Month: October 2022

Gurgul, Ilona; Janczy-Cempa, Ewelina; Mazuryk, Olga; Lekka, Malgorzata; Lomzik, Michal; Suzenet, Franck; Gros, Philippe C.; Brindell, Malgorzata published the artcile< Inhibition of Metastasis by Polypyridyl Ru(II) Complexes through Modification of Cancer Cell Adhesion - In Vitro Functional and Molecular Studies>, COA of Formula: C10H8N2, the main research area is polypyridyl ruthenium complex cancer metastasis cell adhesion.

The effect of polypyridyl Ru(II) complexes on the ability of cancer cells to migrate and invade, two features important in the formation of metastases, is evaluated. In vitro studies are carried out on breast cancer cell lines, MDA-MB-231 and MCF-7, as well as melanoma cell lines A2058 and A375. Three Ru(II) complexes comprising two 4,7-diphenyl-1,10-phenanthroline (dip) ligands and as a third ligand 2,2′-bipyridine (bpy), or its derivative with either 4-[3-(2-nitro-1H-imidazol-1-yl)propyl] (bpy-NitroIm), or 5-(4-{4′-methyl-[2,2′-bipyridine]-4-yl}but-1-yn-1-yl)pyridine-2-carbaldehyde semicarbazone (bpy-SC) moiety attached are examined The low sub-toxic doses of the studied compounds greatly affected the cancer cells by inhibiting cell detachment, migration, invasion, transmigration, and re-adhesion, as well as increasing cell elasticity. The mol. studies revealed that the Ru(II) polypyridyl complexes impact the activity of the selected integrins and upregulate the expression of focal adhesion components such as vinculin and paxillin, leading to an increased number of focal adhesion contacts.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, COA of Formula: C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gu, Tingting; Kwaku Attatsi, Isaac; Zhu, Weihua; Li, Minzhi; Ndur, Samuel A.; Liang, Xu published the artcile< Enhanced electrocatalytic hydrogen evolutions of Co(II)phthalocyanine through axially coordinated pyridine-pyrene>, HPLC of Formula: 3731-53-1, the main research area is cobalt phthalocyanine immobilized multiwalled carbon nanotube electrocatalytic hydrogen evolution.

Non-precious metal catalysts can effectively evolve hydrogen in aqueous media, but a highly efficient metal-based catalyst is still a significant assignment. Herein, Co(II)phthalocyanine was noncovalently immobilized on multiwalled carbon nanotubes through axial coordination via pyridine-pyrene linker and applied towards hydrogen evolution reactions. This material provided a superiorly enhanced electrocatalyzed performance signifying high efficiency. With this behavior, our target material we believe paves the way towards designing efficient energy production and storage devices.

Inorganica Chimica Acta published new progress about Carbon nanotubes (multiwalled). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, HPLC of Formula: 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Futyu, Julia; Ispan, David; Feher, Csaba; Szegedi, Agnes; Juzsakova, Tatjana; Hancsok, Jeno; Skoda-Foldes, Rita published the artcile< Recyclable supported Bronsted acidic ionic liquid catalysts with non-aromatic cations for the oligomerization of isobutene under mild conditions>, COA of Formula: C9H13NO3S, the main research area is bronsted acidic ionic liquid catalyst isobutene oilgomerization jet fuel.

Bronsted acidic ionic liquids with different type of cations (pyridinium, morpholinium, pyrrolidinium, imidazolium), N-sulfoalkyl chain length and different anions (triflate, hydrogensulfate and tetrafluoroborate) were prepared and immobilized on silica by adsorption. The ionic liquids were characterised by NMR and IR. Surface properties and Bronsted/Lewis acidity of the supported catalysts were also determined Their catalytic activity and recyclability were compared in the oligomerisation of isobutene to obtain products that can be used as jet fuel blending components after hydrogenation. The results proved that imidazolium ionic liquids can be replaced by less toxic non-aromatic versions without any loss in their activity and stability. By the introduction of shorter sulfoalkyl chain into the cation, excellent results could be obtained even under milder conditions (lower temperature and shorter reaction time). Catalytic activity was shown to correlate to the Bronsted acidity of the catalyst.

Molecular Catalysis published new progress about Jet aircraft fuels. 21876-43-7 belongs to class pyridine-derivatives, and the molecular formula is C9H13NO3S, COA of Formula: C9H13NO3S.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Moreau, Robert J.; Skepper, Colin K.; Appleton, Brent A.; Blechschmidt, Anke; Balibar, Carl J.; Benton, Bret M.; Drumm, Joseph E.; Feng, Brian Y.; Geng, Mei; Li, Cindy; Lindvall, Mika K.; Lingel, Andreas; Lu, Yipin; Mamo, Mulugeta; Mergo, Wosenu; Polyakov, Valery; Smith, Thomas M.; Takeoka, Kenneth; Uehara, Kyoko; Wang, Lisha; Wei, Jun-Rong; Weiss, Andrew H.; Xie, Lili; Xu, Wenjian; Zhang, Qiong; de Vicente, Javier published the artcile< Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria>, Recommanded Product: 2-Amino-3-nitro-6-picoline, the main research area is triazolopyrimidinone preparation phosphopantetheine adenylyltransferase inhibitory activity; azabenzimidazole preparation phosphopantetheine adenylyltransferase inhibitory activity.

The discovery and development of new antibiotics capable of curing infections due to multidrug-resistant and pandrug-resistant Gram-neg. bacteria is a major challenge with fundamental importance to our global healthcare system. Part of our broad program at Novartis to address this urgent, unmet need includes the search for new agents that inhibit novel bacterial targets. Here we report the discovery and hit-to-lead optimization of new inhibitors of phosphopantetheine adenylyltransferase (PPAT) from Gram-neg. bacteria. Utilizing a fragment-based screening approach, we discovered a number of unique scaffolds capable of interacting with the pantetheine site of E. coli PPAT and inhibiting enzymic activity, including triazolopyrimidinone. Structure-based optimization resulted in the identification of two lead compounds as selective, small mol. inhibitors of bacterial PPAT: triazolopyrimidinone I and azabenzimidazole II efficiently inhibited E. coli and P. aeruginosa PPAT and displayed modest cellular potency against the efflux-deficient E. coli ΔtolC mutant strain.

Journal of Medicinal Chemistry published new progress about Antibiotics. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Recommanded Product: 2-Amino-3-nitro-6-picoline.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Xuan; McNally, Andrew published the artcile< Cobalt-Catalyzed Alkylation of Drug-Like Molecules and Pharmaceuticals Using Heterocyclic Phosphonium Salts>, Application of C10H6Cl2N2, the main research area is alkylheterocycle regioselective preparation; heterocyclic phosphonium salt preparation organozinc alkylation cobalt catalyst; alkyl Negishi; alkylation; cobalt-catalysis; cross-coupling; late-stage; phosphonium salts; pyridines.

Alkylated pyridines are common in pharmaceuticals, and metal catalysis is frequently used to prepare this motif via Csp2-Csp3 coupling processes. We present a cobalt-catalyzed coupling reaction between pyridine phosphonium salts and alkylzinc reagents that can be applied to complex drug-like fragments and for late-stage functionalization of pharmaceuticals. The reaction generally proceeds at room temperature, and 4-position pyridine C-H bonds are the precursors in this strategy. Given the challenges in selectively installing (pseudo)halides in complex pyridines, this two-step process enables sets of mols. to be alkylated that would be challenging using traditional cross-coupling methods.

ACS Catalysis published new progress about Alkylation. 1762-41-0 belongs to class pyridine-derivatives, and the molecular formula is C10H6Cl2N2, Application of C10H6Cl2N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xu, Jianxiong; Du, Guo; Xie, Lei; Yuan, Kai; Zhu, Yirong; Xu, Lijian; Li, Na; Wang, Xianyou published the artcile< Three-Dimensional Walnut-Like, Hierarchically Nanoporous Carbon Microspheres: One-Pot Synthesis, Activation, and Supercapacitive Performance>, Electric Literature of 123-03-5, the main research area is supercapacitor hierarchically nanoporous carbon template walnut like activation.

A one-pot synthesis of three-dimensional walnut-like, hierarchically nanoporous carbon microspheres (HNCMs) via a dual-template method was reported. In our protocol, the organic mesomorphous complexes of hexadecylpyridinium chloride/poly(acrylic acid) (CPC/PAA) were employed as a dynamic soft template; the in situ generated silica during the hydrolysis of tetraethylsiloxane (TEOS) was applied as the hard template and sucrose, as the carbon precursor. When the amount of PAA added was varied, hierarchically nanoporous carbons with other novel morphologies such as having a hexagonal nanoplate, being dumbbell-like, and having a hexagonal microprism were synthesized in a controlled manner. Besides, the pore structure of HNCMs was tailored by tuning the molar ratio of sucrose and TEOS. It was demonstrated that the specific capacitance of the HNCMs was correlated with the orderliness of the mesopores. HNCMs-15 synthesized under the molar ratio of sucrose/TEOS at 15 with well-ordered mesopores exhibited the highest specific capacitance of 232 F g-1 at 1 A g-1. The as-prepared HNCMs-15 was further chem. activated, which resulted in the activated HNCMs-15 (AHNCMs-15) with no obvious morphol. change but a high proportion of micropores, large surface area, and superior electrochem. properties (high specific capacitance of 413 F g-1 at 1 A g-1, excellent rate capability). The AHNCMs-15-based sym. supercapacitor displayed a high energy d. of 14.7 Wh kg-1 at a power d. of 250 W kg-1 and small capacitance fading (only 1.6%) after 10 000 cycles at 2 A g-1. Our strategy provides a way for the controlled synthesis of hierarchically nanoporous carbon with well-defined morphol. and structure and excellent electrochem. properties, which makes them promising electrode materials for high-performance supercapacitors. A one-pot synthesis of three-dimensional walnut-like, hierarchically nanoporous carbon microspheres for high-performance sustainable electrochem. energy device, was reported.

ACS Sustainable Chemistry & Engineering published new progress about Carbonization. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Electric Literature of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nishiyama, Hisao; Yamaguchi, Shinobu; Park, Soon Bong; Itoh, Kenji published the artcile< New chiral bis(oxazolinyl)bipyridine ligand (bipymox): enantioselection in the asymmetric hydrosilylation of ketones>, Formula: C22H26N4O2, the main research area is asym hydrosilylation ketone rhodium complex catalyzed; bisoxazolinylbipyridine rhodium complex preparation catalyst hydrosilylation; stereoselective reduction ketone rhodium complex catalyzed; phenylethanol.

A homochiral chiral bis(oxazolinyl)bipyridine ligand I (bipymox) and its rhodium complex II were synthesized to examine the enantioselectivity in the asym. hydrosilylation of ketones in comparison to other chiral oxazoline ligands such as bis(oxazolinyl)pyridine III (pybox) and mono(oxazolinyl)pyridine IV (pymox). The bipymox-rhodium catalyst gave (S)-1-phenylethanol (90% enantiomeric excess) in the reduction of acetophenone with diphenylsilane, the same as the pybox-rhodium system but opposite to the pymox-rhodium system. The reduction of 4-tert-butylcyclohexanone is also described.

Tetrahedron: Asymmetry published new progress about Hydrosilylation catalysts. 147409-41-4 belongs to class pyridine-derivatives, and the molecular formula is C22H26N4O2, Formula: C22H26N4O2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem