Month: October 2022

Anisimov, Anton A.; Vysochinskaya, Yulia S.; Kononevich, Yuriy N.; Dolgushin, Fedor M.; Muzafarov, Aziz M.; Shchegolikhina, Olga I. published the artcile< Polyhedral phenylnickelsodiumsiloxanolate transformation in the presence of aromatic nitrogen-containing ligands>, Recommanded Product: 2,2′-Bipyridine, the main research area is nickel sodium polyhedral phenyl siloxanolate complex preparation crystal structure.

Two new polyhedral phenylmetallasiloxane complexes, {[PhSi(O)O-]6(Ni2+)6(Na+)2(μ3-OH)2[PhSi(O)O-]6}•2(BIPY)•4(DMF) (1) and {[PhSi(O)O-]6(Ni2+)3(Na+)6(μ5-OH)2[PhSi(O)O-]5}•7(PY)•2(BuOH)•2(H2O) (2) formed in the process of recrystallization of polyhedral phenylnickelsodiumsiloxane (Na+)2{[PhSi(O)O-]6(Ni2+)4(Na+)4(μ3-OH)2[PhSi(O)O-]6}•16(BuOH) (A) from DMF in the presence of 2,2-bipyridine (complex 1) or from pyridine (complex 2) are described. σ-Donor ligands of the pyridine series (pyridine and 2,2-bipyridine) play a crucial role in the process of dissociation of the initial metallasiloxane framework and its reassembly on a new matrix of metal ions. Not only the metal-containing cationic layer is reconstructed with a change in the number, ratio, and spatial arrangement of nickel and sodium cations, but also changes the size of cyclic siloxane ligands.

Inorganica Chimica Acta published new progress about Crystal structure. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Recommanded Product: 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hu, Ziwei; Banothu, Janardhan; Beesu, Mallesh; Gustafson, Collin J.; Brush, Michael J. H.; Trautman, Kathryn L.; Salyer, Alex C. D.; Pathakumari, Balaji; David, Sunil A. published the artcile< Identification of Human Toll-like Receptor 2-Agonistic Activity in Dihydropyridine-Quinolone Carboxamides>, Computed Properties of 56622-54-9, the main research area is dihydropyridine quinolone carboxamide synthesis SAR TLR2 vaccine adjuvant.

Using a multiplexed, reporter gene-based, high-throughput screen, we identified 9-fluoro-7-hydroxy-3-methyl-5-oxo-N-(pyridin-3-ylmethyl)-2,3-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-6-carboxamide as a TLR2 agonist. Preliminary structure-activity relationship studies on the carboxamide moiety led to the identification of analogs that induce chemokines and cytokines in a TLR2-dependent manner. These results represent new leads for the development of vaccine adjuvants.

ACS Medicinal Chemistry Letters published new progress about Chemokines Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 56622-54-9 belongs to class pyridine-derivatives, and the molecular formula is C7H10N2, Computed Properties of 56622-54-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xie, Feng; Li, Yibiao; Chen, Xiuwen; Chen, Lu; Zhu, Zhongzhi; Li, Bin; Huang, Yubing; Zhang, Kun; Zhang, Min published the artcile< Direct synthesis of novel quinoxaline derivatives via palladium-catalyzed reductive annulation of catechols and nitroarylamines>, Product Details of C6H7N3O2, the main research area is catechol nitroarylamine reusable palladium catalyst reductive cyclization; phenazine preparation.

A palladium-catalyzed new hydrogenative annulation reaction of catechols and nitroarylamines, allowing straightforward access to two classes of novel quinoxaline derivatives, was reported. The reaction proceeded with operational simplicity, an easily available catalyst system, a broad substrate scope and without the need for pre-functionalization, which offers the potential for further design of new reductive transformations of renewable resources into value-added products.

Chemical Communications (Cambridge, United Kingdom) published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Product Details of C6H7N3O2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sikder, Amrita; Ray, Debes; Aswal, Vinod K.; Ghosh, Suhrit published the artcile< Supramolecular Assembly of a Molecularly Engineered Protein and Polymer>, Computed Properties of 2127-03-9, the main research area is supramol assembly protein polymer; conjugation; hydrogen bonds; polymers; proteins; self-assembly.

Programmable assembly of biomols. is a fast growing research area that aims to emulate nature’s elegance in creating numerous hierarchical self-assembled structures, which are responsible for unimaginably difficult biol. functions. Protein assembly is a particularly challenging task, owing to their structural diversity, conformational heterogeneity, and high mol. weight This article reveals the ability of a supramol. structure-directing unit (SSDU) to regulate the entropically favorable supramol. assembly of a covalently conjugated protein (bovine serum albumin (BSA)) to produce well-defined protein-decorated micelles with remarkably high thermal stability, suppression of the thermal denaturation of the protein, and retention of enzymic activity. Furthermore, a SSDU-appended thermo-responsive poly(N-isopropylacrylamide) (PNIPAM) coassembles with the SSDU-BSA conjugate because, in both cases, assembly was primarily driven by specific mol. recognition between the SSDUs. However, the resulting supramol. protein-polymer conjugate exhibits distinctly different polymersome structure to that of the micellar particle produced by the protein-SSDU conjugate. In this case, the enzymic activity can be significantly suppressed above the lower critical solution temperature of supramolecularly conjugated PNIPAM, possibly due to collapse of the de-solvated polymer chains on the protein surface.

Chemistry – A European Journal published new progress about Bovine serum albumin Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), PROC (Process) (conjugates with 1,4,5,8-naphthalenetetracarboxylic diimide derivative). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Computed Properties of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zeng, Liyao; Yang, Huaxin; Zhao, Menglong; Wen, Jialin; Tucker, James H. R.; Zhang, Xumu published the artcile< C1-Symmetric PNP Ligands for Manganese-Catalyzed Enantioselective Hydrogenation of Ketones: Reaction Scope and Enantioinduction Model>, Application In Synthesis of 350-03-8, the main research area is ferrocene chiral PNP ligand manganese preparation ketone enantioselective hydrogenation.

A family of ferrocene-based chiral PNP ligands I (R = t-Bu, cyclohexyl, Ph, R’ = Ph; R = Ph, R’ = H, i-Pr, PhCH2) has been reported. These tridentate ligands were successfully applied in Mn-catalyzed asym. hydrogenation of ketones with high enantioselectivities (92-99% ee for aryl alkyl ketones) as well as high efficiencies (TON up to 2000). In addition, dialkyl ketones could also be hydrogenated smoothly. Manganese intermediates that might be involved in the catalytic cycle were analyzed. DFT calculation was carried out to help understand the chiral induction model. The Mn/PNP catalyst could discriminate two groups with different steric properties by deformation of the phosphine moiety in the flexible 5-membered ring.

ACS Catalysis published new progress about Density functional theory. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Application In Synthesis of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sakac, Nikola; Markovic, Dean; Sarkanj, Bojan; Madunic-Cacic, Dubravka; Hajdek, Krunoslav; Smoljan, Bozo; Jozanovic, Marija published the artcile< Direct potentiometric study of cationic and nonionic surfactants in disinfectants and personal care products by new surfactant sensor based on 1,3-dihexadecyl-1H-benzo[d]imidazol-3-ium>, Name: 1-Hexadecylpyridin-1-ium chloride, the main research area is dihexadecyl benzo imidazolium sensor cationic nonionic surfactant disinfectant; cationic surfactants; disinfectants; ionophore; nonionic surfactants; nose drops; personal care products; potentiometry; sensor.

A novel, simple, low-cost, and user-friendly potentiometric surfactant sensor based on the new 1,3-dihexadecyl-1H-benzo[d]imidazol-3-ium-tetraphenylborate (DHBI-TPB) ion-pair for the detection of cationic surfactants in personal care products and disinfectants is presented here. The new cationic surfactant DHBI-Br was successfully synthesized and characterized by NMR (NMR), Fourier transform IR (FTIR) spectrometry, liquid chromatog.-mass spectrometry (LC-MS) and elemental anal. and was further employed for DHBI-TPB ion-pair preparation The sensor gave excellent response characteristics for CTAB, CPC and Hyamine with a Nernstian slope (57.1 to 59.1 mV/decade), whereas the lowest limit of detection (LOD) value was measured for CTAB (0.3 x 10-6 M). The sensor exhibited a fast dynamic response to dodecyl sulfate (DDS) and TPB. High sensor performances stayed intact regardless of the employment of inorganic and organic cations and in a broad pH range (2-11). Titration of cationic and ethoxylated (EO)-nonionic surfactant (NSs) (in Ba2+) mixtures with TPB revealed the first inflexion point for a cationic surfactant and the second for an EO-nonionic surfactant. The increased concentration of EO-nonionic surfactants and the number of EO groups had a neg. influence on titration curves and signal change. The sensor was successfully applied for the quantification of tech.-grade cationic surfactants and in 12 personal care products and disinfectants. The results showed good agreement with the measurements obtained by a com. surfactant sensor and by a two-phase titration A good recovery for the standard addition method (98-102%) was observed

Molecules published new progress about Alcohols, tallow, ethoxylated Role: PRP (Properties), TEM (Technical or Engineered Material Use), USES (Uses) (Genapol T 110, Genapol T 080). 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Name: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Katsuya, Ken; Oikawa, Daisuke; Iio, Kiyosei; Obika, Shingo; Hori, Yuji; Urashima, Toshiki; Ayukawa, Kumiko; Tokunaga, Fuminori published the artcile< Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-kB signaling>, Synthetic Route of 329214-79-1, the main research area is LUBAC HOIPIN nuclear factor signalling; Cytokine; Enzyme inhibitor; Inflammation; NF-κB; Ubiquitin.

Nuclear factor-kB (NF-kB) is a crucial transcription factor family involved in the regulation of immune and inflammatory responses and cell survival. The linear ubiquitin chain assembly complex (LUBAC), composed of the HOIL-1L, HOIP, and SHARPIN subunits, specifically generates Met1-linked linear ubiquitin chains through the ubiquitin ligase activity in HOIP, and activates the NF-kB pathway. We recently identified a chem. inhibitor of LUBAC, which we named HOIPIN-1 (HOIP inhibitor-1). To improve the potency of HOIPIN-1, we synthesized 7 derivatives (HOIPIN-2~8), and analyzed their effects on LUBAC and NF-kB activation. Among them, HOIPIN-8 suppressed the linear ubiquitination activity by recombinant LUBAC at an IC50 value of 11 nM, corresponding to a 255-fold increase over that of HOIPIN-1. Furthermore, as compared with HOIPIN-1, HOIPIN-8 showed 10-fold and 4-fold enhanced inhibitory activities on LUBAC- and TNF-a-induced NF-kB activation resp., without cytotoxicity. These results indicated that HOIPIN-8 is a powerful tool to explore the physiol. functions of LUBAC.

Biochemical and Biophysical Research Communications published new progress about Animal gene, ICAM1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Synthetic Route of 329214-79-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xie, Qiqiang; Dong, Guangbin published the artcile< Programmable Ether Synthesis Enabled by Oxa-Matteson Reaction>, Formula: C11H16BNO2, the main research area is boronate alkyl aryl oxa Matteson oxygen carbenoid insertion reaction; boron substituted ether product preparation.

The Matteson-type reactions have received increasing interest in constructing complex organic mols. via iterative synthetic strategies; however, the current tactics are almost exclusively based on homologation of pure C chains. Here, the authors report the development of the oxa-Matteson reaction that enables sequential O and carbenoid insertions into diverse alkyl- and arylboronates. It offers a distinct entry to a wide range of B-substituted ethers. The utilities of this method are demonstrated in the preparation of various functional ethers, the asym. synthesis of an acetyl-CoA-carboxylase inhibitor, and the programmable construction of polyethers.

Journal of the American Chemical Society published new progress about Boronic acids, esters Role: RCT (Reactant), RACT (Reactant or Reagent) (alkyl and aryl). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Formula: C11H16BNO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gardell, Stephen J.; Hopf, Meghan; Khan, Asima; Dispagna, Mauro; Hampton Sessions, E.; Falter, Rebecca; Kapoor, Nidhi; Brooks, Jeanne; Culver, Jeffrey; Petucci, Chris; Ma, Chen-Ting; Cohen, Steven E.; Tanaka, Jun; Burgos, Emmanuel S.; Hirschi, Jennifer S.; Smith, Steven R.; Sergienko, Eduard; Pinkerton, Anthony B. published the artcile< Boosting NAD+ with a small molecule that activates NAMPT>, Formula: C6H8N2, the main research area is lung carcinoma cell NAMPT SBI797812 NAD.

Pharmacol. strategies that boost intracellular NAD+ are highly coveted for their therapeutic potential. One approach is activation of nicotinamide phosphoribosyltransferase (NAMPT) to increase production of NMN (NMN), the predominant NAD+ precursor in mammalian cells. A high-throughput screen for NAMPT activators and hit-to-lead campaign yielded SBI-797812, a compound that is structurally similar to active-site directed NAMPT inhibitors and blocks binding of these inhibitors to NAMPT. SBI-797812 shifts the NAMPT reaction equilibrium towards NMN formation, increases NAMPT affinity for ATP, stabilizes phosphorylated NAMPT at His247, promotes consumption of the pyrophosphate byproduct, and blunts feedback inhibition by NAD+. These effects of SBI-797812 turn NAMPT into a “”super catalyst”” that more efficiently generates NMN. Treatment of cultured cells with SBI-797812 increases intracellular NMN and NAD+. Dosing of mice with SBI-797812 elevates liver NAD+. Small mol. NAMPT activators such as SBI-797812 are a pioneering approach to raise intracellular NAD+ and realize its associated salutary effects.

Nature Communications published new progress about Biomarkers. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Formula: C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rani, Pooja; Gauri; Husain, Ahmad; Bhasin, K. K.; Kumar, Girijesh published the artcile< A Doubly Interpenetrated CuII Metal-Organic Framework for Selective Molecular Recognition of Nitroaromatics>, COA of Formula: C6H8N2, the main research area is copper pyridinylnaphthalenecarboxamide oxybisbenzoate MOF preparation thermal stability fluorescent sensor; crystal structure copper pyridinylnaphthalenecarboxamide oxybisbenzoate MOF.

Herein, we report the design, synthesis, and structural characterization of a novel 2-fold interpenetrated CuII metal-organic framework Cu-MOF-1 [{Cu2(L)(oba)2}·DMF·H2O]α (where, L = N2,N6-di(pyridin-4-yl)naphthalene-2,6-dicarboxamide and oba2- is 4,41-oxybis(benzoic acid) anion). A single-crystal X-ray anal. reveals that Cu-MOF-1 exhibits a doubly (1 + 1) interpenetrated three-dimensional structure with 6-connected mab topol. Moreover, Cu-MOF-1 showed high fluorescence stability in methanol solution and selectively detected nitroaroms. with high quenching constants and low detection limits of 0.31 × 105 M-1 and 22.65μM for 2,4,6-TNP; 1.34 × 105 M-1 and 18.7μM for 4-NPH; and 1.49 × 105 M-1 and 14.07μM for 4-NA. Notably, ligand L itself did not display any type of recognition for any nitroaroms. in methanol solution The sensing of NACs by Cu-MOF-1 followed mostly the resonance energy transfer mechanism; however, in the case of 4-NPH and 2,4,6-TNP an electron transfer mechanism also exists. Importantly, Cu-MOF-1 shows recyclability up to five cycles without any significant loss in quenching efficiency.

Crystal Growth & Design published new progress about Aromatic nitro compounds Role: ANT (Analyte), ANST (Analytical Study). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, COA of Formula: C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem