Month: October 2022

Xie, Demeng; Wang, Yingwei; Zhang, Xia; Fu, Zhengyan; Niu, Dawen published the artcile< Alkyl/Glycosyl Sulfoxides as Radical Precursors and Their Use in the Synthesis of Pyridine Derivatives>, COA of Formula: C6H4F3N, the main research area is pyridine alkyl regioselective preparation; alkyl glycosyl sulfoxide regioselective stereoselective photochem alkylation methoxypyridinium; Alkyl Sulfoxides; C-Glycosides; Electron Donor-Acceptor Complexes; Photochemistry; Radicals.

Here the use of simple and readily available alkyl sulfoxides as precursors to radicals and their application in the preparation of pyridine derivatives are reported. It was shown that alkyl sulfoxides, N-methoxy pyridinium salts and fluoride anions form electron donor-acceptor (EDA) complexes in solution, which, upon visible light irradiation, undergo a radical chain process to afford various pyridine derivatives smoothly. This reaction displays broad scope with respect to both sulfoxides and N-methoxy pyridinium salts. The synthetic versatility of sulfoxides as a handle in chem. adds to their power as radical precursors. Glycosyl sulfoxides are converted to the corresponding pyridyl C-glycosides with high stereoselectivities. Computational and exptl. studies provide insights into the reaction mechanism.

Angewandte Chemie, International Edition published new progress about Alkylation, regioselective. 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, COA of Formula: C6H4F3N.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Park, Eunsun; Lee, Sun Joo; Moon, Heegyum; Park, Jongmi; Jeon, Hyeonho; Hwang, Ji Sun; Hwang, Hayoung; Hong, Ki Bum; Han, Seung-Hee; Choi, Sun; Kang, Soosung published the artcile< Discovery and Biological Evaluation of N-Methyl-pyrrolo[2,3-b]pyridine-5-carboxamide Derivatives as JAK1-Selective Inhibitors>, Formula: C8H5ClN2O2, the main research area is methyl pyrrolopyridine carboxamide preparation Janus kinase inhibitor mol docking.

Janus kinase 1 (JAK1) plays a key role in most cytokine-mediated inflammatory and autoimmune responses through JAK/STAT signaling; thus, JAK1 inhibition is a promising therapeutic strategy for several diseases. Anal. of the binding modes of current JAK inhibitors to JAK isoforms allowed the design of N-alkyl-substituted 1-H-pyrrolo[2,3-b] pyridine carboxamides I (R = H, Me, cyclopropyl, cyclopentyl) as a JAK1-selective scaffold, and the synthesis of various Me amide derivatives e.g., II, provided III as a potent JAK1-selective inhibitor. In particular, the (S,S)-enantiomer of III exhibited excellent potency for JAK1 and selectivity over JAK2, JAK3, and TYK2. On investigating the effect of III on hepatic fibrosis, it was found that it reduces the proliferation and fibrogenic gene expression of TGF-β-induced hepatic stellate cells (HSCs). Specifically, III significantly inhibited TGF-β-induced migration of HSCs at 0.25μM in wound-healing assays.

Journal of Medicinal Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 920966-03-6 belongs to class pyridine-derivatives, and the molecular formula is C8H5ClN2O2, Formula: C8H5ClN2O2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kanizaj, Lidija; Molcanov, Kresimir; Toric, Filip; Pajic, Damir; Loncaric, Ivor; Santic, Ana; Juric, Marijana published the artcile< Ladder-like [CrCu] coordination polymers containing unique bridging modes of [Cr(C2O4)3]3- and Cr2O72->, Application In Synthesis of 366-18-7, the main research area is crystal structure copper oxalate chromium dichromate diimine coordination polymer; copper oxalate chromium dichromate diimine polymer preparation antiferromagnetic.

Three heterometallic 1-dimensional (1D) coordination polymers {A[CrCu2(bpy)2(C2O4)4]·H2O}n [A = K+ 1 and NH4+ 2; bpy = 2,2′-bipyridine] and [(Cr2O7)Cu2(C2O4)(phen)2]n (3; phen = 1,10-phenanthroline) with uncommon topol. were synthesized using a building block approach and characterized by single-crystal x-ray diffraction, IR and impedance spectroscopies, magnetization measurements, and DFT calculations Due to the partial decomposition of the building block [Cr(C2O4)3]3-, all three compounds contain oxalate-bridged [Cu2(L)2(μ-C2O4)]2+ units [L = bpy 1 and 2 and phen 3]. In compounds 1 and 2, these cations are mutually connected through oxalate groups from [Cr(C2O4)3]3-, thus forming ladder-like topologies. Unusually, three different bridging modes of the oxalate ligand are observed in these chains. In compound 3 Cu(II) ions from cationic units are bridged through the O atoms of Cr2O72- anions in a novel ladder-like mode. Very strong antiferromagnetic coupling observed in all three compounds, determined from the magnetization measurements and confirmed by DFT calculations (J = -343, -371 and -340 cm-1 for 1-3, resp.), appears between two Cu(II) ions interacting through the oxalate bridge.

Dalton Transactions published new progress about Antiferromagnetic exchange. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application In Synthesis of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gallou, Fabrice; Reeves, Jonathan T.; Tan, Zhulin; Song, Jinhua J.; Yee, Nathan K.; Harcken, Christian; Liu, Pingrong; Thomson, David; Senanayake, Chris H. published the artcile< Practical regioselective bromination of azaindoles and diazaindoles>, Reference of 23612-36-4, the main research area is azaindole regioselective bromination copper bromide; diazaindole regioselective bromination; brominated azaindole preparation; pyridine pyrrolo bromo preparation; pyridazine pyrrolo bromo preparation.

A mild and efficient synthesis of various 3-brominated azaindoles and diazaindoles was developed by regioselective halogenation of the parent systems. This practical and high-yielding transformation was achieved with copper(II) bromide in acetonitrile at room temperature

Synlett published new progress about Bromination, regioselective. 23612-36-4 belongs to class pyridine-derivatives, and the molecular formula is C7H5BrN2, Reference of 23612-36-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yang, Shuguang; Chen, Liang; Zhou, Xiaojun; Sun, Ping; Fu, Liwen; You, Yanling; Xu, Man; You, Zhengwei; Kai, Guoyin; He, Chuanglong published the artcile< Tumor-targeted biodegradable multifunctional nanoparticles for cancer theranostics>, Category: pyridine-derivatives, the main research area is tumor targeting biodegradable multifunctional nanoparticle cancer theranostic.

Mesoporous silica nanoparticles (MSN) attract extensive attention in area of cancer diagnosis and therapy because of their controllable nanostructures, easy surface modification and stable synthesis methods. However, their biodegradability was still controversial. This work explored the degradation effect of a type of biodegradable MSN (bMSN) in different environments and simultaneously endowed it with imaging functions and high-efficiency targeting effect on cancer cell, thus forming a multifunctional biodegradable drug carrier (bMSN-ss-GABA) for cancer theranostics. The bovine serum albumin-based Gd/Au complex (BSA-Gd/Au) was wrapped on the surface of bMSN through disulfide linkage, acting as contrast agent for magnetic resonance (MR) and fluorescence imaging, and then folate (FA), whose receptor (FR) is overexpressed in KB human oral epidermoid carcinoma cells, was modified on the nanocarriers as a targeting ligand. TEM revealed the degradation process of bMSN and a series of characterization methods verified the successful construction of bMSN-ss-GABA. Doxorubicin hydrochloride (DOX) loaded bMSN-ss-GABA (DOX@bMSN-ss-GABA) was proved with redox-responsiveness, thereby triggering rapid drug release under specific tumor microenvironment of high glutathione concentration Further, the excellent imaging capability was also fully inspected. What’s more, the results of endocytosis and tumor growth inhibition of DOX@bMSN-ss-GABA demonstrated the highly effective targeting effect of hybrid nanocarriers. Therefore, the prepared DOX@bMSN-ss-GABA might be used as a promising nanotheranostic agent for KB human oral epidermoid carcinoma.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Antitumor agents. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Guo Cheng; Li, Yan; Chi, Jie; Xu, Na; Wang, Xiu Li; Lin, Hong Yan; Chen, Yong Qiang published the artcile< Multi-functional fluorescent responses of cobalt complexes derived from functionalized amide-bridged ligand>, Quality Control of 3731-53-1, the main research area is cobalt methylenepyridinylnaphthalenedicarboxamide dicarboxylate coordination polymer preparation fluorescent indicator; crystal structure cobalt methylenepyridinylnaphthalenedicarboxamide dicarboxylate coordination polymer.

Multi-functional fluorescent detection for inorganic pollutants and biol. protein is important but challenging. Five multi-functional luminescent coordination polymers (LCPs), [Co2(L)2(PDA)2]·H2O (1), [Co(L)(TPD)(H2O)2]·8H2O (2), [Co(L)(1,3-BDC)]·2H2O (3), [Co(L)(MIP)]·H2O (4) and [Co3(L)3(HIPA)3] (5) [H2PDA = 1,3-phenylenediacetic acid, H2TPD = 2,5-thiophenedicarboxylic acid, 1,3-H2BDC = 1,3-benzenedicarboxylic acid, H2MIP = 5-methylisophthalic acid and H2HIPA = 5-hydroxyisophthalic acid] were successfully synthesized from a naphthalene-dicarboxamide [N,N’-bis(4-methylenepyridin-4-yl)-1,4-naphthalene dicarboxamide (L)] with multi-functional spacers. 1 And 2 show 4-c sql networks. 3-5 display mab, pcu and hxg 3-dimensional frameworks, resp. The title complexes exhibit multi-functional fluorescent responses towards metal ion (Fe3+), anions (CrO42-, Cr2O72- and MnO4-) and biol. protein (bovine serum albumin).

Dyes and Pigments published new progress about Bovine serum albumin Role: ANT (Analyte), ANST (Analytical Study). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Quality Control of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Peng, Ling; Yao, Jing-Wen; Wang, Mei; Wang, Lin-Ye; Huang, Xiao-Lan; Wei, Xin-Feng; Ma, Dong-Ge; Cao, Yong; Zhu, Xu-Hui published the artcile< Efficient soluble deep blue electroluminescent dianthracenylphenylene emitters with CIE y (y ≤ 0.08) based on triplet-triplet annihilation>, Formula: C11H16BNO2, the main research area is deep blue electroluminescent dianthracenylphenylene emitter triplet annihilation.

It has been challenging to develop deep blue organic mol. fluorescent emitters with CIE y (y ≤ 0.08) based on triplet-triplet annihilation (TTA). Here, we report facilely available dianthracenylphenylene-based emitters, which have a 3,5-di(4-t-butylphenyl)phenyl moiety at the one end and 4-cyanophenyl or 3-pyridyl at the other end, resp. Both fluorophores show a high glass transition temperature of over 220°C with a thermal decomposition temperature of over 430°C at an initial weight loss of 1%. The preliminary characterizations of the organic light-emitting diodes (OLEDs) that utilized these nondoped emitters provided high EQEs of 4.6%-5.9% with CIE coordinates (0.15, 0.07-0.08). The anal. of the EL transient decay revealed that TTA contributed to the observed performance. The results show that the new emitters are attractive as a potential TTA-based host to afford stable deep blue fluorescent OLEDs.

Science Bulletin published new progress about Electric current-potential relationship. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Formula: C11H16BNO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nallagonda, Rajender; Karimov, Rashad R. published the artcile< Copper-Catalyzed Regio- and Diastereoselective Additions of Boron-Stabilized Carbanions to Heteroarenium Salts: Synthesis of Azaheterocycles Containing Contiguous Stereocenters>, Name: 3-(Trifluoromethyl)pyridine, the main research area is nonaromatic nitrogen heterocycle preparation diastereoselective addition boron carbanion heteroarenium.

Nucleophilic addition of diborylalkyl reagents to N-alkyl or N-acylpyridinium and related heteroarenium salts has been developed as a key step for the synthesis of nonaromatic nitrogen heterocycles that contain contiguous stereogenic centers. Derivatization of the dihydropyridine products for the synthesis of tetrahydropyridines and piperidines have also been described.

ACS Catalysis published new progress about Boranes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (alkyl). 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Name: 3-(Trifluoromethyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gao, Jian; Zhu, Yafeng; Liu, Wenqi; Jiang, Suyu; Zhang, Jie; Ma, Wei published the artcile< Hydrogen Bonds in Disulfonic-Functionalized Acid Ionic Liquids for Efficient Biodiesel Synthesis>, Reference of 21876-43-7, the main research area is biodiesel synthesis ionic liquid catalyst hydrogen bond.

Regulating the states of hydrogen bonds in ionic liquids (ILs) is an effective way to improve their catalytic performance. In this paper, disulfonic-functionalized acidic ionic liquids (DSFAILs) were synthesized successfully, including novel SO3H-functionalized binuclear IL (bis[3-(CH2)3SO3H-1-(CH2)2-Im][HSO4]2). For the biodiesel synthesis, compared with the traditional ILs catalysts, DSFAILs bis[(3-(CH2)3SO3H-1-(CH2)2-Im][HSO4]2, [Im(N (CH2)3SO3H)2][HSO4]) had higher catalytic activity even under mild reaction conditions. Using the d. functional theory (DFT) method, the role of hydrogen bonds in different SO3H-functionalized acidic ionic liquids (SFAILs) was explored. The forms of hydrogen bonds existing in different ILs directly determine their acidity. It suggested that the forming status of the active sites (hydrogen bonds) were diverse in different SFAILs. Also, deep ionization of the hydrogen atoms from the cation-anion strong interaction could increase the acidity and catalytic performance of SFAILs. From this, the structure-activity relationship between the SFAILs structures and the catalytic activity of Me oleate synthesis was proposed. Besides, the exptl. results also showed that bis[3-(CH2)3SO3H-1-(CH2)2-Im][HSO4]2 catalyst had a high catalytic activity to obtain Me oleate and the catalyst could be separated easily owing to its larger mol. weight However, [Im(N(CH2)3SO3H)2][HSO4] had a stronger acidity and a lower steric hindrance and thus a higher catalytic activity and was the optimal catalyst for the Me oleate synthesis. In the presence of a small amount of catalyst (6 wt %) and at low reaction temperature (353 K), the Me oleate yield could reach up to 93%. After six recycles of the catalyst, the Me oleate yield remained at 90%.

ACS Omega published new progress about Acidity. 21876-43-7 belongs to class pyridine-derivatives, and the molecular formula is C9H13NO3S, Reference of 21876-43-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Jiacheng; Siang Tan, Suan; Kyne, Sara Helen; Chan, Philip Wai Hong published the artcile< Minisci-Type Alkylation of N-Heteroarenes by N-(Acyloxy)phthalimide Esters Mediated by a Hantzsch Ester and Blue LED Light>, Safety of 3-(Trifluoromethyl)pyridine, the main research area is alkylated quinoline preparation; quinoline acyloxy phthalimide ester Minisci type alkylation HE mediated; isoquinoline alkylated preparation; acyloxy phthalimide ester isoquinoline Minisci type alkylation HE mediated; pyridine alkylated preparation; phthalimide ester acyloxy pyridine Minisci type alkylation HE mediated.

A synthetic method that enabled the Hantzsch ester (HE)-mediated Minisci-type C2-alkylation of quinolines, isoquinolines and pyridines by N-(acyloxy)phthalimide esters (NHPI) to afford alkylated N-heterocyclic products, e.g., I, under blue LED (light emitting diode) light (456 nm) was described. Achieved under mild reaction conditions at room temperature, the metal-free synthetic protocol was shown to be applicable to primary, secondary and tertiary NHPIs to give the alkylated N-heterocyclic products in yields of 21-99%. On introducing a chiral phosphoric acid, an asym. version of the reaction was also realized and provided product enantiomeric excess (ee) values of 53-99%.

Advanced Synthesis & Catalysis published new progress about Alkylation. 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Safety of 3-(Trifluoromethyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem