Month: October 2022

Parada, Giovanny A.; Goldsmith, Zachary K.; Kolmar, Scott; Pettersson Rimgard, Belinda; Mercado, Brandon Q.; Hammarstroem, Leif; Hammes-Schiffer, Sharon; Mayer, James M. published the artcile< Concerted proton-electron transfer reactions in the Marcus inverted region>, Reference of 396092-82-3, the main research area is concerted proton electron transfer reaction Marcus inverted region.

One of the most counterintuitive features of electron transfer kinetics is the inverted region. As Marcus theory predicts and experiments have borne out, electron transfer slows down once the driving force for it becomes especially favorable. Parada et al. now offer evidence for such inverted behavior in proton-coupled electron transfer. Specifically, they examined a series of compounds with phenol bridging anthracene (electron acceptor) and pyridine (proton acceptor) derivatives Time-resolved spectroscopy and accompanying theory revealed slower rates at higher driving forces in the back reaction that follows light-induced intramol. proton and electron transfer.

Science (Washington, DC, United States) published new progress about Charge separation. 396092-82-3 belongs to class pyridine-derivatives, and the molecular formula is C7H9BrN2, Reference of 396092-82-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Iwata, Takahiro; Hirose, Hisaaki; Sakamoto, Kentarou; Hirai, Yusuke; Arafiles, Jan Vincent V.; Akishiba, Misao; Imanishi, Miki; Futaki, Shiroh published the artcile< Liquid Droplet Formation and Facile Cytosolic Translocation of IgG in the Presence of Attenuated Cationic Amphiphilic Lytic Peptides>, Formula: C10H8N2S2, the main research area is cervical cancer Fc binding ACAL peptide L17E IgG; antibodies; intracellular delivery; liquid droplet; liquid-liquid phase separation (LLPS); peptides.

Fc region binding peptide conjugated with attenuated cationic amphiphilic lytic peptide L17E trimer [FcB(L17E)3] was designed for IgG (IgG) delivery into cells. Particle-like liquid droplets were generated by mixing Alexa Fluor 488 labeled IgG (Alexa488-IgG) with FcB(L17E)3. Droplet contact with the cellular membrane led to spontaneous influx and distribution of Alexa488-IgG throughout cells in serum containing medium. Involvement of cellular machinery accompanied by actin polymerization and membrane ruffling was suggested for the translocation. Alexa488-IgG neg. charges were crucial in liquid droplet formation with pos. charged FcB(L17E)3. Binding of IgG to FcB(L17E)3 may not be necessary. Successful intracellular delivery of Alexa Fluor 594-labeled anti-nuclear pore complex antibody and anti-mCherry-nanobody tagged with supernegatively charged green fluorescence protein allowed binding to cellular targets in the presence of FcB(L17E)3.

Angewandte Chemie, International Edition published new progress about Blood serum. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Formula: C10H8N2S2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dai, Q.; Wang, H.; Wang, Y.; Xiao, M.; Jin, H.; Li, M.; Xia, T. published the artcile< Enhancing the sensory attributes and antioxidant properties of snus by mixing it with tea>, Safety of 3-(Methoxycarbonyl)pyridine, the main research area is tea beverage snus antioxidant sensory property.

In the present work, we investigated the chem. and volatile compositions of three tea-containing snus samples, after which their acceptability on the aromatic and taste coordination was evaluated by a professional panel. Results showed that the tea-containing snus samples exhibited better acceptability on the aroma and taste coordination profiles. Dahongpao tea (DT)-containing snus (DT-snus) exhibited the best acceptability of aromatic coordination, whereas the most favorable taste coordination was exhibited by Keemun black tea (KBT)-containing snus (KBT-snus). The antioxidant activity determined by the DPPH and ABTS assays revealed that Lu’an Guapian tea (LGT)-containing snus (LGT-snus) exhibited the highest free-radical scavenging ability. LGT-snus was also found to have the highest content of total polyphenols, amino acids, and caffeine. The highest levels of total flavonoids and soluble sugars were found in DT-snus and KBT-snus, resp. There were 88, 68, and 74 volatiles found in DT-snus, LGT-snus, and KBT-snus, resp., among which, nitrogenous compounds constituted the major category. High levels of nicotine, megastigmatrienone, neophytadiene, nicotyrine, and cotinine, which are the major volatiles in snus, were detected in the tea-containing snus samples. The mixing of tea introduced the flavor profiles of the volatiles present in the original tea into the tea-containing snus samples. Benzaldehyde, β-ionone, hexanoic acid, 3-(Z)-hexenyl ester, pyrazines, and nerolidol from LGT; furfural, benzeneethanol, nerolidol, linalool, and cedrol from DT; and nonanal, geraniol, cis-jasmone, benzenemethanol, and Me salicylate from KBT were found in high concentrations in the corresponding tea-containing snus samples.

International Food Research Journal published new progress about Acids Role: ANT (Analyte), FFD (Food or Feed Use), PRP (Properties), ANST (Analytical Study), BIOL (Biological Study), USES (Uses). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Safety of 3-(Methoxycarbonyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Huang, Qi; Zard, Samir Z. published the artcile< Modular route to azaindanes>, Electric Literature of 131747-55-2, the main research area is xanthate ester radical cyclization; azaindane preparation.

A convergent radical based route to azaindanes, e.g., I, is described, relying on the degenerative addition transfer of various substituted S-(pyridylmethyl)-O-Et dithiocarbonates (xanthates) to functional alkenes followed by radical cyclization onto the pyridine ring activated by protonation with trifluoroacetic acid. In one case, a richly decorated cyclohepta[b]pyridine could be assembled swiftly by allowing the first adduct to N-phenylmaleimide to undergo addition to N-allylphthalimide prior to cyclization.

Organic Letters published new progress about Heterocyclic compounds Role: SPN (Synthetic Preparation), PREP (Preparation) (azaindanes). 131747-55-2 belongs to class pyridine-derivatives, and the molecular formula is C6H6FNO, Electric Literature of 131747-55-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tiecco, M.; Testaferri, L.; Tingoli, M.; Chianelli, D.; Montanucci, M. published the artcile< A convenient synthesis of bipyridines by nickel-phosphine complex-mediated homo coupling of halopyridines>, Category: pyridine-derivatives, the main research area is coupling halopyridine; bipyridine methoxy; pyridine halo coupling; nickel phosphine complex coupling catalyst.

Coupling of 2-bromopyridine in DMF in the presence of Ni(PPh3)4, prepared in situ from NiCl2, PPh3, and Zn, gave 68% 2,2′-bipyridine. Among the 10 other compounds similarly prepared were: 4,4′-biquinoline and 2,2′-dimethoxy-3,3′-bipyridine.

Synthesis published new progress about Coupling reaction. 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Obradors, Carla; List, Benjamin published the artcile< Azine Activation via Silylium Catalysis>, Synthetic Route of 3796-23-4, the main research area is heteroarene silyl ketene acetal silylium phosphoramidimidate catalyst regioselective addition; silyl alkyl heteroarene preparation oxidation; alkyl heteroarene preparation.

A direct, catalytic and selective functionalization of azines via silylium activation was described. The catalyst design enabled mild conditions and a remarkable functional group tolerance in a one-pot setup.

Journal of the American Chemical Society published new progress about Acetals, ketene, silyl Role: RCT (Reactant), RACT (Reactant or Reagent). 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Synthetic Route of 3796-23-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tan, Yee Seng; Tiekink, Edward R. T. published the artcile< Crystal structure of catena-poly{(μ2-N1,N2-bis[(pyridin-4-yl)methyl]ethanediamide-κ2N:N′)-bis(O,O′-di-isopropyldithiophosphato-κ1S)zinc(II)} - acetonitrile (1/1), C26H42N4O6P2S4Zn[n.8901]C2H3N>, Related Products of 3731-53-1, the main research area is crystal structure catenapolypyridinmethylethanediamideisopropyldithiophosphatoacetonitrile.

C28H45N5O6P2S4Zn, monoclinic, P21/c (number 14), a = 7.73670(10) Å, b = 21.56370(10) Å, c = 23.1184(2) Å, β = 99.121(1)°, V = 3808.12(6) Å3, Z = 4, Rgt(F) = 0.0210, wRref(F2) = 0.0580, T = 100(2) K. CCDC number: 1959644. The Zn[S2P(O-iPr)2]2precursor was prepared in high yield from the in situ reaction of Zn(NO3)2·6 H2O (Alfa Aesar; 14.87 g, 0.05 mol), iPrOH (Merck; 16.05 mL, 0.21 mol), P2S5(Sigma-Aldrich; 11.11 g, 0.05 mol) and 50% weight/weight NaOH solution (Merck; 8.80 mL, 0.11 mol). N, N-Bis(pyridin-4-ylmethyl) ethanediamide (4LH2) was prepared in high yield from the 2:1 reaction (reflux) of 4-picolylamine (Aldrich; 2.03 mL, 0.02 mol) and di-Et oxalate (Aldrich; 1.36 mL, 0.01 mol) in ethanol solution (Merck; 5 mL). The title compound was obtained by mixing a suspension of Zn[S2P(O-iPr)2]2(0.50 g, 1.02 mmol) and N,N-bis(pyridin-4-ylmethyl)ethanediamide (0.28 g, 1.04 mmol) in DMF (Merck; 5 mL), followed by stirring for 30 min at 373 K. The solution was filtered, the filtrate taken in acetonitrile (Merck; 1 mL) and transferred to a vial for crystallization Yellow crystals formed after one day.

Zeitschrift fuer Kristallographie – New Crystal Structures published new progress about Crystal structure. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Related Products of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lamb, Claire J. C.; Vilela, Filipe; Lee, Ai-Lan published the artcile< Pd(II)-Catalyzed Enantioselective Desymmetrization of Polycyclic Cyclohexenediones: Conjugate Addition versus Oxidative Heck>, Product Details of C13H15F3N2O, the main research area is polycyclic cyclohexenedione arylboronic acid stereoselective palladium desymmetrization Heck reaction.

Pd(II)-catalyzed desymmetrization of polycyclic cyclohexenediones has been achieved with high enantio- and diastereoselectivities. Up to five contiguous stereocenters are desymmetrized, while simultaneously, an addnl. stereocenter is created by the enantioselective conjugate addition Surprisingly, the conjugate addition products dominate even under typical oxidative Heck conditions, and these observations may provide some insight into the competition between the two related reactions.

Organic Letters published new progress about Arylboronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Product Details of C13H15F3N2O.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Patel, Paresh N.; Desai, Dipen H.; Patel, Nilam C.; Deshmukh, Amar G. published the artcile< Efficient multicomponent processes for synthesis of novel poly-nuclear hetero aryl substituted terpyridine scaffolds: Single crystal XRD study>, Category: pyridine-derivatives, the main research area is naphthalenyl terpyridine preparation uv vis spectra fluorescence; benzothiophenyl terpyridine preparation; acetyl pyridine naphthaldehyde benzothiophene aldehyde multicomponent condensation reaction.

Authors studied the synthesis of novel terpyridine scaffolds from poly-nuclear and hetero-aryl aldehydes by the multicomponent condensation reactions with various acetyl pyridine derivatives in the presence of ammonium hydroxide. Comparative studies of two different processes catalyzed by potassium hydroxide and pyrrolidine have been performed and presented in this report. The structures of all the newly prepared terpyridine mols. have been well established by preforming various spectral anal. and single crystal XRD studies for selected mols. This approach addressed some structural miscellany concerns currently facing in photo-luminescent chem., and the derived hybrid pyridines could be used as suitable precursors for the synthesis of related photo-luminescent systems. The prepared scaffolds as such and their d-block or f-block metal complexes and coordination polymers may provide an efficient candidate for photo-luminescent chem.

Journal of Molecular Structure published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gajeles, Ghellyn; Kim, Se Mi; Yoo, Jong-Cheol; Lee, Kyung-Koo; Lee, Sang Hee published the artcile< Recyclable anhydride catalyst for H2O2 oxidation: N-oxidation of pyridine derivatives>, Category: pyridine-derivatives, the main research area is pyridine oxide green preparation; oxidation pyridine poly maleic anhydride alt octadecene catalyst.

The catalytic efficiency and recyclability of poly(maleic anhydride-alt-1-octadecene) (Od-MA) and poly(maleic anhydride-alt-1-isobutylene) (Bu-MA) were evaluated for use in the development of a metal-free, reusable catalyst for the oxidation of pyridines to pyridine N-oxides, such as I [R = 2-Cl, 3-Br, 2-CO2H, etc.] in the presence of H2O2. The Od-MA catalyst was easily recovered via filtration with recovery yields exceeding 99.8%. The catalyst retained its activity after multiple uses and did not require any treatment for reuse. The Od-MA and H2O2 catalytic system described herein was eco-friendly, operationally simple, and cost-effective; thus, it was industrially applicable. Od-MA and H2O2 could potentially be used in place of percarboxylic acid as an oxidant in a wide range of oxidation reactions.

RSC Advances published new progress about Green chemistry. 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem