Month: October 2022

Yang, Huan; Zhang, Li; Zhou, Fei-Yu; Jiao, Lei published the artcile< An umpolung approach to the hydroboration of pyridines: a novel and efficient synthesis of N-H 1,4-dihydropyridines>, Name: 3-(Methoxycarbonyl)pyridine, the main research area is diboron pyridine inverse hydroboration deuteration; dihydropyridine preparation.

The first inverse hydroboration of pyridine with a diboron compound and a proton source was realized under simple basic and catalyst-free conditions. This process consisted of a formal boryl anion addition to pyridine, which produced an N-boryl pyridyl anion complex and the subsequent protonation of the anion complex. This process enabled a simple and efficient method for the synthesis of multi-substituted N-H 1,4-dihydropyridine (1,4-DHP) derivatives that were difficult to prepare using established methods. Furthermore, this method allowed facile preparation of 4-deuterated 1,4-DHPs from an easily accessible deuterium ion source. This inverse hydroboration reaction represented a new mode for pyridine functionalization.

Chemical Science published new progress about Deuteration, regioselective. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Name: 3-(Methoxycarbonyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Allen, Jamie R.; Bahamonde, Ana; Furukawa, Yukino; Sigman, Matthew S. published the artcile< Enantioselective N-Alkylation of Indoles via an Intermolecular Aza-Wacker-Type Reaction>, SDS of cas: 1428537-19-2, the main research area is indolylalkanal chemoselective enantioselective preparation; chemoselective enantioselective aza Wacker reaction allylic homoallylic alc indole; enantioselective alkylation indole allylic homoallylic alc palladium catalyst; stereochem mechanism aza Wacker reaction deuterated allylic alc indole.

In the presence of Pd(MeCN)2(OTs)2 and a nonracemic pyridinyloxazoline, 3-substituted indoles such as 3-phenylindole underwent intermol., chemoselective, and enantioselective alkylation/aza-Wacker reactions with cis-allylic and cis-homoallylic alcs. such as (Z)-EtCH:CHCH2OH mediated by p-benzoquinone in 1,2-dichloroethane to yield nonracemic β- and γ-(1-indolyl)alkanals such as I; enamines generated under other conditions were not formed. The mechanism was studied using the reaction of a deuterium-labeled allylic alc.; the stereochem. of the product supported a syn amino-palladation mechanism for the reaction.

Journal of the American Chemical Society published new progress about Alcohols, homoallylic Role: RCT (Reactant), RACT (Reactant or Reagent). 1428537-19-2 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, SDS of cas: 1428537-19-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Van Lommel, Ruben; Rutgeerts, Laurens A. J.; De Borggraeve, Wim M.; De Proft, Frank; Alonso, Mercedes published the artcile< Rationalising Supramolecular Hydrogelation of Bis-Urea-Based Gelators through a Multiscale Approach>, Application of C6H8N2, the main research area is urea gelator supramol hydrogelation density functional theory mol dynamics; aggregation; gels; molecular dynamics; noncovalent interactions; self-assembly.

The current approach to designing low-mol.-weight gelators relies on a laborious trial-and-error process, mainly because of the lack of an accurate description of the noncovalent interactions crucial for supramol. gelation. In this work, we report a multiscale bottom-up approach composed of several computational techniques to unravel the key interactions in a library of synthesized bis-urea-based gelators and rationalize their exptl. observed hydrogelation performance. In addition to d. functional theory calculations and mol. dynamics, the noncovalent interaction index is applied as a tool to visualise and identify the different types of noncovalent interactions. Interestingly, as well as hydrogen bonds between urea moieties, hydrogen bonds between a urea moiety and a pyridine ring were shown to play a detrimental role in the early aggregation phase. These findings enabled us to explain the hydrogelation performance observed in a library of twelve bis-urea derivatives, which were synthesized with 58-95 % yields. From this library, three compounds were discovered to effectively gel water, with the most efficient hydrogelator only requiring a concentration of 0.2 w/v%.

ChemPlusChem published new progress about Aggregation. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Application of C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Watanabe, Taiki; Sasabe, Hisahiro; Owada, Tsukasa; Maruyama, Tomohiro; Watanabe, Yuichiro; Katagiri, Hiroshi; Kido, Junji published the artcile< Chrysene-based Electron-transporters Realizing Highly Efficient and Stable Phosphorescent OLEDs>, Category: pyridine-derivatives, the main research area is chrysene electron transporter phosphorescence organic light emitting diode.

A series of chrysene-based electron-transporters named BnPyPCs (n = 2, 3, 4) end-capped with two 3,5-di(pyridin-n-yl)phenyl moieties with high thermal and elec. stability were successfully developed. BnPyPCs showed Tm values greater than 390°C and were used for highly efficient green phosphorescent OLEDs with maximum external quantum efficiency values greater than 20% and long operation lifetime at high brightness of approx. 11000 cd m-2 at a c.d. of 25 mA cm-2.

Chemistry Letters published new progress about Density functional theory. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chen, Tiffany Q.; Pedersen, P. Scott; Dow, Nathan W.; Fayad, Remi; Hauke, Cory E.; Rosko, Michael C.; Danilov, Evgeny O.; Blakemore, David C.; Dechert-Schmitt, Anne-Marie; Knauber, Thomas; Castellano, Felix N.; MacMillan, David W. C. published the artcile< Unified Approach to Decarboxylative Halogenation of (Hetero)aryl Carboxylic Acids>, Quality Control of 777931-67-6, the main research area is hetero aryl halide preparation photochem; aryl hetero carboxylic acid decarboxylative halogenation copper catalyst.

A general catalytic method for direct decarboxylative halogenation of (hetero)aryl carboxylic acids RC(O)OH (R = 4-sulfamoylphenyl, 5-methylpyridin-2-yl, isoquinolin-1-yl, etc.) via ligand-to-metal charge transfer was reported. This strategy accommodates an exceptionally broad scope of substrates. An aryl radical intermediate is leveraged toward divergent functionalization pathways: (1) atom transfer to access bromo- or iodo(hetero)arenes or (2) radical capture by copper and subsequent reductive elimination to generate chloro- or fluoro(hetero)arenes. The proposed ligand-to-metal charge transfer mechanism is supported through an array of spectroscopic studies.

Journal of the American Chemical Society published new progress about Aromatic carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 777931-67-6 belongs to class pyridine-derivatives, and the molecular formula is C6H5BrClNO, Quality Control of 777931-67-6.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Watanabe, Hiroyuki; Tatsumi, Haruka; Kaide, Sho; Shimizu, Yoichi; Iikuni, Shimpei; Ono, Masahiro published the artcile< Structure-Activity Relationships of Radioiodinated 6,5,6-Tricyclic Compounds for the Development of Tau Imaging Probes>, Recommanded Product: 2-Bromo-N,N-dimethylpyridin-4-amine, the main research area is structure radioiodinated tricyclic compound Tau imaging probe.

Tau aggregate, which is the main component of the neurofibrillary tangle, is an attractive imaging target for diagnosing and monitoring the progression of Alzheimer’s disease (AD). In this study, we designed and synthesized six radioiodinated 6,5,6-tricyclic compounds to explore novel scaffolds for tau imaging probes. On in vitro autoradiog. of AD brain sections, pyridoimidazopyridine and benzimidazopyrimidine derivatives ([125I]21 and [125I]22, resp.) showed selective binding affinity for tau aggregates, whereas carbazole, pyrrolodipyridine, and pyridoimidazopyrimidine derivatives ([125I]10, [125I]12, and [125I]23, resp.) bound β-amyloid aggregates. In a biodistribution study using normal mice, [125I]21 and [125I]22 showed high initial uptakes (5.73 and 5.66% ID/g, resp., at 2 min postinjection) into and rapid washout (0.14 and 0.10% ID/g, resp., at 60 min postinjection) from the brain. Taken together, two novel scaffolds including pyridoimidazopyridine and benzimidazopyrimidine may be applied to develop useful tau imaging probes.

ACS Medicinal Chemistry Letters published new progress about Alzheimer disease (potential diagnosis). 396092-82-3 belongs to class pyridine-derivatives, and the molecular formula is C7H9BrN2, Recommanded Product: 2-Bromo-N,N-dimethylpyridin-4-amine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Barroso, Santiago; Joksch, Markus; Puylaert, Pim; Tin, Sergey; Bell, Stephen J.; Donnellan, Luke; Duguid, Stewart; Muir, Colin; Zhao, Peichao; Farina, Vittorio; Tran, Duc N.; de Vries, Johannes G. published the artcile< Improvement in the Palladium-Catalyzed Miyaura Borylation Reaction by Optimization of the Base: Scope and Mechanistic Study>, Synthetic Route of 329214-79-1, the main research area is palladium catalyzed Miyaura borylation aryl halide base optimization; Arylboronic acid ester preparation.

Aryl boronic acids and esters are important building blocks in API synthesis. Pd-catalyzed Suzuki Miyaura borylation is the most common method for their preparation This paper describes an improvement of the current reaction conditions. By using lipophilic bases such as K 2-Et hexanoate, borylation reaction could be achieved at 35° in <2 h with very low Pd loading (0.5 mol %). A preliminary mechanistic study shows a hitherto unrecognized inhibitory effect by the carboxylate anion on the catalytic cycle, whereas 2-Et hexanoate minimizes this inhibitory effect. This improved methodol. enables borylation of a wide range of substrates under mild conditions. Journal of Organic Chemistry published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Synthetic Route of 329214-79-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Shichen; Ren, Jianing; Ding, Chengcheng; Wang, Yishou; Ma, Chen published the artcile< N,N-Dimethylformamide as Carbon Synthons for the Synthesis of N-Heterocycles: Pyrrolo/Indolo[1,2-a]quinoxalines and Quinazolin-4-ones>, Formula: C6H7N3O2, the main research area is pyrroloquinoxaline preparation; aminophenyl pyrrole DMF heterocyclization; indoloquinoxaline preparation; DMF aminophenyl indole heterocyclization; quinazolinone preparation; aminobenzamide DMF heterocyclization.

N,N-dimethylformamide (DMF) as synthetic precursors contributing especially the Me, acyl, and amino groups has played a significant role in heterocycle syntheses and functionalization. In this protocol, a wide range of pyrrolo[1,2-a]quinoxalines I (R = H, Cl, Me; R1 = H, Cl, Me; R2 = H, Cl, F, Br, Me, OMe; R3 = H, Cl, F, Br, Me, CN), II /indolo[1,2-a]quinoxalines III (R4 = H, Cl, Me, CN, etc.; R5 = H, F, Cl, Me) and quinazolin-4-ones IV (R6 = H, 4-Cl, 4-NO2, 5-Fl, 5-Br; R7 = n-Bu, cyclohexyl, Ph, Bn, etc.) were obtained in moderate to good yields by using elemental iodine without any metal or peroxides. N-Me and N-acyl of DMF that participate and complete the reaction sep. through different mechanisms, which displayed potential still to be explored of DMF were considered.

Journal of Organic Chemistry published new progress about Anilines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Formula: C6H7N3O2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kashiwagi, Yukiyasu; Kubono, Koji; Tamai, Toshiyuki published the artcile< Crystal structure of catena-poly[[[bis(3-oxo-1,3-diphenylprop-1-enolato-κ2O,O')zinc(II)]- μ2-tris[4-(pyridin-3-yl)phenyl]amine-k2N:N'] tetrahydrofuran monosolvate]>, Recommanded Product: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, the main research area is crystal coordination polymer structure hydrogen bond geometry; C—H⋯π inter­actions; coordination polymer; crystal structure; tri­aryl­amine; β-diketonato zinc(II).

The reaction of bis(3-oxo-1,3-diphenylprop-1-enolato-k2O,O’)zinc(II), [Zn(dbm)2], with tris[4-(pyridin-3-yl)phenyl]amine (T3PyA) in THF (THF) afforded the title crystalline coordination polymer, {[Zn(C15H11O2)2(C33H24N4)].C4H8O}n. The asym. unit contains two independent halves of Zn(dbm)2, one T3PyA and one THF. Each ZnII atom is located on an inversion center and adopts an elongated octahedral coordination geometry, ligated by four O atoms of two dbm ligands in equatorial positions and by two N atoms of pyridine moieties from two different bridging T3PyA ligands in axial positions. The crystal packing shows a one-dimensional polymer chain in which the two pyridyl groups of the T3PyA ligand bridge two independent Zn atoms of Zn(dbm)2. In the crystal, the coordination polymer chains are linked via C-H…π interactions into a sheet structure parallel to (010). The sheets are crosslinked via further C-H…π interactions into a three-dimensional network. The solvate THF mol. shows disorder over two sets of at. sites having occupancies of 0.631 (7) and 0.369 (7).

Acta Crystallographica, Section E: Crystallographic Communications published new progress about Crystal structure. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Recommanded Product: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ismail, Hani K. published the artcile< Electrodeposition of a mirror zinc coating from a choline chloride-ethylene glycol-based deep eutectic solvent modified with methyl nicotinate>, Related Products of 93-60-7, the main research area is electrodeposition zinc choline chloride ethylene glycol solvet; deep eutectic solvent modified methyl nicotinate.

A number of studies have reported the effects of additives on metal coatings electrochem. deposited from deep eutectic solvents (DESs). However, no previous study has studied the influences of Me nicotinate (MN) as an additive on the electrodeposition of Zn on a Cu substrate from a DES. The results of this study show that MN significantly develops the Zn deposition in this system compared to the corresponding system in its absence. This is the 1st study to date to show that a mirror Zn coating can be obtained on a Cu substrate using such a mechanism. Various electrochem. methods such as cyclic voltammetry, chronocoulometry, and chronoamperometry were used to understand the electrochem. properties of Zn electrolytes in the absence and presence of MN. These experiments found that the redox reaction currents decline when the additive was included in the Zn electrolyte, and that Zn deposition followed an instantaneous nucleation mechanism in the absence of the additive while in its presence the mechanism was closer to that of progressive growth. Further, the current efficiency decreased from 98.99% in the absence of additive to ∼82% as a result of including the additive in the Zn plating bath, according to electrochem. quartz crystal microbalance (EQCM) data. The resultant roughness, thickness and surface morphol. of the deposited Zn were characterized using at. force microscopy, SEM, and x-ray diffraction, indicating that Me nicotinate, as an additive, functions as a highly influential brightener that gave highly homogeneous and flat Zn deposits.

Journal of Electroanalytical Chemistry published new progress about Chronoamperometry. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Related Products of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem