Month: October 2022

Related Products of 1692-25-7In 2021 ,《Catalytic Enantioselective Synthesis of Pyridyl Sulfoximines》 appeared in Journal of the American Chemical Society. The author of the article were Tang, Yu; Miller, Scott J.. The article conveys some information:

The synthesis of chiral sulfoximines, e.g., I, through the desymmetrizing N-oxidation of pyridyl sulfoximines, e.g., II, using an aspartic-acid-containing peptide catalyst III (R = Ts, Boc) was reported. Various mono- and bis-pyridyl sulfoximine oxides, e.g., I and IV, are obtained with up to 99:1 er. The directing group introduced on the substrate highly enhances the enantioinduction and could be easily removed to give the free N-H sulfoximines V. Addnl., peptides with Me ester and the Me amide C-terminal protecting group give the opposite enantiomers of the product. A binding model is proposed to explain this phenomenon. The experimental process involved the reaction of Pyridin-3-ylboronic acid(cas: 1692-25-7Related Products of 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Related Products of 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C7H9NOIn 2019 ,《Merging Photochemistry with Electrochemistry: Functional-Group Tolerant Electrochemical Amination of C(sp3)-H Bonds》 appeared in Angewandte Chemie, International Edition. The author of the article were Wang, Fei; Stahl, Shannon S.. The article conveys some information:

A combined electrochem./photochem. method for dehydrogenative C(sp3)-H/N-H coupling that exhibits good reactivity with both sp2 and sp3 N-H bonds has been reported. The results show how use of iodide as an electrochem. mediator, in combination with light-induced cleavage of intermediate N-I bonds, enables the electrochem. process to proceed at low electrode potentials. This approach significantly improves the functional-group compatibility of electrochem. C-H amination, for example, tolerating electron-rich aromatic groups that undergo deleterious side reactions in the presence of high electrode potentials. The experimental process involved the reaction of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2COA of Formula: C7H9NO)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. COA of Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C7H6BrNO2In 2015 ,《Dosage delivery of sensitive reagents enables glove-box-free synthesis》 appeared in Nature (London, United Kingdom). The author of the article were Sather, Aaron C.; Lee, Hong Geun; Colombe, James R.; Zhang, Anni; Buchwald, Stephen L.. The article conveys some information:

Contemporary organic chemists employ a broad range of catalytic and stoichiometric methods to construct mols. for applications in the material sciences, and as pharmaceuticals, agrochems., and sensors. The utility of a synthetic method may be greatly reduced if it relies on a glove box to enable the use of air- and moisture-sensitive reagents or catalysts. Furthermore, many synthetic chem. laboratories have numerous containers of partially used reagents that have been spoiled by exposure to the ambient atm. This is exceptionally wasteful from both an environmental and a cost perspective. Here we report an encapsulation method for stabilizing and storing air- and moisture-sensitive compounds We demonstrate this approach in three contexts, by describing single-use capsules that contain all of the reagents (catalysts, ligands, and bases) necessary for the glove-box-free palladium-catalyzed carbon-fluorine, carbon-nitrogen, and carbon-carbon bond-forming reactions. This strategy should reduce the number of error-prone, tedious and time-consuming weighing procedures required for such syntheses and should be applicable to a wide range of reagents, catalysts, and substrate combinations. In the experiment, the researchers used many compounds, for example, Methyl 5-bromopicolinate(cas: 29682-15-3Electric Literature of C7H6BrNO2)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Electric Literature of C7H6BrNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 53939-30-3In 2022 ,《Rigid α-diimine palladium complexes as direct C-H arylation precatalysts for thiophenes and heteroaryl bromides》 was published in Inorganic Chemistry Communications. The article was written by Gao, Tai-Heng; Ying Xiong; Guo, Pengfeng; Liu, Feng-Shou; Zhao, Limin. The article contains the following contents:

The direct C-H heteroarylation of thiophenes, promoted by rigid α-diimine palladium complexes is described. This approach exhibits broad substrate scopes with functional group tolerant, and proceeds with the formation of regioselective products. After reading the article, we found that the author used 5-Bromo-2-chloropyridine(cas: 53939-30-3HPLC of Formula: 53939-30-3)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. HPLC of Formula: 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C12H12N2In 2019 ,《A Ru(II) polypyridyl complex bearing aldehyde functions as a versatile synthetic precursor for long-wavelength absorbing photodynamic therapy photosensitizers》 was published in Bioorganic & Medicinal Chemistry. The article was written by Karges, Johannes; Heinemann, Franz; Maschietto, Federica; Patra, Malay; Blacque, Olivier; Ciofini, Ilaria; Spingler, Bernhard; Gasser, Gilles. The article contains the following contents:

The use of Photodynamic Therapy (PDT) for the treatment of several kinds of cancer as well as bacterial, fungal or viral infections has received increasing attention during the last decade. However, the currently clin. approved photosensitizers (PSs) have several drawbacks, including photobleaching, slow clearance from the organism and poor water solubility To overcome these shortcomings, many efforts have been made in the development of new types of PSs, such as Ru(II) polypyridyl complexes. Nevertheless, most studied Ru(II) polypyridyl complexes have a low absorbance in the spectral therapeutic window. In this work, we show that, by carefully selecting substituents on the polypyridyl complex, it is possible to prepare a complex absorbing at a much higher wavelength. Specifically, we report on the synthesis as well as in-depth exptl. and theor. characterization of a Ru(II) polypyridyl complex (complex 3) combining a shift in absorbance towards the spectral therapeutic window with a high 1O2 production To overcome the absence or poor selectivity of most approved PSs into targeted cells/bacteria, they can be linked to targeting moieties. In this line, compound 3 was designed with reactive aldehyde groups, which can be used as a highly versatile synthetic precursor for further conjugation. As a proof of concept, 3 was reacted with benzylamine and the stability of the resulting conjugate 4 was investigated in DMSO, PBS and cell media. 4 showed an impressive ability to act as a PDT PS with no measurable dark cytotoxicity and photocytotoxicity in the low micromolar range against cancerous HeLa cells from 450 nm up to 540 nm. In the experiment, the researchers used many compounds, for example, 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6COA of Formula: C12H12N2)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.COA of Formula: C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: 4,4′-Dimethyl-2,2′-bipyridineIn 2020 ,《Hierarchical CoS2/N-Doped Carbon@MoS2 Nanosheets with Enhanced Sodium Storage Performance》 was published in ACS Applied Materials & Interfaces. The article was written by Xiao, Fengping; Yang, Xuming; Wang, Hongkang; Yu, Denis Y. W.; Rogach, Andrey L.. The article contains the following contents:

We introduce a hierarchical nanostructure of CoS2/N-doped carbon@MoS2 comprising two transition-metal sulfides CoS2 and MoS2, with enhanced sodium storage performance in sodium-ion batteries. A micron-sized Co metal-organic framework (MOF) is transformed into a CoS2/N-doped carbon composite, followed by a solvothermal growth of MoS2 nanosheets on the surface. The resulting composite material offers several specific advantages for sodium storage: (i) accelerated sodium-ion diffusion kinetics due to its heterogeneous interface; (ii) shortened ion diffusion path and exposed active sites for sodium storage due to its hierarchical nanosheet architecture; and (iii) homogeneous nitrogen doping of the MOF-derived carbon, which is beneficial for electronic conductivity Due to these merits, this composite exhibits excellent electrochem. performance with a specific capacity of 596 mAh g-1 after 100 cycles at 0.1 A g-1 and 395 mAh g-1 at 5.0 A g-1.4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Name: 4,4′-Dimethyl-2,2′-bipyridine) was used in this study.

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Name: 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 13534-97-9In 2013 ,《Synthesis of aryl trimethylstannanes from aryl amines: a Sandmeyer-type stannylation reaction》 was published in Angewandte Chemie, International Edition. The article was written by Qiu, Di; Meng, He; Jin, Liang; Wang, Shuai; Tang, Shengbo; Wang, Xi; Mo, Fanyang; Zhang, Yan; Wang, Jianbo. The article contains the following contents:

Aryl and heterocyclic stannanes ArSnMe3 were prepared by a Sandmeyer-type diazotization-stannylation reaction of aromatic amines ArNH2 with tBuONO and distannane Me3SnSnMe3. The reaction proceeds in mild conditions, using 1.5 equiv of the diazotization reagent, tert-Bu nitrite in 1,2-dichloroethane solution and is promoted by Bronsted or Lewis acids, optimally, by 1.2 equiv of TsOH. The reaction proceeds via radical intermediates, as shown by complete inhibition with 1.5 mol equiv of TEMPO. The yields of electron-deficient aryl and heterocyclic stannanes were generally lower, which were explained by longer time required for diazotization of the corresponding amines. The results came from multiple reactions, including the reaction of 6-Bromopyridin-3-amine(cas: 13534-97-9Product Details of 13534-97-9)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Product Details of 13534-97-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of fac-Tris(2-phenylpyridine)iridiumIn 2020 ,《Photocatalytic Isomerization of Styrenyl Halides: Stereodivergent Synthesis of Functionalized Alkenes》 was published in European Journal of Organic Chemistry. The article was written by Zhang, Hao; Xu, Qing; Yu, Lei; Yu, Shouyun. The article contains the following contents:

An efficient and general method for the isomerization of styrenyl halides under different photocatalytic conditions (fac-Ir(ppy)3 in methanol for E to Z isomerization and fluorescein in 1,4-dioxane for Z to E isomerization, resp.) was disclosed. A series of stereospecific transformations constitute preliminary validation of this strategy in the synthesis of functionalized alkenes, including two diaryl alkenes, a styrenyl boronic ester and an enyne. The photocatalytic isomerization and subsequent cross coupling reaction can be run in a one-pot manner. The stereodivergent synthesis of all four isomers of a conjugated diene, as well as the antitumor agent DMU-212 and its (Z)-isomer highlights the synthetic applicability of this method. In the experiment, the researchers used many compounds, for example, fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Reference of fac-Tris(2-phenylpyridine)iridium)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Reference of fac-Tris(2-phenylpyridine)iridium

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C6H4BrNOIn 2019 ,《An approach to the synthesis of 3-substituted piperidines bearing partially fluorinated alkyl groups》 was published in Journal of Fluorine Chemistry. The article was written by Subota, Andrii I.; Ryabukhin, Sergey V.; Gorlova, Alina O.; Grygorenko, Oleksandr O.; Volochnyuk, Dmitriy M.. The article contains the following contents:

An approach to the synthesis of 3-substituted piperidines bearing partially fluorinated alkyl groups I [X = Y = H, F; R = H, Me, i-Pr] was proposed. The method was based on the DAST-mediated nucleophilic fluorination of easily available 2-bromopyridin-3-yl alcs. and ketones affording 2-bromo-3-(1-fluoroalkyl)pyridines and 2-bromo-3-(1,1-difluoroalkyl)pyridines II [R1 = H, Me, i-Pr, Ph; R2 = H, F], followed by catalytic hydrogenation. The hydrogenation step was studied with common heterogeneous Pd-, Pt-, and Rh-based catalyst. It was found that in the case of fluoroalkyl derivatives, the pyridine core reduction was accompanied by hydrodefluorination, which became a limitation of the strategy. Nevertheless, the method worked well with 1,1-difluoroalkyl derivatives The results came from multiple reactions, including the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Electric Literature of C6H4BrNO)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Electric Literature of C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 13534-97-9In 2010 ,《Switchable Cucurbituril-Bipyridine Beacons》 was published in Chemistry – A European Journal. The article was written by Sinha, Mantosh K.; Reany, Ofer; Parvari, Galit; Karmakar, Ananta; Keinan, Ehud. The article contains the following contents:

4-Aminobipyridine derivatives form strong inclusion complexes with cucurbit[6]uril, exhibiting remarkably large enhancements in fluorescence intensity and quantum yields. The remarkable complexation-induced pKa shift (ΔpKa=3.3) highlights the strong charge-dipole interaction upon binding. The reversible binding phenomenon can be used for the design of switchable beacons that can be incorporated into cascades of binding networks. This concept is demonstrated herein by three different applications: (1) a switchable fluorescent beacon for chem. sensing of transition metals and other ligands; (2) direct measurement of binding constants between cucurbit[6]uril and various nonfluorescent guest mols.; and (3) quant. monitoring of biocatalytic reactions and determination of their kinetic parameters. The latter application is illustrated by the hydrolysis of an amide catalyzed by penicillin G acylase and by the elimination reaction of a β-cabamoyloxy ketone catalyzed by aldolase antibody 38C2. The experimental process involved the reaction of 6-Bromopyridin-3-amine(cas: 13534-97-9SDS of cas: 13534-97-9)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.SDS of cas: 13534-97-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem