Month: October 2022

《A BODIPY based emission signal turn-on probe toward multiple heavy metals》 was published in Molecular Crystals and Liquid Crystals in 2020. These research results belong to Li, Xiaochuan; Tian, Guixiu; Shao, Danyang; Xu, Yue; Wang, Yan; Ji, Guangqian; Ryu, Jiwon; Son, Young-A.. SDS of cas: 1539-42-0 The article mentions the following:

A heavy metals sensor (2-N,N-bis(pyridin-2-ylmethyl)methanamine-BODIPY, ) for the recognition of Pb2+, Ba2+, Cr2+, Cd2+, Hg2+, Sn2+, and Zn2+ was developed by anchoring (bis(pyridin-2-ylmethyl)amine) DPA unit to the BODIPY framework. It exhibited excellent sensitivity and selectivity against other competent metal ions. The stoichiometry of and metal ions were determined to be 1:1. The limit of detection of toward Pb2+, Ba2+, Cr2+, Cd2+, Hg2+, Sn2+, and Zn2+ was ranged from 60.07 to 89.37 nM. Photo induced transfer (PET) leads to the weak emission of BODIPY unit. When metal ions anchored with DPA, PET was blocked due to the weak electron donating ability of N in DPA to BODIPY and the highly emissive character of BODIPY was recovered, establishing a fluorescence switch. After reading the article, we found that the author used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0SDS of cas: 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. SDS of cas: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Generation of Alkyl Radical through Direct Excitation of Boracene-Based Alkylborate》 was published in Journal of the American Chemical Society in 2020. These research results belong to Sato, Yukiya; Nakamura, Kei; Sumida, Yuto; Hashizume, Daisuke; Hosoya, Takamitsu; Ohmiya, Hirohisa. Safety of 4-Cyanopyridine The article mentions the following:

The generation of tertiary, secondary, and primary alkyl radicals has been achieved by the direct visible-light excitation of a boracene-based alkylborate. This system is based on the photophys. properties of the organoboron mol. The protocol is applicable to decyanoalkylation, Giese addition, and nickel-catalyzed carbon-carbon bond formations such as alkyl-aryl cross-coupling or vicinal alkylarylation of alkenes, enabling the introduction of various C(sp3) fragments to organic mols. After reading the article, we found that the author used 4-Cyanopyridine(cas: 100-48-1Safety of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Safety of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis and Structure-Activity Relationships of 5′-Aryl-14-alkoxypyridomorphinans: Identification of a μ Opioid Receptor Agonist/δ Opioid Receptor Antagonist Ligand with Systemic Antinociceptive Activity and Diminished Opioid Side Effects》 was written by Vekariya, Rakesh H.; Lei, Wei; Ray, Abhisek; Saini, Surendra K.; Zhang, Sixue; Molnar, Gabriella; Barlow, Deborah; Karlage, Kelly L.; Bilsky, Edward J.; Houseknecht, Karen L.; Largent-Milnes, Tally M.; Streicher, John M.; Ananthan, Subramaniam. Related Products of 197958-29-5 And the article was included in Journal of Medicinal Chemistry in 2020. The article conveys some information:

We previously identified a pyridomorphinan (6, SRI-22138) possessing a 4-chlorophenyl substituent at the 5′-position on the pyridine and a 3-phenylpropoxy at the 14-position of the morphinan as a mixed μ opioid receptor (MOR) agonist and δ/κ opioid receptor (DOR/KOR) antagonist with potent antinociceptive activity and diminished tolerance and dependence in rodents. Structural variations at the 5′- and 14-positions of this mol. gave insights into the structure-activity relationships for binding and functional activity. Subtle structural changes exerted significant influence, particularly on the ability of the compounds to function as agonists at the MOR. In vivo evaluation identified compound 20(I) (SRI-39067) as a MOR agonist/DOR antagonist that produced systemically active potent antinociceptive activity in tail-flick assay in mice, with diminished tolerance, dependence/withdrawal, reward liability, and respiratory depression vs. morphine. These results support the hypothesis that mixed MOR agonist/DOR antagonist ligands may emerge as novel opioid analgesics with reduced side effects. The experimental part of the paper was very detailed, including the reaction process of 2-Pyridinylboronic acid(cas: 197958-29-5Related Products of 197958-29-5)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Related Products of 197958-29-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Peptide-Conjugated Long-Lived Theranostic Imaging for Targeting GRPr in Cancer and Immune Cells》 was written by Wang, Wanhe; Wu, Ke-Jia; Vellaisamy, Kasipandi; Leung, Chung-Hang; Ma, Dik-Lung. Category: pyridine-derivatives And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

Gastrin-releasing peptide receptor (GRPr) plays proliferative and inflammatory roles in living systems. Here, the authors report a highly selective GRPr antagonist (JMV594)-tethered iridium(III) complex for probing GRPr in living cancer cells and immune cells. This probe exhibited desirable photophys. properties and also displayed negligible cytotoxicity, overcoming the inherent toxicity of the iridium(III) complex. Its long emission lifetime enabled its luminescence signal to be readily distinguished from the interfering fluorescence of organic dyes by using a time-resolved technique. This probe selectively visualized living cancer cells via specific binding to GRPr, while it also modulated the function of GRPr on TNF-α secretion in immune cells. To the authors′ knowledge, this is the first peptide-conjugated iridium(III) complex developed as a GRPr bioimaging probe and modulator of GRPr activity. This theranostic agent shows great potential at unmasking the diverse roles of GRPr in living systems. The results came from multiple reactions, including the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Category: pyridine-derivatives)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Category: pyridine-derivatives Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Diiminepyridine-Supported Phosphorus(I) and Phosphorus(III) Complexes: Synthesis, Characterization, and Electrochemistry》 was written by Gray, Paul A.; Braun, Jason D.; Rahimi, Naser; Herbert, David E.. Recommanded Product: 626-05-1 And the article was included in European Journal of Inorganic Chemistry in 2020. The article conveys some information:

Diiminepyridines (DIP) are popular redox noninnocent ligands with widespread application in late, 1st-row transition metal mediated catalysis and coordination chem. Here, the authors report the isolation and characterization of a pair of P coordination complexes in the +1 and +3 oxidation states supported by the same ligand framework bearing sterically imposing and electron-releasing tBu substituents on the imine carbons of the DIP backbone. Electrochem. anal. demonstrates that the DIP scaffold can retain its ability to serve as an electron reservoir when coordinated to a reduced pnicogen center, with a reversible reduction observed for the PI complex. The experimental process involved the reaction of 2,6-Dibromopyridine(cas: 626-05-1Recommanded Product: 626-05-1)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Recommanded Product: 626-05-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Plasmonic enhancement of stability and brightness in organic light-emitting devices》 was written by Fusella, Michael A.; Saramak, Renata; Bushati, Rezlind; Menon, Vinod M.; Weaver, Michael S.; Thompson, Nicholas J.; Brown, Julia J.. Application of 94928-86-6 And the article was included in Nature (London, United Kingdom) in 2020. The article conveys some information:

An organic light-emitting device (OLED) is demonstrated that uses the decay rate enhancement of a plasmonic system to increase device stability, while maintaining efficiency by incorporating a nanoparticle-based out-coupling scheme to extract energy from the plasmon mode. Using an archetypal phosphorescent emitter, a 2-fold increase is achieved in operational stability at the same brightness as a reference conventional device while simultaneously extracting 16% of the energy from the plasmon mode as light. The approach to increasing OLED stability avoids material-specific designs and is applicable to all com. OLEDs that are currently used for lighting panels, televisions, and mobile displays. After reading the article, we found that the author used fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Application of 94928-86-6)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Application of 94928-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Sheng; Li, Lijun; Li, Jingjing; Shi, Jianxue; Xu, Kun; Gao, Wenchao; Zong, Luyi; Li, Guigen; Findlater, Michael published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Electrochemical Arylation of Aldehydes, Ketones, and Alcohols: from Cathodic Reduction to Convergent Paired Electrolysis》.Electric Literature of C6H4N2 The article contains the following contents:

Arylation of carbonyls, one of the most common approaches toward alcs., has received tremendous attention, as alcs. are important feedstocks and building blocks in organic synthesis. Despite great progress, there is still a great gap to develop an ideal arylation method featuring mild conditions, good functional group tolerance, and readily available starting materials. We now show that electrochem. arylation can fill the gap. By taking advantage of synthetic electrochem., com. available aldehydes (ketones) and benzylic alcs. can be readily arylated to provide a general and scalable access to structurally diverse alcs. (97 examples, >10 g-scale). More importantly, convergent paired electrolysis, the ideal but challenging electrochem. technol., was employed to transform low-value alcs. into more useful alcs. Detailed mechanism study suggests that two plausible pathways are involved in the redox neutral α-arylation of benzylic alcs. After reading the article, we found that the author used 4-Cyanopyridine(cas: 100-48-1Electric Literature of C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Electric Literature of C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ishaq, Muhammad Waqas; Nawaz, Raziq; Jalil, Abdul; Hashmi, Muhammad Ali; Zheng, Tao; Li, Lianwei published their research in Journal of Molecular Structure in 2021. The article was titled 《Ligand Exchange Reaction in [Co4O4]-Cobalt Cubane: A Versatile Strategy Towards the Preparation of Cobalt Cubane-based Functional Small Molecules and Polymeric Materials》.SDS of cas: 2510-22-7 The article contains the following contents:

Herein, we report the mechanistic and application study of ligand exchange reaction in Co4O4-cobalt cubane, a well-known water oxidation catalyst (WOC). The ligand exchange reaction involves the instantaneous dissociation of attached pyridine ligand and replacement of target ligand in an appropriate solvent. The kinetic and thermodn. parameters were quantified for the ligand exchange reaction under mild conditions. Activation parameters revealed that the ligand exchange mechanism follows dissociative (D) or interchange-dissociative (Id) pathway in case of Co4O4, as it is evident by the high activation enthalpy (ΔH+) and the pos. activation entropy (ΔS+) values. The effects of ligand derivatization, reaction temperature and type of the solvent on the exchange kinetics and the product purity were also investigated in detail. Furthermore, our theor. studies disclosed the most probable ligand exchange pathway in case of Co4O4. Finally, this methodol. was successfully applied to the preparation of Co4O4-containning functional poly-4vinylpyridine (P4VP) and cross-linked heterogeneous polymeric catalysts. The present mechanistic study clearly demonstrates that the ligand exchange method is an efficient and versatile method for the preparation of Co4O4-based functional materials. In the experimental materials used by the author, we found 4-Ethynylpyridine(cas: 2510-22-7SDS of cas: 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. SDS of cas: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fang, Zhen; Liu, Yang; Zhang, Rong; Chen, Qiang; Wang, Tianqi; Yang, Wei; Fan, Yan; Yu, Chundong; Xiang, Rong; Yang, Shengyong published an article in 2021. The article was titled 《Discovery of a potent and selective inhibitor of histone lysine demethylase KDM4D》, and you may find the article in European Journal of Medicinal Chemistry.Reference of 2-Pyridinylboronic acid The information in the text is summarized as follows:

Histone lysine demethylase 4D (KDM4D) plays an important role in the regulation of tumorigenesis, progression and drug resistance and has been considered a potential target for cancer treatment. However, there is still a lack of potent and selective KDM4D inhibitors. In this investigation, we report a new class of KDM4D inhibitors containing the 2-(aryl(pyrrolidine-1-yl)methyl)phenol scaffold, identified through AlphaLisa-based screening, structural optimization, and structure-activity relationship analyses. Among these inhibitors, 24s (I) was the most potent, with an IC50 value of 0.023 ± 0.004μM. This compound exhibited more than 1500-fold selectivity towards KDM4D vs. KDM4A as well as other JMJD subfamily members, indicating good selectivity for KDM4D. Kinetic anal. indicated that 24s did not occupy the 2-oxoglutarate binding pocket. In an in vitro assay, 24s significantly suppressed the proliferation and migration of colorectal cancer (CRC) cells. Overall, this study has identified a good tool compound to explore the biol. function of KDM4D and a good lead compound for drug discovery targeting KDM4D. After reading the article, we found that the author used 2-Pyridinylboronic acid(cas: 197958-29-5Reference of 2-Pyridinylboronic acid)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Reference of 2-Pyridinylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Guo, Zhewen; Li, Guangfeng; Wang, Heng; Zhao, Jun; Liu, Yuhang; Tan, Hongwei; Li, Xiaopeng; Stang, Peter J.; Yan, Xuzhou published an article in 2021. The article was titled 《Drum-like Metallacages with Size-Dependent Fluorescence: Exploring the Photophysics of Tetraphenylethylene under Locked Conformations》, and you may find the article in Journal of the American Chemical Society.Electric Literature of C5H6BNO2 The information in the text is summarized as follows:

Materials with aggregation-induced emission (AIE) properties are of growing interest due to their widespread applications. AIEgens, such as tetraphenylethylene units, display varying emission behaviors during their conformational changes. However, the structure-property relationships of the intermediate conformations have rarely been explored. Herein, the authors show that the conformational restriction on TPE units can affect the structural relaxation in the excited state and the resulting photophys. behaviors. Specifically, three metallacages of different sizes were prepared via the coordination-driven self-assembly of a TPE-based tetrapyridyl donor with length-increasing Pt(II) acceptors. While the metallacages share similar scaffolds, they exhibit a trend of red-shifted fluorescence and attenuated quantum yield with the increase of their sizes. Furthermore, spectroscopic and computational studies together with a control experiment were conducted, revealing that the degree of cage tension imposed on the excited-state conformational relaxation of TPE moieties resulted in their distinct photophys. properties. The precise control of conformation holds promise as a strategy for understanding the AIE mechanism as well as optimizing the photophys. behaviors of materials on the platform of supramol. coordination complexes. After reading the article, we found that the author used Pyridin-3-ylboronic acid(cas: 1692-25-7Electric Literature of C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Electric Literature of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem