Month: October 2022

Xiao, Fengping; Wang, Hongkang; Yao, Tianhao; Zhao, Xin; Yang, Xuming; Yu, Denis Y. W.; Rogach, Andrey L. published their research in ACS Applied Materials & Interfaces in 2021. The article was titled 《MOF-Derived CoS2/N-Doped Carbon Composite to Induce Short-Chain Sulfur Molecule Generation for Enhanced Sodium-Sulfur Battery Performance》.Electric Literature of C12H12N2 The article contains the following contents:

Dissolution of intermediate sodium polysulfides (Na2Sx; 4≤x≤8) is a crucial obstacle for the development of room-temperature sodium-sulfur (Na-S) batteries. One promising strategy to avoid this issue is to load short-chain sulfur (S2-4), which could prohibit the generation of soluble polysulfides during the sodiation process. Herein, unlike in the previous reported cases where short-chain sulfur was stored by confinement within a small-pore-size (≤0.5 nm) carbon host, we report a new strategy to generate short-chain sulfur in larger pores (>0.5 nm) by the synergistic catalytic effect of CoS2 and appropriate pore size. Based on d. functional theory calculations, we predict that CoS2 can serve as a catalyst to weaken the S-S bond in the S8 ring structure, facilitating the formation of short-chain sulfur mols. By exptl. tuning the pore size of the CoS2-based hosts and comparing their performances as cathodes in Na-S and Li-S batteries, we conclude that such a catalytic effect depends on the proximity of sulfur to CoS2. This avoids the generation of soluble polysulfides and results in superior electrochem. properties of the composite materials introduced here for Na-S batteries. As a result, the optimized CoS2/N-doped carbon/S electrode showed excellent electrochem. performance with high reversible specific capacities of 488 mA h g-1 (962 mA h g(s)-1) after 100 cycles (0.1 A g-1) and 403 mA h g-1 after 1000 cycles (1 A g-1) with a superior rate performance (262 mA h g-1 at 5.0 A g-1). The experimental process involved the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Electric Literature of C12H12N2)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Electric Literature of C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Guagnini, Francesca; Pedrini, Alessando; Dalcanale, Enrico; Massera, Chiara published their research in Chemistry – A European Journal in 2021. The article was titled 《Multidentate, V-Shaped Pyridine Building Blocks as Tectons for Crystal Engineering》.Name: 2,6-Dibromopyridine The article contains the following contents:

The formation of supramol. structural units through self-assembly is a powerful method to design new architectures and materials endowed with specific properties. With the aim of adding a group of versatile tectons to the toolkit of crystal engineers, 4 new V-shaped building blocks characterized by an aryl acetylene scaffold comprising 3 substituted pyridine rings connected by 2 triple bonds were have devised and synthesized. The judicious choice of different substituents on the pyridine rings provides these tectons with distinctive steric, electrostatic and self-assembly properties, which influence their crystal structures and their ability to form co-crystals. Co-crystals of the tectons with tetrafluorodiiodobenzene were obtained both via traditional and mechanochem. crystallization strategies, proving their potential use in crystal engineering. The energetic contributions of the supramol. interactions at play in the crystal lattice also were evaluated to better understand their nature and strength and to rationalize their role in designing mol. crystals. After reading the article, we found that the author used 2,6-Dibromopyridine(cas: 626-05-1Name: 2,6-Dibromopyridine)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Name: 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Downs, Ryan P.; Xiao, Zhousheng; Ikedionwu, Munachi O.; Cleveland, Jacob W.; Chin, Ai Lin; Cafferty, Abigail E.; Darryl Quarles, L.; Carrick, Jesse D. published their research in Bioorganic & Medicinal Chemistry in 2021. The article was titled 《Design and development of FGF-23 antagonists: Definition of the pharmacophore and initial structure-activity relationships probed by synthetic analogues》.Reference of 2-Bromonicotinaldehyde The article contains the following contents:

Hereditary hypophosphatemic disorders, TIO, and CKD conditions are believed to be influenced by an excess of Fibroblast Growth Factor-23 (FGF-23) which activates a binary renal FGFRs/α-Klotho complex to regulate homeostatic metabolism of phosphate and vitamin D. Adaptive FGF-23 responses from CKD patients with excess FGF-23 frequently lead to increased mortality from cardiovascular disease. A reversibly binding small mol. therapeutic has yet to emerge from research and development in this area. Current outcomes described in this work highlight efforts related to lead identification and modification using organic synthesis of strategic analogs to probe structure-activity relationships and preliminarily define the pharmacophore of a computationally derived hit obtained from virtual high-throughput screening. Synthetic strategies for the initial hit and analog preparation, as well as preliminary cellular in vitro assay results highlighting sub micromolar inhibition of the FGF-23 signaling sequence at a concentration well below cytotoxicity are reported herein. In the experiment, the researchers used 2-Bromonicotinaldehyde(cas: 128071-75-0Reference of 2-Bromonicotinaldehyde)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Reference of 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Malik, Magdalena; Bienko, Dariusz C.; Komarnicka, Urszula K.; Kyziol, Agnieszka; Drys, Magdalena; Switlicka, Anna; Dyguda-Kazimierowicz, Edyta; Jedwabny, Wiktoria published an article in 2021. The article was titled 《Synthesis, structural characterization, docking simulation and in vitro antiproliferative activity of the new gold(III) complex with 2-pyridineethanol》, and you may find the article in Journal of Inorganic Biochemistry.Name: 2-(2-Hydroxyethyl)pyridine The information in the text is summarized as follows:

Gold(III) complex containing 2-pyridineethanol has been synthesized and characterized structurally by single crystal X-ray diffraction, vibrational spectroscopy, 1H NMR spectroscopy, electrochem. study, and DFT calculations The Au(III) ion is four coordinated with one N-donor ligand (L) and three Cl anions. The Okuniewski′s has been used to estimate the angular distortion from ideal square planar geometry. The vibrational spectroscopy studies, in the solid state and DMSO solution and cyclic voltammetry, have been performed to determine its stability and redox activity, resp. A complete assignment of the IR and Raman spectra has been made based on the calculated potential energy distribution (PED). The theor. calculations have been made for two functionals and several basis sets. The compound has been evaluated for its antiproliferative properties in a human lung adenocarcinoma cell line (A549), mouse colon carcinoma (CT26), human breast adenocarcinoma (MCF-7), human prostate carcinoma derived from the metastatic site in the brain (DU-145), and PANC-1 human pancreas/duct carcinoma cell line and non-tumorigenic cell lines: HaCat (human keratinocyte), and HEK293T (human embryonic kidney). Au(III) complex cytotoxicity is significantly against A549 and MCF-7 cells as in the reference drug: cisplatin. Studies of the interactions of Au(III) complex with DNA, HSA (human serum albumin) have been performed. The results from modeling docking simulations indicate that the title complex exerts anticancer effects in vitro based on different mechanisms of action to compare with cisplatin. The experimental part of the paper was very detailed, including the reaction process of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Name: 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Name: 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Le Manach, Claire; Dam, Jean; Woodland, John G.; Kaur, Gurminder; Khonde, Lutete P.; Brunschwig, Christel; Njoroge, Mathew; Wicht, Kathryn J.; Horatscheck, Andre; Paquet, Tanya; Boyle, Grant A.; Gibhard, Liezl; Taylor, Dale; Lawrence, Nina; Yeo, Tomas; Mok, Sachel; Eastman, Richard T.; Dorjsuren, Dorjbal; Talley, Daniel C.; Guo, Hui; Simeonov, Anton; Reader, Janette; van der Watt, Mariette; Erlank, Erica; Venter, Nelius; Zawada, Jacek W.; Aswat, Ayesha; Nardini, Luisa; Coetzer, Theresa L.; Lauterbach, Sonja B.; Bezuidenhout, Belinda C.; Theron, Anjo; Mancama, Dalu; Koekemoer, Lizette L.; Birkholtz, Lyn-Marie; Wittlin, Sergio; Delves, Michael; Ottilie, Sabine; Winzeler, Elizabeth A.; von Geldern, Thomas W.; Smith, Dennis; Fidock, David A.; Street, Leslie J.; Basarab, Gregory S.; Duffy, James; Chibale, Kelly published an article in 2021. The article was titled 《Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts》, and you may find the article in Journal of Medicinal Chemistry.HPLC of Formula: 53939-30-3 The information in the text is summarized as follows:

A novel diazaspiro[3.4]octane series was identified from a Plasmodium falciparum whole-cell high-throughput screening campaign. Hits displayed activity against multiple stages of the parasite lifecycle, which together with a novel sp3-rich scaffold provided an attractive starting point for a hit-to-lead medicinal chem. optimization and biol. profiling program. Structure-activity-relationship studies led to the identification of compounds that showed low nanomolar asexual blood-stage activity (<50 nM) together with strong gametocyte sterilizing properties that translated to transmission-blocking activity in the standard membrane feeding assay. Mechanistic studies through resistance selection with one of the analogs followed by whole-genome sequencing implicated the P. falciparum cyclic amine resistance locus in the mode of resistance. In the experimental materials used by the author, we found 5-Bromo-2-chloropyridine(cas: 53939-30-3HPLC of Formula: 53939-30-3)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.HPLC of Formula: 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Clark, Brandon; Gilles, Genesis; Tarpeh, William A. published an article in 2022. The article was titled 《Resin-Mediated pH Control of Metal-Loaded Ligand Exchangers for Selective Nitrogen Recovery from Wastewaters》, and you may find the article in ACS Applied Materials & Interfaces.Product Details of 1539-42-0 The information in the text is summarized as follows:

Highly selective separation materials that recover total ammonia nitrogen (i.e., ammonia plus ammonium, or TAN) from wastewaters as a pure product can supplement energy-intensive ammonia production and incentivize pollution mitigation. We recently demonstrated that com. acrylate cation exchange polymer resins loaded with transition metal cations, or metal-loaded ligand exchangers, can recover TAN from wastewater with high selectivity (TAN/K+ equilibrium selectivity of 10.1) via metal-ammine bond formation. However, the TAN adsorption efficiency required further improvement (35%), and the optimal concentration and pH ranges were limited by both low ammonia fractions and an insufficiently strong resin carboxylate-metal bond that caused metal elution. To overcome these deficiencies, we used a zinc-acrylate ligand exchange resin and a tertiary amine acrylic weak base resin (pH buffer resin) together to achieve resin-mediated pH control for optimal adsorption conditions. The high buffer capacity around pH 9 facilitated gains in the adsorbed TAN per ligand resin mass that enhanced the TAN adsorption efficiency to greater than 90%, and constrained zinc elution (below 0.01% up to 1 M TAN) because of decreased ammonia competition for zinc-carboxylate bonds. During TAN recovery, resin-mediated pH buffering facilitated recovery of greater than 99% of adsorbed TAN with 0.2% zinc elution, holding the pH low enough to favor ammonium but high enough to prevent carboxylate protonation. For selective ion separation, solid phase buffers outperform aqueous buffers because the initial solution pH, the buffering capacity, and the ion purity can be independently controlled. Finally, because preserving the resin-zinc bond is crucial to sustained ligand exchange performance, the properties of an ideal ligand resin functional group were investigated to improve the properties beyond those of carboxylate. Ultimately, ligand exchange adsorbents combined with solid pH buffers can advance the selective recovery of nitrogen and potentially other solutes from wastewaters. In the part of experimental materials, we found many familiar compounds, such as Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Product Details of 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Product Details of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Kole, Goutam Kumar; Koscak, Marta; Amar, Anissa; Majhen, Dragomira; Bozinovic, Ksenija; Brkljaca, Zlatko; Ferger, Matthias; Michail, Evripidis; Lorenzen, Sabine; Friedrich, Alexandra; Krummenacher, Ivo; Moos, Michael; Braunschweig, Holger; Boucekkine, Abdou; Lambert, Christoph; Halet, Jean-Francois; Piantanida, Ivo; Mueller-Buschbaum, Klaus; Marder, Todd B. published an article in Chemistry – A European Journal. The title of the article was 《Methyl Viologens of Bis-(4′-Pyridylethynyl)Arenes – Structures, Photophysical and Electrochemical Studies, and their Potential Application in Biology》.Quality Control of 4-Ethynylpyridine The author mentioned the following in the article:

A series of bis-(4′-pyridylethynyl)arenes (arene = benzene, tetrafluorobenzene, and anthracene) were synthesized and their bis-N-methylpyridinium compounds were investigated as a class of π-extended Me viologens. Their structures were determined by single crystal X-ray diffraction, and their photophys. and electrochem. properties (cyclic voltammetry), as well as their interactions with DNA/RNA were investigated. The dications showed bathochromic shifts in emission compared to the neutral compounds The neutral compounds showed very small Stokes shifts, which are a little larger for the dications. All of the compounds showed very short fluorescence lifetimes (<4 ns). The neutral compound with an anthracene core has a quantum yield of almost unity. With stronger acceptors, the analogous bis-N-methylpyridinium compound showed a larger two-photon absorption cross-section than its neutral precursor. All of the dicationic compounds interact with DNA/RNA; while the compounds with benzene and tetrafluorobenzene cores bind in the grooves, the one with an anthracene core intercalates as a consequence of its large, condensed aromatic linker moiety, and it aggregates within the polynucleotide when in excess over DNA/RNA. Moreover, all cationic compounds showed highly specific CD spectra upon binding to ds-DNA/RNA, attributed to the rare case of forcing the planar, achiral mol. into a chiral rotamer, and negligible toxicity toward human cell lines at ≤10μM concentrations The anthracene-analog exhibited intracellular accumulation within lysosomes, preventing its interaction with cellular DNA/RNA. However, cytotoxicity was evident at 1μM concentration upon exposure to light, due to singlet oxygen generation within cells. These multi-faceted features, in combination with its two-photon absorption properties, suggest it to be a promising lead compound for development of novel light-activated theranostic agents. The experimental part of the paper was very detailed, including the reaction process of 4-Ethynylpyridine(cas: 2510-22-7Quality Control of 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Quality Control of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem