Month: October 2022

Qin, Qi-Pin; Wang, Zhen-Feng; Tan, Ming-Xiong; Huang, Xiao-Ling; Zou, Hua-Hong; Zou, Bi-Qun; Shi, Bei-Bei; Zhang, Shu-Hua published the artcile< Complexes of lanthanides(III) with mixed 2,2'-bipyridyl and 5,7-dibromo-8-quinolinoline chelating ligands as a new class of promising anti-cancer agents>, Application of C10H8N2, the main research area is cervical ovarian cancer lanthanide III metal chelation.

Five novel lanthanides(III) complexes, [Lu(Me)(MBrQ)2NO3] (MeMBrQ-Lu), [Ho(MeO)(MBrQ)2NO3] (MeOMBrQ-Ho), [Ho(Me)(MBrQ)2NO3] (MeMBrQ-Ho), [La(Me)2(BrQ)2NO3] (MeBrQ-La) and [Sm(Me)(BrQ)2(CH3OH)NO3] (MeBrQ-Sm) were synthesized in which 2,2′-bipyridyl (4,4′-dimethyl-2,2′-bipyridyl (Me) and 4,4′-dimethoxy-2,2′-bipyridine (MeO)) and 5,7-dibromo-8-quinolinoline derivatives (5,7-dibromo-2-methyl-8-quinolinol (MBrQ-H) and 5,7-dibromo-8-quinolinol (BrQ-H)) act as chelating ligands. The in vitro cytotoxic activities of five Ln(III) complexes have been studied with SK-OV-3/DDP, NCI-H460 and HeLa cancer cells. MeMBrQ-Lu, MeOMBrQ-Ho, MeMBrQ-Ho, MeBrQ-La and MeBrQ-Sm show higher cytotoxicity against the HeLa cells than cisplatin (13.11 ± 0.53 μM). In particular, the MeOMBrQ-Ho and MeMBrQ-Ho complexes exhibit superior cytotoxic activity, with IC50 values at 1.00 ± 0.34 nM and 125.00 ± 1.08 nM. We further demonstrate that MeOMBrQ-Ho and MeMBrQ-Ho inhibit the proliferation of HeLa cells by inhibiting telomerase and targeting mitochondria to induce DNA damage-mediated apoptosis. In addition, MeOMBrQ-Ho significantly inhibits tumor growth with a tumor growth inhibition rate (IR) of 50.8% in a HeLa mouse xenograft model. Taken together, MeOMBrQ-Ho is a novel lanthanide(III) complex with promising antitumor activity.

Metallomics published new progress about Antitumor agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wu, Wen Xin; Liu, Hu Cheng; Jin, Wei Jun published the artcile< Halogen Bonding Adsorbent Pyridine N-oxides for Iodine Capture in Water>, Recommanded Product: 2-Mercaptopyridinen-oxide sodiumsalt, the main research area is anthracene naphthaline pyridine oxide adsorbent single crystal surface structure; SC-SC transformation; halogen bonds; iodine capture; nonporous materials; pyridine N-oxide.

Rapid capture of 129I with high volatility and toxicity in the environment has attracted much attention. Herein we reported a firstly synthesized nonporous material: pyridine N-oxides (NTPO and ATPO) as iodine adsorbent. Both of NTPO and ATPO exhibit remarkable performance on the adsorption of iodine in aqueous solution, vapor state and organic solvents. Upon the capture of iodine, pyridine N-oxides were transformed to binary cocrystals combined with the pyridine N-oxides and iodine which is driven by halogen bond between iodine and oxygen atoms. Moreover, pyridine N-oxides shows high chem., thermal and moisture stability.

Chemistry – A European Journal published new progress about Adsorption. 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Recommanded Product: 2-Mercaptopyridinen-oxide sodiumsalt.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tong, Xiaogang; Shi, Bingfei; Liu, Qian; Huo, Yanman; Xia, Chengfeng published the artcile< Retro-biosynthetic construction of corynanthe alkaloid skeletons from rhynchophylline alkaloids>, Quality Control of 93-60-7, the main research area is retro biosynthetic Wagner Meerwein rearrangement rhynchophylline corynanthe alkaloid.

Rhynchophylline alkaloids are bio-synthesized from corynanthe alkaloids via an oxidative rearrangement. We demonstrate here that corynanthe alkaloids could be generated from rhynchophylline alkaloids in a retro-biosynthetic manner via a Wagner-Meerwein rearrangement [e.g., I → II (85%) in presence of TFA in DCM]. A series of corynanthe analogs were afforded with good functional group tolerance and satisfactory yields.

Organic & Biomolecular Chemistry published new progress about Biomimetic synthesis (retro-biomimetic). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Quality Control of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Meng; Mu, Yan-Fei; Yao, Shuang; Guo, Song; Guo, Xiang-Wei; Zhang, Zhi-Ming; Lu, Tong-Bu published the artcile< Photosensitizing single-site metal-organic framework enabling visible-light-driven CO2 reduction for syngas production>, Recommanded Product: 2,2′-Bipyridine, the main research area is photosensitizing MOF carbon reduction syngas.

Photocatalytic CO2 reduction into syngas (CO and H2) is one of sustainable strategies for recycling CO2 into value-added products. Herein, a simple and effective two-step self-assembly process was developed to functionalize phosphorescent metal-organic framework (MOF) with single site catalyst. The resulting (Co/Ru)n-UiO-67(bpydc) supplied mol. platform to enable fast multielectron injection from photosensitizers (PSs) to Co-catalyst, leading to the first MOF-based composite photocatalyst for efficient syngas production with a yield of 13,600μmol·g-1 (H2 : CO = 2 : 1) in 16 h, 29.2-fold higher than that of its homogeneous counterpart. The H2/CO ratios can be well controlled by carefully adjusting the molar ratio of PS/catalyst in the MOF platform and the water content in the photocatalytic system. This work provides a prospective strategy for recycling CO2 into H2-rich syngas by merging PSs and single-site catalysts into a MOF platform.

Applied Catalysis, B: Environmental published new progress about Photocatalysts. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Recommanded Product: 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ren, Linning; Wang, Manman; Fang, Benyao; Yu, Wenquan; Chang, Junbiao published the artcile< Iodine-mediated oxidative N-N coupling of secondary amines to hydrazines>, Product Details of C11H10N2, the main research area is aromatic secondary amine iodine mediator oxidative dimerization; diaryl hydrazine preparation.

An I2-mediated N-N coupling reaction was established for oxidative dimerization of N-aryl aminopyridines to a variety of novel hydrazine derivatives under mild conditions. This synthetic method does not required the use of transition metals and was conveniently carried out on a gram scale. It was also applicable to diphenylamine and N-alkyl aniline substrates.

Organic & Biomolecular Chemistry published new progress about Hydrazines Role: SPN (Synthetic Preparation), PREP (Preparation). 22961-45-1 belongs to class pyridine-derivatives, and the molecular formula is C11H10N2, Product Details of C11H10N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Haixian; Song, Feifei; Dong, Caihong; Yu, Luodan; Chang, Cai; Chen, Yu published the artcile< Co-delivery of nanoparticle and molecular drug by hollow mesoporous organosilica for tumor-activated and photothermal-augmented chemotherapy of breast cancer>, Safety of 1,2-Di(pyridin-2-yl)disulfane, the main research area is diethyldithiocarbamate hybrid hollow mesoporous organosilica nanoparticle chemotherapy breast cancer; Breast cancer; Copper; Disulfiram; Mesoporous organosilica; Photothermal.

In comparison with traditional therapeutics, it is highly preferable to develop a combinatorial therapeutic modality for nanomedicine and photothermal hyperthermia to achieve safe, efficient, and localized delivery of chemotherapeutic drugs into tumor tissues and exert tumor-activated nanotherapy. Biocompatible organic-inorganic hybrid hollow mesoporous organosilica nanoparticles (HMONs) have shown high performance in mol. imaging and drug delivery as compared to other inorganic nanosystems. Disulfiram (DSF), an alc.-abuse drug, can act as a chemotherapeutic agent according to its recently reported effectiveness for cancer chemotherapy, whose activity strongly depends on copper ions. In this work, a therapeutic construction with high biosafety and efficiency was proposed and developed for synergistic tumor-activated and photothermal-augmented chemotherapy in breast tumor eradication both in vitro and in vivo. The proposed strategy is based on the employment of HMONs to integrate ultrasmall photothermal CuS particles onto the surface of the organosilica and the mol. drug DSF inside the mesopores and hollow interior. The ultrasmall CuS acted as both photothermal agent under near-IR (NIR) irradiation for photonic tumor hyperthermia and Cu2+ self-supplier in an acidic tumor microenvironment to activate the nontoxic DSF drug into a highly toxic diethyldithiocarbamate (DTC)-copper complex for enhanced DSF chemotherapy, which effectively achieved a remarkable synergistic in-situ anticancer outcome with minimal side effects. This work provides a representative paradigm on the engineering of combinatorial therapeutic nanomedicine with both exogenous response for photonic tumor ablation and endogenous tumor microenvironment-responsive in-situ toxicity activation of a mol. drug (DSF) for augmented tumor chemotherapy.

Journal of Nanobiotechnology published new progress about Animalia. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Safety of 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Marcelo, Goncalo A.; Montpeyo, David; Novio, Fernando; Ruiz-Molina, Daniel; Lorenzo, Julia; Oliveira, Elisabete published the artcile< Luminescent silicon-based nanocarrier for drug delivery in colorectal cancer cells>, Name: 1,2-Di(pyridin-2-yl)disulfane, the main research area is luminescent silicon nanocarrier drug delivery colorectal cancer cell.

Nanocarriers sensitive to exogenous or endogenous stimuli emerged as an attractive alternative to target drug delivery, with inorganic silica mesoporous nanoparticles (MNs) playing a core role in the development of a new generation of non-toxic and tuneable nanocarriers. A sensitive nanovector (NANO1) comprising luminescent silicon quantum dots (SiQDs) and functionalized with MNs was synthesized and loaded with doxorubicin (DOX). NANO1 nanoparticles have a size of 74 ± 10 nm and DOX loading percentages of ca. 43%. As a control sample, a similar nanocarrier (NANO2), without SiQDs, was also synthesized and loaded with DOX. Release profile studies, in PBS, revealed the strong NANO1@DOX pH-dependant behavior, with a pH 5.0 favoring the release of DOX to percentages of ca. 70%. Cytotoxicity assessments of both free and DOX-loaded nanocarriers were evaluated in human cell lines of colon, revealing both free drug and drug-loaded nanoparticles to be concentration-dependent.

Dyes and Pigments published new progress about Antitumor agents. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Name: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Giacobbe, Thomas J.; McGregor, Stanley D.; Beman, Floyd L. published the artcile< Ultraviolet spectra of the chloropyridines and chlorinated pyridines possessing a sulfur (0SR), nitrogen (-NR2), or oxygen (-OR) substituent in either the 2 or 4 position. Convenient method for distinguishing such positional isomers>, Reference of 14121-36-9, the main research area is chloropyridine UV isomerism; pyridine chloro UV.

A correlation is established between the position (2 versus 4) of the S, N, or O substituent on the chlorinated pyridines and their uv spectra. The chlorinated pyridines with S, N, or O substitution at the 2-position give uv spectra whose longest wavelength absorption maxima are enhanced (moved to a greater wavelength and an increased extinction coefficient) when compared to the spectra of the 4-substituted isomers. The number of Cl atoms, and not their position, is the more significant factor in determining the overall character of the spectra.

Journal of Heterocyclic Chemistry published new progress about Isomers. 14121-36-9 belongs to class pyridine-derivatives, and the molecular formula is C5HCl4N, Reference of 14121-36-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ghorbani, Zeynab; Abdollahifar, Mohammad Amin; Vakili, Kimia; Moghaddam, Meysam Hassani; Mehdizadeh, Mehdi; Marzban, Hassan; Rasoolijazi, Homa; Aliaghaei, Abbas published the artcile< Melittin administration ameliorates motor function, prevents apoptotic cell death and protects Purkinje neurons in the rat model of cerebellar ataxia induced by 3-Acetylpyridine>, Formula: C7H7NO, the main research area is acetylpyridine melittin CA motor apoptotic cell death Purkinje neuron; Cerebellar ataxia; Inflammation; Melittin; Motor skills; Neuroprotection.

Cerebellar ataxia (CA) is a condition in which cerebellar dysfunction leads to movement disorders such as dysmetria, asynergy and dysdiadochokinesia. This study investigates the therapeutic effects of Melittin (MEL) on 3-acetylpyridine-induced (3-AP) cerebellar ataxia (CA) rat model. Initially, CA rat models were generated by 3-AP administration followed by the i.p. injection of MEL. Then, motor performance and electromyog. (EMG) activity were assessed. Afterwards, the pro-inflammatory cytokines were analyzed in the cerebellar tissue. Moreover, the anti-apoptotic role of MEL in CA and its relationship with the protection of Purkinje cells were explored. The findings showed that the administration of MEL in a 3-AP model of ataxia improved motor coordination (P < 0.001) and neuro-muscular activity (p < 0.05), prevented the cerebellar volume loss (P < 0.01), reduced the level of inflammatory cytokines (p < 0.05) and thwarted the degeneration of Purkinje cells against 3-AP toxicity (P < 0.001). Overall, the findings imply that the MEL attenuates the 3-AP-induced inflammatory response. As such, it could be used as a treatment option for CA due to its anti-inflammatory effects. Toxicon published new progress about Animal tissue. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Formula: C7H7NO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kiss, Levente; Pop, Alexandra; Shova, Sergiu; Rat, Ciprian I.; Silvestru, Cristian published the artcile< Synthesis and characterization of [4-{(CH2O)2CH}C6H4]2Hg, [4-(O:CH)C6H4]2Hg and [(E)-4-(RN:CH)C6H4]2Hg (R = 2'-py, 4'-py, 2'-pyCH2, 4'-pyCH2)>, Synthetic Route of 3731-53-1, the main research area is crystal structure mol mercury diaryl compound supramol preparation homocoupling.

The reaction of 4-[(CH2O)2CH]C6H4Br (1) with n-BuLi, followed by addition of HgCl2 to the in situ formed organolithium derivative, affords [4-{(CH2O)2CH}C6H4]2Hg (2). Deprotection of the formyl groups of 2 in presence of p-TsOH (p-Ts = 4-MeC6H4SO3) leads to [4-(O:CH)C6H4]2Hg (3). Condensation reactions of 3 with 2-aminopyridine (2-pyNH2), 4-aminopyridine (4-pyNH2), 2-aminomethylpyridine (2-pyCH2NH2), and 4-aminomethylpyridine (4-pyCH2NH2), in CH2Cl2, affords the novel diorganomercury(II) compounds of type [(E)-4-(RN:C)C6H4]2Hg [R = 2′-py (4), 4′-py (5), 2′-pyCH2- (6), 4′-pyCH2 (7)]. Compounds 2 and 3 were useful precursors for the preparation of the corresponding homocoupling products [4-{(CH2O)2CH}C6H4]2 (8) and [4-(O:CH)C6H4]2 (9) in presence of catalytic amounts of palladium(II) acetate. Compounds 2-9 were characterized by multinuclear magnetic resonance (NMR) (1H, 13C{1H}, and 199Hg{1H}, when appropriate) and IR (IR) spectroscopy and by mass spectrometry. The mol. structures of 3, 5, 6, 8, and 9 were determined by single-crystal X-ray diffraction.

Applied Organometallic Chemistry published new progress about Condensation reaction. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Synthetic Route of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem