Month: October 2022

In 2022,Hupfer, Maximilian L.; Ghosh, Soumik; Wang, Yingchun; Opsomer, Tomas; Mayerhofer, Thomas G.; Dehaen, Wim; Presselt, Martin published an article in Advanced Materials Interfaces. The title of the article was 《Dichroic Dipole Antenna Membranes from Aligned Linear BOPHY Dyes》.SDS of cas: 2510-22-7 The author mentioned the following in the article:

Linear dyes are mol. mimics of dipole antennas that receive UV-vis light. In this work the assembly of linear dyes via the Langmuir technique to achieve uniform dye alignment for optically anisotropic mol. dipole antenna arrays is presented. The mol. orientations in these arrays are quantified from Langmuir isotherms, topog. data, and from polarization- and angle-dependent UV-vis transmission spectra. It is achieved the smallest angles by which the transition dipole moment orientation deviates from vertical alignment (16°-30°) in the antenna arrays that have been reported in literature so far. The resulting maximum absorption contrast between grazing and vertical incidence amounts to 75%. This high optical anisotropy enables application as anisotropic receiver arrays in optical communication, as optical layers for privacy applications, or other applications building on dichroic dye layers. In the part of experimental materials, we found many familiar compounds, such as 4-Ethynylpyridine(cas: 2510-22-7SDS of cas: 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. SDS of cas: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Naidu, B. Narasimhulu; Patel, Manoj; McAuliffe, Brian; Ding, Bo; Cianci, Christopher; Simmermacher, Jean; Jenkins, Susan; Parker, Dawn D.; Sivaprakasam, Prasanna; Khan, Javed A.; Kish, Kevin; Lewis, Hal; Hanumegowda, Umesh; Krystal, Mark; Meanwell, Nicholas A.; Kadow, John F. published an article in Journal of Medicinal Chemistry. The title of the article was 《Design, Synthesis, and Preclinical Profiling of GSK3739936 (BMS-986180), an Allosteric Inhibitor of HIV-1 Integrase with Broad-Spectrum Activity toward 124/125 Polymorphs》.Category: pyridine-derivatives The author mentioned the following in the article:

The design, synthesis, and optimization of pyridine-based I [R = Ph, 4-MeC6H4, 4-ClC6H4, etc.] and II [R1 = 3-(4-fluorophenyl)propyl, 2-(4-fluorophenyl)ethylamino, 3-(4-fluorophenyl)propoxy, etc.] allosteric integrase inhibitors were reported. Optimization was conducted with a specific emphasis on the inhibition of the 124/125 polymorphs such that the designed compounds showed excellent potency in-vitro against majority of the 124/125 variants. In vivo profiling of promising preclin. lead I [R = 4-FC6H4] showed that it exhibited a good pharmacokinetic (PK) profile in preclin. species, which resulted in a low predicted human efficacious dose. However, findings in rat toxicol. studies precluded further development of I [R = 4-FC6H4]. The results came from multiple reactions, including the reaction of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Category: pyridine-derivatives)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 4,4′-Dimethyl-2,2′-bipyridineIn 2020 ,《Polymeric Encapsulation of a Ruthenium Polypyridine Complex for Tumor Targeted One- and Two-Photon Photodynamic Therapy》 appeared in ACS Applied Materials & Interfaces. The author of the article were Karges, Johannes; Li, Jia; Zeng, Leli; Chao, Hui; Gasser, Gilles. The article conveys some information:

Photodynamic therapy is a medical technique, which is gaining increasing attention to treat various types of cancer. Among the investigated classes of photosensitizers (PSs), the use of Ru(II) polypyridine complexes is gaining momentum. However, the currently investigated compounds generally show poor cancer cell selectivity. As a consequence, high drug doses are needed, which can cause side effects. To overcome this limitation, there is a need for the development of a suitable drug delivery system to increase the amount of PS delivered to the tumor. Herein, we report the encapsulation of a promising Ru(II) polypyridyl complex into polymeric nanoparticles with terminal biotin groups. Thanks to this design, the particles showed much higher selectivity for cancer cells in comparison to noncancerous cells in a 2D monolayer and 3D multicellular tumor spheroid model. As a highlight, upon i.v. injection of an identical amount of the Ru(II) polypyridine complex of the nanoparticle formulation, an improved accumulation inside an adenocarcinomic human alveolar basal epithelial tumor of a mouse up to a factor of 8.7 compared to the Ru complex itself was determined The nanoparticles were found to have a high phototoxic effect upon one-photon (500 nm) or two-photon (800 nm) excitation with eradication of adenocarcinomic human alveolar basal epithelial tumor inside a mouse model. Overall, this work describes, to the best of our knowledge, the first in vivo study demonstrating the cancer cell selectivity of a very promising Ru(II)-based PDT photosensitizer encapsulated into polymeric nanoparticles with terminal biotin groups. The experimental process involved the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Application In Synthesis of 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Application In Synthesis of 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 4-EthynylpyridineIn 2021 ,《Modular Synthesis of trans-A2B2-Porphyrins with Terminal Esters: Systematically Extending the Scope of Linear Linkers for Porphyrin-Based MOFs》 appeared in Chemistry – A European Journal. The author of the article were Marschner, Stefan M.; Haldar, Ritesh; Fuhr, Olaf; Woell, Christof; Braese, Stefan. The article conveys some information:

Differently functionalized porphyrin linkers represent the key compounds for the syntheses of new porphyrin-based metal-organic frameworks (MOFs), which have gathered great interest within the last two decades. Herein we report the synthesis of a large range of 5,15-bis(4-ethoxycarbonylphenyl)porphyrin derivatives, through Suzuki and Sonogashira cross-coupling reactions of an easily accessible corresponding meso-dibrominated trans-A2B2-porphyrin with com. available boronic acids or terminal alkynes. The resulting porphyrins were fully characterized through NMR, MS, and IR spectroscopy and systematically investigated through UV/Vis absorption. Finally, selected structures were saponified to the corresponding carboxylic acids and subsequently proven to be suitable for the synthesis of surface-anchored MOF thin films. In the experiment, the researchers used many compounds, for example, 4-Ethynylpyridine(cas: 2510-22-7Reference of 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Reference of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of Bis(pyridin-2-ylmethyl)amineIn 2019 ,《High in vitro and in vivo antitumor activities of luminecent platinum(II) complexes with jatrorrhizine derivatives》 appeared in European Journal of Medicinal Chemistry. The author of the article were Qin, Qi-Pin; Zou, Bi-Qun; Wang, Zhen-Feng; Huang, Xiao-Ling; Zhang, Ye; Tan, Ming-Xiong; Wang, Shu-Long; Liang, Hong. The article conveys some information:

Two highly active anticancer Pt(II) complexes, [Pt(Jat1)Cl]Cl (Pt1) and [Pt(Jat2)Cl]Cl (Pt2), containing jatrorrhizine derivative ligands (Jat1 and Jat2) are described. Cell intake study showed high accumulation in cell nuclear fraction. Pt1 and Pt2 exhibited high selectivity for HeLa cancer cells (IC50 = 15.01 ± 1.05 nM and 1.00 ± 0.17 nM) comparing with HL-7702 normal cells (IC50 > 150μM), by targeting p53 and telomerase. Pt2 containing Jat2 ligand was more potent and showed high selectivity for telomerase. It also caused mitochondria and DNA damage, sub-G1 phase arrest, and a high rate of cell apoptosis at the low dose of 1.00 nM. The HeLa tumor inhibition rate (TIR) of Pt2 was 48.8%, which was even higher than cisplatin (35.2%). In addition, Pt2 displayed green luminescent property and potent telomerase inhibition. Our findings demonstrated the promising development of platinum(II) complexes containing jatrorrhizine derivatives as novel Pt-based anticancer agents. The results came from multiple reactions, including the reaction of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Application In Synthesis of Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Application In Synthesis of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C7H6BrNO2In 2014 ,《Pyridine-N-Oxide 2-Carboxylic Acid: An Acceptor Group for Organic Sensitizers with Enhanced Anchoring Stability in Dye-Sensitized Solar Cells》 appeared in Asian Journal of Organic Chemistry. The author of the article were Cecconi, Bianca; Mordini, Alessandro; Reginato, Gianna; Zani, Lorenzo; Taddei, Maurizio; Fabrizi de Biani, Fabrizia; De Angelis, Filippo; Marotta, Gabriele; Salvatori, Paolo; Calamante, Massimo. The article conveys some information:

A D-π-A organic dye carrying a pyridine-N-oxide 2-carboxylic acid anchoring group (BC1) was synthesized together with two analogs lacking the N-oxide (BC2) or the carboxylic acid moiety (BC3). The distribution and energy of their MOs was determined, and modeling of their spectroscopic properties was performed through a TD-DFT computational study. The photo- and electrochem. properties of the dyes were assessed together with their desorption kinetics from nanocrystalline TiO2. In solution, the absorption spectra of dyes BC1 and BC3 were red-shifted compared with BC2, with the maximum absorption wavelength influenced by the dye protonation level. The 2-substituted carbonitrile dye BC3 was not adsorbed on the titania surface. On the other hand, the pseudo-first order desorption rate constants of BC1 and BC2 suggest that BC1 was removed from TiO2 more slowly than BC2 a reference cyanoacrylate dye, demonstrating that simultaneous use of the N-oxide and the carboxylic acid anchoring functions enhanced the stability of the dye/semiconductor assembly. When used as a photosensitizer for dye-sensitized solar cells, the photovoltaic performance of BC1 was better than BC2, which corresponds to approx. 66 % of that recorded with the reference dye. In addition to this study using Methyl 5-bromopicolinate, there are many other studies that have used Methyl 5-bromopicolinate(cas: 29682-15-3COA of Formula: C7H6BrNO2) was used in this study.

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.COA of Formula: C7H6BrNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 1122-54-9In 2022 ,《Synthesis, biological activities of chalcones and novel 4-acetylpyridine oximes, molecular docking of the synthesized products as acetylcholinesterase ligands》 appeared in Journal of Molecular Structure. The author of the article were Ould Lamara, Kamilia; Makhloufi-Chebli, Malika; Benazzouz-Touami, Amina; Terrachet-Bouaziz, Souhila; Robert, Anthony; Machado-Rodrigues, Carine; Behr, Jean-Bernard. The article conveys some information:

Heterocyclic chalcones I [X = O; R = C6H5, 4-MeOC6H4, 2-thienyl, etc.] were synthesized by reaction of 4-acetylpyridine with the corresponding aromatic aldehydes under Claisen Schmidt conditions. These chalcones I were used as starting material for the synthesis of oximes I [X = HON; R = 4-MeOC6H4, 4-ClC6H4, 2-thienyl, etc.] and II in the presence of hydroxylamine hydrochloride. The structures of the synthesized compounds I and II were confirmed by IR, 1H NMR, 13C NMR and ESI-MS, HRMS spectral analyses. All the synthesized compounds I and II were evaluated for their antioxidant activity by DPPH• method and their in-vitro antimicrobial activity by disk diffusion method against two Gram-neg. bacteria, one Gram-pos. bacteria and two fungal strains (C. albicans and A. niger). The results showed that the synthesized compounds I and II did not display significant antioxidant activity. However, I [X = O; R = 3-thienyl, C6H5, 4-O2NC6H4, 4-ClC6H4, 2,6-di-ClC6H3] showed excellent antibacterial activity better than the standard drug against the bacterial strain S. aureus (ATCC 25923). The two compounds I [X = O; R = (E)-styryl, C6H5] proved very active against the fungal strain A. niger (MIC= 7.81μg/ mL, 15.62μg/mL resp.) while the antifungal drug used as reference (Fluconazole) was inactive. Mol. docking and mol. dynamics results revealed that the synthesized compounds, I [X = HON; R = 4-MeOC6H4, (E)-styryl] and II were involved in a large number of favorable interactions with the active site residues of the acetylcholinesterase protein, which can stabilize the ligands in the active site and increase their affinities. In addition to this study using 4-Acetylpyridine, there are many other studies that have used 4-Acetylpyridine(cas: 1122-54-9HPLC of Formula: 1122-54-9) was used in this study.

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.HPLC of Formula: 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 3510-66-5In 2021 ,《Cobalt(III)-Catalyzed C-6 Alkenylation of 2-Pyridones by Using Terminal Alkyne with High Regioselectivity》 appeared in Journal of Organic Chemistry. The author of the article were Mohanty, Smruti Ranjan; Prusty, Namrata; Gupta, Lokesh; Biswal, Pragati; Ravikumar, Ponneri Chandrababu. The article conveys some information:

Co(III)-catalyzed alkenylation of 2-pyridones by using terminal alkyne as a reaction partner with high regioselectivity has been demonstrated for the first time. The reaction conditions are mild and compatible with a wide range of substrate combinations. It also shows good functional group tolerance. It proceeds through cyclometalation followed by alkyne insertion and protodemetalation steps. The formation of five- and seven-membered cobaltacycle intermediates was also detected through high-resolution mass spectrometry. The results came from multiple reactions, including the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Application of 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Application of 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 4-CyanopyridineIn 2019 ,《Reactivity of Selected Mono- and Dimethylpyridines under Conditions of Oxidative Ammonolysis》 appeared in Russian Journal of General Chemistry. The author of the article were Vorobyev, P. B.; Serebryanskaya, A. P.. The article conveys some information:

The reactivity of 3-methyl-, 4-methyl-, 2,3-dimethyl-, and 3,4-dimethylpyridines under the oxidative ammonolysis on vanadium oxide catalysts has been studied. The yield of monocyanopyridines has been related to the simulated values of the deprotonation enthalpy of Me substituents being converted into the cyano group, both in the gas phase and under conditions simulating chemisorption at the acid center of the catalyst. Differences in the mechanism of conversion of the primary products of oxidative ammonolysis of 2,3- and 3,4-dimethylpyridines (2-cyano-3-methyl- and 4-cyano-3-methylpyridines) at elevated temperature have been revealed. In addition to this study using 4-Cyanopyridine, there are many other studies that have used 4-Cyanopyridine(cas: 100-48-1Safety of 4-Cyanopyridine) was used in this study.

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Safety of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 2-Pyridinylboronic acidIn 2020 ,《Green-Synthesized Nickel Nanoparticles on Reduced Graphene Oxide as an Active and Selective Catalyst for Suzuki and Glaser-Hay Coupling Reactions》 appeared in Applied Organometallic Chemistry. The author of the article were Murugan, Karthik; Nainamalai, Devarajan; Kanagaraj, Pavithara; Nagappan, Saravana Ganesan; Palaniswamy, Suresh. The article conveys some information:

The present work disclosed the potential catalytic application of the as-prepared RGO-Ni nanocomposite in Csp2-Csp2 Suzuki type homocoupling and Csp-Csp Glaser-Hay coupling reactions. A mild and benign methodol. to synthesize biaryls Ar-Ar [Ar = Ph, 3-MeOC6H4, 2-pyridyl, etc.] and 1,3-diynes R-CC-CC-R [R = t-Bu, 3-FC6H4, 4-EtC6H4, etc.] was demonstrated using the nickel nanoparticles supported on reduced graphene oxide (RGO-Ni) as a heterogeneous catalyst which was prepared using green reagents. A series of substituted biaryls Ar-Ar and 1,3-diynes R-CC-CC-R was synthesized in good to excellent yields via reduced graphene oxide supported nickel nanoparticles catalyzed Suzuki coupling of arylboronic acids and Glaser-Hay coupling of terminal alkynes resp. using 1,4-dioxane as a benign solvent. The present ligand-free catalytic system proceeded smoothly under mild conditions, avoided noble and stoichiometric metal reagents and tolerated sensitive functional groups such as nitrogen and sulfur containing heteroaryl boronic acids. Hot filtration test unambiguously proved the true heterogeneity of the catalyst and which supported for the further reusability of the catalyst for several times without any change in the activity. The easy preparation and simple magnetic separation, stability and reusability revealed that as-prepared RGO-Ni as a versatile catalyst for the synthesis of polyaromatic compounds both in academia and industries. The results came from multiple reactions, including the reaction of 2-Pyridinylboronic acid(cas: 197958-29-5Reference of 2-Pyridinylboronic acid)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Reference of 2-Pyridinylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem