Month: October 2022

Application In Synthesis of 4,4′-Dimethyl-2,2′-bipyridineIn 2022 ,《Syntheses, characterizations and structures of ruthenium carbene and allenylidene complexes supported by 1,4,7-trimethyl-1,4,7-triazacyclononane (Me3tacn) ligands》 was published in Journal of Organometallic Chemistry. The article was written by Qian, Bing-Feng; Gao, Yang; Xu, Qian-Ya; Jia, Ai-Quan; Shi, Hua-Tian; Zhang, Qian-Feng. The article contains the following contents:

Treatment of ruthenium(II) precursor [(Me3tacn)Ru(dmso)Cl2] (Me3tacn = 1,4,7-trimethyl-1,4,7-triazacyclononane, dmso = dimethylsulfoxide) (1) with concentrated HCl in the presence of air afforded the ruthenium(III) complex [(Me3tacn)RuCl3·H2O] (2), from which a series of bipyridine-ruthenium(II) complexes [(Me3tacn)Ru(R-bpy)(H2O)](PF6)2 (bpy = 2,2′-bipyridine) was obtained according to our previous work. Reactions of [(Me3tacn)Ru(R-bpy)(H2O)](PF6)2 and 1,1-diphenylpropargyl alc. afforded ruthenium(II) methoxycarbene complexes [(Me3tacn)(R-bpy)Ru:C(OMe)CH:CPh2](PF6)2 (3, 5, 7, 9; R = H, 4,4′-Me2, 5,5′-Me2, 4,4′-tBu2) and ruthenium(II) allenylidene complexes [(Me3tacn)(R-bpy)Ru:C:C:CPh2](PF6)2 (4, 6, 8, 10; R = H, 4,4′-Me2, 5,5′-Me2, 4,4′-tBu2) under different solvent conditions. Complexes 3-10 were well characterized by IR, UV/Vis, mass spectrometry, and NMR spectroscopies. The mol. structures of complexes 5, 7, and 8 have been also established by single-crystal X-ray diffraction. In the experimental materials used by the author, we found 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Application In Synthesis of 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Application In Synthesis of 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesIn 2021 ,《Nickel-Copper bimetallic mesoporous nanoparticles: As an efficient heterogeneous catalyst for N-alkylation of amines with alcohols》 was published in Applied Organometallic Chemistry. The article was written by Nasresfahani, Zahra; Kassaee, Mohamad Z.. The article contains the following contents:

A bimetallic catalyst (Ni/Cu-MCM-41) is prepared via co-condensation method. Catalytic performance of Ni/Cu-MCM-41 is probed in N-alkylation of amines with alcs. through a hydrogen autotransfer process. Noteworthy, this catalytic system appears very efficient for synthesis of a range of secondary and tertiary amines in good to excellent isolated yields. Moreover, the catalyst is successfully recovered and reused four times without notable decrease in its activity. In the part of experimental materials, we found many familiar compounds, such as 2,6-Diaminopyridine(cas: 141-86-6Category: pyridine-derivatives)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Computed Properties of C7H9NOIn 2019 ,《A biocatalytic synthesis of heteroaromatic N-oxides by whole cells of Escherichia coli expressing the multicomponent, soluble di-iron monooxygenase (SDIMO) PmlABCDEF》 was published in Advanced Synthesis & Catalysis. The article was written by Petkevicius, Vytautas; Vaitekunas, Justas; Tauraite, Daiva; Stankeviciute, Jonita; Sarlauskas, Jonas; Cenas, Narimantas; Meskys, Rolandas. The article contains the following contents:

Aromatic N-oxides (ArN-OX) are desirable biol. active compounds with a potential for application in pharmacy and agriculture industries. As biocatalysis is making a great impact in organic synthesis, there is still a lack of efficient and convenient enzyme-based techniques for the production of aromatic N-oxides. In this study, a recombinant soluble di-iron monooxygenase (SDIMO) PmlABCDEF overexpressed in Escherichia coli was showed to produce various aromatic N-oxides. Out of 98 tested N-heterocycles, seventy were converted to the corresponding N-oxides without any side oxidation products. This whole-cell biocatalyst showed a high activity towards pyridines, pyrazines, and pyrimidines. It was also capable of oxidizing bulky N-heterocycles with two or even three aromatic rings. Being entirely biocatalytic, our approach provides an environmentally friendly and mild method for the production of aromatic N-oxides avoiding the use of strong oxidants, organometallic catalysts, undesirable solvents, or other environment unfriendly reagents. The sequence of the p577A clone containing pmlABCDEF gene cluster was deposited in GenBank under the accession number MK037457. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Computed Properties of C7H9NO)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Computed Properties of C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesIn 2021 ,《On-Surface Synthesis of Giant Conjugated Macrocycles》 was published in Angewandte Chemie, International Edition. The article was written by Fan, Cunrui; Sun, Bangjin; Li, Zhanbo; Shi, Jiwei; Lin, Tao; Fan, Jian; Shi, Ziliang. The article contains the following contents:

We have achieved an on-surface synthesis of giant conjugated macrocycles having a diameter of ≈7 nm and consisting of up to 30 subunits. The synthesis started with a debrominative coupling of the mol. precursors on a hot Ag(111) surface, leading to the formation of arched oligomeric chains and macrocycles. These products were revealed by scanning tunneling microscopy in combination with d. functional theory to be covalent oligomers. These intermediates also display C-Ag organometallic bonds between parallel mol. subunits due to site-selective debromination and the asym. mol. conformation. Subsequent cyclodehydrogenation at higher temperatures steered the final conjugation of the macrocycles. Our findings provide a novel design strategy toward π-conjugated macrocycles and open up new opportunities for the precise synthesis of organic nanostructures. The results came from multiple reactions, including the reaction of 2,6-Dibromopyridine(cas: 626-05-1Category: pyridine-derivatives)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: Pyridin-3-ylboronic acidIn 2019 ,《A Mild and Direct Site-Selective sp2 C-H Silylation of (Poly)Azines》 was published in Journal of the American Chemical Society. The article was written by Gu, Yiting; Shen, Yangyang; Zarate, Cayetana; Martin, Ruben. The article contains the following contents:

A base-mediated protocol that allows for the site-selective sp2 C-H silylation of pyridines, pyrazines, pyridazines, pyrimidines and quinolines by Et3SiBpin is described. The substitution typically proceeds in 4- or 2-position of the pyridine ring. This method is distinguished by its mild conditions, simplicity and excellent site-selective modulation for a diverse set of azines, even in the context of late-stage functionalization, while exhibiting orthogonal reactivity with classical silylation reactions.Pyridin-3-ylboronic acid(cas: 1692-25-7Name: Pyridin-3-ylboronic acid) was used in this study.

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Name: Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 141-86-6In 2020 ,《Supramolecular triblock copolymers through the formation of hydrogen bonds: synthesis, characterization, association effects in solvents of different polarity》 was published in Polymers (Basel, Switzerland). The article was written by Bitsi, Spyridoula-Lida; Droulia, Margarita; Pitsikalis, Marinos. The article contains the following contents:

Anionic polymerization techniques were employed for the synthesis of linear polystyrene (PS) and block copolymer of PS and polyisoprene (PI) PS-b-PI bearing end hydroxyl groups. Following suitable organic chem. transformation, the -OH end groups were converted to moieties able to form complementary hydrogen bonds including 2,6-diaminopurine (Dap), thymine (Thy), and the so-called Hamilton receptor, (Ham). The formation of hydrogen bonds was examined between the polymers PS-Dap and PS-b-PI-Thy, along with the polymers PS-Ham and PS-b-PI-Thy. The conditions under which supramol. triblock copolymers are formed and the possibility to form aggregates were examined both in solution and in the solid state using a variety of techniques such as 1H-NMR spectroscopy, size exclusion chromatog., dilute solution viscometry, dynamic light scattering, thermogravimetric anal., differential thermogravimetry, and differential scanning calorimetry. In addition to this study using 2,6-Diaminopyridine, there are many other studies that have used 2,6-Diaminopyridine(cas: 141-86-6Recommanded Product: 141-86-6) was used in this study.

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Recommanded Product: 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of Bis(pyridin-2-ylmethyl)amineIn 2021 ,《Electrochemical Sensing of Adenosin Triphosphate by Specific Binding to Dipicolylamine Group in Cyclodextrin Supramolecular Complex》 was published in ACS Applied Bio Materials. The article was written by Casulli, Maria Antonietta; Taurino, Irene; Hashimoto, Takeshi; Carrara, Sandro; Hayashita, Takashi. The article contains the following contents:

Electrochem. detection based on cyclodextrin supramol. complexes is founded on the competitive binding between electroactive probes and target mols. This limits their versatility to be used for sensing a broad range of metabolites. In this work, we demonstrate the significant role of zinc ions as well as of β-cyclodextrins modified with dipicolylamine and of a phenylboronic acid-modified ferrocene probe to address a selective electrochem. detection of ATP (ATP). Our findings will definitively have an impact in oncol. point-of-care systems, since a high level of extracellular ATP reveals the inflammatory response due to chemotherapeutic treatments. The experimental part of the paper was very detailed, including the reaction process of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Application In Synthesis of Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Application In Synthesis of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C5H6BNO2In 2020 ,《Organoboron-Functionalization Enables the Hierarchical Assembly of Giant Polyoxometalate Nanocapsules》 was published in Angewandte Chemie, International Edition. The article was written by Li, Shujun; Zhou, Yanfang; Ma, Nana; Zhang, Jie; Zheng, Zhiping; Streb, Carsten; Chen, Xuenian. The article contains the following contents:

The aggregation of mol. metal oxides into larger superstructures can bridge the gap between mol. compounds and solid-state materials. Here, we report that functionalization of polyoxotungstates with organo-boron substituents leads to giant polyoxometalate-based nanocapsules with dimensions of up to 4 nm. A “”lock and key”” mechanism enables the site-specific anchoring of aromatic organo-boronic acids to metal-functionalized Dawson anions [M3P2W15O62]9- (M = TaV or NbV), resulting in unique nanocapsules containing up to twelve POM units. Exptl. and theor. studies provide initial insights into the role of the organo-boron moieties and the metal-functionalized POMs for the assembly of the giant aggregates. The study therefore lays the foundations for the design of organo-POM-based functional nanostructures. In the experiment, the researchers used Pyridin-3-ylboronic acid(cas: 1692-25-7Electric Literature of C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Electric Literature of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of C6H7Br2NIn 2018 ,《Catalytic Synthesis of Indolines by Hydrogen Atom Transfer to Cobalt(III)-Carbene Radicals》 was published in Chemistry – A European Journal. The article was written by Karns, Alexander S.; Goswami, Monalisa; de Bruin, Bas. The article contains the following contents:

A new method was reported for the synthesis of tert-butyl-2-arylindoline-1-carboxylates such as I [R = Ph, 4-MeOC6H4, 2-pyridyl, etc.; R1 = H, 4-Me, 5-MeO, 5-CF3] from ring-closing reaction of o-aminoarylidine-N-tosylhydrazones II proceeded through cobalt(III)-carbene radical intermediate via rapid intramol. 1,5-hydrogen atom transfer (1,5-HAT). This methodol. employed the use of inexpensive com. available reagents and allowed the transformation of easily derivatized benzaldehyde-derived precursors to functionalized indoline products via formation of compounds II. This transformation was the first reported example of the synthesis of nitrogen-containing heterocycles from cobalt(III)-carbene radical precursors. Computational investigations using d. functional theory identified remarkably low barriers for 1,5-HAT and subsequent radical rebound displacement, hence provided support for the proposed mechanism. Furthermore, the steric and electronic effects of substituents on aniline ring and on nitrogen atom were evaluated and highlighted the importance of adequate resonance stabilization of radical intermediates to the success of this transformation. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Synthetic Route of C6H7Br2N)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Synthetic Route of C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: 2-(2-Hydroxyethyl)pyridineIn 2018 ,《Anion-Radical Salts of 7,7,8,8-Tetracyanoquinodimethane with Cations in the Basis of Alkylolpyridines》 was published in Russian Journal of General Chemistry. The article was written by Starodub, T. N.. The article contains the following contents:

Anion-radical salts of 7,7,8,8-tetracyanoquinodimethane with cations on the basis of methylol- and ethylolpyridines, N-methyl- and N-Et alkylolpyridines, were synthesized. Their composition is determined by the method of electronic spectroscopy, and the thermal stability is studied. The nature of the salts is investigated by the method of IR spectroscopy: it is shown that the conducting properties depend both on the nature of the alkyl group and on the position of the alkylol substituent. The presence of hydroxy groups in the conducting anion-radical salts allow their application as electronic organic materials for the design of conducting film coatings. The experimental part of the paper was very detailed, including the reaction process of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Name: 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Name: 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem