Month: October 2022

Titi, Abderrahim; Messali, Mouslim; Alqurashy, Bakhet A.; Touzani, Rachid; Shiga, Takuya; Oshio, Hiroki; Fettouhi, Mohammed; Rajabi, Mehdi; Almalki, Faisal A.; Ben Hadda, Taibi published the artcile< Synthesis, characterization, X-ray crystal study and bioactivities of pyrazole derivatives: Identification of antitumor, antifungal and antibacterial pharmacophore sites>, Reference of 21901-29-1, the main research area is pyrazole preparation antitumor antifungal antibacterial human crystal structure mol; pharmacokinetic toxicity pyrazole.

The new pyrazole derivatives I [R = R1 = H, Me; R2 = H, CO2Et; X = C, N; Y = N, CNO2, CCO2H] were synthesized by reaction of hydroxymethyl pyrazole derivatives with primary amines and evaluated for their antifungal, antitumor and antibacterial activities. The structure of synthesized compounds I was identified by FT-IR, UV-visible, proton NMR spectroscopy, mass spectroscopy and single crystal X-ray crystallog. The pyrazoles I [R = R1 = R2 = H, X = Y = N], I [R = R1 = R2 = H, X = C, Y = CCO2H] and I [R = R1 = Me, R2 = CO2Et, X = N, Y = CNO2] were crystallized in space groups C2/c, P21/n and P-1 resp. Crystallog. anal. revealed that N-H of the amine group and nitrogen or oxygen atoms were in-plane with aromatic ring. The aminomethyl chain formed a distorted second plane. The angle between two planes was observed to be 76.07° (N2-C7-N5-N19) for compound I [R = R1 = R2 = H, X = Y = N], 62.12° (N34-C63-N22-N35) for compound I [R = R1 = R2 = H, X = C, Y = CCO2H], 60.84° (N3-C8-N2-N1) and 0.41° (N1-C4-C3-O1/O2) for compound I [R = R1 = Me, R2 = CO2Et, X = N, Y = CNO2]. Theor., phys. and chem. properties calculations had been performed on the pyrazoles I using three different programs: Petra, Osiris and Molinspiration (POM). The geometric parameters of optimized structure were in agreement with exptl. data obtained from X-ray structures.

Journal of Molecular Structure published new progress about Antibacterial agents. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Reference of 21901-29-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chen, Qingping; Deady, Leslie W. published the artcile< Synthesis of some benzo[b][1,6]naphthyridines and benzo[b][1,7]naphthyridines>, Reference of 55279-29-3, the main research area is benzonaphthyridine methyl; naphthyridine benzo.

Pfitzinger (1-benzylpiperidin-4-one with 7-methylisatin) and Friedlaender (3-aminopyridine-4-carbaldehyde with 2-methylcyclohexanone) syntheses, resp., were used to prepare the title azaacridines I and II containing a Me substituent peri to the central nitrogen. Oxidation of this group gave the corresponding aldehyde and carboxylic acid. In the [1,6] case, especially, the 10-position was also easily oxidized to give acridone analogs. Nitration occurred exclusively in the benzenoid rings.

Australian Journal of Chemistry published new progress about 55279-29-3. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, Reference of 55279-29-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Arora, Amandeep; Weaver, Jimmie D. published the artcile< Photocatalytic Generation of 2-Azolyl Radicals: Intermediates for the Azolylation of Arenes and Heteroarenes via C-H Functionalization>, HPLC of Formula: 370878-69-6, the main research area is carbon hydrogen bond activation arylation photocatalysis.

The 2-azolyl radical, generated from 2-bromoazoles via photocatalysis, is a powerful intermediate for the intermol. arylation of unmodified (hetero)arenes. The reaction is characterized by mild conditions, operational simplicity, tolerance toward functional and sterically demanding groups, broad scope, and anti-Minisci selectivity. A working mechanism is provided, and a low-solubility amine is essential for successful coupling. The utility of the reaction is demonstrated via late-stage functionalization of Me estrone and application toward other bromoarenes.

Organic Letters published new progress about C-H bond activation. 370878-69-6 belongs to class pyridine-derivatives, and the molecular formula is C33H21F3IrN3, HPLC of Formula: 370878-69-6.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Smolyar, N. N.; Yutilov, Yu. M. published the artcile< Reduction of 2-amino-3- and -5-nitropyridine derivatives with hydrazine hydrate>, Name: 6-Amino-3-nitro-2-picoline, the main research area is nitropyridinamine reduction hydrazine hydrate; pyridinamine preparation.

The reactions of 3- and 5-nitro-2-pyridinamine with N2H4.H2O resulted in elimination of the NH2 group and reduction of the NO2 group with formation of 3-pyridinamine. A probable reaction mechanism involves addition of N2H4.H2O to the N-C(2) bond, followed by elimination of NH3 and reduction of the NO2 group to NH2. 4- And 5-methyl-3-nitro-2-pyridinamine reacted with N2H4.H2O in a similar way.

Russian Journal of Organic Chemistry published new progress about Aromatic amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 22280-62-2 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Name: 6-Amino-3-nitro-2-picoline.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Halevas, Eleftherios; Mavroidi, Barbara; Antonoglou, Orestis; Hatzidimitriou, Antonios; Sagnou, Marina; Pantazaki, Anastasia A.; Litsardakis, George; Pelecanou, Maria published the artcile< Structurally characterized gallium-chrysin complexes with anticancer potential>, Formula: C10H8N2, the main research area is gallium chrysin complex preparation cancer.

Chemotherapeutic metal-based compounds are effective anticancer agents; however, their cytotoxic profile and significant side effects limit their wide application. Natural products, especially flavonoids, are a prominent alternative source of anticancer agents that can be used as ligands for the generation of new bioactive complexes with metal ions of known biochem. and pharmacol. activities. Herein, we present the synthesis and detailed structural and physicochem. characterizations of three novel complex assemblies of Ga(III) with the flavonoid chrysin and the ancillary aromatic chelators 1,10-phenanthroline, 2,2′-bipyridine and imidazole. The complexes constitute the only crystallog. characterized structures having a metal core from the boron group elements and a flavonoid as the ligand. The in vitro biol. evaluation of the three complexes in a series of cancer cell lines of different origin established their cytotoxicity and ROS generating potential. In particular, the Ga(III)-chrysin-imidazole complex displayed the highest anticancer efficacy against all cancer cell lines with IC50 values in the low micromolar range (<1.18 μM), a result worth further investigation. Dalton Transactions published new progress about Antitumor agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Formula: C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kim, Sangmin; Loose, Florian; Bezdek, Mate J.; Wang, Xiaoping; Chirik, Paul J. published the artcile< Hydrogenation of N-Heteroarenes Using Rhodium Precatalysts: Reductive Elimination Leads to Formation of Multimetallic Clusters>, Synthetic Route of 3796-23-4, the main research area is phenylpyridinyl benzoquinolinyl cyclometalated pentamethylcyclopentadienylrhodium hydride multinuclear preparation crystal structure; hydrogenation heteroarene rhodium precatalyst reductive multimetallic rhodium cluster; crystal mol structure pentamethylcyclopentadienylrhodium multimetallic cluster.

A rhodium-catalyzed method for the hydrogenation of N-heteroarenes is described. A diverse array of unsubstituted N-heteroarenes including pyridine, pyrrole, and pyrazine, traditionally challenging substrates for hydrogenation, were successfully hydrogenated using the organometallic precatalysts, [(η5-C5Me5)Rh(N-C)H] (N-C = 2-phenylpyridinyl (ppy) or benzo[h]quinolinyl (bq)). In addition, the hydrogenation of polyaromatic N-heteroarenes exhibited uncommon chemoselectivity. Studies into catalyst activation revealed that photochem. or thermal activation of [(η5-C5Me5)Rh(bq)H] induced C(sp2)-H reductive elimination and generated the bimetallic complex, [(η5-C5Me5)Rh(μ2,η2-bq)Rh(η5-C5Me5)H]. In the presence of H2, both of the [(η5-C5Me5)Rh(N-C)H] precursors and [(η5-C5Me5)Rh(μ2,η2-bq)Rh(η5-C5Me5)H] converted to a pentametallic rhodium hydride cluster, [(η5-C5Me5)4Rh5H7], the structure of which was established by NMR spectroscopy, x-ray diffraction, and neutron diffraction. Kinetic studies on pyridine hydrogenation were conducted with each of the isolated rhodium complexes to identify catalytically relevant species. The data are most consistent with hydrogenation catalysis prompted by an unobserved multimetallic cluster with formation of [(η5-C5Me5)4Rh5H7] serving as a deactivation pathway.

Journal of the American Chemical Society published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent) (N-heteroarenes). 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Synthetic Route of 3796-23-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mora Vargas, Jorge Andres; Ortega, Julieth Orduna; Correia dos Santos, Maite Bernardo; Metzker, Gustavo; Gomes, Eleni; Boscolo, Mauricio published the artcile< A new synthetic methodology for pyridinic sucrose esters and their antibacterial effects against Gram-positive and Gram-negative strains>, Synthetic Route of 93-60-7, the main research area is sucrose pyridinic monoester antibacterial effect gram pos neg bacteria; Acoustic cavitation; Antibacterial activity; Homogeneous catalysis; Pyridinic methyl esters; ucrose esters.

Described are the development of a new synthetic method using ultrasonic irradiation and Na methoxide as catalyst for pyridinic sucrose esters (py-SEs), derived from transesterification of sucrose with picolinic, nicotinic and isonicotinic Me esters. The reaction was optimized using a 32 x 2 exptl. design, the reaction time, temperature and sucrose:Me ester molar ratio being evaluated. The method proved to be efficient for obtaining monosubstituted esters (≥83%) with high Me ester consumption (≥79%). The monosubstituted py-SEs were isolated by semipreparative HPLC, characterized by high-resolution mass spectrometry, calorimetry, vibrational spectroscopy, and 1H and 13C NMR. The py-SEs were tested against E. coli, S. aureus, and P. aeruginosa bacteria with min. inhibitory concentration values equal or inferior to the reference drugs for both E. coli and P. aeruginosa.

Carbohydrate Research published new progress about Antibacterial agents. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Synthetic Route of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rezania, Hamidreza; Vatanpour, Vahid; Salehi, Ehsan; Gavari, Niloofar; Shockravi, Abbas; Ehsani, Morteza published the artcile< Wholly Heterocycles-Based Polyamide-Sulfide Containing Pyridine and Thiazole Rings: A Super-Adsorbent Polymer for Lead Removal>, Related Products of 350-03-8, the main research area is lead polyamide sulfide pyridine polymer adsorbent thermal property.

Wholly heterocycles-based polyamide-sulfide (PAS) containing pyridine and thiazole rings with thioether linkage was synthesized and used as a novel adsorbent for lead ion removal from water. The polymer adsorbent was fully characterized via FTIR, NMR and SEM (SEM). The thermal properties of the synthesized polyamide were also studied by thermogravimetric anal. and the outcome showed that the polymer has a good to moderate thermal stability. The SEM was used to investigate the morphol. of the wholly heterocycles-based polyamide and the outcomes displayed a porous and globular-like morphol., which guarantee effective metal adsorption. Pb(II) ion removal capacity of the synthesized polymer was studied by varying the contact time and the adsorbent concentration The maximum removal of Pb(II) was obtained as 99%. Equilibrium behavior and kinetic of the adsorption were also investigated using prevalent isotherm and kinetic models. The adsorption capacity was obtained to be around 714 mg g-1. The Langmuir isotherm and the pseudo-second order kinetic model suggested superior agreement with the equilibrium and kinetic adsorption data, resp. Generally, the results of this research demonstrated that the synthesized polymer is a super-adsorbent for heavy metal removal from water.

Journal of Polymers and the Environment published new progress about Adsorption (Langmuir isotherm). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Related Products of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lozovan, Vasile; Kravtsov, Victor Ch.; Gorincioi, Elena; Rotaru, Andrei; Coropceanu, Eduard B.; Siminel, Nikita; Fonari, Marina S. published the artcile< Chromism, positional, conformational and structural isomerism in a series of Zn(II) and Cd(II) coordination polymers based on methylated azine N,N'-donor linkers>, Synthetic Route of 350-03-8, the main research area is zinc cadmium pyridinylethylidenehydrazine iodide nitrate polymer preparation luminescence; thermal stability zinc cadmium pyridinylethylidenehydrazine iodide nitrate polymer; crystal structure zinc cadmium pyridinylethylidenehydrazine iodide nitrate polymer.

Seven new coordination polymers [Zn(I)2(4-bpmhz)]n (1), [Cd(I)2(4-bpmhz)]n (2), [Zn(I)2(3-bpmhz)]n (3), [Cd(I)2(3-bpmhz)2]n (4), [Zn(NO3)2(H2O)2(4-bpmhz)]n·0.5n(EtOH) (5), [Cd(NO3)2(4-bpmhz)3/2(MeOH)]n·0.5nH2O (6) and [Zn(NO3)2(3-bpmhz)2]n (7) were prepared following the reactions of the zinc and cadmium iodide or nitrate salts with the methylated azine ligands of the bis-monodentate N,N’-donor type, 1,2-bis(1-(pyridin-4-yl)ethylidene)hydrazine (4-bpmhz) and 1,2-bis(1-(pyridin-3-yl)ethylidene)hydrazine (3-bpmhz). The single-crystal X-ray diffraction studies show that compounds 1-5, and 7 display 1D chain structures, while compound 6 shows a 2D coordination network, and both 4-bpmhz and 3-bpmhz act as bidentate bridging ligands. The crystals 1 and 2 are isomorphous, and differ by the metal cation only. The single coordination chains in 1-3 have zigzag structures; they are linear in 5, while 4 and 7 display similar double-chain structures. The crystal packing in 5 and 6 provides cavities occupied by solvent mols., ethanol and water. The compounds were characterized in the solid state and in solution by spectroscopic (FTIR, UV-Vis, NMR) methods; the solid state emissive properties were studied for all compounds, while their thermal stability and behavior were investigated by thermogravimetry under inert atm., while the thermochromism for several compounds was registered and discussed.

Polyhedron published new progress about Conformers. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Synthetic Route of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Yangmin; Yang, Hanmin; Chi, Quan; Zhang, Zehui published the artcile< Nitrogen-Doped Carbon-Supported Nickel Nanoparticles: A Robust Catalyst to Bridge the Hydrogenation of Nitriles and the Reductive Amination of Carbonyl Compounds for the Synthesis of Primary Amines>, Related Products of 3731-53-1, the main research area is primary amine preparation; nitrogen doped carbon supported nickel nanoparticle catalyst preparation; nitrile aldehyde hydrogenation reductive amination; amines; hydrogenation; nickel; nitrogen-doped carbon; reductive amination.

An efficient method was developed for the synthesis of primary amines either from the hydrogenation of nitriles or reductive amination of carbonyl compounds The reactions were catalyzed by nitrogen-doped mesoporous carbon (MC)-supported nickel nanoparticles (abbreviated as MC/Ni). The MC/Ni catalyst demonstrated high catalytic activity for the hydrogenation of nitriles into primary amines in high yields (81.9-99 %) under mild reaction conditions (80° and 2.5 bar H2). The MC/Ni catalyst also promoted the reductive amination of carbonyl compounds for the synthesis of primary amines at 80° and 1 bar H2. The hydrogenation of nitriles and the reductive amination proceeded through the same intermediates for the generation of the primary amines. To the best of knowledge, no other heterogeneous non-noble metal catalysts have been reported for the synthesis of primary amines under mild conditions, both from the hydrogenation of nitriles and reductive amination.

ChemSusChem published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Related Products of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem