Month: October 2022

The author of 《Gas-phase structures of hemiporphyrazine and dicarbahemiporphyrazine: Key role of interactions inside coordination cavity》 were Otlyotov, Arseniy A.; Zhabanov, Yuriy A.; Pogonin, Alexander E.; Kuznetsova, Alexandra S.; Islyaikin, Mikhail K.; Girichev, Georgiy V.. And the article was published in Journal of Molecular Structure in 2019. HPLC of Formula: 141-86-6 The author mentioned the following in the article:

The structures of free hemiporphyrazine and dicarbahemiporphyrazine mols. were determined by gas-phase electron diffraction and DFT calculations Distance corrections (re – ra) were calculated using two different approaches: commonly applied Sipachev’s algorithm and a recently developed technique based on mol. dynamics simulations. Both approaches examined against each other for the first time in the refinement of a relatively large (52 atoms) structure were found to result in almost the same final structural parameters. Gas-phase structures of hemiporphyrazine and dicarbahemiporphyrazine are saddle distorted, in contrast to the planar structure previously found for the solid-state hemiporphyrazine. Doubly charged anionic form of hemiporphyrazine was calculated to be significantly saddle distorted, while the anion of dicarbahemiporphyrazine was determined to possess a planar equilibrium structure. Structural features of the mols. and their doubly charged anionic forms are discussed in terms of AIM and NBO analyses.2,6-Diaminopyridine(cas: 141-86-6HPLC of Formula: 141-86-6) was used in this study.

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.HPLC of Formula: 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《High in vitro and in vivo antitumor activities of Ln(III) complexes with mixed 5,7-dichloro-2-methyl-8-quinolinol and 4,4′-dimethyl-2,2′-bipyridyl chelating ligands》 were Meng, Ting; Qin, Qi-Pin; Chen, Zi-Lu; Zou, Hua-Hong; Wang, Kai; Liang, Fu-Pei. And the article was published in European Journal of Medicinal Chemistry in 2019. Recommanded Product: 4,4′-Dimethyl-2,2′-bipyridine The author mentioned the following in the article:

Three novel Ln(III) complexes, namely, [Pm(dmbpy)(ClQ)2NO3] (1), [Yb(dmbpy)(ClQ)2NO3] (2), and [Lu(dmbpy)(ClQ)2NO3] (3), with mixed 5,7-dichloro-2-methyl-8-quinolinol (H-ClQ) and 4,4′-dimethyl-2,2′-bipyridyl (dmbpy) chelating ligands were 1st synthesized. The cytotoxic activity of Ln(III) complexes 1-3, H-ClQ, and dmbpy against a panel of human normal and cancer cell lines, namely, human nonsmall cell lung cancer cells (NCI-H460), human cervical adenocarcinoma cancer cells, human ovarian cancer cells, and human normal hepatocyte cells, were evaluated by using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. The three novel Ln(III) complexes showed a high in vitro antitumor activity toward the NCI-H460 with IC50 of 1.00 ± 0.25 nM for 1, 5.13 ± 0.44 μM for 2, and 11.87 ± 0.79 μM for 3, resp. Ln(III) complexes 1 and 2 exerted their in vitro antitumor activity/mechanism mainly via the mitochondrial death pathway and caused a G2/M phase arrest in the following order: 1 > 2. An NCI-H460 tumor xenograft mouse model was used to evaluate the Pm(III) complex 1 in vivo antitumor activity. Pm(III) complex 1 showed a high in vivo antitumor activity, and the tumor growth inhibition rate (IR) was 56.0% (p < 0.05). In summary, the authors' study on Pm(III) complex 1 revealed promising results in vitro and in vivo antitumor activity assays. In the experiment, the researchers used 4,4'-Dimethyl-2,2'-bipyridine(cas: 1134-35-6Recommanded Product: 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Recommanded Product: 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Building an electron push-pull system of linear conjugated polymers for improving photocatalytic hydrogen evolution efficiency》 were Wang, Zijian; Mao, Na; Zhao, Yongbo; Yang, Tongjia; Wang, Feng; Jiang, Jia-Xing. And the article was published in Polymer Bulletin (Heidelberg, Germany) in 2019. Recommanded Product: 624-28-2 The author mentioned the following in the article:

Abstract: A series of linear conjugated polymers with different acceptor units has been synthesized and applied as photocatalysts for hydrogen evolution from water splitting. It was found that the introduction of nitrogen atom into the polymer skeleton could efficiently improve the photocatalytic performance due to the improvement in charge carriers’ transport and separation, and the enhanced interfacial wettability from the hydrogen-bonding interaction between nitrogen atom and water mol. The replacement position of nitrogen atom also has a big influence on the photocatalytic performance due to the enhanced internal dipole orientation. A high hydrogen evolution rate of 18.7 μmol h-1 was achieved by PyPm with strong acceptor unit of pyrimidine. The results demonstrate that the construction of an electronic push-pull system is an efficient strategy to produce linear conjugated polymer photocatalysts with high photocatalytic performance. Graphical abstract: [Figure not available: see full text.]. The experimental process involved the reaction of 2,5-Dibromopyridine(cas: 624-28-2Recommanded Product: 624-28-2)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Recommanded Product: 624-28-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Photoelectrochemical CO2 Reduction Using a Ru(II)-Re(I) Supramolecular Photocatalyst Connected to a Vinyl Polymer on a NiO Electrode》 were Kamata, Ryutaro; Kumagai, Hiromu; Yamazaki, Yasuomi; Sahara, Go; Ishitani, Osamu. And the article was published in ACS Applied Materials & Interfaces in 2019. SDS of cas: 1134-35-6 The author mentioned the following in the article:

A Ru(II)-Re(I) supramol. photocatalyst and a Ru(II) redox photosensitizer were both deposited successfully on a NiO electrode by using Me phosphonic acid anchoring groups and the electrochem. polymerization of the ligand vinyl groups of the complexes. This new mol. photocathode, poly-RuRe/NiO, adsorbed a larger amount of the metal complexes compared to one using only Me phosphonic acid anchor groups, and the stability of the complexes on the NiO electrode were much improved. The poly-RuRe/NiO acted as a photocathode for the photocatalytic reduction of CO2 at E = -0.7 V vs. Ag/AgCl under visible-light irradiation in an aqueous solution The poly-RuRe/NiO produced ∼2.5 times more CO, and its total faradaic efficiency of the reduction products improved from 57 to 85%. In the experiment, the researchers used many compounds, for example, 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6SDS of cas: 1134-35-6)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.SDS of cas: 1134-35-6 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Discovery of N-ethylpyridine-2-carboxamide derivatives as a novel scaffold for orally active γ-secretase modulators》 was published in Bioorganic & Medicinal Chemistry in 2020. These research results belong to Sekioka, Ryuichi; Honda, Shugo; Honjo, Eriko; Suzuki, Takayuki; Akashiba, Hiroki; Mitani, Yasuyuki; Yamasaki, Shingo. Formula: C7H6BrNO2 The article mentions the following:

Gamma-secretase modulators (GSMs) are promising disease-modifying drugs for Alzheimer’s disease because they can selectively decrease pathogenic amyloid-β42 (Aβ42) levels. Here we report the discovery of orally active N-ethylpyridine-2-carboxamide derivatives as GSMs. The isoindolinone moiety of 5-[8-(benzyloxy)-2-methylimidazo[1,2-a]pyridin-3-yl]-2-ethyl-2,3-dihydro-1H-isoindol-1-one hydrogen chloride (1a) was replaced with a picolinamide moiety. Optimization of the benzyl group significantly improved GSM activity and mouse microsomal stability. 5-{8-[([1,1′-Biphenyl]-4-yl)methoxy]-2-methylimidazo[1,2-a]pyridin-3-yl}-N-ethylpyridine-2-carboxamide hydrogen chloride (1v) potently reduced Aβ42 levels with an IC50 value of 0.091μM in cultured cells without inhibiting CYP3A4. Moreover, 1v demonstrated a sustained pharmacokinetic profile and significantly reduced brain Aβ42 levels in mice.Methyl 5-bromopicolinate(cas: 29682-15-3Formula: C7H6BrNO2) was used in this study.

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Formula: C7H6BrNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Aryl-Diadamantyl Phosphine Ligands in Palladium-Catalyzed Cross-Coupling Reactions: Synthesis, Structural Analysis, and Application》 was published in European Journal of Organic Chemistry in 2020. These research results belong to Sinai, Adam; Simko, Daniel Cs.; Szabo, Fruzsina; Paczal, Attila; Gati, Tamas; Benyei, Attila; Novak, Zoltan; Kotschy, Andras. Computed Properties of C5H5BrN2 The article mentions the following:

Synthesis, temperature-dependent NMR structure study and use of a new, stable and easily accessible aryl-diadamantylphosphine ligand family is reported. The bulky and electron-rich phosphorus center of the ligand enhances the catalytic activity of palladium in cross-coupling reactions of sterically demanding ortho-substituted aryl halides. In the authors’ study, the authors demonstrated the synthetic applicability of the new phosphine ligands in Buchwald-Hartwig and tosyl hydrazone coupling reactions.6-Bromopyridin-3-amine(cas: 13534-97-9Computed Properties of C5H5BrN2) was used in this study.

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Computed Properties of C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《LaIII and ZnII Cooperatively Template a Metal-Organic Capsule》 was published in Journal of the American Chemical Society in 2020. These research results belong to Yang, Dong; Greenfield, Jake L.; Ronson, Tanya K.; von Krbek, Larissa K. S.; Yu, Le; Nitschke, Jonathan R.. Product Details of 624-28-2 The article mentions the following:

An organic subcomponent was designed with 2-formyl-8-aminoquinoline and triazole-pyridine ends. The relative orientations and geometries of these two ends enabled this subcomponent to assemble together with ZnII and LaIII cations to generate a heterobimetallic tetrahedral capsule. The LaIII cations each template three imine bonds that hold together a 3-fold-sym. metallo-ligand, defining the center of each tetrahedron face. The ZnII cations occupy the other ends of these C3 axes, defining the vertices of the tetrahedron. This is the first example where subcomponent self-assembly brought into being the faces of a polyhedron, as opposed to the vertices. Host-guest studies show pos. cooperative binding toward ReO4-, the encapsulation of which also resulted in the quenching of capsule fluorescence. In the experimental materials used by the author, we found 2,5-Dibromopyridine(cas: 624-28-2Product Details of 624-28-2)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Product Details of 624-28-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A bis-acridinium macrocycle as multi-responsive receptor and selective phase-transfer agent of perylene》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Hu, Johnny; Ward, Jas S.; Chaumont, Alain; Rissanen, Kari; Vincent, Jean-Marc; Heitz, Valerie; Jacquot de Rouville, Henri-Pierre. Application In Synthesis of 2,6-Dibromopyridine The article mentions the following:

A bis-acridinium cyclophane incorporating switchable acridinium moieties linked by a 3,5-dipyridylanisole spacer was studied as a multi-responsive host for polycyclic aromatic hydrocarbon guests. Complexation of perylene was shown to be the most effective and was characterized in particular by a charge-transfer band as signal output. Effective catch and release of the guest was triggered by both chem. (proton/hydroxide) and redox stimuli. Moreover, the dicationic host was also easily switched between organic and perfluorocarbon phases for applications related to the enrichment of perylene from a mixture of polycyclic aromatic hydrocarbons. In the experiment, the researchers used 2,6-Dibromopyridine(cas: 626-05-1Application In Synthesis of 2,6-Dibromopyridine)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Application In Synthesis of 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Efficient Phosphorus-Free Chlorination of Hydroxy Aza-Arenes and Their Application in One-Pot Pharmaceutical Synthesis》 was published in Organic Process Research & Development in 2020. These research results belong to Wang, Jian; Li, Yan-Hui; Pan, Song-Cheng; Li, Ming-Fang; Du, Wenting; Yin, Hong; Li, Jing-Hua. Name: 5-Bromo-2-chloropyridine The article mentions the following:

The chlorination of hydroxy aza-arenes with bis(trichloromethyl) carbonate (BTC) and SOCl2 has been effectively performed by refluxing with 5 weight % 4-(dimethylamino)pyridine (DMAP) as a catalyst. Various substrates are chlorinated with high yields. The obtained chlorinated aza-arenes can be used directly with simple workup for succedent one-pot synthesis on a large scale. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-chloropyridine(cas: 53939-30-3Name: 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Name: 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Ditopic dithiocarbamate ligands for the production of trinuclear species》 was published in Arabian Journal of Chemistry in 2020. These research results belong to Marin-Carrillo, Edgar; Ruiz-Martinez, Adrian; Valdes, Hugo; Reyes-Martinez, Reyna; Hernandez-Ortega, Simon; Adriana Aguilar-Castillo, Bethsy; Morales-Morales, David. Application of 1539-42-0 The article mentions the following:

Reactions of group 10 transition metals with the ditopic ligand dipicolyldithiocarbamate (DPDTC) were performed. Thus, 1:2 reactions of [Ni(CH3COO)2], [Pd(COD)Cl2] or [Pt(COD)Cl2] with DPDTC produced monomeric complexes of the type [M(κ2-SCS-DPDTC)2, M = Ni (1), Pd (2) or Pt (3)] with the dithiocarbamate ligand (DTC) coordinated in a typical chelate κ2-SCS fashion. Interestingly, the reaction of [NiCl2] with DPDTC, under similar conditions, afforded the organic compound 2-(pyridin-2-ylmethyl)imidazo[1,5-a]pyri-dine-3(2 H)-thione (4) as unique product. In order to prove the ditopic nature of the ligand DPDTC, complex [Pd(κ2-SCS-DPDTC)2] (2) was further reacted with [ZnCl2] in a 1:2 M ratio to yield the trinuclear complex [Cl2Zn(κ2-NN-DPDTC-SCS-κ2)Pd(κ2-SCS-DPDTC-NN-κ2)ZnCl2] (5). The mol. structures of all compounds were determinate by typical anal. techniques including the unequivocal determination of all structures by single crystal x-ray diffraction anal. As expected, complexes 1-3 are isostructural, and the metal centers exhibiting slightly distorted square-planar geometries. While in 5, the trinuclear nature of the complex in confirmed exhibiting a nice combination of tetrahedral-square planar-tetrahedral geometries for the Zn-Pd-Zn centers resp. In the experiment, the researchers used many compounds, for example, Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Application of 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Application of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem