Month: October 2022

Paul, Lindsey; Enkhbold, Khuslen; Robinson, Sydney; Aye, Than Thar; Chung, Yuna; Harrison, Daniel P.; Pollock, Julie A.; Norris, Michael R. published the artcile< Unravelling the role of [Ru(bpy)2(OH2)2]2+ complexes in photo-activated chemotherapy>, COA of Formula: C10H8N2, the main research area is Breast cancer; Cytotoxicity; Lung cancer; Photoactivation; Polypyridyl; Ruthenium.

Photoactivated chemotherapy (PACT) has emerged as a promising strategy to selectively target cancer cells by using light irradiation to generate cytotoxic complexes in situ through a mechanism involving ligand-loss. Due to their rich optical properties and excited state chem., Ru polypyridyl complexes have attracted significant attention for PACT. However, studying PACT is complicated by the fact that many of these Ru complexes can also undergo excited-state electron transfer to generate 1O2 species. In order to deconvolute the biol. roles of possible photo-decomposition products without the added complication of excited-state electron transfer chem., we have developed a methodol. to systematically investigate each product individually, and assess the structure-function relationship. Here, we synthesized a series of eight distinct Ru polypyridyl complexes: Ru-Xa ([Ru(NN)3]2+), Ru-Xb ([Ru(NN)2py2]2+), and Ru-Xc ([Ru(NN)(OH2)2]2+) where NN = 2,2′-bipyridine, 4,4′-dimethyl-2,2′-bipyridine, or di-Me 2,2′-bipyridine-4,4′-dicarboxylate and py = pyridine. The cytotoxicity of these complexes was investigated in two cell lines amenable to PACT: H23 (breast cancer) and T47D (lung cancer). We confirmed that light irradiation of Ru-Xa and Ru-Xb complexes generate Ru-Xc complexes through UV-visible spectroscopy, and observed that the Ru-Xc complexes are the most toxic against the cancer cell lines. In addition, we have shown that ligand release and biol. activity including bovine serum albumin (BSA) binding, lipophilicity, and DNA interaction are altered when different groups are appended to the bipyridine ligands. We believe that the methodol. presented here will enhance the development of more potent and selective PACT agents moving forward.

Journal of Inorganic Biochemistry published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, COA of Formula: C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhou, Changjian; Sun, Rong; Zhang, Yuting; Xiong, Biao; Dai, Hui; Dai, Yong published the artcile< Co-N-Si/AC Catalyst for Aerobic Oxidation of Benzyl Alcohols to Esters under Mild Conditions>, Reference of 93-60-7, the main research area is ester preparation green chem; benzyl alc aerobic oxidative esterification cobalt catalyst; aerobic oxidation; benzyl alcohols; heterogeneous cobalt.

A stable, earth-abundant, reusable cobalt-based heterogeneous catalyst is developed for the oxidative esterification of alcs. RCH2OH (R = Ph, naphthalen-1-yl, thiophen-2-yl, etc.) under ambient conditions, featuring broad substrate scope, providing good to excellent product yields. This protocol enables easy recyclability of the catalyst, measured up to five times without significant loss of efficiency. The active sites of Co-N-Si/AC are proposed to be Co-N species.

Molecules published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Reference of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Srivastava, Payal; Shukla, Manjulika; Kaul, Grace; Chopra, Sidharth; Patra, Ashis K. published the artcile< Rationally designed curcumin based ruthenium(II) antimicrobials effective against drug-resistant Staphylococcus aureus>, Synthetic Route of 366-18-7, the main research area is curcumin ruthenium complex antimicrobial drug resistant Staphylococcus aureus.

Two new curcumin containing octahedral ruthenium(II) polypyridyl complexes, viz. [Ru(NN)2(cur)](PF6) [NN = bpy (1), phen (2)], were designed to explore the antimicrobial activity against ESKAPE pathogens, especially with the Gram-pos. drug resistant S. aureus. Solid-state structural characterization by single-crystal X-ray crystallog. shows the RuII-center in a distorted octahedral {RuN4O2} geometry. The tested compounds showed significant inhibitory activity and high selectivity (MIC = 1μg mL-1, SI = 80) against a wide variety of methicillin and vancomycin-resistant S. aureus strains. Compound 1 exhibited strong anti-biofilm activity (48% reduction of biofilm) at 10× MIC compared to the other approved drugs. The murine model of Staphylococcus infection significantly reduced the mean bacterial counts when treated with complex 1 compared to vancomycin, demonstrating its antimicrobial potential in vivo.

Dalton Transactions published new progress about Antibiofilm agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Synthetic Route of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mkrtchyan, Satenik; Jakubczyk, Michal; Lanka, Suneel; Yar, Muhammad; Ayub, Khurshid; Shkoor, Mohanad; Pittelkow, Michael; Iaroshenko, Viktor O. published the artcile< Mechanochemical Transformation of CF3 Group: Synthesis of Amides and Schiff Bases>, Recommanded Product: 3-(Trifluoromethyl)pyridine, the main research area is trifluoromethyl group nitro compound ytterbium catalyst mechanochem coupling transformation; amide preparation; methanimine preparation; indole preparation.

Two mild, solvent-free mechanochem. coupling transformations of CF3 group with nitro compounds into amides or Schiff bases employing Ytterbia as a catalyst were reported. This process proceeded via C-F bond activation, accompanied with utilization of Si-based reductants/oxygen scavengers – reductants of the nitro group. The scope and limitations of the disclosed methodologies were thoroughly studied. To the best of author knowledge, this work was the first example of mech. energy promoted transformation of the inert CF3 group into other functionalities.

Advanced Synthesis & Catalysis published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Recommanded Product: 3-(Trifluoromethyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Suschitzky, H.; Chivers, G. E. published the artcile< Polyhaloaromatic compounds. XXI. Novel reagent system for the N-oxidation of weakly basic N-heteroaromatic compounds>, Safety of 2,3,4,6-Tetrachloropyridine, the main research area is pyridine oxidation pyridine oxide preparation; pyridazine oxidation pyridazine oxide preparation; pyrazine oxidation pyrazine oxide preparation; substitution nucleophilic pyridine.

By use of H2O2-H2SO4-AcOH or-CF3CO2H, pentachloro-, 2,3,4,6-tetrachloro-, 2,6-dichloro-, tetrachloro-4-nitro-, and pentabromopyridine, and tetrachloropyridazine and -pyrazine were oxidized to their N-oxides in >50% yields. 3,5-Dichloro-2,4,6-trifluoropyridine was oxidized by H2O2-polyphosphoric acid to give 3,5-dichloro-2,4-difluoro-6-hydroxypyridine 1-oxide; pentachloropyridine reacted with AcOH-H2SO4 to give 2,3,4,5-tetrachloro-6-hydroxypyridine by nucleophilic substitution.

Journal of the Chemical Society [Section] C: Organic published new progress about Oxidation. 14121-36-9 belongs to class pyridine-derivatives, and the molecular formula is C5HCl4N, Safety of 2,3,4,6-Tetrachloropyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Matsumoto, Kyosuke; Kusaba, Shunsuke; Tanaka, Yuya; Sei, Yoshihisa; Akita, Munetaka; Aritani, Kazushi; Haga, Masa-aki; Yoshizawa, Michito published the artcile< A Peanut-Shaped Polyaromatic Capsule: Solvent-Dependent Transformation and Electronic Properties of a Non-Contacted Fullerene Dimer>, Reference of 329214-79-1, the main research area is palladium pyridylanthracene derivative capsule guest encapsulation fullerene complex preparation; crystal structure palladium pyridylanthracene derivative guest encapsulation fullerene complex; cyclic voltammetry palladium pyridylanthracene derivative guest encapsulation fullerene complex; coordination capsules; encapsulation; fullerenes; radical anions; supramolecular chemistry.

Synthesis of mol. containers capable of incorporating multiple fullerenes remains challenging. Reported here is that room-temperature mixing of metal ions with W-shaped bispyridine ligands featuring polyaromatic panels results in the quant. formation of a peanut-shaped M2L4 capsule. The capsule reversibly converts into two mols. of an ML2 double tube in response to changes in the solvent. Notably, the capsule allows the incorporation of two fullerene mols. into the connected two spherical cavities at room temperature The close proximity yet non-contact of the encapsulated C60 mols., with a separation of 6.4 Å, was revealed by x-ray crystallog. anal. The resultant, unusual fullerene dimer undergoes sequential reduction within the capsule to generate (C60.-)2, C60.-·C602-, and (C602-)2 species. Furthermore, temperature-controlled stepwise incorporation of two C60 mols. into the capsule is demonstrated.

Angewandte Chemie, International Edition published new progress about Cage compounds Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), SPN (Synthetic Preparation), PROC (Process), PREP (Preparation). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Reference of 329214-79-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sharma, Rahul; Mondal, Avijit; Samanta, Arup; Biswas, Nandita; Das, Babulal; Srimani, Dipankar published the artcile< Well-Defined Ni-SNS Complex Catalyzed Borrowing Hydrogenative α-Alkylation of Ketones and Dehydrogenative Synthesis of Quinolines>, Product Details of C7H7NO, the main research area is nickel catalyst preparation crystal structure; acetophenone alc nickel catalyst alkylation; aryl alkyl ketone preparation green chem; ketone aminophenyl methanol nickel catalyst alkylation; quinoline preparation green chem.

Here presented a synthesis of non-phosphine, easily accessible and bench stable SNS-Ni complexes. The Ni-catalyst was successfully applied for the C-alkylation of ketone enolates to α-alkylated ketones. Primary alc. with different functional groups and various heteroaromatic alcs. were well tolerated. The present catalyst system was efficiently applied to gram scale synthesis and also the green chem. metrics of the reaction were calculated The present protocol was also extended successfully for the synthesis of biol. important quinoline moieties. Finally, various control experiments and deuterium labeled experiments suggested that the reaction proceeds via borrowing hydrogen pathway.

Advanced Synthesis & Catalysis published new progress about Alkylation. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Product Details of C7H7NO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Phuan, P.-W.; Kozlowski, M. C. published the artcile< Product class 8: naphthyridines>, Product Details of C6H6N2O, the main research area is review naphthyridine cyclization ring transformation.

A review of synthetic methods to prepare naphthyridines which include cyclization and ring transformations.

Science of Synthesis published new progress about 55279-29-3. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, Product Details of C6H6N2O.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Acharjee, Animesh; Rakshit, Atanu; Chowdhury, Suman; Datta, Indukamal; Barman, Milan Krishna; Ali, Ansar Md.; Saha, Bidyut published the artcile< Micellar catalysed oxidation of hydrophobic fatty alcohol in aqueous medium>, Recommanded Product: 2,2′-Bipyridine, the main research area is octanol micellar catalyst oxidation mechanism kinetics.

Oxidation of a hydrophobic fatty alc. was carried out under pseudo 1st order reaction condition in aqueous micellar medium efficiently. In addition to the dissolution of alc. micelles are found to catalyze the oxidation reaction. Use of promoters further enhanced the rate of the reaction with almost instant completion of the reaction via the formation of active oxidants (AO+). The product was confirmed by IR and NMR study. Fluorescence studies and DLS measurements were done to confirm the formation of AO+. NMR studies were carried out to establish the interaction between the surfactants and 1-Octanol. Calculated activation parameters (ΔH≠, ΔS≠) also support the exptl. findings.

Journal of Molecular Liquids published new progress about Activation enthalpy. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Recommanded Product: 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Xuefu; Wang, Jun; Ba, Wanyu; Zhang, Suqiu; Lin, Zhenxian; Gao, Ming; Tian, Hua; Ru, Shaoguo published the artcile< Mechanistic revealing of reproductive behavior impairment in male guppy (Poecilia reticulata) induced by environmentally realistic 2,2'-dithiobis-pyridine exposure>, SDS of cas: 2127-03-9, the main research area is transcriptome dithiobis pyridine reproductive behavior impairment Poecilia; (PS)(2); Ecological safety; Mechanism study; Sexual behavior.

Although (PS)2, the primary degradation product of emerging antifouling biocides metal pyrithiones (MePTs), can disrupt the reproductive behavior of fish at an environmentally relevant ng/L level, the underlying mechanism is still largely unknown. This study exposed sexually mature male guppy (Poecilia reticulata) to 20, 200, and 2000 ng/L (PS)2 to explore the compromised effect of (PS)2 on reproductive behavior through a realistic competing scenario. The results showed that (PS)2 suppressed male guppies’ sexual interest to stimulus females, reduced their competitive behavior frequencies toward rival males, and decreased their mating time and frequency. (PS)2 exposure did not affect male guppies’ secondary sexual characteristics or induce estrogenic activity. Whole-brain transcriptome sequencing identified 1070 differentially expressed genes (DEGs) with 872 up-regulated genes, which were functionally enriched into Gene Ontol. terms pertaining to extracellular matrix (ECM) and extracellular region. KEGG enrichment for the DEGs uncovered that the activations of ECM-receptor interaction and focal adhesion pathways could be the underlying mol. mechanism implicated in the (PS)2 induced reproductive behavior impairment. This work would deliver a substantial contribution to the understanding of the ecol. safety of MePTs biocides.

Chemosphere published new progress about Behavior. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, SDS of cas: 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem