Month: October 2022

Du, Zhengyin; Li, Zuopeng; Deng, Youquan published the artcile< Synthesis and characterization of sulfonyl-functionalized ionic liquids>, Computed Properties of 21876-43-7, the main research area is ionic liquid sulfonyl functionalized preparation media catalyst.

Novel sulfonyl-functionalized ionic liquids with -SO3H and -SO2Cl groups were designed, synthesized, and characterized. Being strong acidic substances, these ionic liquids have great potential as media and catalysts in many acid-catalyzed reactions.

Synthetic Communications published new progress about Imidazolium compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 21876-43-7 belongs to class pyridine-derivatives, and the molecular formula is C9H13NO3S, Computed Properties of 21876-43-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ye, Shanghui; Wu, Congjin; Gu, Pengfei; Xiang, Tai; Zhang, Senyu; Jing, Tongtong; Wang, Shi; Yang, Xiaodi; Li, Yonghua; Huang, Wei published the artcile< A benzoindole-cored building block for deep blue fluorescent materials: synthesis, photophysical properties, and applications in organic light-emitting diodes>, Formula: C6H8N2, the main research area is benzoindole cored blue fluorescent material organic light emitting diode; LED organic benzoindole cored blue fluorescent material; electroluminescent device organic benzoindole cored blue fluorescent material.

Deep blue fluorescent materials are crucial in the commercialization of organic light-emitting diodes (OLEDs) for full-color displays or solid-state lighting sources. Aromatic ring compounds based on a newly designed 2-(pyridine-4-yl)-3-phenyl-1H-benzo[g]indole core, were synthesized, on which donor (D) and acceptor (A) groups are bonded in a Y-typed configuration, forming a D-π-A-π-D structure. The electronic structure and photophys. properties were explored, as well as the applications in the blue OLEDs. Multi-state couplings exist between the D-π-A-π-D 3 moieties, resulting in high luminescence quantum yield ≤76.1% peaking at ∼410 nm, and depressed efficiency roll-off at high luminance. The deep blue OLEDs based on CzCNBPyIp emitter exhibits stable emission peaking at 416 nm with negligible efficiency roll-off at high luminance range of 1,000-10,000 cd m-2, and corresponding CIEx,y = (0.162, 0.085) and maximum EQE = 2.6%, making it among the highest performance solution processed deep blue fluorescent devices. This work provides an alternative method for the deep blue fluorescent materials design toward solution processing OLEDs.

Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about Electron acceptors. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Formula: C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Inai, Makoto; Ouchi, Hitoshi; Asahina, Aya; Asakawa, Tomohiro; Hamashima, Yoshitaka; Kan, Toshiyuki published the artcile< Practical total syntheses of acromelic acids A and B>, Name: 3-Bromo-2-chloro-6-methoxypyridine, the main research area is natural product acromelic acid total regioselective enantioselective synthesis pyrrolidine; reductive amination ortho lithiation bromination dichloropyridine; nitroalkene asym conjugate addition ketoester nickel catalyst epimerization.

Practical total syntheses of acromelic acids A and B, which were scarce natural products isolated from toxic mushroom by Shirahama and Matsumoto, were accomplished in 13 (36% total yield) and 17 steps (6.9% total yield), resp., from 2,6-dichloropyridine. Beginning with regioselective transformation of sym. 2,6-dichloropyridine by either ortho-lithiation or bromination, nitroalkenes (I) (R1 = CO2Me, OMe; R2 = OMe, CO2t-Bu) were provided. Stereoselective construction of the vicinal stereocenters at the C-3, 4 positions of acromelic acids A and B was performed by a Ni-catalyzed asym. conjugate addition of α-ketoesters to the nitroalkenes. Construction of the pyrrolidine ring was accomplished in a single operation via a sequence consisting of reduction of the nitro group, intramol. condensation with the ketone, and reduction of the resulting ketimine.

Chemical & Pharmaceutical Bulletin published new progress about Amino acids Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 777931-67-6 belongs to class pyridine-derivatives, and the molecular formula is C6H5BrClNO, Name: 3-Bromo-2-chloro-6-methoxypyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xu, Liping; Hilton, Margaret J.; Zhang, Xinhao; Norrby, Per-Ola; Wu, Yun-Dong; Sigman, Matthew S.; Wiest, Olaf published the artcile< Mechanism, Reactivity, and Selectivity in Palladium-Catalyzed Redox-Relay Heck Arylations of Alkenyl Alcohols>, Recommanded Product: (S)-4-(tert-Butyl)-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole, the main research area is palladium catalyzed redox relay Heck arylation alkenyl alc mechanism.

The enantioselective Pd-catalyzed redox-relay Heck arylation of acyclic alkenyl alcs. allows access to various useful chiral building blocks from simple olefinic substrates. Mechanistically, after the initial migratory insertion, a succession of β-hydride elimination and migratory insertion steps yields a saturated carbonyl product instead of the more general Heck product, an unsaturated alc. Here, we investigate the reaction mechanism, including the relay function, yielding the final carbonyl group transformation. M06 calculations predict a ΔΔG# of 1 kcal/mol for the site selectivity and 2.5 kcal/mol for the enantioselectivity, in quant. agreement with exptl. results. The site selectivity is controlled by a remote electronic effect, where the developing polarization of the alkene in the migratory insertion transition state is stabilized by the C-O dipole of the alc. moiety. The enantioselectivity is controlled by steric repulsion between the oxazoline substituent and the alc.-bearing alkene substituent. The relay efficiency is due to an unusually smooth potential energy surface without high barriers, where the hydroxyalkyl-palladium species acts as a thermodn. sink, driving the reaction toward the carbonyl product. Computational predictions of the relative reactivity and selectivity of the double bond isomers are validated exptl.

Journal of the American Chemical Society published new progress about Alkenyl alcohols Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), RCT (Reactant), PROC (Process), RACT (Reactant or Reagent). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Recommanded Product: (S)-4-(tert-Butyl)-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lv, Tengteng; Song, Tongxiang; Liu, Huijie; Peng, Ruibing; Jiang, Xiamin; Zhang, Weiwei; Han, Qingxi published the artcile< Isolation and characterization of a virulence related Vibrio alginolyticus strain Wz11 pathogenic to cuttlefish, Sepia pharaonis>, HPLC of Formula: 366-18-7, the main research area is Vibrio Sepia virulence hemolysin gene; Bacterial swarming; Haemolysin; Sepia pharaonis; Siderophore production; Vibrio alginolyticus.

Vibrio alginolyticus is a ubiquitous marine opportunistic pathogen that can infect various hosts in marine environment. In the present study, V. alginolyticus strain Wz11 was isolated from diseased cuttlefish, Sepia pharaonis, with 20% of promoted death and high survival capacity in skin mucus and tissue liquid Its growth, siderophore production, and expressions of haemolysin and swarming related genes were characterized under iron limited conditions. The minimal inhibitory concentration (MIC) of 2,2-dipyridyl (DP) to V. alginolyticus strain Wz11 was 640μM. While growth of V. alginolyticus strain Wz11 was inhibited by DP, production of iron-seizing substances, haemolytic activity and swarming motility were increased. Moreover, expressions of haemolysin related genes tlh, tdh and vah and flagellar related genes flgH, fliC, fliD and fliS were also characterized using real-time reverse transcriptase PCR. Expression of tdh was up-regulated to 7.7-fold, while expressions of tlh and vah were down-regulated to 0.016-fold and 0.03-fold, resp. The expression of fliC, flgH, fliD and fliS was up-regulated to 4.9-, 3.8-, 8.6- and 4.5-fold, resp. Concluded from our results suggested that V. alginolyticus strain Wz11 was considered as a potential pathogen of S. pharaonis, and iron level played an important role in the production of iron-seizing substances, and activities of haemolysin and bacterial swarming as well as their related gene expressions.

Microbial Pathogenesis published new progress about Aeromonas hydrophila. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, HPLC of Formula: 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Lin; Fan, Junhua; Chong, Jer-Hong; Cesena, Angela; Tam, Betty Y. Y.; Gilson, Charles; Boykin, Christina; Wang, Deping; Aivazian, Dikran; Marcotte, Doug; Xiao, Guangqing; Le Brazidec, Jean-Yves; Piao, Jinhua; Lundgren, Karen; Hong, Kevin; Vu, Khang; Nguyen, Khanh; Gan, Liang-Shang; Silvian, Laura; Ling, Leona; Teng, Min; Reff, Mitchell; Takeda, Nicole; Timple, Noel; Wang, Qin; Morena, Ron; Khan, Samina; Zhao, Shuo; Li, Tony; Lee, Wen-Cherng; Taveras, Arthur G.; Chao, Jianhua published the artcile< Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I)>, Related Products of 220731-04-4, the main research area is pyrazolopyrimidine sulfonamide preparation multiple mitotic kinase inhibitor.

A novel class of pyrazolopyrimidine-sulfonamides was discovered as selective dual inhibitors of aurora kinase A (AKA) and cyclin-dependent kinase 1 (CDK1). These inhibitors were originally designed based on an early lead (compound I). SAR development has led to the discovery of potent inhibitors with single digit nM IC50s towards both AKA and CDK1. An exemplary compound II has demonstrated good efficacy in an HCT116 colon cancer xenograft model.

Bioorganic & Medicinal Chemistry Letters published new progress about Alkylation. 220731-04-4 belongs to class pyridine-derivatives, and the molecular formula is C10H15N3O2, Related Products of 220731-04-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fier, Patrick S.; Kim, Suhong; Cohen, Ryan D. published the artcile< A Multifunctional Reagent Designed for the Site-Selective Amination of Pyridines>, Synthetic Route of 3796-23-4, the main research area is Boc protected aminopyridine chemoselective regioselective preparation; pyridine tert butyl chloro dicyanopyrazinyl oxy carbamate amination.

The development of a multifunctional reagent for the direct conversion of pyridines to Boc-protected 2-aminopyridines such as I [R = H, 3-Br, 4-Ph, etc.] with exquisite site selectivity and chemoselectivity was reported. The novel reagent was prepared on 200g scale in a single step, reacted in title reaction under mild conditions without precautions toward air or moisture, and is tolerant of nearly all common functionality. Exptl. and in situ spectroscopic monitoring techniques provided detailed insights and unexpected findings for the unique reaction mechanism.

Journal of the American Chemical Society published new progress about Amination, regioselective (chemoselective). 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Synthetic Route of 3796-23-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Eastman, Kyle J.; Parcella, Kyle; Yeung, Kap-Sun; Grant-Young, Katharine A.; Zhu, Juliang; Wang, Tao; Zhang, Zhongxing; Yin, Zhiwei; Beno, Brett R.; Sheriff, Steven; Kish, Kevin; Tredup, Jeffrey; Jardel, Adam G.; Halan, Vivek; Ghosh, Kaushik; Parker, Dawn; Mosure, Kathy; Fang, Hua; Wang, Ying-Kai; Lemm, Julie; Zhuo, Xiaoliang; Hanumegowda, Umesh; Rigat, Karen; Donoso, Maria; Tuttle, Maria; Zvyaga, Tatyana; Haarhoff, Zuzana; Meanwell, Nicholas A.; Soars, Matthew G.; Roberts, Susan B.; Kadow, John F. published the artcile< The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase>, Application In Synthesis of 777931-67-6, the main research area is hepatitis C virus NS5B polymerase 7 azabenzofuran.

The development of a series of novel 7-azabenzofurans exhibiting pan-genotype inhibition of HCV NS5B polymerase via binding to the primer grip site is presented. Many challenges, including poor oral bioavailability, high clearance, bioactivation, high human serum shift, and metabolic stability were encountered and overcome through SAR studies. This work culminated in the selection of BMS-986139 (43) as a preclin. candidate.

MedChemComm published new progress about Blood serum. 777931-67-6 belongs to class pyridine-derivatives, and the molecular formula is C6H5BrClNO, Application In Synthesis of 777931-67-6.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fu, Ming-Chen; Shang, Rui; Zhao, Bin; Wang, Bing; Fu, Yao published the artcile< Photocatalytic decarboxylative alkylations mediated by triphenylphosphine and sodium iodide>, Related Products of 350-03-8, the main research area is photocatalytic decarboxylative alkylation triphenylphosphine sodium iodide.

Most photoredox catalysts in current use are precious metal complexes or synthetically elaborate organic dyes, the cost of which can impede their application for large-scale industrial processes. We found that a combination of triphenylphosphine and sodium iodide under 456-nm irradiation by blue light-emitting diodes can catalyze the alkylation of silyl enol ethers by decarboxylative coupling with redox-active esters in the absence of transition metals. Deaminative alkylation using Katritzky’s N-alkylpyridinium salts and trifluoromethylation using Togni’s reagent are also demonstrated. Moreover, the phosphine/iodide-based photoredox system catalyzes Minisci-type alkylation of N-heterocycles and can operate in tandem with chiral phosphoric acids to achieve high enantioselectivity in this reaction.

Science (Washington, DC, United States) published new progress about Acid catalysis (chiral Bronsted acid). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Related Products of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gujjarappa, Raghuram; Vodnala, Nagaraju; Musib, Dulal; Malakar, Chandi C. published the artcile< Organocatalytic Decarboxylation and Dual C(sp3)-H Bond Functionalization Toward Facile Access to Divergent 2,6-Diarylpyridines>, Electric Literature of 350-03-8, the main research area is diarylpyridine preparation; ketone amino acid decarboxylation proline catalyst.

An effective organocatalytic protocol toward the assembly of sym. and unsym. 2,6-diarylpyridines I (R1 = H, Me, CN; R2 = Ph, 4-methylphenyl, 2H-1,3-benzodioxol-5-yl, etc.; R3 = Ph, 4-nitrophenyl, pyridin-3-yl, etc.) is demonstrated. The reaction proceeds through organocatalytic decarboxylation of amino acids R4CH(NH2)C(O)OH and dual C(sp3)-H bond oxidation of carbonyl compounds R1CH2C(O)R2 and R1CH2C(O)R3. Catalyst screening revealed that explicit choice of L-proline could lead to the formation of product with maximum yield and selectivity. The developed process appears with operational simplicity and is consistent with broad range of functional groups.

Asian Journal of Organic Chemistry published new progress about Amino acids Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Electric Literature of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem