Month: October 2022

Jackson, Matthew Irick published the artcile< Macronutrient Proportions and Fat Type Impact Ketogenicity and Shape the Circulating Lipidome in Dogs>, Application In Synthesis of 93-60-7, the main research area is macronutrient fat ketogenicity lipidome circulation dog; canine; ketosis; lipidome; macronutrients; metabolome.

Many physiol. processes including ketogenesis are similar in dogs and humans, but there is little information available on the effect of carbohydrate restriction in dogs. Here, the ketogenicity and serum metabolic profiles of dogs were assessed after they had consumed high carbohydrate (HiCHO); high protein, low carbohydrate (PROT_LoCHO); or high fat, low carbohydrate (FAT_LoCHO) foods. Thirty-six dogs were fed HiCHO for 4 wk, then randomized to PROT_LoCHO or FAT_LoCHO for 5 wk. Dogs then crossed over to the other food for an addnl. 5 wk. Generally, reduction of dietary carbohydrate by replacement with either protein or fat increased the energy required to maintain body weight, and fat had a greater effect. Postabsorptive energy availability derived mainly from glucose and triglycerides with HiCHO, from gluconeogenic amino acids and fatty acids with PROT_LoCHO, and from fatty acids and β-hydroxybutyrate with FAT_LoCHO. This study demonstrated that the reduction of carbohydrate in canine foods is potentially beneficial to dogs based on improvements in metabolism and supports the use of low-carbohydrate foods as safe and effective for healthy adult dogs.

Metabolites published new progress about Absorption. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Application In Synthesis of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cai, Pengfei; Gao, Zhan; Yin, Xinchi; Luo, Yuanqing; Zhao, Xiaoyong; Pan, Yuanjiang published the artcile< facile enantioseparation and recognition of mandelic acid and its derivatives in self-assembly interaction with chiral ionic liquids>, Synthetic Route of 3796-23-4, the main research area is enantioseparation mandelic acid derivatives self assembly chiral ionic liquids; chiral separation; coprecipitation; ionic liquids; mandelic acid.

Mandelic acid and its derivatives are important medical intermediates in the pharmaceutical industry. Different stereoisomers exhibited distinct biol. properties to human bodies. Given that, enantioselective recognition and separation of mandelic acid are of great importance. In this study, four novel different types of chiral ionic liquids bearing designed functional groups were synthesized and successful enantioselective precipitation with mandelic acid and its derivatives That is, (R, R)-chiral ionic liquid 1 can coprecipitated with S-mandelic acid and its derivatives was observed In addition, good correlation coefficient is achieved by using electrospray mass spectrum at neg. ion pattern for quick anal. of the enantioselective precipitation, which could be served as a method of enantioselective recognition. The possible intermol. interactions are established after systematical studies by NMR spectroscopy and DFT calculations

Journal of Separation Science published new progress about Chiral resolution. 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Synthetic Route of 3796-23-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Grongsaard, Pintipa; Bulger, Paul G.; Wallace, Debra J.; Tan, Lushi; Chen, Qinghao; Dolman, Sarah J.; Nyrop, Jason; Hoerrner, R. Scott; Weisel, Mark; Arredondo, Juan; Itoh, Takahiro; Xie, Chengfu; Wen, Xianghui; Zhao, Dalian; Muzzio, Daniel J.; Bassan, Ephraim M.; Shultz, C. Scott published the artcile< Convergent, Kilogram Scale Synthesis of an Akt Kinase Inhibitor>, Synthetic Route of 1050501-88-6, the main research area is convergent synthesis AKT kinase inhibitor.

The development of a convergent, chromatog.-free synthesis of an allosteric Akt kinase inhibitor is described. The route comprised 17 total steps and was used to produce kilogram quantities of the target mol. A key early transformation, for which both batch and flow protocols were developed, was formylation of a dianion derived by deprotonation and subsequent lithium-halogen exchange from a 2-bromo-3-aminopyridine precursor. Improved reaction yield and practicality were achieved in the continuous processing mode. Further significant process developments included the safe execution of a high temperature and pressure hydrazine displacement, separation of substituted cyclobutane diastereomers by means of chemoselective ester hydrolysis, and a late-stage Suzuki fragment coupling under mild conditions.

Organic Process Research & Development published new progress about Formylation. 1050501-88-6 belongs to class pyridine-derivatives, and the molecular formula is C5H4BrClN2, Synthetic Route of 1050501-88-6.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liang, Lijuan; Wu, Xiaoyun; Shi, Chuanling; Wen, Haoyu; Wu, Shouhai; Chen, Jing; Huang, Chunxia; Wang, Yi; Liu, Yunjun published the artcile< Synthesis and characterization of polypyridine ruthenium(II) complexes and anticancer efficacy studies in vivo and in vitro>, Application of C10H8N2, the main research area is Apoptosis; Cell cytotoxicity; Mitochondria; Ruthenium(II) complexes; Toxic activity in vivo.

In this article, ligand IPP (IPP = 4-(1H-imidazo[4,5-f][1,10]phenanthrolin-2-yl)-N,N-diphenylaniline) and its three Ru(II) complexes: [Ru(bpy)2(IPP)](ClO4)2 (1) (bpy = 2,2′-bipyridine), [Ru(dmbpy)2(IPP)](ClO4)2 (2) (dmbpy = 4,4′-dimethyl-2,2′-bipyridine), and [Ru(phen)2(IPP)](ClO4)2 (3) (phen = 1,10-phenanthroline) were synthesized and characterized. The anticancer activity in vitro of the complexes was investigated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. The scratching and colony-forming experiments confirmed the complexes 1, 2, 3 interfered with the proliferation and migration ability of cells. The accumulation of the complexes in cells was researched and we found that these complexes directly accumulated in mitochondria, then the complexes cause a decline of the mitochondrial membrane potential and induce an increase of intracellular reactive oxygen species (ROS) levels. The growth of B16 cells were inhibited by 1, 2 and 3 at G0/G1 phase. Apoptosis was induced through mitochondrial pathway and the expression of apoptosis-related factors was regulated. In addition, the complexes promoted the transition of poly(ADP-ribose)polymerase (PARP) into the cleaved form (Cleaved PARP), downregulated the anti-apoptotic proteins, and upregulated the pro-apoptotic proteins. Consequently, complexes 1, 2 and 3 exerted their anticancer activity by regulating B-cell lymphoma-2 (Bcl-2) family proteins. Complex 2 showed excellent antitumor effects with a high inhibitory rate of 65.95% in vivo. Taken together, the complexes cause apoptosis in B16 cells through a ROS-mediated mitochondrial dysfunction pathway.

Journal of Inorganic Biochemistry published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yue, Cheng-Yang; Yue, Yun-Di; Sun, Hai-Xiao; Li, Dong-Yang; Lin, Na; Wang, Xin-Ming; Jin, Ying-Xue; Dong, Yu-Han; Jing, Zhi-Hong; Lei, Xiao-Wu published the artcile< Transition metal complex dye-sensitized 3D iodoplumbates: syntheses, structures and photoelectric properties>, Electric Literature of 366-18-7, the main research area is bipyridine iron cobalt nickel manganese iodoplumbate preparation crystal structure; photoelec property dye sensitized iodoplumbate.

Here, authors prepared the first series of 3D hybrid iodoplumbates with novel porous frameworks of [Pb8I21]5- directed by transition metal complex (TMC) cationic dyes of [TM(2.2-bipy)3]2+. The microporous materials exhibit outstanding visible light-driven photoelec. properties due to the effective photosensitization of the TMC dyes. The coexistence of stronger face- and weaker corner-shared connecting manners affords the feasibility of tailoring the 3D framework into low-dimensional skeletons, which provide a new structural prototype to modify the semiconducting properties similar to those of classic perovskites.

Chemical Communications (Cambridge, United Kingdom) published new progress about Cationic dyes. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Electric Literature of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Bin; Xu, Zhi-Qiang; Xu, Ying-Bo; Yong, Guo-Ping published the artcile< Effects of substituent groups on the crystal structures and luminescence properties of zero-/two-dimensional Zn(II) complexes>, Electric Literature of 350-03-8, the main research area is crystal structure zinc imidazopyridine polymeric monomeric preparation luminescence.

The 3-position substituted imidazo[1,2-a]pyridine ligands C7H4N2Cl-2-(CH:CHC(:O)R)-3 (L1, R = 3-pyridinyl) and (HL2, R = COOH) were facilely synthesized, and used for construction of two novel luminescent Zn(II) complexes, [ZnCl2(L1)2] (1) and [Zn(L2)2]n (2). Single-crystal x-ray diffraction anal. shows that 1 has a zero-dimensional structure, whereas, 2 possesses a two-dimensional polymeric network with rhombic grid motifs. The structural differences between 1 and 2 should be determined by the different substituent groups adjacent to the carbonyl groups of the 3-position substituted imidazo[1,2-a]pyridine ligands. Complex 1 reveals a red shifted emission band, compared to free L1 ligand, whereas, 2 displays a similar emission spectrum as the free HL2 ligand. Such results are also ascribed to substituent group effects and corresponding structural differences.

Inorganic Chemistry Communications published new progress about Crystal structure. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Electric Literature of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Stavber, Stojan; Zupan, Marko published the artcile< Reactions of cesium fluoroxysulfate with pyridine>, Name: 3-Chloro-2-methoxypyridine, the main research area is pyridine fluorination cesium fluoroxysulfate solvent effect.

Pyridine readily reacts with CsSO4F in various solvents at room temperature producing a mixture of up to three products (2-fluoropyridine, 2-pyridyl fluorosulfonate and 2-chloro or 2-alkoxypyridine), their distribution strongly depending on the solvent used. Reaction of 3-chloropyridine with CsSO4F in methanol leads regioselectively to 2-methoxy-3-chloropyridine, while 3-methylpyridine was converted into 2-methoxy-3-Me and 2-methoxy-5-methylpyridine in a 2:1 relative ratio.

Tetrahedron Letters published new progress about Fluorination. 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, Name: 3-Chloro-2-methoxypyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yang, Qin; Lei, Xiaoli; Yin, Zhijian; Deng, Zhihong; Peng, Yiyuan published the artcile< Copper-Catalyzed NaBAr4-Based N-Arylation of Amines>, Synthetic Route of 22961-45-1, the main research area is arylamine preparation; amine tetraaryl borate Cham Lam cross coupling copper catalyst.

NaBAr4 Based Cham-Lam cross-coupling of amines for the synthesis of arylamines RNHAr [R = n-Bu, Ph, benzyl, etc.; Ar = Ph, 4-MeC6H4, 4-ClC6H4, etc.] in the presence of catalytic copper (II) acetate monohydrate in acetonitrile at room temperature under air was described. In particular, the reaction of alkylamine and NaBAr4 proceeded smoothly to offered the corresponding products in good to excellent yields.

Synthesis published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 22961-45-1 belongs to class pyridine-derivatives, and the molecular formula is C11H10N2, Synthetic Route of 22961-45-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Ze; Li, Wenwei; Lu, Maolin; Bess, Julian Jr; Chao, Cara W.; Gorman, Jason; Terry, Daniel S.; Zhang, Baoshan; Zhou, Tongqing; Blanchard, Scott C.; Kwong, Peter D.; Lifson, Jeffrey D.; Mothes, Walther; Liu, Jun published the artcile< Subnanometer structures of HIV-1 envelope trimers on aldrithiol-2-inactivated virus particles>, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane, the main research area is .

Abstract: The HIV-1 envelope glycoprotein (Env) trimer, composed of gp120 and gp41 subunits, mediates viral entry into cells. Recombinant Env trimers have been studied structurally, but characterization of Env embedded in intact virus membranes has been limited to low resolution Here, we deploy cryo-electron tomog. and subtomogram averaging to determine the structures of Env trimers on aldrithiol-2 (AT-2)-inactivated virions in ligand-free, antibody-bound and CD4-bound forms at subnanometer resolution Tomog. reconstructions document mol. features consistent with high-resolution structures of engineered soluble and detergent-solubilized Env trimers. One of three conformational states previously predicted by smFRET was not observed by cryo-ET, potentially owing to AT-2 inactivation. We did observe Env trimers to open in situ in response to CD4 binding, with an outward movement of gp120-variable loops and an extension of a critical gp41 helix. Overall features of Env trimer embedded in AT-2-treated virions appear well-represented by current engineered trimers.

Nature Structural & Molecular Biology published new progress about 2127-03-9. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sahani, Rajkumar Lalji; Diana-Rivero, Raquel; Vernekar, Sanjeev Kumar V.; Wang, Lei; Du, Haijuan; Zhang, Huanchun; Castaner, Andres Emanuelli; Casey, Mary C.; Kirby, Karen A.; Tedbury, Philip R.; Xie, Jiashu; Sarafianos, Stefan G.; Wang, Zhengqiang published the artcile< Design, synthesis and characterization of HIV-1 CA-targeting small molecules: conformational restriction of PF74>, Computed Properties of 53636-56-9, the main research area is indolyl pyridyl amide preparation antiviral SAR cytotoxicity mol docking; imidazolyl indolyl amide preparation antiviral SAR cytotoxicity mol docking; HIV-1; PF74; capsid protein; conformational constraint; metabolic stability.

Designed and synthesized three series of PF74-like analogs featuring conformational constraints at the aniline terminus or the phenylalanine carboxamide moiety, and characterized them using a biophys. thermal shift assay (TSA), cell-based antiviral and cytotoxicity assays, and in vitro metabolic stability assays in human and mouse liver microsomes. These studies showed that the two series with the phenylalanine carboxamide moiety replaced by a pyridine or imidazole ring can provide viable hits. Subsequent SAR identified an improved analog I which effectively inhibited HIV-1 (EC50 = 0.31μM), strongly stabilized CA hexamer (ΔTm = 8.7°C), and exhibited substantially enhanced metabolic stability (t1/2 = 27 min for 15 vs. 0.7 min for PF74). Metabolic profiles from the microsomal stability assay also indicate that blocking the C5 position of the indole ring could lead to increased resistance to oxidative metabolism

Viruses published new progress about Amides Role: PAC (Pharmacological Activity), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 53636-56-9 belongs to class pyridine-derivatives, and the molecular formula is C7H6BrNO2, Computed Properties of 53636-56-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem