Month: October 2022

Hayashi, Mikihiro; Kimura, Takahiro; Oba, Yuta; Takasu, Akinori published the artcile< One-Pot Synthesis of Dual Supramolecular Associative PMMA-Based Copolymers and the Precise Thermal Property Tuning>, Recommanded Product: Pyridin-4-ylmethanamine, the main research area is onepot dual supramol associative PMMA copolymer.

Dual supramol. associative polymers have attracted attention for efficient phys. property modification. Herein, a one-pot synthesis of dual supramol. associative poly(Me methacrylate)-based copolymers via reversible addition fragmentation chain transfer (RAFT) copolymerization using a novel methacrylate-type monomer (coded as UP-MA) bearing a urea bond and a pendant pyridine group is demonstrated. UP-MA is synthesized by reacting 4-picolylamine and 2-isocyanatoethyl methacrylate. The subsequent RAFT copolymerization of UP-MA and Me methacrylate (MMA) can be performed by directly adding MMA, a chain transfer agent, and a radical initiator into the reaction solution of UP-MA. The estimated values of radical reactivity ratio (r) for UP-MA and MMA are close to unity, attaining a nearly ideal random sequence of the dual supramol. associative units in the copolymer chain. By blending a metal salt into the random copolymer, coordination bonds between the salt and the pyridine groups are formed, and the urea groups simultaneously form hydrogen bonds, generating a dual supramol. associative network. Precise tuning of the thermal property is realized by changing the fraction of the metal salt and associative groups in the copolymers.

Macromolecular Chemistry and Physics published new progress about Glass transition temperature. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Recommanded Product: Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zheng, Danqing; Studer, Armido published the artcile< Asymmetric Synthesis of Heterocyclic γ-Amino-Acid and Diamine Derivatives by Three-Component Radical Cascade Reactions>, Safety of 3-(Methoxycarbonyl)pyridine, the main research area is asym synthesis heterocyclic amino acid diamine multicomponent radical cascade; Brønsted acids; amino acids; asymmetric synthesis; photochemistry; radicals.

An enantioselective three-component radical reaction of quinolines or pyridines with enamides and α-bromo carbonyl compounds by dual photoredox and chiral Bronsted acid catalysis is presented. A range of valuable chiral γ-amino-acid derivatives are accessible in high chemo-, regio-, and enantioselectivity from simple, readily available starting materials under mild reaction conditions. Using the same strategy, the asym. synthesis of 1,2-diamine derivatives is also reported. Thus, e.g., 4-methylquinoline + N-vinylacetamide + Me bromoacetate → I (88%, 96:4 er).

Angewandte Chemie, International Edition published new progress about Carbonyl compounds (organic), halo carbonyl compounds Role: RCT (Reactant), RACT (Reactant or Reagent) (quinoline/pyridine + N-vinylacetamide + α-bromo carbonyl compound → γ-amino acid). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Safety of 3-(Methoxycarbonyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Saud, Zack; Tyrrell, Victoria J.; Zaragkoulias, Andreas; Protty, Majd B.; Statkute, Evelina; Rubina, Anzelika; Bentley, Kirsten; White, Daniel A.; Rodrigues, Patricia Dos Santos; Murphy, Robert C.; Kofeler, Harald; Griffiths, William J.; Alvarez-Jarreta, Jorge; Brown, Richard William; Newcombe, Robert G.; Heyman, James; Pritchard, Manon; Mcleod, Robert WJ.; Arya, Arvind; Lynch, Ceri-Ann; Owens, David; Jenkins, P. Vince; Buurma, Niklaas J.; O’Donnell, Valerie B.; Thomas, David W.; Stanton, Richard J. published the artcile< The SARS-CoV2 envelope differs from host cells, exposes procoagulant lipids, and is disrupted in vivo by oral rinses>, Related Products of 123-03-5, the main research area is lipidome cetylpyridinium chloride oral rinse phospholipid SARSCoV2 envelope; CPC; aminophospholipids; cetylpyridinium chloride; clinical trials; coagulation; inflammation; lipidomics; mouthwash; phospholipids; virology.

The lipid envelope of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an essential component of the virus; however, its mol. composition is undetermined Addressing this knowledge gap could support the design of antiviral agents as well as further our understanding of viral-host protein interactions, infectivity, pathogenicity, and innate immune system clearance. Lipidomics revealed that the virus envelope comprised mainly phospholipids (PLs), with little cholesterol or sphingolipids, indicating significant differences from host membranes. Unlike cellular membranes, procoagulant amino-PLs were present on the external side of the viral envelope at levels exceeding those on activated platelets. Accordingly, virions directly promoted blood coagulation. To investigate whether these differences could enable selective targeting of the viral envelope in vivo, we tested whether oral rinses containing lipid-disrupting chems. could reduce infectivity. Products containing PL-disrupting surfactants (such as cetylpyridinium chloride) met European virucidal standards in vitro; however, components that altered the critical micelle concentration reduced efficacy, and products containing essential oils, povidone-iodine, or chlorhexidine were ineffective. This result was recapitulated in vivo, where a 30-s oral rinse with cetylpyridinium chloride mouthwash eliminated live virus in the oral cavity of patients with coronavirus disease 19 for at least 1 h, whereas povidone-iodine and saline mouthwashes were ineffective. We conclude that the SARS-CoV-2 lipid envelope (i) is distinct from the host plasma membrane, which may enable design of selective antiviral approaches; (ii) contains exposed phosphatidylethanolamine and phosphatidylserine, which may influence thrombosis, pathogenicity, and inflammation; and (iii) can be selectively targeted in vivo by specific oral rinses.

Journal of Lipid Research published new progress about Antiviral agents. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Related Products of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Elvidge, J. A.; Zaidi, N. A. published the artcile< Heterocyclic syntheses with malonyl chloride. IX. 2-Substituted 4-chloro-6-pyrimidones from certain nitriles>, Application of C5HCl4N, the main research area is nitriles malonyl chloride; malonyl chloride nitriles; pyrimidines; pyridines.

Chloroacetonitrile with malonyl chloride yielded 2,3-dichloro-4,6-dihydroxypyridine (I) together with an unexpected product, 4-chloro-2-chloromethyl-6-pyrimidone (II). Further examples of this new synthesis of 2-substituted 4-chloro-6-pyrimidones were obtained with fluoro- and bromoacetonitrile, α-bromopropionitrile, and acetonitrile. Propio- and butyronitrile each gave a mixture of pyridine and pyrimidine product, while various other nitriles gave only the pyridine products. The expected fully substituted pyrimidone was obtained from fluoroacetonitrile and chloromalonyl chloride, and from dibromoacetonitrile with bromomalonyl chloride. Some novel halogen-transfer reactions were encountered in other cases.

Journal of the Chemical Society [Section] C: Organic published new progress about Nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 14121-36-9 belongs to class pyridine-derivatives, and the molecular formula is C5HCl4N, Application of C5HCl4N.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Timperley, Christopher M.; Banks, R. Eric; Young, Ian M.; Haszeldine, Robert N. published the artcile< Synthesis of some fluorine-containing pyridinealdoximes of potential use for the treatment of organophosphorus nerve-agent poisoning>, SDS of cas: 22280-62-2, the main research area is fluorinated pyridinealdoxime preparation treatment organophosphorus nerve agent poisoning; sarin poisoning fluorinated pyridinealdoxime preparation treatment.

Fluoroheterocyclic aldoximes were screened as therapeutic agents for the treatment of anticholinesterase poisoning. 2-Fluoropyridine-3- and -6-aldoxime and 3-fluoropyridine-2- and -4-aldoxime were synthesized. Attempts to obtain 3,5,6-trifluoropyridine-2,4-bis(aldoxime) and -2-aldoxime, however, proved unsuccessful. Pentafluorobenzaldoxime was prepared by oximation of pentafluorobenzaldehyde. Acid dissociation constants (pKa) and second-order rate constants (kox-) of the fluorinated pyridinealdoximes towards sarin were measured. 2,3,5,6-Tetrafluoropyridine-4-aldoxime had the best profile: its kox- approached that of the therapeutic oxime P2S (310 vs. 120 l mol-1 min-1), but its higher pKa (9.1 vs. 7.8) fell short of the target figure of 8 required for reactivation of inhibited acetylcholinesterase in vivo. N-alkylation of the fluorinated pyridine-aldoximes may reduce their pKa nearer to 8 and enhance their therapeutic potential.

Journal of Fluorine Chemistry published new progress about Antidotes. 22280-62-2 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, SDS of cas: 22280-62-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cotton, Simon A.; Raithby, Paul R.; Schiffers, Stephanie; Teat, Simon J.; Warren, John E. published the artcile< The Synthesis and Structure of a Scandium Nitrate Hydroxy-Bridged Dimeric Complex Supported by Bipyridyl Ligands †>, Application of C10H8N2, the main research area is crystal structure; eight coordinate complex; hydroxy group; nitrate complex; scandium complex.

The current discussion on whether scandium, yttrium and lanthanum should represent Group 3 in the Periodic Table or whether lutetium should replace lanthanum in the group has prompted us to further explore the structural chem. of the Group 3 elements and compare the coordination numbers and coordination geometries adopted. The steric and electronic properties of the coordinated ligands have a major influence on the structures adopted. We report the synthesis and crystal structure determination of an unusual dinuclear scandium complex [(bipy)(NO3)2Sc(μ-OH)2Sc(NO3)2(bipy)] obtained by the reaction of hydrated scandium nitrate with 2,2′-bipyridyl (bipy) in either ethanol or nitromethane. The crystal structure of the complex shows that the scandium centers are eight coordinate, and the structure obtained contrasts with related complexes found in the lanthanide series [Ln(bipy)2(NO3)3] and [Ln(phen)2(NO3)3] (phen = phenanthroline) and in [M(terpy)(NO3)3] (M = Sc, Er-Lu), where these complexes are all mononuclear.

Molecules published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Arya, Kritika; Kumar, Sudesh; Arya, Anand Kumar; Kumar, Mahendra published the artcile< Ionic Liquid [PyN(CH2)4SO3H][CH3PhSO3] Mediated & Promoted Eco-Friendly One-Pot Domino Synthesis of Benzothiazolopyrano/Chromenopyrimidine Derivatives>, Application In Synthesis of 21876-43-7, the main research area is benzothiazolopyranopyrimidinone preparation green chem; aldehyde aminobenzothiazole pyrone multicomponent domino heterocyclization pyridinium ionic liquid; benzothiazolochromenopyrimidinone preparation green chem; hydroxycoumarin aldehyde aminobenzothiazole multicomponent domino heterocyclization pyridinium ionic liquid; pyridinium toluenesulfonic acid ionic liquid catalyst preparation.

The pyridinium based p-toluenesulfonic acid functionalized [Py(CH2)4SO3H][CH3PhSO3] ionic liquid has been employed as eco-friendly solvent cum promoter for the multicomponent domino heterocyclization of substituted 2-aminobenzothiazoles I (R1 = H, Me; R2 = H, Me; R3 = H, Me, Br; R4 = H, Me) with 4-hydroxy-6-methyl-2-pyrone/4-hydroxycoumarin and aryl aldehydes 4-R5C6H4CHO (R5 = MeO, Cl) to produce benzothiazolo[2,3-b]pyrano [3,4-e]pyrimidin-4-ones II and benzothiazolo[2,3-b]chromeno[3,4-e]pyrimidin-6-ones III in excellent yields. The Bronsted acidic ionic liquid could be reused five-times without a significant loss of catalytic activity. The protocol proves to be efficient and facile in terms of high yields, operational simplicity, reduced reaction time and ease of recovery of the reaction medium.

Current Organocatalysis published new progress about Benzothiazoles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 21876-43-7 belongs to class pyridine-derivatives, and the molecular formula is C9H13NO3S, Application In Synthesis of 21876-43-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Van der Plas, Steven E.; Kelgtermans, Hans; Mammoliti, Oscar; Menet, Christel; Tricarico, Giovanni; De Blieck, Ann; Joannesse, Caroline; De Munck, Tom; Lambin, Dominique; Cowart, Marlon; Dropsit, Sebastien; Martina, Sebastien L. X.; Gees, Maarten; Wesse, Anne-Sophie; Conrath, Katja; Andrews, Martin published the artcile< Discovery of GLPG2451, a Novel Once Daily Potentiator for the Treatment of Cystic Fibrosis>, Formula: C6H5BrN2O2, the main research area is preparation GLPG2451 analog CFTR potentiator cystic fibrosis structure.

Cystic fibrosis (CF) is a life-threatening recessive genetic disease caused by mutations in the gene encoding for the cystic fibrosis transmembrane conductance regulator (CFTR). With the discovery of Ivacaftor and Lumacaftor, it has been shown that administration of one or more small mols. can partially restore the CFTR function. Correctors are small mols. that enhance the amount of CFTR on the cell surface, while potentiators improve the gating function of the CFTR channel. Herein, the discovery and optimization of a novel potentiator series are described. Scaffold hopping, focusing on retaining the different intramol. contacts, was crucial in the whole discovery process to identify a novel series devoid of genotoxic liabilities. From this series, the clin. candidate GLPG2451 was selected based on its pharmacokinetic properties, allowing QD dosing and based on its low CYP induction potential.

Journal of Medicinal Chemistry published new progress about CFTR (cystic fibrosis transmembrane conductance regulator) Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 870997-85-6 belongs to class pyridine-derivatives, and the molecular formula is C6H5BrN2O2, Formula: C6H5BrN2O2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mujahed, Shrouq; Hey-Hawkins, Evamarie; Gelman, Dmitri published the artcile< A High-Valent Ru-PCP Pincer Catalyst for Hydrogenation of Carbonyl and Carboxyl Compounds under Molecular Hydrogen>, HPLC of Formula: 350-03-8, the main research area is high valent ruthenium phosphorus carbon PCP pincer catalyst hydrogenation; carbonyl carboxyl nitrile compound hydrogenation catalyst preparation; crystal mol structure ruthenium phosphorus carbon PCP pincer complex; cooperative catalysis; esters; high-valent ruthenium; hydrogenation; pincer complexes.

Low-valent metals traditionally dominate the domain of catalytic hydrogenation. However, metal-ligand cooperating (MLC) catalytic systems, operating through heterolytic H-H bond splitting by a Lewis acidic metal and a basic ligand site, do not require an electron-rich metal. On the contrary, high-valent metals that induce weaker back donation facilitate heterolytic bond activation. Here authors report, for the first time, the efficient hydrogenation of carbonyl and carboxyl compounds under mol. hydrogen catalyzed by a structurally well-defined RuIV catalyst bearing a bifunctional PCP pincer ligand. The catalyst exhibits reactivity toward mol. hydrogen superior to that of the low-valent analog and allows hydrogen activation even at room temperature

Chemistry – A European Journal published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, HPLC of Formula: 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shvydkiy, Nikita V.; Vyhivskyi, Oleksandr; Nelyubina, Yulia V.; Perekalin, Dmitry S. published the artcile< Design of Manganese Phenol Pi-complexes as Shvo-type Catalysts for Transfer Hydrogenation of Ketones>, Formula: C7H7NO, the main research area is manganese phenol pi complex preparation; secondary alc preparation; ketone transfer hydrogenation manganese complex catalyst.

The ability of the manganese pi-complexes to act as Shvo-type catalysts for transfer hydrogenation of ketones to afford secondary alcs. RCH(OH)(R1) [R = Ph, 3-pyridyl, 1-naphthyl, etc.; R1 = Me, n-Pr, Ph, etc.] was explored. DFT calculations suggested that the transfer of hydrogen atoms from the hypothetical intermediate [(C6Me3H2OH)Mn(CO)2H] to acetone had low activation barrier of 10.9 kcal mol-1. Exptl. a number of ketones with various functional groups were successfully reduced in isopropanol in the presence of the complex [(C6Me3H2OH)Mn(CO)3]BF4 (1 mol %) and tBuOK (75 mol %). However, further investigation revealed that the reduction was mainly promoted by base rather than the manganese complex.

ChemCatChem published new progress about Ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Formula: C7H7NO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem