data. In vivo anti-inflammatory activity was carried out for screening of anti-inflammatory potential of synthesized compounds All the compounds were tested for acute inflammatory activity by using carrageenan induced acute inflammation model. Compounds I (R¹ = 8-Me, R² = NMe₂; R¹ = 7-Me, R² = NMe₂; R¹ = 7-Me, R² = H) had shown promising acute anti-inflammatory activity and they were further tested for formalin induced chronic inflammation model. Compound I (R¹ = 7-Me, R² = NMe₂)10c showed both acute and chronic anti-inflammatory activity. Compound I also showed promising results in AlCl3 induced AD model. Studies on various behavioral parameters suggested improved amnesic performance of compound I treated rats. Compound I treated rats also exhibited excellent antioxidant and neuroprotective effect with inherent gastrointestinal safety.

1603-41-4, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, COA of Formula: C6H8N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem