Month: October 2022

Canakci, Mine; Singh, Khushboo; Munkhbat, Oyuntuya; Shanthalingam, Sudarvili; Mitra, Ankita; Gordon, Mallory; Osborne, Barbara A.; Thayumanavan, S. published the artcile< Targeting CD4+ Cells with Anti-CD4 Conjugated Mertansine-Loaded Nanogels>, Related Products of 2127-03-9, the main research area is tumor antitumor T cell antibody CD4 mertansine.

CD4+ T lymphocytes play an important role in controlling many malignancies. The modulation of CD4+ T cells through immunomodulatory or cytotoxic drugs could change the course of disease progression for disorders such as autoimmunity, immunodeficiency, and cancer. Here, we demonstrate that anti-CD4 conjugated polymeric nanogels can deliver a small mol. cargo to primary CD4+ T cells and a CD4high T cell lymphoma. The antibody conjugation not only increased the uptake efficiency of the nanogel (NG) by CD4+ T cells but also decreased the non-specific uptake of the NG by CD4- lymphocytes. For T lymphoma cell lines, the mertansine-loaded conjugate displayed a dose-dependent cell growth inhibition at 17 ng/mL antibody concentration On the other hand, antibody-drug conjugate (ADC)-type formulation of the anti-CD4 reached similar levels of cell growth inhibition only at the significantly higher concentration of 1.8μg/mL. NG and antibody conjugates have the advantage of carrying a large payload to a defined target in a more efficient manner as it needs far less antibody to achieve a similar outcome.

Biomacromolecules published new progress about Antibodies and Immunoglobulins Role: BPN (Biosynthetic Preparation), PAC (Pharmacological Activity), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses) (mertansine-polymer conjugates). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Related Products of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gupta, Shivangi; Maji, Ankur; Panja, Dibyajyoti; Halder, Mita; Kundu, Sabuj published the artcile< CuO NPs catalyzed synthesis of quinolines, pyridines, and pyrroles via dehydrogenative coupling strategy>, Recommanded Product: 1-(Pyridin-3-yl)ethanone, the main research area is hydroxymethyl aniline ketone copper nanocatalyst oxidative coupling reaction; quinoline preparation; hydroxypropanamine ketone copper nanocatalyst oxidative coupling reaction; pyridine preparation; hydroxyethanamine ketone copper nanocatalyst oxidative coupling reaction; pyrrole preparation.

Copper oxide nanoparticles catalyzed efficient synthesis of quinolines, pyridines, and pyrroles via alc. dehydrogenative coupling strategy are reported. Employing this catalytic system, various functionalized quinolines, pyridines, and pyrroles were synthesized efficiently from different amino alcs. with a diverse range of ketones. A number of control experiments were performed to shed light on the mechanism. This catalyst was recycled up to 6th run and notably, no significant loss was observed in its catalytic activity.

Journal of Catalysis published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Recommanded Product: 1-(Pyridin-3-yl)ethanone.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bej, Somnath; Nandi, Mandira; Ghosh, Pradyut published the artcile< Development of fluorophoric [2]pseudorotaxanes and [2]rotaxane: selective sensing of Zn(II)>, Name: 2,2′-Bipyridine, the main research area is .

Fluorophoric [2]pseudorotaxanes {NiPR1(ClO4)2-NiPR3(ClO4)2} are synthesized by utilizing newly designed fluorophoric bidentate ligands (L1-L3) and a heteroditopic naphthalene containing macrocycle (NaphMC) with high yields via Ni(II) templation and π-π stacking interactions. Subsequently, a fluorophoric [2]rotaxane (NAPRTX) is established through a Cu(I) catalyzed click reaction between an azide terminated pseudorotaxane, {NiPR4(ClO4)2}, which contains the newly designed fluorophoric ligand L4, and alkyne terminated bulky stopper units. All these fluorophoric [2]pseudorotaxanes and the [2]rotaxane were characterized using numerous techniques such as mass spectrometry, NMR, UV/Vis, PL, and elemental anal., wherever applicable. Furthermore, to investigate the effect of the fluorophoric moieties, the coordinating ability of chelating units, and size and shape of the three dimensional cavity generated by the mech. bond in the interlocked [2]rotaxane (NAPRTX), we have performed a sensing study of various metal ions. Thus, the interlocked [2]rotaxane is found to have potential as a selective fluorescent sensor for Zn(II) metal ions over other transition, alkali and alk. earth metal ions, where the 2,2′-bipyridyl arylvinylene moiety of the axle acts as a fluorescence signalling unit.

Organic & Biomolecular Chemistry published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Name: 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Haemmerle, Michael; Le, Minh Hien; Hekmat, Omid published the artcile< GC-FID-based quantification of the sum of the three forms of vitamin B3 from animal liver>, Reference of 93-60-7, the main research area is gas chromatog flame ionization detector vitamin B3 liver; Flame ionization detection; Gas chromatography; Nicotinamide; Nicotinamide adenine dinucleotide; Nicotinic acid; Vitamin B(3).

Vitamin B3 (nicotinic acid, nicotinamide) is an essential water-soluble vitamin and cellular energy metabolism depends on the vitamin B3-derived cofactors. Inaccessible covalently-linked nicotinic acid in food such as maize can cause vitamin B3 deficiency in animals since maize is also deficient in tryptophan, the precursor of nicotinic acid. A sensitive and reproducible GC-FID-based method for the quantification of the sum of the three forms of vitamin B3 from animal liver was developed. Free nicotinic acid, free nicotinamide and nicotinamide moiety of NAD+/NADP+ (and their riboside precursors) were simultaneously derivatized as Me nicotinate. Reaction time and temperature and the extraction procedure for Me nicotinate were optimized. Starting from wild boar liver, removal of proteins, solvent exchange, derivatization, and chloroform extraction resulted in sufficient enrichment and baseline separation of Me nicotinate. The within-laboratory reproducibility of the full procedure was determined with relative standard deviation <10%. On-column limit of detection and lower limit of quantification for Me nicotinate were both sub-picomole. The accuracy of the method was determined from the recoveries of the pre-extraction spiked-in vitamin B3 standards The overall recovery for the full procedure was 16% but very consistent (relative standard deviation = 7%), enabling determination of apparent vitamin B3 concentrations for relative quant. comparison. Analytical Biochemistry published new progress about Esterification (methyl-). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Reference of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Simmons, Bryan J.; Hoffmann, Marie; Champagne, Pier Alexandre; Picazo, Elias; Yamakawa, Katsuya; Morrill, Lucas A.; Houk, K. N.; Garg, Neil K. published the artcile< Understanding and Interrupting the Fischer Azaindolization Reaction>, Reference of 832735-54-3, the main research area is Fischer Azaindolization Reaction mechanism.

Exptl. and computational studies pertaining to the Fischer azaindolization reaction are reported. These studies explain why pyridylhydrazines are poorly reactive in Fischer indolization reactions, in addition to the origin of hydrazine substituent effects. Addnl., an interrupted variant of Fischer azaindolization methodol. is disclosed, which provides a synthetic entryway into fused azaindoline scaffolds.

Journal of the American Chemical Society published new progress about Fischer indole synthesis. 832735-54-3 belongs to class pyridine-derivatives, and the molecular formula is C18H22BNO3, Reference of 832735-54-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ma, Xiurong; Lu, Junjian; Yang, Peixin; Zhang, Zheng; Huang, Bo; Li, Rongtao; Ye, Ruirong published the artcile< 8-Hydroxyquinoline-modified ruthenium(II) polypyridyl complexes for JMJD inhibition and photodynamic antitumor therapy>, COA of Formula: C10H8N2, the main research area is .

As an ideal scaffold for metal ion chelation, 8-hydroxyquinoline (8HQ) can chelate different metal ions, such as Fe2+, Cu2+, Zn2+, etc. Here, by integrating 8HQ with a ruthenium(II) polypyridyl moiety, two Ru(II)-8HQ complexes (Ru1 and Ru2), [Ru(N-N)2L](PF6)2 (L = 2-(1H-imidazo[4,5-f][1,10]phenanthrolin-2-yl)quinolin-8-ol; N-N: 2,2′-bipyridine (bpy, in Ru1), 1,10-phenanthroline (phen, in Ru2)) were designed and synthesized. In both complexes, ligand L is an 8HQ derivative designed to chelate the cofactor Fe2+ of jumonji C domain-containing demethylase (JMJD). As expected, Ru1 and Ru2 could inhibit the activity of JMJD by chelating the key cofactor Fe2+ of JMJD, resulting in the upregulation of histone-methylation levels in human lung cancer (A549) cells, and the upregulation was more pronounced under light conditions. In addition, MTT data showed that Ru1 and Ru2 exhibited lower dark toxicity, and light irradiation could significantly enhance their antitumor activity. The marked photodynamic activities of Ru1 and Ru2 could induce the elevation of reactive oxygen species (ROS), depolarization of mitochondrial membrane potential (MMP), and activation of caspases. These mechanistic studies indicated that Ru1 and Ru2 could induce apoptosis through the combination of JMJD inhibitory and PDT activities, thereby achieving dual antitumor effects.

Dalton Transactions published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, COA of Formula: C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Zi-Chen; Li, Rui-Tao; Ma, Qiang; Chen, Jia-Yi; Ni, Shao-Fei; Li, Ming; Wen, Li-Rong; Zhang, Lin-Bao published the artcile< Electrochemically enabled rhodium-catalyzed [4+2] annulations of arenes with alkynes>, Application of C10H8N2, the main research area is azaarene internal alkyne rhodium regioselective electrooxidative cycloaddition green chem; azaarenium hexafluorophosphate preparation; azobenzene internal alkyne rhodium regioselective electrooxidative cycloaddition green chem; cinnolinium hexafluorophosphate preparation.

Electrochem. driven, Rh(III)-catalyzed regioselective annulations of arenes with alkynes was established. The strategy, combining the use of a rhodium catalyst with electricity, not only avoided the need for using a stoichiometric amount of external oxidant, but also ensured that the transformations proceeded under mild and green conditions, which enabled broad functional group compatibility with a variety of substrates, including drugs and pharmaceutical motifs. Moreover, the electrolysis reaction was made operationally simple by employing an undivided cell and proceeded efficiently in aqueous solution in air.

Green Chemistry published new progress about [4+2] Cycloaddition reaction (electrochem., regioselective). 581-47-5 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hara, Naofumi; Uemura, Nao; Nakao, Yoshiaki published the artcile< C2-Selective silylation of pyridines by a rhodium-aluminum complex>, Safety of 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, the main research area is dehydrogenative silylation CH activation pyridine rhodium aluminum heterobimetallic catalyst; Lewis acid rhodium aluminum heterobimetallic complex dehydrogenative silylation catalyst; crystal mol structure rhodium aluminum heterobimetallic complex.

We have developed a C2-selective dehydrogenative mono-silylation of a variety of pyridines using a Rh-Al complex [(R2PCH2N-1,2-C6H4NMe-1,2-C6H4NCH2PR2)AlClRhCl(L)]n (R = Ph, iPr; n = 1, L = nbd; n = 2, L void). Both the site- and mono-selectivity are controlled via the pyridine coordination to the Lewis-acidic Al center prior to the activation of the pyridine C(2)-H bond at the proximal Rh center. A reaction mechanism is proposed based on several mechanistic studies, including the isolation of a (2-pyridyl)silylrhodium intermediate.

Chemical Communications (Cambridge, United Kingdom) published new progress about C-H bond activation. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Safety of 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Xue; Ling, Liang; Luo, Meiming; Zeng, Xiaoming published the artcile< Accessing Difluoromethylated and Trifluoromethylated cis-Cycloalkanes and Saturated Heterocycles: Preferential Hydrogen Addition to the Substitution Sites for Dearomatization>, Name: 3-(Trifluoromethyl)pyridine, the main research area is difluoromethyl cis cycloalkane saturated heterocycle diastereoselective preparation; arene heteroarene cycloalkyl amino carbene rhodium catalyst dearomative reduction; trifluoromethyl cis cycloalkane saturated heterocycle diastereoselective preparation; heteroarene arene cycloalkyl amino carbene rhodium catalyst dearomative reduction; N-heterocyclic carbenes; fluorine; hydrogenation; reduction; rhodium.

A straightforward process in which a cyclic (alkyl)(amino)carbene/Rh catalyst system facilitates preferential addition of hydrogen to substitution sites of difluoromethylated and trifluoromethylated arenes and heteroarenes, leading to dearomative reduction was reported. This strategy enabled diastereoselective synthesis of cis-difluoromethylated and cis-trifluoromethylated cycloalkanes such as I [R = 2-COMe, 4-pyrazolyl, 3-OTBS, etc.; R1 = CF2H, CF3] and saturated heterocycles, e.g. II, and even allowed formation of all-cis multi-trifluoromethylated cyclic products with a defined equatorial orientation of the di- and trifluoromethyl groups. Deuterium-labeling studies indicated that hydrogen preferentially attacked substitution sites of planar arenes, resulting in dearomatization, possibly with heterogeneous Rh as reactive species, followed by either reversible or irreversible hydrogen addition to nonsubstitution sites.

Angewandte Chemie, International Edition published new progress about Aromatic compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Name: 3-(Trifluoromethyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nie, Xufeng; Zheng, Yanling; Ji, Li; Fu, Haiyan; Chen, Hua; Li, Ruixiang published the artcile< Acceptorless dehydrogenation of amines to nitriles catalyzed by N-heterocyclic carbene-nitrogen-phosphine chelated bimetallic ruthenium (II) complex>, Name: Pyridin-4-ylmethanamine, the main research area is heterocyclic carbene nitrogen phosphine chelate bimetallic ruthenium complex preparation; amine ruthenium complex catalyst dehydrogenation green chem; nitrile preparation.

A clean, atom-economical and environmentally friendly route for acceptorless dehydrogenation of amines to nitriles by combining a new dual N-heterocyclic carbene-nitrogen-phosphine ligand R(CNP)2 (R = o-xylyl) with a ruthenium precursor [RuCl2(η6-C6H6)]2 was developed. In this system, the electronic and steric factors of amines had a negligible influence on the reaction and a broad range of functional groups were well tolerated. All of the investigated amines was converted to nitriles in good yield of up to 99% with excellent selectivity. The unprecedented catalytic performance of this system was attributed to the synergistic effect of two ruthenium centers chelated by R(CNP)2 and a plausible reaction mechanism was proposed according to the active species found via in-situ NMR and HRMS.

Journal of Catalysis published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Name: Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem