Month: October 2022

Recommanded Product: 1206978-15-5On November 30, 2017 ,《Tri- and difluoromethoxylated N-based heterocycles – Synthesis and insecticidal activity of novel F3CO- and F2HCO-analogues of Imidacloprid and Thiacloprid》 appeared in Journal of Fluorine Chemistry. The author of the article were Landelle, Gregory; Schmitt, Etienne; Panossian, Armen; Vors, Jean-Pierre; Pazenok, Sergiy; Jeschke, Peter; Gutbrod, Oliver; Leroux, Frederic R.. The article conveys some information:

The preparation of F3CO- and F2HCO-analogs of Imidacloprid and Thiacloprid, I (R = CF3, CHF2) and II, resp., and the evaluation of their biol. activity have been performed. For this purpose, a first synthetic approach allowed the preparation of a desired F3CO-containing key intermediate, 3-(chloromethyl)-6-(trifluoromethoxy)pyridine. To allow facile access to the corresponding F2HCO-containing key intermediate, the difluoromethylation of hydroxylated N-based heterocycles has been developed using difluoromethyl triflate (a liquid non-ODS reagent) under air in aqueous conditions and with very short reaction time. The broad diversity of compatible heterocycles includes a large series of substituted hydroxy-pyridines, but also -pyrazoles, -pyrazine, -pyridazine, and -quinolines. The couplings of both key intermediates with the required 4,5-dihydro-N-nitro-1H-imidazol-2-amine and [N(Z)]-N-2-thiazolidinylidene-cyanamide were successfully achieved using literature conditions. This work enables the preparation of valuable building blocks, which could lead to the discovery of new bioactive entities. In the part of experimental materials, we found many familiar compounds, such as 2-Chloro-4-(difluoromethoxy)pyridine(cas: 1206978-15-5Recommanded Product: 1206978-15-5)

2-Chloro-4-(difluoromethoxy)pyridine(cas: 1206978-15-5) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Recommanded Product: 1206978-15-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formula: C9H11BrClNOOn September 8, 2016 ,《Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors》 was published in Journal of Medicinal Chemistry. The article was written by DiMauro, Erin F.; Altmann, Stephen; Berry, Loren M.; Bregman, Howard; Chakka, Nagasree; Chu-Moyer, Margaret; Bojic, Elma Feric; Foti, Robert S.; Fremeau, Robert; Gao, Hua; Gunaydin, Hakan; Guzman-Perez, Angel; Hall, Brian E.; Huang, Hongbing; Jarosh, Michael; Kornecook, Thomas; Lee, Josie; Ligutti, Joseph; Liu, Dong; Moyer, Bryan D.; Ortuno, Daniel; Rose, Paul E.; Schenkel, Laurie B.; Taborn, Kristin; Wang, Jean; Wang, Yan; Yu, Violeta; Weiss, Matthew M.. The article contains the following contents:

The majority of potent and selective hNaV1.7 inhibitors possess common pharmacophoric features that include a heteroaryl sulfonamide headgroup and a lipophilic aromatic tail group. Recently, reports of similar aromatic tail groups in combination with an acyl sulfonamide headgroup have emerged, with the acyl sulfonamide bestowing levels of selectivity over hNaV1.5 comparable to the heteroaryl sulfonamide. Beginning with com. available carboxylic acids that met selected pharmacophoric requirements in the lipophilic tail, a parallel synthetic approach was applied to rapidly generate the derived acyl sulfonamides. A biaryl acyl sulfonamide hit from this library was elaborated, optimizing for potency and selectivity with attention to physicochem. properties. The resulting novel leads are potent, ligand and lipophilic efficient, and selective over hNaV1.5. Representative lead I demonstrates selectivity over other human NaV isoforms and good pharmacokinetics in rodents. The biaryl acyl sulfonamides reported herein may also offer ADME advantages over known heteroaryl sulfonamide inhibitors. In the experiment, the researchers used 5-Bromo-3-chloro-2-isobutoxypyridine(cas: 1289093-31-7Formula: C9H11BrClNO)

5-Bromo-3-chloro-2-isobutoxypyridine(cas: 1289093-31-7) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Formula: C9H11BrClNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 18437-58-6On October 17, 2020 ,《Zinc-Catalyzed N-Alkylation of Aromatic Amines with Alcohols: A Ligand-Free Approach》 was published in Advanced Synthesis & Catalysis. The article was written by Sankar, Velayudham; Kathiresan, Murugavel; Sivakumar, Bitragunta; Mannathan, Subramaniyan. The article contains the following contents:

An efficient zinc-catalyzed N-alkylation reaction of aromatic amines was achieved using aliphatic, aromatic and heteroaromatic alcs. as the alkylating reagent. A variety of aniline derivatives, including heteroaromatic amines, underwent the N-alkylation reaction and furnished N-alkyl amines in good to excellent yields. The application of reaction was also further demonstrated by the synthesis of 2-phenylquinoline from acetophenone and 2-aminobenzyl alc. Deuterium labeling experiments showed that the reaction proceeded via a borrowing hydrogen process. The experimental part of the paper was very detailed, including the reaction process of 4-Amino-2-picoline(cas: 18437-58-6Related Products of 18437-58-6)

4-Amino-2-picoline(cas: 18437-58-6) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Related Products of 18437-58-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Barsanti, Paul A.; Pan, Yue; Lu, Yipin; Jain, Rama; Cox, Matthew; Aversa, Robert J.; Dillon, Michael P.; Elling, Robert; Hu, Cheng; Jin, Xianming; Knapp, Mark; Lan, Jiong; Ramurthy, Savithri; Rudewicz, Patrick; Setti, Lina; Subramanian, Sharadha; Mathur, Michelle; Taricani, Lorena; Thomas, George; Xiao, Linda; Yue, Qin published an article on January 8 ,2015. The article was titled 《Structure-Based Drug Design of Novel, Potent, and Selective Azabenzimidazoles (ABI) as ATR Inhibitors》, and you may find the article in ACS Medicinal Chemistry Letters.Quality Control of 2-Bromo-5-nitropyridin-4-amine The information in the text is summarized as follows:

Compound I was discovered through morphing of the ATR biochem. HTS hit I. The ABI series was potent and selective for ATR. Incorporation of a 6-azaindole afforded a marked increase in cellular potency but was associated with poor PK and hERG ion channel inhibition. DMPK experiments established that CYP P 450 and AO metabolism in conjunction with Pgp and BCRP efflux were major causative mechanisms for the observed PK. The series also harbored the CYP3A4 TDI liability driven by the presence of both a morpholine and an indole moiety. Incorporation of an adjacent fluorine or nitrogen into the 6-azaindole addressed many of the various medicinal chem. issues encountered. In addition to this study using 2-Bromo-5-nitropyridin-4-amine, there are many other studies that have used 2-Bromo-5-nitropyridin-4-amine(cas: 84487-15-0Quality Control of 2-Bromo-5-nitropyridin-4-amine) was used in this study.

2-Bromo-5-nitropyridin-4-amine(cas: 84487-15-0) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Quality Control of 2-Bromo-5-nitropyridin-4-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Duan, Yu-Hao; Zhu, Xiao-Zhao; Zhang, Qian; Yang, Yang published an article in Inorganic Chemistry Communications. The title of the article was 《Molecular enantiopure homometallic Zn14L24 cubic cages with luminescence properties》.Product Details of 1214363-66-2 The author mentioned the following in the article:

Chiral homometallic high-nuclearity cages are rare and of synthetic challenge. Herein, the authors report the syntheses and structures of a pair of enantiopure homometallic high-nuclearity [Zn14L24]28+ cages. The mol. cage has a cubic framework with pseudo-O symmetry and encloses a large void inside. The chirality of the framework is directed by the point chirality of the chiral amine applied, which is verified by the crystal structure and CD studies. The formation processes are probed by NMR and CD studies. The cage complexes also possess blue luminescence properties. They represent the first enantiopure homometallic cubic cages and rare examples of high-nuclearity enantiopure cages. In the experimental materials used by the author, we found [3,4′-Bipyridine]-6-carboxylic acid(cas: 1214363-66-2Product Details of 1214363-66-2)

[3,4′-Bipyridine]-6-carboxylic acid(cas: 1214363-66-2) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Product Details of 1214363-66-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kirilov, Plamen; Matondo, Hubert; Vicendo, Patricia; Garrigues, Jean-Christophe; Baboulene, Michel; Nguyen, Hoang-Phuong; Rico-Lattes, Isabelle published an article on February 28 ,2006. The article was titled 《Synthesis and photophysical properties of novel amphiphilic ruthenium(II) complexes containing 4,4′-dialkyl-aminomethyl-2,2′-bipyridyl ligands》, and you may find the article in Applied Organometallic Chemistry.HPLC of Formula: 138219-98-4 The information in the text is summarized as follows:

The synthesis of new 2,2′-bipyridine ligands (L = 4,4′-dialkyl-aminomethyl-2,2′-bipyridine; alkyl = octyl, dodecyl, octadodecyl) functionalized with bulky amino side groups is reported. Three homoleptic polypyridyl ruthenium(II) complexes [Ru(L)3]2+(PF6-)2 have been synthesized. These compounds were characterized and their photophys. properties examined The electronic spectra of three complexes show pyridyl π → π* transitions in the UV region and metal-to-ligand charge transfer bands in the visible region. In the experiment, the researchers used 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4HPLC of Formula: 138219-98-4)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. HPLC of Formula: 138219-98-4The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tripathi, Suparna; Hossain, Anowar; Seth, Saikat Kumar; Mukhopadhyay, Subrata published an article on February 15 ,2021. The article was titled 《Supramolecular association and quantification of intermolecular interactions of 4′-functionalized 2,2′:6′,2”-terpyridines: Experimental observation and theoretical studies》, and you may find the article in Journal of Molecular Structure.Synthetic Route of C20H14N4 The information in the text is summarized as follows:

Three versatile 4′-substituted 2,2′:6′,2”-terpyridine compounds (1-3) having different substitutions (4-ethoxyphenyl, 4-methoxyphenyl and pyridyl) at 4′-position of the central pyridine ring have been synthesized and structurally characterized. Three representative crystal structures have been determined through single crystal X-ray diffraction anal. X-ray crystallog. revels that the structures are stabilized through C-H···π and π-π stacking interactions. In the solid-state, the supramol. assemblies of the title compounds have been explored in detail. Compounds (1) and (3) exhibits both C-H···π and π-π interactions in building supramol. assemblies whereas compound (2) exhibit π-π interaction only. All the intermol. interactions that are involved within the structures are quantified through Hirshfeld surface analyses. The weak noncovalent interactions that played significant role in building supramol. assemblies are further characterized by Bader’s theory of ‘atoms-in-mols.’ (AIM). Finally, the supramol. networks are characterized by theor. ‘Noncovalent Interaction’ (NCI) plot index. The supramol. solid-state frameworks of three 4′-functionalized 2,2′:6′,2”-terpyridine derivatives have been quantified which are further characterized theor. by the Bader’s theory of ‘atoms-in-mols.'(AIM) and ‘noncovalent interaction’ (NCI) plot index. In the part of experimental materials, we found many familiar compounds, such as 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3Synthetic Route of C20H14N4)

4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Synthetic Route of C20H14N4 Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2013,Zhang, Yuanyuan; Yang, Weiqing; Xu, Keping; Ma, Menglin; Wang, Yuliang published 《Synthesis and antibacterial activities of pleuromutilin derivatives containing aryl urea groups》.Letters in Drug Design & Discovery published the findings.Safety of 6-Bromopyridin-3-amine The information in the text is summarized as follows:

A series of novel pleuromutilin derivatives containing aryl urea groups was synthesized and their antibacterial activity was evaluated in vitro against Staphylococcus aureus ATCC 26113, Staphylococcus aureus SC, Staphylococcus albus ATCC 8799 and Pseudomonas aeruginosa ATCC 27853. Most of compounds exhibited more potent activities than reference drug Tiamulin against Staphylococcus aureus ATCC 26113 and Saphylococcus aureus SC. Several compounds containing a pyridine urea group and a compound with a quinoline urea group showed excellent activity with the MIC value less than 0.001 μg/mL against Staphylococcus aureus SC. The title compounds thus formed included a thioether urea pyridine derivative (I) and related substances. The synthesis of the target compounds was achieved by a reaction of 2-[(2-amino-1,1-dimethylethyl)thio]acetic acid 6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester with 2,2,2-trichloro-N-phenylacetamide derivatives and analogs. In the experiment, the researchers used 6-Bromopyridin-3-amine(cas: 13534-97-9Safety of 6-Bromopyridin-3-amine)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Safety of 6-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2014,Flanagan, Jack U.; Atwell, Graham J.; Heinrich, Daniel M.; Brooke, Darby G.; Silva, Shevan; Rigoreau, Laurent J. M.; Trivier, Elisabeth; Turnbull, Andrew P.; Raynham, Tony; Jamieson, Stephen M. F.; Denny, William A. published 《Morpholylureas as a new class of potent and selective inhibitors of the type 5 17-β-hydroxysteroid dehydrogenase (AKR1C3)》.Bioorganic & Medicinal Chemistry published the findings.Computed Properties of C5H3BrClN The information in the text is summarized as follows:

Inhibitors of the aldo-keto reductase enzyme AKR1C3 are of interest as potential drugs for leukemia and hormone-related cancers. A series of non-carboxylate morpholino(phenylpiperazin-1-yl)methanones were prepared by palladium-catalyzed coupling of substituted Ph or pyridyl bromides with the known morpholino(piperazin-1-yl)methanone, and shown to be potent (IC50 ∼ 100 nM) and very isoform-selective inhibitors of AKR1C3. Lipophilic electron-withdrawing substituents on the Ph ring were pos. for activity, as was an H-bond acceptor on the other terminal ring, and the ketone moiety (as a urea) was essential. These structure-activity relationships are consistent with an X-ray structure of a representative compound bound in the AKR1C3 active site, which showed H-bonding between the carbonyl oxygen of the drug and Tyr55 and His117 in the ‘oxyanion hole’ of the enzyme, with the piperazine bridging unit providing the correct twist to allow the terminal benzene ring to occupy the lipophilic pocket and align with Phe311.5-Bromo-2-chloropyridine(cas: 53939-30-3Computed Properties of C5H3BrClN) was used in this study.

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Computed Properties of C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2015,Maity, Pintu; Kundu, Debasish; Ranu, Brindaban C. published 《Visible-Light-Photocatalyzed Metal-Free C-H Heteroarylation of Heteroarenes at Room Temperature: A Sustainable Synthesis of Biheteroaryls》.European Journal of Organic Chemistry published the findings.Application In Synthesis of 6-Bromopyridin-3-amine The information in the text is summarized as follows:

An efficient C-H heteroarylation of heteroarenes is achieved through visible-light photoredox-catalyzed diazotization of heteroarylamines in situ by tBuONO at room temperature A library of functionalized biheteroaryls is obtained by using this protocol. The reaction avoids the use of transition-metal catalysts, additives, and acidic reaction medium. In addition to this study using 6-Bromopyridin-3-amine, there are many other studies that have used 6-Bromopyridin-3-amine(cas: 13534-97-9Application In Synthesis of 6-Bromopyridin-3-amine) was used in this study.

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Application In Synthesis of 6-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem