Month: October 2022

Ceglowski, Michal; Marien, Yoshi W.; Smeets, Sander; De Smet, Lieselot; D′hooge, Dagmar R.; Schroeder, Grzegorz; Hoogenboom, Richard published the artcile< Molecularly Imprinted Polymers with Enhanced Selectivity Based on 4-(Aminomethyl)pyridine-Functionalized Poly(2-oxazoline)s for Detecting Hazardous Herbicide Contaminants>, HPLC of Formula: 3731-53-1, the main research area is molecularly imprinted polymer aminomethylpyridine functionalized polyoxazoline detecting herbicide contaminant; trichlorophenoxyacetate adsorption molecularly imprinted polymer adsorbent.

The detection of hazardous compounds is of importance to control (drinking) water quality. Here, we report the development of poly(2-oxazoline)-based molecularly imprinted polymers (MIPs) for the detection of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T). In view of enhanced selectivity of the MIPs, it was hypothesized that incorporation of pyridine groups would lead to stronger interactions with 2,4,5-T. The synthesis of 4-(aminomethyl)pyridine (4-AMP)-functionalized poly(2-methoxycarbonylpropyl-2-oxazoline)s with various degrees of modification was, therefore, investigated via stoichiometric and kinetic control over the functionalization degree. The mol. imprinting of 2,4,5-T is performed by direct amidation of the Me ester side chains with diethylenetriamine. The exptl. data of 2,4,5-T adsorption were interpreted with various models to quantify the adsorption thermodn. and kinetics. The best fit was obtained for a single-site Langmuir model, indicating uniform binding site energies. A further investigation shows that the maximum adsorption capacity is reached at low 4-AMP modification degrees, whereas greater adsorption energies and higher selectivities are observed for higher 4-AMP modification degrees. Finally, the developed 4-AMP-modified MIP adsorbents were successfully used for quantification of 2,4,5-T by direct anal. with ambient mass spectrometry. In comparison with the pure analyte solution, the detection limits decreased by three orders of magnitude.

Chemistry of Materials published new progress about Adsorbents. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, HPLC of Formula: 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Oyamada, Nobuaki; Minamimoto, Hiro; Murakoshi, Kei published the artcile< Room-Temperature Molecular Manipulation via Plasmonic Trapping at Electrified Interfaces>, Safety of 2,2′-Bipyridine, the main research area is plasmonic trapping electrified interface Raman spectra optical tweezers.

For the motion control of individual mols. at room temperature, optical tweezers could be one of the best approaches to realize desirable selectivity with high resolution in time and space. Because of phys. limitations due to the thermal fluctuation, optical manipulation of small mols. at room temperature is still a challenging subject. The difficulty of the manipulation also emerged from the variation of mol. polarizability depending on the choice of mols. as well as the mol. orientation to the optical field. In this article, we have demonstrated plasmonic optical trapping of small size mols. with less than 1 nm at the gap of a single metal nanodimer immersed in an electrolyte solution In situ electrochem. surface-enhanced Raman scattering measurements prove that a plasmonic structure under electrochem. potential control realizes not only the selective mol. condensation but also the formation of unique mixed mol. phases which is distinct from those under a thermodn. equilibrium Through detailed analyses of optical trapping behavior, we established the methodol. of plasmonic optical trapping to create the novel adsorption isotherm under applying an optical force at electrified interfaces.

Journal of the American Chemical Society published new progress about Chemical potential. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Safety of 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Singh, Malvinder P.; Joseph, Tomi; Kumar, Surat; Bathini, Yadagiri; Lown, J. William published the artcile< Synthesis and sequence-specific DNA binding of a topoisomerase inhibitory analog of Hoechst 33258 designed for altered base and sequence recognition>, COA of Formula: C6H7N3O2, the main research area is topoisomerase inhibitor DNA binding preparation; DNA binding Hoechst 33258 analog sequence; safety benzoyl peroxide explosive; health hazard methoxymethyl chloride nitrobenzene.

The preparation and DNA binding characteristics of a structural analog of Hoechst 33258 bearing 2 pyridine N atoms are described. The 1H NMR signals of the complex formed between the new ligand I and decadeoxyribonucleotide d(CATGGCCATG)2 were assigned by employing 1- and 2-dimensional NMR techniques. Intermol. nuclear Overhauser effects (NOE) between the ligand and the DNA receptor fragment confirm that the ligand binds in the minor groove of the DNA, interacting with the centrally located 5′-GGCCA segment. In contrast to the steric interaction between the benzimidazole rings of the parent Hoechst 33258 mol. and the guanine 2-NH2 groups, which renders it G·C avoiding and thus A·T base pair preferring, the ligand I described here overcomes these unfavorable interactions and instead exhibits a marked preference for G·C base pairs. This behavior appears to arise from addnl. stabilization due to H-bonding with the guanine 2-NH2 groups. Although a ligand-induced distortion at the binding site is qual. assessable, the overall B-type conformation of the DNA fragment is retained upon complexation. The structural conclusions drawn from the NOE-NMR evidence were confirmed by mol. mechanics and mol. modeling studies. Safety in the use of methoxymethyl chloride and nitrobenzene, suspected toxins and benzyl peroxide, a potential explosive, is emphasized.

Chemical Research in Toxicology published new progress about DNA, complexes Role: BIOL (Biological Study). 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, COA of Formula: C6H7N3O2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Qin, Yin; Li, Yilin; Guo, Kaimeng; Tang, Huabiao; Hou, Lifen; Li, Gang published the artcile< Water-assisted proton conductivity of two highly stable imidazole multi-carboxylate-based MOFs>, Safety of 2,2′-Bipyridine, the main research area is crystal structure manganese zinc carboxylimidazoledicarboxylate bipyridine metal organic framework; manganese zinc carboxylimidazoledicarboxylate bipyridine MOF preparation proton conductivity.

Two new chain-like metal-organic frameworks (MOFs), {[Mn(o-CPhH2IDC)(4.4′-bipy)0.5(H2O)2]·3H2O}n (1) (o-CPhH4IDC = 2-phenyl(2-carboxyl)-1-H-imidazole-4,5-dicarboxylic acid; 4,4′-bipy = 4,4′-bipyridine) and {[Zn5(o-CPhH2IDC)2(o-CPhHIDC)2(2,2′-bipy)5]·5H2O}n (2) (2,2′-bipy = 2,2′-bipyridine) were designed and solvothermally or hydrothermally synthesized and structurally characterized. By SEM determinations and PXRD analyses, the high H2O stability and acid and alkali resistance of both MOFs were determined The affluent H-bond networks inside the frameworks formed by imidazole multi-carboxylate ligands and H2O mols. would favor the transfer of protons. Also, the temperature- and humidity-dependent proton conduction properties of the two MOFs were demonstrated. Also, the proton conducting mechanisms will be highlighted herein.

New Journal of Chemistry published new progress about Activation energy (proton conductivity). 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Safety of 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dziuganowska, Zofia A.; Slepokura, Katarzyna; Volle, Jean-Noel; Virieux, David; Pirat, Jean-Luc; Kafarski, Pawel published the artcile< Structural Analogues of Selfotel>, Recommanded Product: Methyl 3-bromo-2-pyridinecarboxylate, the main research area is phosphonate pyridinecarboxylic piperidinecarboxylic preparation phosphonylation bromopyridine hydrogenation; NMDA antagonist library phosphonate pyridinecarboxylic piperidinecarboxylic acid preparation activity; crystal structure phosphonate pyridinecarboxylic piperidinecarboxylic acid NMDA antagonist; mol structure phosphonate pyridinecarboxylic piperidinecarboxylic acid NMDA antagonist.

A small library of phosphonopiperidylcarboxylic acids, analogs of NMDA antagonist selfotel (CGS 19755), was synthesized. First, the series of aromatic esters was obtained via a palladium-catalyzed cross-coupling reaction (Hirao coupling) of dialkyl phosphites with bromopyridinecarboxylates, followed by their hydrolysis. Then, hydrogenation of the resulting phosphonopyridylcarboxylic acids over PtO2 yielded the desired phosphonopiperidylcarboxylic acids. NMR studies indicated that the hydrogenation reaction proceeds predominantly by cis addition Several compounds were obtained as monocrystal structures. Preliminary biol. studies performed on cultures of neurons suggest that the obtained compounds possess promising activity toward NMDA receptors.

Journal of Organic Chemistry published new progress about Carboxylic esters Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 53636-56-9 belongs to class pyridine-derivatives, and the molecular formula is C7H6BrNO2, Recommanded Product: Methyl 3-bromo-2-pyridinecarboxylate.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Munoz-Basagoiti, J.; Perez-Zsolt, D.; Leon, R.; Blanc, V.; Raich-Regue, D.; Cano-Sarabia, M.; Trinite, B.; Pradenas, E.; Blanco, J.; Gispert, J.; Clotet, B.; Izquierdo-Useros, N. published the artcile< Mouthwashes with CPC Reduce the Infectivity of SARS-CoV-2 Variants In Vitro>, Formula: C21H38ClN, the main research area is cetylpyridinium chloride mouthwash virucide COVID19; COVID-19; airborne transmission; cellular infection; coronaviruses; oral hygiene; virucide.

Oral mouthwashes decrease the infectivity of several respiratory viruses including SARS-CoV-2. However, the precise agents with antiviral activity in these oral rinses and their exact mechanism of action remain unknown. Here we show that cetylpyridinium chloride (CPC), a quaternary ammonium compound in many oral mouthwashes, reduces SARS-CoV-2 infectivity by inhibiting the viral fusion step with target cells after disrupting the integrity of the viral envelope. We also found that CPC-containing mouth rinses decreased more than a thousand times the infectivity of SARS-CoV-2 in vitro, while the corresponding vehicles had no effect. This activity was effective for different SARS-CoV-2 variants, including the B.1.1.7 or Alpha variant originally identified in United Kingdom, and in the presence of sterilized saliva. CPC-containing mouth rinses could therefore represent a cost-effective measure to reduce SARS-CoV-2 infectivity in saliva, aiding to reduce viral transmission from infected individuals regardless of the variants they are infected with.

Journal of Dental Research published new progress about Antiviral agents. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Formula: C21H38ClN.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hikawa, Hidemasa; Nakayama, Taku; Nakamura, Shunki; Kikkawa, Shoko; Azumaya, Isao published the artcile< Dehydrative amination of benzhydrols with electron-withdrawing group-substituted 2-aminopyridines utilizing Au(III)/TPPMS catalyst system in water>, HPLC of Formula: 21901-29-1, the main research area is benzyl aminopyridine preparation; benzhydrol aminopyridine dehydrative amination gold sodium diphenylphosphinobenzene sulfonate water.

Authors report a method for gold(III)/sodium diphenylphosphinobenzene-3-sulfonate (TPPMS)-catalyzed direct amination of benzhydrols using 2-aminopyridines with poor nucleophilic character in water. Various functional groups such as electron-withdrawing nitro, cyano and halogen groups were tolerated well to form the desired N-benzylated 2-aminopyridine compounds On the basis of mechanistic studies including kinetic profiles, Hammett study and isotope effects, authors propose a pathway in which a Lewis acidic gold cation species activates the sp3 C-O bond of the alc. in the rate-determining step.

Organic & Biomolecular Chemistry published new progress about Amination (dehydrative). 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, HPLC of Formula: 21901-29-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Grivas, Spiros; Schuisky, Peter published the artcile< Synthesis of imidazonaphthyridines and -quinolines>, Application of C6H6N2O, the main research area is imidazonaphthyridine imidazoquinoline preparation; cyclocondensation aromatic aldehyde aminoimidazolinone.

Four 2-amino-3-methylimidazo[4,5-b][1,x]naphthyridines (x = 5-8), e.g., I, have been obtained from aromatic aldehydes and 2-amino-1-methyl-2-imidazolin-5-one in one step. The N1- and N3-Me isomes of 2-aminoimidazo[4,5-b]quinoline (II and III) were prepared from 2-nitrobenzaldehyde via the isolated E-isomers of imidazolin-5-ones.

Heterocycles published new progress about Cyclocondensation reaction. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, Application of C6H6N2O.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Khayat, Maan T.; Omar, Abdelsattar M.; Elfaky, Mahmoud A.; Muhammad, Yosra A.; Felemban, Elaf A.; El-Say, Khalid M.; El-Araby, Moustafa E. published the artcile< Reexamining povarov reaction′s scope and limitation in the generation of HCV-NS4A peptidomimetics>, Recommanded Product: tert-Butyl (5-aminopyridin-2-yl)carbamate, the main research area is hepatitis C virus NS4A peptidomimetics.

Chronic Hepatitis C is a global health threat and a silent killer. Regardless of the profound progress in preventing and treating this disease, research continues to discover new direct antiviral agents (DAAs), especially against novel targets. Our research has been directed to leverage the NS4A binding site to develop peptidomimetic inhibitors of the hepatitis C virus (HCV) NS3 protease. In previous reports, we could provide evidence of tunability of this site by peptide and nonpeptide NS3/4A inhibitors. In this report, we used structure-based techniques to design 1,2,3,4-tetrahydro-1,7-naphthyridine derivative as NS4A core mimics that cover the region between residues Ile-25′ to Arg-28′. The synthetic plan featured the Povarov reaction as an efficient strategy to construct the 1,7-naphthyridine core. Although this reaction has been reported in many literatures, critical assessments for its scope and limitations are scarce. In our work, we found that Povarov was extremely sensitive to alkene and aldehyde reactants. Moreover, using pyridine amines was not as successful as anilines. The most striking results were the lack of stability of compounds during purification and storage. The four compounds that survived the stability problems (1a-1d) did not show significant binding potency with NS3, because their structures were too simple to resemble the originally planned compounds

Heteroatom Chemistry published new progress about Aggregation (temperature). 220731-04-4 belongs to class pyridine-derivatives, and the molecular formula is C10H15N3O2, Recommanded Product: tert-Butyl (5-aminopyridin-2-yl)carbamate.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ma, Teng; Chen, Yate; Li, Yuxiu; Ping, Yuanyuan; Kong, Wangqing published the artcile< Nickel-Catalyzed Enantioselective Reductive Aryl Fluoroalkenylation of Alkenes>, Recommanded Product: (R)-4-(tert-Butyl)-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole, the main research area is nickel catalyzed enantioselective reductive aryl monofluoroalkenylation alkene; aryl bromide gem difluoroalkene monofluoroalkenylation; oxindole monofluoroalkenyl substituent preparation.

Enantioselective Ni-catalyzed reductive aryl monofluoroalkenylation of alkenes between aryl bromides and gem-difluoroalkenes has been developed. The reaction proceeding under room temperature and base-free reaction conditions tolerates a wide range of functional groups on both coupling partners. Various synthetically useful oxindoles containing monofluoroalkenyl substituent are obtained in good yields with 85%-95% enantiomeric excess. In addition, the synthetic method can be further applied to the late-stage monofluoroalkenylation of complex biol. active compounds

ACS Catalysis published new progress about Alkenylation (monofluoro-). 1428537-19-2 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Recommanded Product: (R)-4-(tert-Butyl)-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem