Month: October 2022

Pratap, Ramendra; Yorimitsu, Hideki published the artcile< Palladium-Catalyzed Amination of Aryl Sulfides and Sulfoxides with Azaarylamines of Poor Nucleophilicity>, Recommanded Product: N-Phenylpyridin-4-amine, the main research area is heteroaryl amine preparation; sulfide aryl azaarylamine amination palladium catalyst; sulfoxide aryl azaarylamine amination palladium catalyst.

The amination of aryl sulfides and sulfoxides (Ar)2S and (Ar)2SO2 [Ar = C6H5, 2-naphthyl, biphenyl-4-yl, etc.] with azaarylamines R1NH2 (R1 = pyrimidin-2-yl, pyrazin-2-yl, quinolin-3-yl, etc.) is investigated using a palladium-N-heterocyclic carbene (NHC) complex I. Because azaarylamines are less nucleophilic than anilines, more reactive diaryl sulfides and sulfoxides are found to be suitable coupling partners that liberate better leaving arenethiolate or arenesulfenate anions, instead of aryl Me sulfides RSCH3 [R = 4-FC6H4, 2-naphthyl, 4-(2,5,5-trimethyl-1,3-dioxan-2-yl)phenyl, etc.] as reported previously.

Synthesis published new progress about Amination. 22961-45-1 belongs to class pyridine-derivatives, and the molecular formula is C11H10N2, Recommanded Product: N-Phenylpyridin-4-amine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mondal, Rakesh; Chakraborty, Gargi; Guin, Amit Kumar; Pal, Subhasree; Paul, Nanda D. published the artcile< Iron catalyzed metal-ligand cooperative approaches towards sustainable synthesis of quinolines and quinazolin-4(3H)-ones>, Quality Control of 350-03-8, the main research area is quinoline quinazolinone preparation; alc ketone aminobenzamide dehydrogenative coupling iron catalyst metal ligand.

Herein authors report simple, efficient, and economically affordable metal-ligand cooperative strategies for synthesizing quinolines and quinazolin-4(3H)-ones via dehydrogenative functionalization of alcs. Various polysubstituted quinolines and quinazolin-4(3H)-ones were prepared in good yields via dehydrogenative coupling of readily available alcs. with ketones and 2-aminobenzamides, resp. under air using a well-defined Fe(II)-catalyst, ([FeL1Cl2]) bearing a redox-active azo-aromatic pincer 2-((4-chlorophenyl), (diazenyl)-1,10-phenanthroline) (L1). Control experiments and mechanistic investigation disclose that the one-electron reduced mono-anionic species [1]- bearing an iron-stabilized azo-anion radical ligand catalyzes these reactions. Both iron and the redox-active arylazo ligand participate synergistically during the different steps of these catalytic reactions.

Tetrahedron published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Quality Control of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Webster, Alyssa A.; Huo, Jianqiang; Milliken, Jenna; Sullivan, Pat; Kubelka, Jan; Hoberg, John O. published the artcile< Hydrogen gas formation from the photolysis of rhenium hydrides - mechanistic and computational studies>, COA of Formula: C10H6Cl2N2, the main research area is dihydrogen elimination kinetics photolysis bipyridine rhenium hydride substituent effect; bipyridine rhenium hydride preparation kinetics photolysis dihydrogen elimination; optimized geometry bipyridine rhenium hydride photolysis dihydrogen elimination DFT.

The photolysis of 4,4′-disubstituted, 2,2′-bipyridine fac-Re(bpy)(CO)3H derivatives produces stoichiometric H2 gas. The rate of production varies greatly depending on the electronic nature of the disubstituted bipyridine (bpy) with halogenated substituents increasing the rate. Isotope labeling studies along with B3LYP geometry optimization DFT modeling studies indicate a mechanism involving a Re-H-Re bridging complex that leads to a dimeric Re-Re(η2-H2) state prior to dissociating H2 gas.

Dalton Transactions published new progress about Hydrides Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), PROC (Process), RACT (Reactant or Reagent), PREP (Preparation) (bipyridine rhenium hydrides). 1762-41-0 belongs to class pyridine-derivatives, and the molecular formula is C10H6Cl2N2, COA of Formula: C10H6Cl2N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Qingxu; Li, Yan; Zhi, Ying; Liu, Bo; Sun, Jingyong published the artcile< design, synthesis and bioactivity evaluation of novel quinazoline based KRASG12C inhibitors>, SDS of cas: 329214-79-1, the main research area is quinazoline antitumor mol docking sarcoma inhibitor.

KRAS is a member of the RAS gene family, which is involved in the regulation of human life activities. KRASG12C mutation is distributed in many tumors and has been the focus of attention. In our study, we analyzed the binding of BAY-293 to KRAS protein using mol. docking technol. We designed and synthesized 20 compounds and tested their bioactivity. At the same time, we found that compound 8P (IC50 = 2.6 ± 1.2 μM) had good inhibitory activity against the A549 cell line and compound 8e had a good inhibitory effect on the McF-7 cell line with IC50 = 5.5 ± 0.3 μM.

New Journal of Chemistry published new progress about Antitumor agents. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, SDS of cas: 329214-79-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chaubey, Surabhi; Yadav, Rajesh K.; Tripathi, Santosh K.; Yadav, Bal Chandra; Singh, Sudhir N.; Kim, Tae Wu published the artcile< Covalent Triazine Framework as an Efficient Photocatalyst for Regeneration of NAD(P)H and Selective Oxidation of Organic Sulfide>, Product Details of C10H8N2, the main research area is NADPH covalent triazine framework photocatalyst organic sulfide selective oxidation.

Covalent triazine frameworks (CTFs), belonging to the super-family of covalent organic frameworks, have attracted significant attention as a new type of photosensitizer due to the superb light-harvesting ability and efficient charge transfer originating from the large surface area. However, the wide optical band gap in CTFs, which is larger than 3.0 eV, hinders the efficient light harvesting in the visible range. To overcome this limitation, we developed the new type CTFs photocatalyst based on the donor-acceptor conjugation scheme by using melamine (M) and 2,6-diaminoanthraquinone (AQ) as monomeric units. The melamine-2,6-diaminoanthraquinone-based covalent triazine frameworks (M-AQ-CTFs) photocatalyst shows the excellent light-harvesting capacity with high molar extinction coefficient, and the suitable optical band gap involving the internal charge transfer character. Combination of M-AQ-CTFs and artificial photosynthetic system including the organometallic rhodium complex, acting as an electron mediator, exhibited the excellent photocatalytic efficiency for the regeneration of the nicotinamide cofactors such as NAD(P)H. In addition, this photocatalyst showed the high photocatalytic efficiency for the metal-free aerobic oxidation of sulfide. This study demonstrates the high potential of CTFs photocatalyst with the donor-acceptor conjugated scheme can be actively used for artificial photosynthesis.

Photochemistry and Photobiology published new progress about Anaerobic oxidation. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Product Details of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Wendian; Yang, Hailong; Li, Ruihao; Lv, Hui; Zhang, Xumu published the artcile< Kinetic Resolution of Racemic 3,4-Disubstituted 1,4,5,6-Tetrahydropyridine and 3,4-Disubstituted 1,4- Dihydropyridines via Rh-Catalyzed Asymmetric Hydrogenation>, Application In Synthesis of 93-60-7, the main research area is piperidine tetrahydropyridine preparation; tetrahydropyridine dihydropyridine asym hydrogenation rhodium catalyst.

Kinetic resolution of racemic 3,4-disubstituted 1,4,5,6-tetrahydropyridines and 3,4-disubstituted 1,4-dihydropyridines was developed by Rh-catalyzed asym. hydrogenation, affording chiral 3,4-disubstituted piperidines and chiral 3,4-disubstituted 1,4,5,6-tetrahydropyridines with high selectivity factors (s = up to 1057). Remarkably, all four stereoisomers of 3,4-disubstituted piperidine can be easily prepared using this method. Furthermore, the synthetic utility of this methodol. was demonstrated by efficient synthesis of antidepressant drug (-)-paroxetine.

ACS Catalysis published new progress about Diastereoselective synthesis. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Application In Synthesis of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gautam, Varsha; Kumar, Avshish; Kumar, Ramesh; Husain, Mushahid; Jain, Vinod Kumar; Nagpal, Suman published the artcile< Ultrafast trace-level detection of methyl nicotinate biomarker using TiO2/SiNWs nanocomposite-based sensing platform>, Product Details of C7H7NO2, the main research area is titanium dioxide silicon nanowire nanocomposite methyl nicotinate biomarker detection.

The reported work presents an ultrafast and ultrasensitive sensing platform for the precise and reliable trace-level detection of Me nicotinate (MN) leading to early stage diagnosis of Tuberculosis (TB). The design and fabrication of the sensor was done using silicon nanowires (SiNWs) and titanium dioxide (TiO2) nanoparticles-based nanocomposite. The structural morphol. and elemental anal. of the fabricated sensor were done using various characterization tools such as SEM (SEM), transmission electron microscopy (TEM), Fourier transform IR spectroscopy (FTIR), energy dispersive X-ray spectroscopy (EDX), Energy Dispersive X-Ray Analyzer (EDA) and X-ray diffraction (XRD). With a very precise limit of detection (LOD) (10 ppb), the sensor response was observed to be 1.02. The fabricated TiO2/SiNWs sensor demonstrates good accuracy and reproducibility along with very fast response and recovery time, i.e., 20s and 30s, resp. Hence, the results reported in the present work and the developed sensing platform using TiO2/SiNWs nanocomposite could be utilized for reliable and precise identification of TB at an early stage.

Journal of Materials Science: Materials in Electronics published new progress about Adsorption. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Product Details of C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jeon, So Mi; Lim, Je Sun; Kim, Hyung-Ryong; Lee, Jong-Ho published the artcile< PFK activation is essential for the odontogenic differentiation of human dental pulp stem cells>, Electric Literature of 123-03-5, the main research area is human dental pulp stem cell odontogenic differentiation PFK activation; Aerobic glycolysis; Differentiation; Human dental pulp stem cell; Odontoblast; PFK.

Dental pulp stem cells (DPSCs) can differentiate into diverse cell lineages, including odontogenic cells that are responsible for dentin formation, which is important in pulp repair and tooth regeneration. While glycolysis plays a central role in various cellular activities in both physiol. and pathol. conditions, its role and regulation in odontogenic differentiation are unknown. Here, we show that aerobic glycolysis is induced during odontoblastic differentiation from human DPSCs. Importantly, we demonstrate that during odontoblastic differentiation, protein expression levels of phosphofructokinase 1 muscle isoform (PFKM) and PFK2, but not other glycolytic enzymes, are mainly upregulated by AKT activation, resulting in increased total PFK enzyme activity. Increased PFK activity is essential to enhance aerobic glycolysis, which plays an important role in the odontoblastic differentiation of human DPSCs. These findings underscore that PFK activation-induced aerobic glycolysis accompanies, and participates in, human DPSCs differentiation into odontogenic lineage, and could play a role in the regulation of dental pulp repair.

Biochemical and Biophysical Research Communications published new progress about Dental pulp. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Electric Literature of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pitre, Spencer P.; Muuronen, Mikko; Fishman, Dmitry A.; Overman, Larry E. published the artcile< Tertiary Alcohols as Radical Precursors for the Introduction of Tertiary Substituents into Heteroarenes>, Computed Properties of 93-60-7, the main research area is tertiary alkyl substituted heterocycle preparation; heterocycle tertiary alc oxalate radical alkylation photocatalyst.

Despite many recent advances in the radical alkylation of electron-deficient heteroarenes since the seminal reports by Minisci and co-workers, methods for the direct incorporation of tertiary alkyl substituents into nitrogen heteroarenes are limited. This report describes the use of tert-alkyl oxalate salts, derived from tertiary alcs., to introduce tertiary substituents into a variety of heterocyclic substrates. This reaction has reasonably broad scope, proceeds rapidly under mild conditions, and is initiated by either photochem. or thermal activation. Insights into the underlying mechanism of the higher yielding visible-light initiated process were obtained by flash photolysis studies, whereas computational studies provided insight into the reaction scope.

ACS Catalysis published new progress about Computational chemistry. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Computed Properties of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhu, YuLi; Xu, Wei; OuYang, LiangLiang; Wang, Hong; Mao, WeiWei; Zhou, HuiXiang; Shen, Chao; Hu, ZhiJian; Tan, YunChang published the artcile< Topical Application of Methyl Nicotinate Solution Enhances Peripheral Blood Collection.>, Product Details of C7H7NO2, the main research area is T lymphocyte subsets; blood collection; methyl nicotinate solution; nicotinic acid; peripheral blood; routine blood tests; topical application.

OBJECTIVE: The purpose of this study was to investigate whether local application of methyl nicotinate solution can change the content and proportion of blood cells in peripheral blood samples and to determine whether this treatment is a safe and reliable method for improving peripheral blood collection. METHODS: Routine blood analysis and flow cytometry were used to analyze the contents and proportions of blood cells and T lymphocyte subsets in peripheral blood samples. Experimental blood specimens were collected from earlobes treated with different concentrations of methyl nicotinate solution, and the control group consisted of blood specimens collected from untreated earlobes. RESULTS: The blood flow in the earlobe was significantly increased after methyl nicotinate solution stimulation, especially when the methyl nicotinate solution concentration was greater than 10-4 mol/L. There were no significant changes in the proportions of white blood cells, red blood cells, platelets, neutrophils, eosinophils, basophils, monocytes, or lymphocytes in the peripheral blood obtained from earlobes treated with methyl nicotinate solution. The proportion of T lymphocytes increased in the experimental group, but this difference was not significant. CONCLUSION: Local application of methyl nicotinate solution is a feasible method for improving peripheral blood collection, especially for patients with venous blood collection phobia or an inability to provide venous blood samples.

Laboratory medicine published new progress about 93-60-7. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Product Details of C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem