Month: October 2022

Galico, Diogo A.; Ramdani, Rayan; Murugesu, Muralee published the artcile< Phonon-assisted molecular upconversion in a holmium(III)-based molecular cluster-aggregate>, Reference of 73018-09-4, the main research area is holmium gadolinium ytterbium mol cluster aggregate upconversion emission spectra.

Upconversion (UC) is a fascinating process in which higher energy photons can be emitted from excitation by lower energy photons. The current challenge remains in downscaling and effectively achieving upconversion with lanthanide ions at the mol. scale. Here, using a rationally designed mol. cluster-aggregate (MCA), we demonstrate for the first time HoIII ion mol. upconversion. The synthesized MCA exhibits identifiable HoIII green and red UC emissions with a uniquely enhanced red to green ratio as well as a conventional near-IR (NIR) emission. A combined rigid spherical cluster core with reduced mol. vibrations, ideally matched donor and acceptor excited levels via a phonon-assisted mechanism, led to an upconversion quantum yield of 5.24 x 10-6%.

Nanoscale published new progress about Aggregates. 73018-09-4 belongs to class pyridine-derivatives, and the molecular formula is C5H4ClNO, Reference of 73018-09-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yang, Zeyu; Fu, Hengwei; Ye, Wenjie; Xie, Youyu; Liu, Qinghai; Wang, Hualei; Wei, Dongzhi published the artcile< Efficient asymmetric synthesis of chiral alcohols using high 2-propanol tolerance alcohol dehydrogenase SmADH2 via an environmentally friendly TBCR system>, Category: pyridine-derivatives, the main research area is asym synthesis chiral alc propanol oxidation alc dehydrogenase; thermostatic bubble column reactor system alc dehydrogenase ketone reduction.

Alc. dehydrogenases (ADHs) together with the economical substrate-coupled cofactor regeneration system play a pivotal role in the asym. synthesis of chiral alcs.; however, severe challenges concerning the poor tolerance of enzymes to 2-propanol and the adverse effects of the byproduct, acetone, limit its applications, causing this strategy to lapse. Herein, a novel ADH gene smadh2 was identified from Stenotrophomonas maltophilia by traditional genome mining technol. The gene was cloned into Escherichia coli cells and then expressed to yield SmADH2. SmADH2 has a broad substrate spectrum and exhibits excellent tolerance and superb activity to 2-propanol even at 10.5 M (80%, volume/volume) concentration Moreover, a new thermostatic bubble column reactor (TBCR) system is successfully designed to alleviate the inhibition of the byproduct acetone by gas flow and continuously supplement 2-propanol. The organic waste can be simultaneously recovered for the purpose of green synthesis. In the sustainable system, structurally diverse chiral alcs. are synthesized at a high substrate loading (>150 g L-1) without adding external coenzymes. Among these, about 780 g L-1 (6 M) Et acetoacetate is completely converted into Et (R)-3-hydroxybutyrate in only 2.5 h with 99.9% ee and 7488 g L-1 d-1 space-time yield. Mol. dynamics simulation results shed light on the high catalytic activity toward the substrate. Therefore, the high 2-propanol tolerance SmADH2 with the TBCR system proves to be a potent biocatalytic strategy for the synthesis of chiral alcs. on an industrial scale.

Catalysis Science & Technology published new progress about Alcohols, chiral Role: BPN (Biosynthetic Preparation), BIOL (Biological Study), PREP (Preparation). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ager, Ernest; Chivers, Geoffrey E.; Suschitzky, Hans published the artcile< Polyhalo aromatic compounds. XXVI. Photochemistry of pentachloropyridine and some derivatives>, Related Products of 14121-36-9, the main research area is photochem chloropyridine; pyridine chloro photochem; azabicyclohexenone tetrachloro.

Irradiation of pentachloropyridine in cyclohexane, Et2O, or dioxane gave 2,3,4,6-tetrachloropyridine (I) whereas in C6H6, tetrachloro-3-phenyl-pyridine was formed. Irradiation of pentachloropyridine 1-oxide and tetrachloro-N-methyl-2-pyridone gave CCl2:CClCCl:CClNCO and tetrachloro-2-methyl-2-azabicyclo[2.2.0]hex-5-en-3-one (II) resp. Nucleophilic substitution reactions of I were also examined

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Dechlorination. 14121-36-9 belongs to class pyridine-derivatives, and the molecular formula is C5HCl4N, Related Products of 14121-36-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Kaizhi; Jiang, Pengbo; Yang, Ming; Ma, Ping; Qin, Jiaheng; Huang, Xiaokang; Ma, Lei; Li, Rong published the artcile< Metal-free nitrogen -doped carbon nanosheets: a catalyst for the direct synthesis of imines under mild conditions>, Recommanded Product: Pyridin-4-ylmethanamine, the main research area is transfer hydrogenation nitrile nitrogen doped carbon nanocatalyst; imine preparation amine oxidation nitrile nitrogen doped carbon nanocatalyst.

Herein, a highly stable, porous, multifunctional and metal-free catalyst was developed, which exhibited significant catalytic performance in the oxidation of amines and transfer hydrogenation of nitriles under mild conditions; this could be attributed to the presence of numerous active sites and their outstanding BET surface area. The obtained results showed that most of the yields of imines exceeded 90%, and the cycling performance of the catalyst could be at least seven runs without any decay in the reaction activity, which could be comparable to those of metal catalysts. Subsequently, a kinetic study has demonstrated that the apparent activation energy for the direct synthesis of imines from amines is 67.39 kJ mol-1, which has been performed to testify that the catalytic performances are rational. Via catalyst characterizations and exptl. data, graphitic-N has been proven to be the active site of the catalyst. Hence, this study is beneficial to comprehend the mechanism of action of a metal-free N-doped carbon catalyst in the formation of imines.

Green Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Recommanded Product: Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shen, Ni; Li, Runhan; Liu, Can; Shen, Xuzhong; Guan, Wei; Shang, Rui published the artcile< Photocatalytic Cross-Couplings of Aryl Halides Enabled by o-Phosphinophenolate and o-Phosphinothiophenolate>, Application of C11H16BNO2, the main research area is phosphinophenolate catalyzed cross coupling aryl halide boronate phosphite pyrrole; thiophenolate catalyzed cross coupling aryl halide boronate phosphite pyrrole; arylboronic acid ester preparation; aryl phosphonate preparation; arylpyrrole derivative preparation.

O-Phosphinophenolate and o-phosphinothiophenolate are potent photocatalysts with strong reducing ability to activate aryl chlorides and bromides under visible light for borylation, arylation, and phosphorylation. Exptl. and theor. studies revealed that the o-diphenylphosphino substituent results in a narrow optical gap and facilitates intersystem crossing to access triplet states, which promote phenolate and thiophenolate to function as effective visible-light-photoredox catalysts. The results presented herein suggest promising utility of synthetically modified phenolates and thiophenolates as photoredox catalysts.

ACS Catalysis published new progress about Amination. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Application of C11H16BNO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lennon, Kyle R.; Geri, Michela; McKinley, Gareth H.; Swan, James W. published the artcile< Medium amplitude parallel superposition (MAPS) rheology. Part 2: Experimental protocols and data analysis>, Computed Properties of 123-03-5, the main research area is medium amplitude parallel superposition rheol.

An exptl. protocol is developed to directly measure the new material functions revealed by medium amplitude parallel superposition (MAPS) rheol. This protocol measures the medium amplitude response of a material to a simple shear deformation composed of three sine waves at different frequencies, revealing a rich dataset consisting of up to 19 measurements of the third-order complex modulus at distinct three-frequency coordinates. We discuss how the choice of input frequencies influences the features of the MAPS domain studied by the experiment A polynomial interpolation method for reducing the bias of measured values from spectral leakage and reducing variance due to noise is discussed, including a derivation of the optimal range of amplitudes for the input signal. This leads to the conclusion that conducting the experiment in a stress-controlled fashion possesses a distinct advantage to the strain-controlled mode. The exptl. protocol is demonstrated through measurements of the MAPS response of a model complex fluid: a surfactant solution of wormlike micelles. The resulting dataset is indeed large and feature-rich, while still acquired in a time comparable to similar medium amplitude oscillatory shear (MAOS) experiments We demonstrate that the data represent measurements of an intrinsic material function by studying its internal consistency, compatibility with low-frequency predictions for Coleman-Noll simple fluids, and agreement with data obtained via MAOS amplitude sweeps. Finally, the data are compared to predictions from the corotational Maxwell model to demonstrate the power of MAPS rheol. in determining whether a constitutive model is consistent with a material’s time-dependent response. (c) 2020 American Institute of Physics.

Journal of Rheology (Melville, NY, United States) published new progress about Computer program. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Computed Properties of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pinkerton, Anthony B.; Sessions, E. Hampton; Hershberger, Paul; Maloney, Patrick R.; Peddibhotla, Satyamaheshwar; Hopf, Meghan; Sergienko, Eduard; Ma, Chen-Ting; Smith, Layton H.; Jackson, Michael R.; Tanaka, Jun; Tsuji, Takashi; Akiu, Mayuko; Cohen, Steven E.; Nakamura, Tsuyoshi; Gardell, Stephen J. published the artcile< Optimization of a urea-containing series of nicotinamide phosphoribosyltransferase (NAMPT) activators>, Reference of 3731-53-1, the main research area is urea nicotinamide phosphoribosyltransferase activator; NAD(+) booster; NAMPT; NAMPT activators; Ureas.

NAD+ is a crucial cellular factor that plays multifaceted roles in wide ranging biol. processes. Low levels of NAD+ have been linked to numerous diseases including metabolic disorders, cardiovascular disease, neurodegeneration, and muscle wasting disorders. A novel strategy to boost NAD+ is to activate nicotinamide phosphoribosyltransferase (NAMPT), the putative rate-limiting step in the NAD+ salvage pathway. We previously showed that NAMPT activators increase NAD+ levels in vitro and in vivo. Herein we describe the optimization of our NAMPT activator prototype (SBI-0797812) leading to the identification of 1-(4-((4-chlorophenyl)sulfonyl)phenyl)-3-(oxazol-5-ylmethyl)urea (34) that showed far more potent NAMPT activation and improved oral bioavailability.

Bioorganic & Medicinal Chemistry Letters published new progress about Cardiovascular disease. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Reference of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Iddon, Brian; Mack, Arthur G.; Suschitzky, Hans; Taylor, Jack A.; Wakefield, Basil J. published the artcile< Polyhaloaromatic compounds. Part 42. Carbon-13 NMR spectra of polyhalopyridines and 2-pyrimidines>, Synthetic Route of 14121-36-9, the main research area is carbon NMR polyhalo pyridine pyrimidine; substituent effect NMR halopyridine.

13C NMR spectra are reported for 103 polyhalopyridines and 8 polyhalopyrimidines. Substituent effects were calculated and the results used to assign structures.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about NMR (nuclear magnetic resonance). 14121-36-9 belongs to class pyridine-derivatives, and the molecular formula is C5HCl4N, Synthetic Route of 14121-36-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Vijeta, Arjun; Reisner, Erwin published the artcile< Carbon nitride as a heterogeneous visible-light photocatalyst for the Minisci reaction and coupling to H2 production>, Computed Properties of 93-60-7, the main research area is heterogeneous Minisci hydrogen evolution reaction photocatalyst.

Cyanamide functionalized carbon nitride powder is reported as a photocatalyst for direct Minisci-type coupling of heteroarenes with ethers, alcs., and amides using atm. oxygen as the oxidant at room temperature This mild protocol displays broad substrate scope, good functional group tolerance and the catalyst can be easily isolated and reused for several cycles. It thereby addresses the two major limitations of previously reported photoredox-mediated Minisci reactions: (i) use of expensive and potentially harmful non-recyclable photocatalysts, and (ii) requirement of a stoichiometric amount of strong chem. oxidant. Finally, using platinum as a co-catalyst with the carbon nitride allows this light-mediated reaction to generate two value-added products under an anaerobic atm. – functionalized heteroarenes and H2 fuel.

Chemical Communications (Cambridge, United Kingdom) published new progress about Hydrogen evolution reaction catalysts. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Computed Properties of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Blache, Yves; Gueiffier, Alain; Chavignon, Olivier; Viols, Henry; Teulade, Jean Claude; Chapat, Jean Pierre published the artcile< Compared reactivity of 3-, 5-, 6-, and 8-aminoimidazo[1,2-α]pyridines in Combes reaction: access to imidazonaphthyridines and dipyrido[1,2-a:3',2'-d]imidazole>, Application of C6H7N3O2, the main research area is aminoimidazopyridine Combes reaction; imidazonaphthyridine; dipyridoimidazole.

The synthesis of imidazo[1,2-a][1,8]naphthyridines and dipyrido[1,2-a:3′,2′-d]imidazole by treatment of aminoimidazo[1,2-a]pyridines following the Combes procedure is described.

Heterocycles published new progress about 22280-62-2. 22280-62-2 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Application of C6H7N3O2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem