Month: October 2022

Lu, Fangjie; Xu, Dong; Lu, Yusheng; Dai, Bin; Zhu, Mingyuan published an article in 2021. The article was titled 《High nitrogen carbon material with rich defects as highly efficient metal-free catalyst for excellent catalytic performance of acetylene hydrochlorination》, and you may find the article in Chinese Journal of Chemical Engineering.Product Details of 141-86-6 The information in the text is summarized as follows:

In this work, we developed a simple strategy to synthesize a carbon material with high nitrogen and rich carbon defects. Our approach polymerized diaminopyridine (DAP) and ammonium persulfate (APS). Following a range of different temperature pyrolysis approaches, the resulting rough surface was shown to exhibit edge defects due to N-doping on graphite carbon. A series of catalysts were evaluated using a variety of characterization techniques and tested for catalytic performance. The catalytic performance of the N-doped carbon material enhanced alongside an increment in carbon defects. The NC-800 catalyst exhibited outstanding catalytic activity and stability in acetylene hydrochlorination (C2H2 GHSV = 30 h-1, at 220 °C, the acetylene conversion rate was 98%), with its stability reaching up to 450 h. Due to NC-800 having a nitrogen content of up to 13.46%, it had the largest sp. surface area and a high defect amount, as well as strong C2H2 and HCl adsorption. NC-800 has excellent catalytic activity and stability to reflect its unlimited potential as a carbon material. In addition to this study using 2,6-Diaminopyridine, there are many other studies that have used 2,6-Diaminopyridine(cas: 141-86-6Product Details of 141-86-6) was used in this study.

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Product Details of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Stahlberger, M.; Steinlein, O.; Adam, C. R.; Rotter, M.; Hohmann, J.; Nieger, M.; Koeberle, B.; Braese, S. published an article in 2022. The article was titled 《Fluorescent annulated imidazo[4,5-c]isoquinolines via a GBB-3CR/imidoylation sequence – DNA-interactions in pUC-19 gel electrophoresis mobility shift assay》, and you may find the article in Organic & Biomolecular Chemistry.Electric Literature of C6H4BrNO The information in the text is summarized as follows:

The development of a sequential synthesis route towards annulated imidazo[4,5-c]isoquinolines comprising a GBB-3CR, followed by an intramol. imidoylative cyclization was reported. X-Ray crystallog. revealed a flat 3D structure of the obtained polyheterocycles. Thus, their interactions with double-stranded DNA was evaluated by establishing a pUC-19 plasmid-based gel electrophoresis mobility shift assay, revealing a stabilizing effect on ds-DNA against strand-break inducing conditions.2-Bromonicotinaldehyde(cas: 128071-75-0Electric Literature of C6H4BrNO) was used in this study.

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Electric Literature of C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Lei; Pfund, Bjorn; Wenger, Oliver S.; Hu, Xile published an article in 2022. The article was titled 《Oxidase-Type C-H/C-H Coupling Using an Isoquinoline-Derived Organic Photocatalyst》, and you may find the article in Angewandte Chemie, International Edition.Name: 4-Cyanopyridine The information in the text is summarized as follows:

Herein, an isoquinoline-derived diaryl ketone-type photocatalyst I, which has much enhanced absorption of blue and visible light compared to conventional diaryl ketones was reported. This photocatalyst enables dehydrogenative cross-coupling of heteroarenes e.g., II with inactivated and activated alkanes viz. cyclohexane, THF, adamantane, etc. as well as aldehydes viz. propanal, pentanal, 3-methylbutanal, cyclopropanecarbaldehyde, cyclopentanecarbaldehyde using air as the oxidant. A wide range of heterocycles with various functional groups are suitable substrates. Transient absorption and excited-state quenching experiments point to an unconventional mechanism that involves an excited state ”self-quenching” process to generate the N-radical cation form of the sensitizer, which subsequently abstracts a hydrogen atom from the alkane substrate to yield a reactive alkyl radical. After reading the article, we found that the author used 4-Cyanopyridine(cas: 100-48-1Name: 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Name: 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nau, Jennifer; Bruening, Vincent; Biesen, Lukas; Knedel, Tim-Oliver; Janiak, Christoph; Mueller, Thomas J. J. published an article in 2022. The article was titled 《Synthesis and Electronic Properties of Conjugated syn,syn-Dithienothiazine Donor-Acceptor-Donor Dumbbells》, and you may find the article in European Journal of Organic Chemistry.Category: pyridine-derivatives The information in the text is summarized as follows:

A series of conjugated syn,syn-dithienothiazine donor-acceptor-donor dumbbells was readily synthesized by Suzuki coupling or a one-pot α-lithiation-zincation-Negishi coupling sequence in moderate to good yield. The title compounds were all electron-rich reversible oxidizable redox systems with a relatively narrow range of oxidation potentials according to cyclic voltammetry. UV/Vis and fluorescence spectroscopy however showed a significant effect of the electronic nature of the conjugated bridging system on absorption and emission characteristics. Furthermore, a highly polar excited state was corroborated by Lippert-Mataga anal. of the emission solvatochromicity as well as by TD-DFT calculation of absorption and emission maxima, which classified these dumbbell systems as redox active, luminescent low band gap chromophores with exptl. determined optical band gaps between 2.20 and 2.50 eV. In the part of experimental materials, we found many familiar compounds, such as 2,5-Dibromopyridine(cas: 624-28-2Category: pyridine-derivatives)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Yang, Dongxu; Chen, Xiangyi; He, Dongsheng; Frommhold, Andreas; Shi, Xiaoqing; Boden, Stuart A.; Lebedeva, Maria A.; Ershova, Olga V.; Palmer, Richard E.; Li, Ziyou; Shi, Haofei; Gao, Jianzhi; Pan, Minghu; Khlobystov, Andrei N.; Chamberlain, Thomas W.; Robinson, Alex P. G. published an article in Journal of Physical Chemistry Letters. The title of the article was 《A Fullerene-Platinum Complex for Direct Functional Patterning of Single Metal Atom-Embedded Carbon Nanostructures》.Name: 4,4′-Dimethyl-2,2′-bipyridine The author mentioned the following in the article:

The development of patterning materials (“”resists””) at the nanoscale involves two distinct trends-one is toward high sensitivity and resolution for miniaturization, the other aims at functionalization of the resists to realize bottom-up construction of distinct nanoarchitectures. Patterning of carbon nanostructures, a seemingly ideal application for organic functional resists, has been highly reliant on complicated pattern transfer processes due to a lack of patternable precursors. Here we present a fullerene-metal coordination complex as a fabrication material for direct functional patterning of sub-10 nm metal-containing carbon structures. The attachment of one platinum atom per fullerene mol. not only leads to significant improvement of sensitivity and resolution, but also enables stable at. dispersion of the platinum ions within the carbon matrix, which may gain fundamentally new interest in functional patterning of hierarchical carbon nanostructures. In the part of experimental materials, we found many familiar compounds, such as 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Name: 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Name: 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C5H3BrClNIn 2015 ,《Iridium-Catalyzed Asymmetric Hydrogenation of 2-Pyridyl Cyclic Imines: A Highly Enantioselective Approach to Nicotine Derivatives》 appeared in Journal of the American Chemical Society. The author of the article were Guo, Cui; Sun, Dong-Wei; Yang, Shuang; Mao, Shen-Jie; Xu, Xiao-Hua; Zhu, Shou-Fei; Zhou, Qi-Lin. The article conveys some information:

A highly efficient asym. hydrogenation of cyclic imines containing a pyridyl moiety was established by using iridium catalysts with chiral spiro phosphine-oxazoline ligands. This process will facilitate the development of new nicotine-related pharmaceuticals I [R = 6-F, 6-Cl, 6-Me, etc; n = 1, 2, 3]. The introduction of a substituent at the ortho position of the pyridyl ring to reduce its coordinating ability ensures the success of the hydrogenation and excellent enantioselectivity. After reading the article, we found that the author used 5-Bromo-2-chloropyridine(cas: 53939-30-3COA of Formula: C5H3BrClN)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. COA of Formula: C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 2-BromonicotinaldehydeIn 2018 ,《Synthesis of Pyrimidine Fused Quinolines by Ligand-Free Copper-Catalyzed Domino Reactions》 appeared in Journal of Organic Chemistry. The author of the article were Panday, Anoop Kumar; Mishra, Richa; Jana, Asim; Parvin, Tasneem; Choudhury, Lokman H.. The article conveys some information:

Herein we report two novel methods for the synthesis of pyrimidine fused quinolines using one-pot C-C and C-N bond forming strategy from the reaction of 6-amino uracils with 2-bromo benzaldehydes or 2-bromobenzyl bromide derivatives in the presence of 10-mol% CuCl2 without using any ligand. The reaction of 2-bromobenzaldehyde or its derivatives with 6-amino-uracils in the presence K2CO3 as base and catalytic amount of CuCl2 in DMF medium under microwave heating conditions provide corresponding pyrimidine-fused quinoline derivatives in good yields within 30 min. Alternatively, pyrimidine fused quinoline derivatives have been synthesized from the reaction of 2-bromobenzyl bromides with 6-amino-uracil derivatives in the presence of mol. oxygen, CuCl2 (10-mol%) and K2CO3 as base in DMF under reflux conditions. Structures of all the products were unambiguously confirmed by spectroscopic techniques and by recording single crystal XRD of I. In addition to this study using 2-Bromonicotinaldehyde, there are many other studies that have used 2-Bromonicotinaldehyde(cas: 128071-75-0Recommanded Product: 2-Bromonicotinaldehyde) was used in this study.

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Recommanded Product: 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 141-86-6In 2019 ,《A new ratiometric, colorimetric and ”turn-on” fluorescent chemosensor for the detection of cyanide ions based on a phenol-bisthiazolopyridine hybrid》 appeared in New Journal of Chemistry. The author of the article were Assadollahnejad, Nazafarin; Kargar, Maryam; Darabi, Hossein Reza; Abouali, Negar; Jamshidi, Shadi; Sharifi, Ali; Aghapoor, Kioumars; Sayahi, Hani. The article conveys some information:

A novel C2-sym. ratiometric fluorescence and colorimetric cyanide (CN-) sensor 1 (I) based on a phenol-bisthiazolopyridine hybrid was synthesized and characterized. Among the various screened anions, this chromogenic receptor 1 showed only a distinct visible color change from colorless to yellow and blue to green fluorescence toward CN- in both pure methanol and aqueous methanol. The ”turn-on” ratiometric fluorescence (emission shift = 95 nm) and colorimetric (absorbance shift = 45 nm) detection of CN- can be attributed to the deprotonation of the OH groups of 1, as evidenced by OH- and 1H NMR experiments The binding mode of 1 with CN- was determined to be a 1 : 1 stoichiometry through a Job plot. Probe 1 was also highly sensitive (LOD = 75 nM) as measured by ratiometric fluorescence (I420/I515 nm) methods. Moreover, the reversibility of the deprotonated 1 by HCl in both solution and the solid state (TLC paper test strips) was successful. In general, probe 1 is a promising CN- indicator in terms of its ease-of-use, selectivity, sensitivity, rapid response (<1 s), reversibility and test kit application. In the experiment, the researchers used many compounds, for example, 2,6-Diaminopyridine(cas: 141-86-6Related Products of 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Related Products of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C6H4BrNOIn 2018 ,《Synthetic Access to Functionalized Dipolarophiles of Lewis Basic Complexant Scaffolds through Sonogashira Cross-Coupling》 was published in Journal of Organic Chemistry. The article was written by Chaudhuri, Sauradip; Carrick, Jesse D.. The article contains the following contents:

Soft Lewis basic complexants that facilitate selective removal of discrete ions resident in spent nuclear fuel can decrease repository volume and radiotoxicity and are of significant interest. Optimization of chelation efficacy is predicated on modular access to synthons to rapidly evaluate structure-activity relationships. The following work highlights efficient access to functionalized synthons for use as potential dipolarophiles in subsequent cycloaddition processes via Sonogashira coupling of 3-(6-bromo-pyridin-2-yl)-[1,2,4]triazine scaffolds. The 41 examples explored during method development evaluated electrophile and nucleophile diversity affording the desired coupled products in 31-96% isolated yield. Method optimization, substrate scope, a scale-up reaction, and downstream product functionalization are reported herein. After reading the article, we found that the author used 2-Bromonicotinaldehyde(cas: 128071-75-0COA of Formula: C6H4BrNO)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. COA of Formula: C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 1539-42-0In 2021 ,《Going the dHis-tance: Site-Directed Cu2+ Labeling of Proteins and Nucleic Acids》 was published in Accounts of Chemical Research. The article was written by Gamble Jarvi, Austin; Bogetti, Xiaowei; Singewald, Kevin; Ghosh, Shreya; Saxena, Sunil. The article contains the following contents:

Conspectus: In this Account, we showcase site-directed Cu2+ labeling in proteins and DNA, which has opened new avenues for the measurement of the structure and dynamics of biomols. using ESR (EPR) spectroscopy. In proteins, the spin label is assembled in situ from natural amino acid residues and a metal complex and requires no post-expression synthetic modification or purification procedures. The labeling scheme exploits a double histidine (dHis) motif, which utilizes endogenous or site-specifically mutated histidine residues to coordinate a Cu2+ complex. Pulsed EPR measurements on such Cu2+-labeled proteins potentially yield distance distributions that are up to 5 times narrower than the common protein spin label-the approach, thus, overcomes the inherent limitation of the current technol., which relies on a spin label with a highly flexible side chain. This labeling scheme provides a straightforward method that elucidates biophys. information that is costly, complicated, or simply inaccessible by traditional EPR labels. Examples include the direct measurement of protein backbone dynamics at β-sheet sites, which are largely inaccessible through traditional spin labels, and rigid Cu2+-Cu2+ distance measurements that enable higher precision in the anal. of protein conformations, conformational changes, interactions with other biomols., and the relative orientations of two labeled protein subunits. Likewise, a Cu2+ label has been developed for use in DNA, which is small, is nucleotide independent, and is positioned within the DNA helix. The placement of the Cu2+ label directly reports on the biol. relevant backbone distance. Addnl., for both of these labeling techniques, we have developed models for interpretation of the EPR distance information, primarily utilizing mol. dynamics (MD) simulations. Initial results using force fields developed for both protein and DNA labels have agreed with exptl. results, which has been a major bottleneck for traditional spin labels. Looking ahead, we anticipate new combinations of MD and EPR to further our understanding of protein and DNA conformational changes, as well as working synergistically to investigate protein-DNA interactions. In addition to this study using Bis(pyridin-2-ylmethyl)amine, there are many other studies that have used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Recommanded Product: 1539-42-0) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Recommanded Product: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem