Month: October 2022

Bhattarai, Rajan Sharma; Kumar, Virender; Romanova, Svetlana; Bariwal, Jitender; Chen, Hao; Deng, Shanshan; Bhatt, Vijaya R.; Bronich, Tatiana; Li, Wei; Mahato, Ram I. published an article in 2021. The article was titled 《Nanoformulation design and therapeutic potential of a novel tubulin inhibitor in pancreatic cancer》, and you may find the article in Journal of Controlled Release.HPLC of Formula: 626-05-1 The information in the text is summarized as follows:

Successful treatment of pancreatic cancer remains a challenge due to desmoplasia, development of chemoresistance, and systemic toxicity. Herein, we synthesized (6-(3-hydroxy-4-methoxylphenyl)pyridin-2-yl) (3,4,5-trimethoxyphenyl)methanone (CH-3-8), a novel microtubule polymerization inhibitor with little susceptible to transporter-mediated chemoresistance. CH-3-8 binding to the colchicine-binding site in tubulin protein was confirmed by tubulin polymerization assay and mol. modeling. CH-3-8 disrupted microtubule dynamics at the nanomolar concentration in MIA PaCa-2 and PANC-1 pancreatic cancer cell lines. CH-3-8 significantly inhibited the proliferation of these cells, induced G2/M cell cycle arrest, and led to apoptosis. CH-3-8 is hydrophobic with an aqueous solubility of 0.97 ± 0.16 μg/mL at pH 7.4. We further conjugated it with dodecanol through diglycolate linker to increase hydrophobicity and thus loading in lipid-based delivery systems. Hence, we encapsulated CH-3-8 lipid conjugate (LDC) into methoxy poly(ethylene glycol)-block-poly(2-methyl-2-carboxyl-propylene carbonate-graft-dodecanol) (mPEG-b-PCC-g-DC) polymeric nanoparticles (NPs) by solvent evaporation, resulting in a mean particle size of 125.6 ± 2.3 nm and drug loading of 10 ± 1.0% (weight/weight) while the same polymer could only load 1.6 ± 0.4 (weight/weight) CH-3-8 using the same method. Systemic administration of 6 doses of CH-3-8 and LDC loaded NPs at the dose of 20 mg/kg into orthotopic pancreatic tumor-bearing NSG mice every alternate day resulted in significant tumor regression. Systemic toxicity was negligible, as evidenced by histol. evaluations. In conclusion, CH-3-8 LDC loaded NPs have the potential to improve outcomes of pancreatic cancer by overcoming transporter-mediated chemoresistance and reducing systemic toxicity. In the experimental materials used by the author, we found 2,6-Dibromopyridine(cas: 626-05-1HPLC of Formula: 626-05-1)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.HPLC of Formula: 626-05-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ma, Yuting; Kottisch, Veronika; McLoughlin, Elizabeth A.; Rouse, Zachary W.; Supej, Michael J.; Baker, Shefford P.; Fors, Brett P. published an article in 2021. The article was titled 《Photoswitching Cationic and Radical Polymerizations: Spatiotemporal Control of Thermoset Properties》, and you may find the article in Journal of the American Chemical Society.Application In Synthesis of fac-Tris(2-phenylpyridine)iridium The information in the text is summarized as follows:

The ability to fabricate polymeric materials with spatially controlled phys. properties has been a challenge in thermoset manufacturing To address this challenge, this work takes advantage of a photoswitchable polymerization that selectively incorporates different monomers at a growing chain by converting from cationic to radical polymerizations through modulation of the wavelength of irradiation By regulating the dosage and wavelength of light applied to the system, the mech. properties of the crosslinked material can be temporally and spatially tuned. Furthermore, photopatterning can be achieved both on the macro scale and micro scale, enabling precise spatial control of crosslink d. that results in high resolution control over mech. properties. In the experiment, the researchers used fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Application In Synthesis of fac-Tris(2-phenylpyridine)iridium)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Application In Synthesis of fac-Tris(2-phenylpyridine)iridium

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Akishina, E. A.; Dikusar, E. A.; Stepin, S. G.; Alekseyev, R. S.; Bumagin, N. A.; Potkin, V. I. published an article in 2022. The article was titled 《Synthesis of 4-Acetyl- and 4-Benzoylpyridine Derivatives with 1,2-Azole Fragments》, and you may find the article in Russian Journal of General Chemistry.Safety of 4-Acetylpyridine The information in the text is summarized as follows:

A method for the synthesis of 5-arylisoxazole- and 4,5-dichloroisothiazole-3-carboxylic acids derivatives I (R1 = H, Me, Ph; R2 = H, Cl; R3 = Cl, Ph, 4-methylphenyl, 4-nitrophenyl; X = S, O) based on 4-acetyl- and 4-benzoylpyridine has been developed. Esters I and amides II were prepared by acylation of (pyridin-4-yl)methanols III (R4 = OH) and (pyridin-4-yl)methanamines III (R4 = NH2) with acid chlorides of substituted 1,2-azole-3-carboxylic acids IV in ether or methylene chloride in the presence of triethylamine. Quaternary ammonium salts V of synthesized pyridine derivatives were also obtained. In the experiment, the researchers used many compounds, for example, 4-Acetylpyridine(cas: 1122-54-9Safety of 4-Acetylpyridine)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Safety of 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Wu, Terence; Tatton, Matthew R.; Greaney, Michael F. published an article in Angewandte Chemie, International Edition. The title of the article was 《NHC Catalysis for Umpolung Pyridinium Alkylation via Deoxy-Breslow Intermediates》.Safety of Pyridin-3-ylboronic acid The author mentioned the following in the article:

Umpolung N-heterocyclic carbene (NHC) catalysis of non-aldehyde substrates offers new pathways for CC bond formation, but has proven challenging to develop in terms of viable substrate classes. Here, the authors demonstrate that pyridinium ions can undergo NHC addition and subsequent intramol. C-C bond formation through a deoxy-Breslow intermediate. The alkylation demonstrates, for the first time, that deoxy-Breslow intermediates are viable for catalytic umpolung of areniums. In the part of experimental materials, we found many familiar compounds, such as Pyridin-3-ylboronic acid(cas: 1692-25-7Safety of Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Safety of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 100-48-1In 2021 ,《Mechanochemical Release of Non-Covalently Bound Guests from a Polymer-Decorated Supramolecular Cage》 appeared in Angewandte Chemie, International Edition. The author of the article were Kueng, Robin; Pausch, Tobias; Rasch, Dustin; Goestl, Robert; Schmidt, Bernd M.. The article conveys some information:

Supramol. coordination cages show a wide range of useful properties including, but not limited to, complex mol. machine-like operations, confined space catalysis, and rich host-guest chemistries. Here we report the uptake and release of non-covalently encapsulated, pharmaceutically-active cargo from an octahedral Pd cage bearing polymer chains on each vertex. Six poly(ethylene glycol)-decorated bipyridine ligands are used to assemble an octahedral PdII6(TPT)4 cage. The supramol. container encapsulates progesterone and ibuprofen within its hydrophobic nanocavity and is activated by shear force produced by ultrasonication in aqueous solution entailing complete cargo release upon rupture, as shown by NMR and GPC analyses. In the experiment, the researchers used many compounds, for example, 4-Cyanopyridine(cas: 100-48-1Related Products of 100-48-1)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Related Products of 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 2-(2-Hydroxyethyl)pyridineIn 2018 ,《Coordination Chemistry of N-(2-Pyridylethyl)-Substituted Bulky Amidinates and Triazenides of Magnesium》 appeared in European Journal of Inorganic Chemistry. The author of the article were Kalden, Diana; Krieck, Sven; Goerls, Helmar; Westerhausen, Matthias. The article conveys some information:

The amidines Dipp-N:C(R)-NH(C2H4R’) [R = tBu, R’ = Ph (1a); R = Ph, R’ = Py (1b)] as well as 1-(2,4,6-triisopropylphenyl)-3-(2-pyridylethyl)triazene (1c) are magnesiated with com. available dibutylmagnesium yielding the complexes [(THF)Mg{Dipp-N:C(tBu)-N(C2H4Ph)}2] (3a), [Mg{Dipp-N:C(Ph)-N(C2H4Py)}2] (3b), and [Mg{Tripp-N:N-N(C2H4Py)}2] (3c). Handling and isolation of triazene 1c has been performed at room temperature or below to avoid elimination of dinitrogen and formation of 2-pyridylethyl-(2,4,6-triisopropylphenyl)amine (2). In the solid state, the compounds 1b and 1c form dimers via intermol. hydrogen bridges to the pyridyl groups of neighboring mols. The results came from multiple reactions, including the reaction of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Recommanded Product: 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Recommanded Product: 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 13534-97-9In 2020 ,《Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase Inhibitor》 appeared in ACS Medicinal Chemistry Letters. The author of the article were Wilson, Jonathan E.; Patel, Gaurav; Patel, Chirag; Brucelle, Francois; Huhn, Annissa; Gardberg, Anna S.; Poy, Florence; Cantone, Nico; Bommi-Reddy, Archana; Sims, Robert J.; Cummings, Richard T.; Levell, Julian R.. The article conveys some information:

The histone acetyltransferases, CREB binding protein (CBP) and EP300, are master transcriptional co-regulators that have been implicated in numerous diseases, such as cancer, inflammatory disorders, and neurodegeneration. A novel, highly potent, orally bioavailable EP300/CBP histone acetyltransferase (HAT) inhibitor, CPI-1612 or 17, was developed from the lead compound 3. Replacement of the indole scaffold of 3 with the aminopyridine scaffold of 17 led to improvements in potency, solubility, and bioavailability. These characteristics resulted in a 20-fold lower efficacious dose for 17 relative to lead 3 in a JEKO-1 tumor mouse xenograft study. The experimental process involved the reaction of 6-Bromopyridin-3-amine(cas: 13534-97-9SDS of cas: 13534-97-9)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.SDS of cas: 13534-97-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formula: C12H12N2In 2019 ,《Optimisation of octahedral iron(II) and cobalt(II) spin-crossover metal complex for thermoelectric application》 appeared in Materials Chemistry and Physics. The author of the article were Ibrahim, N. M. J. N.; Said, S. M.; Hasnan, M. M. I. M.; Sabri, M. F. M.; Abdullah, N.; Mainal, A.; Salleh, M. F. M.; Izam, T. F. T. M. N.. The article conveys some information:

Four spin-crossover (SCO) complexes with general formulas, [M2(CH3COO)4(L)2] and [M(L)3](BF4)2, where M = Fe(II) and Co(II), containing extended π-conjugated bipyridyl ligand and N3-Schiff bases appended with linear C16 carbon chains at the N atoms were successfully synthesized and characterized. Correlation of its structural properties to thermoelec. behavior was studied: (1)structure of complexes, (2)choice of metal center and (3)choice of counterions. The structure of the mol., i.e. mol. vs. ionic has the largest impact on the SCO behavior. The mol. complexes with higher percentage of high-spin (73.4% HS for Fe-dinuc and 78% HS for Co-dinuc) produced the highest Seebeck values in mV K-1 (-0.57 ± 0.01 for Fe-dinuc and -0.58 ± 0.01 for Co-dinuc) due to the weaker metal-to-ligand bonds resulting in the increase mobility of the I- during agglomeration formed, thus increased the entropy in the solution Addnl., choice of metal center also was a factor to determine the magnitude of Seebeck performance due to the spin state transition during electron transfer. For counterion effect, it has the effect of determining the sign of the Seebeck value where I- is easier to oxidize/reduce process compared to CH3COO- and BF4- due to lower redox potential. These findings will assist in a systematic mol. design pathway for high potential SCO complexes for thermoelec. applications. In addition to this study using 4,4′-Dimethyl-2,2′-bipyridine, there are many other studies that have used 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Formula: C12H12N2) was used in this study.

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Formula: C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 6-Bromopyridin-3-amineIn 2010 ,《Selective inducible microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors derived from an oxicam template》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Wang, Jane; Limburg, David; Carter, Jeff; Mbalaviele, Gabriel; Gierse, James; Vazquez, Michael. The article conveys some information:

Here we describe the SAR of a series of potent and selective mPGES-1 inhibitors based on an oxicam template. Compound 13j demonstrated low nanomolar mPGES-1 inhibition in an enzyme assay. In addition, it displayed PGE2 inhibition in a cell-based assay (0.42 μM) and had over 238-fold selectivity for mPGES-1 over COX-2 and over 200-fold selectivity for mPGES-1 over 6-keto PGF1α. In the part of experimental materials, we found many familiar compounds, such as 6-Bromopyridin-3-amine(cas: 13534-97-9Safety of 6-Bromopyridin-3-amine)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Safety of 6-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of Methyl 5-bromopicolinateIn 2011 ,《Fluorogenic N,O-chelates built on a C2-symmetric aryleneethynylene platform: Spectroscopic and structural consequences of conformational preorganization and ligand denticity》 appeared in Journal of Organometallic Chemistry. The author of the article were Park, Byung Gyu; Pink, Maren; Lee, Dongwhan. The article conveys some information:

Using π-extended aryleneethynylene as a rigid structural skeleton, a C2-sym. bis(picolinate) ligand I was prepared Binding of Zn(II) or Cd(II) ion to this formally tetradentate N2O2-chelate resulted in significant red shifts and enhancement in emission. The metal-ligand interaction responsible for such structural change was studied by isolation and characterization of a tetrazinc(II) complex, in which the picolinate group functions not only as terminal bidentate but also as bridging with its μ-1,3 carboxylate unit. In the experiment, the researchers used Methyl 5-bromopicolinate(cas: 29682-15-3Reference of Methyl 5-bromopicolinate)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Reference of Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem