Month: October 2022

Day, Jon I.; Singh, Kamaljeet; Trinh, Winston; Weaver, Jimmie D. published the artcile< Visible Light Mediated Generation of trans-Arylcyclohexenes and Their Utilization in the Synthesis of Cyclic Bridged Ethers>, Name: Ir(p-F-ppy)3, the main research area is visible light mediated generation trans arylcyclohexene; cyclic bridged ether preparation reaction mechanism hydrogen bonding.

While accessible via UV-irradiation of cis-cyclohexene, trans-cyclohexene has thus far been an investigation driven by curiosity, and due primarily to its short lifespan, has until recently not been employed for productive synthesis. Herein, we present straightforward conditions that provide access to a class of trans-arylcyclohexenes and demonstrate their utility in the formation of oxabicyclic ethers, which are otherwise inaccessible from the corresponding cis-cyclohexene. A key challenge to utilizing the incredible ca. 52 kcal/mol strain energy of trans-cyclohexene to drive synthesis was overcoming its short lifetime. Herein, we show that preorganization via hydrogen bonding between the substrate and the reaction partner prior to isomerization is a viable strategy to overcome the inherently short lifetime of trans-cyclohexene.

Journal of the American Chemical Society published new progress about Bridged bicyclic compounds Role: SPN (Synthetic Preparation), PREP (Preparation). 370878-69-6 belongs to class pyridine-derivatives, and the molecular formula is C33H21F3IrN3, Name: Ir(p-F-ppy)3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ngo, Khang; Collins-Kautz, Chelsey; Gerstenecker, Stefan; Wagner, Bjoern; Heine, Andreas; Klebe, Gerhard published the artcile< Protein-Induced Change in Ligand Protonation during Trypsin and Thrombin Binding: Hint on Differences in Selectivity Determinants of Both Proteins?>, Product Details of C6H8N2, the main research area is Protein Induced ligand protonation trypsin thrombin.

Trypsin and thrombin, structurally similar serine proteases, recognize different substrates; thrombin cleaves after Arg, whereas trypsin cleaves after Lys/Arg. Both recognize basic substrate headgroups via Asp189 at the bottom of the S1 pocket. By crystallog. and isothermal titration calorimetry (ITC), we studied a series of D-Phe/D-DiPhe-Pro-(amino)pyridines. Identical ligand pairs show the same binding poses. Surprisingly, one ligand binds to trypsin in protonated state and to thrombin in unprotonated state at P1 along with differences in the residual solvation pattern. While trypsin binding is mediated by an ordered water mol., in thrombin, water is scattered over three hydration sites. Although having highly similar S1 pockets, our results suggest different electrostatic properties of Asp189 possibly contributing to the selectivity determinant. Thrombin binds a specific Na+ ion next to Asp189, which is absent in trypsin. The electrostatic properties across the S1 pocket are further attenuated by charged Glu192 at the rim of S1 in thrombin, which is replaced by uncharged Gln192 in trypsin.

Journal of Medicinal Chemistry published new progress about Enzyme functional sites, active. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Product Details of C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Singh, Malvinder P.; Bathini, Yadagiri; Lown, J. William published the artcile< Site selective alkoxymethylation of imidazo[4,5-b]pyridines: structural analysis by high field NMR methods>, Product Details of C6H7N3O2, the main research area is alkylation alkoxymethylation imidazopyridine regiochem; aryl imidazopyridine preparation structure; tautomer nucleophile alkoxymethylation regiochem imidazopyridine; solvent effect alkoxymethylation benzimidazole methoxyphenyl; benzimidazole alkoxymethyl methoxyphenyl mol structure; mol structure alkoxymethyl methoxyphenyl imidazopyridine.

The alkylation reactions of 2-aryl-1(3)H-imidazo[4,5-b]pyridines (equivalent to 1-deazapurines) with alkoxymethyl chlorides and bromoacetonitrile are described. The structural assignments of the products were made using 2-dimensional 1H-1H NOE (NOESY) and selective INEPT (INAPT) 13C NMR experiments using polarization transfer from C-bound hydrogens in the alkyl side chains to selected 13C resonances via long-range 3JCH couplings. Although 3 isomeric N-alkyl derivatives could arise from a single heterocycle based on considerations of tautomeric equilibrium, however, the reactions exhibit marked site selectivity even under quite different reaction conditions. Thus, N-3 alkyl derivatives are produced exclusively in basic (Et3N/NaH) nonpolar media following an SEE2cB mechanism. Solvent effects are evident in a loss of N-3 vs. N-1 selectivity for alkylation when the polar aprotic solvent DMF is used. Under neutral conditions direct alkylation occurs at the N-4 position following an SE2′ mechanism. The overall site selectivity appears to be governed by the relative reactivity of individual nucleophilic sites rather than the tautomeric composition in solution The regioselective alkoxymethylation of 2-(4-methoxyphenyl)benzimidazole, and methyl-2-(4-methoxyphenyl)imidazopyridines I (R = hydrogen, methyl; X = CH, N) were reported. Bis(imidazo[4,5-b]pyridine analogs of Hoechst 33258 were prepared

Heterocycles published new progress about Molecular structure. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Product Details of C6H7N3O2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kuwata, Yoshiyuki; Sonoda, Motohiro; Tanimori, Shinji published the artcile< Facile Synthesis of Phenanthridinone Alkaloids via Suzuki-Miyaura Cross-coupling>, Electric Literature of 53636-56-9, the main research area is phenanthridinone alkaloid crinasiadine dihydrobicolorine trisphaeridine bicolorine facile synthesis; aminophenylboronic acid Suzuki Miyaura cross coupling bromobenzoate bromoheteroarenecarboxylate.

Phenanthridinone alkaloids crinasiadine (I) and N-alkylcrinasiadines II [R = CH2CH2CHMe2, CH2CH2CO2Et, CH2CH2Ph, CH2CH2CH2CO2Et] have been synthesized based on palladium-catalyzed tandem C-C and C-N bond formation starting from 2-aminophenylboronic acid and 2-bromobenzoate in short steps. Related alkaloids, 5,6-dihydrobicolorine (III), trisphaeridine (IV), and bicolorine (V) have also been synthesized.

Journal of Heterocyclic Chemistry published new progress about Alkaloids Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (phenanthridine). 53636-56-9 belongs to class pyridine-derivatives, and the molecular formula is C7H6BrNO2, Electric Literature of 53636-56-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Keawkim, Kannika; Na Jom, Kriskamol published the artcile< Metabolomics and flavoromics analysis of chemical constituent changes during roasting of germinated Sacha inchi (Plukenetia volubilis L.)>, Related Products of 93-60-7, the main research area is metabolome flavorome roasting browning germination Plukenetia.

This study examined the changes in metabolites together with the flavor profiles of germinated Sacha inchi seeds during roasting by using gas chromatog. The results indicated that roasting partially increased the browning index, amino acid levels, total phenolic content, and antioxidant capacity, but slightly decreased the levels of reducing sugars. Oxidized and rancid compounds were significantly decreased at a 180 °C roasting temperature Pyrazine, furan, and pyrrole were Maillard reaction products that were increased at 180 °C of roasting. Roasting at 145 °C for 45 min after germination for 4 days was determined to be the optimal conditions for roasting germinated Sacha inchi seeds, which reduced the off-flavor and burned taste. The roasted germinated Sacha inchi seed contains higher amino acids than raw seed, which could be used as an alternative source for food products and supplements. In addition, the roasted germinated seeds at 4 days were recommended for food applications.

Food Chemistry: X published new progress about Alcohols Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Related Products of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sanders, Georgine M.; Van Dijk, M.; Van der Plas, H. C. published the artcile< Reactions of haloquinolizinium bromides with diethylamine>, Recommanded Product: Methyl 3-bromo-2-pyridinecarboxylate, the main research area is quinolizinium bromide diethylamine reaction.

The reactions of quinolizinium bromide (QB) and its four monobromo derivatives with diethylamine have been investigated. For Br in position 2 or 4, substitution is the main process, whereas for Br in positions 1 and 3 quant. ring opening is found. The substituted pyridylbutadienes formed by ring opening, are cis-trans-butadienes, which isomerize into the all-trans forms. The steric course of the ring opening is explained.

Journal of Heterocyclic Chemistry published new progress about 53636-56-9. 53636-56-9 belongs to class pyridine-derivatives, and the molecular formula is C7H6BrNO2, Recommanded Product: Methyl 3-bromo-2-pyridinecarboxylate.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Serrano-Ruiz, Juan Carlos; Campelo, Juan M.; Francavilla, Matteo; Romero, Antonio A.; Luque, Rafael; Menendez-Vazquez, Carmen; Garcia, Ana B.; Garcia-Suarez, Eduardo J. published the artcile< Efficient microwave-assisted production of furfural from C5 sugars in aqueous media catalyzed by Broensted acidic ionic liquids>, SDS of cas: 21876-43-7, the main research area is ionic liquid xylose hydrolysis dehydration catalyst furfural microwave.

Small amounts of SO3H-functionalized room temperature synthesized ionic liquids efficiently dehydrate aqueous xylose to furfural under microwave heating at mild reaction conditions. The RT-ionic liquid catalysts were also found to be effective catalysts for the two step one-pot simultaneous hydrolysis and dehydration of a lignocellulosic waste biorefinery-derived syrup enriched in C5 sugar oligomers.

Catalysis Science & Technology published new progress about Bronsted acidity. 21876-43-7 belongs to class pyridine-derivatives, and the molecular formula is C9H13NO3S, SDS of cas: 21876-43-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Conejos-Sanchez, I.; Gallon, E.; Nino-Pariente, A.; Smith, J. A.; De la Fuente, A. G.; Di Canio, L.; Pluchino, S.; Franklin, R. J. M.; Vicent, M. J. published the artcile< Polyornithine-based polyplexes to boost effective gene silencing in CNS disorders>, Related Products of 2127-03-9, the main research area is polyornithine siRNA polyplex central nervous system disorder.

Gene silencing therapies have successfully suppressed the translation of target proteins, a strategy that holds great promise for the treatment of central nervous system (CNS) disorders. Advances in the current knowledge on multimol. delivery vehicles are concentrated on overcoming the difficulties in delivery of small interfering (si)RNA to target tissues, which include anatomical accessibility, slow diffusion, safety concerns, and the requirement for specific cell uptake within the unique environment of the CNS. The present work addressed these challenges through the implementation of polyornithine derivatives in the construction of polyplexes used as non-viral siRNA delivery vectors. Physicochem. and biol. characterization revealed biodegradability and biocompatibility of our polyornithine-based system and the ability to silence gene expression in primary oligodendrocyte progenitor cells (OPCs) effectively. In summary, the well-defined properties and neurol. compatibility of this polypeptide-based platform highlight its potential utility in the treatment of CNS disorders.

Nanoscale published new progress about Biocompatibility. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Related Products of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Al-Busaidi, Idris Juma; Ilmi, Rashid; Zhang, Danyang; Dutra, Jose D. L.; Oliveira, Willyan F.; Al Rasbi, Nawal K.; Zhou, Liang; Wong, Wai-Yeung; Raithby, Paul R.; Khan, Muhammad S. published the artcile< Synthesis and photophysical properties of ternary β-diketonate europium(III) complexes incorporating bipyridine and its derivatives>, COA of Formula: C10H8N2, the main research area is trifluoromethyl phenyl butanedione phenylethynyl bromo bipyridine europium preparation photophys; ternary beta diketonate europium bipyridine preparation photophys photoluminescence.

Two new octa-coordinated ternary europium(III) complexes of the type [Eu(btfa)3(Br2-bpy)] (Eu-1) and [Eu(btfa)3(PhE2-bpy)] (Eu-2) (where btfa = 4,4,4-trifluoro-1-phenyl-1,3-butanedione, Br2-bpy = 5,5′-dibromo-2,2′-bipyridine, PhE2-bpy 5,5′-bis(phenylethynyl)-2,2′-bipyridine) together with a previously reported complex [Eu(btfa)3(bpy)] (Eu-3) have been synthesized. The complexes have been characterized by anal. and spectroscopic methods. The photophys. properties of the complexes have also been analyzed both exptl. and theor. The contribution of each ligand to the sensitized Eu(III) photoluminescence (PL) has been analyzed and is discussed. An energy transfer (ET) mechanism is proposed and discussed for the sensitized Eu(III) emission using exptl. and theor. data. The Eu(III) complex incorporating the parent bpy showed impressive performance as a double-emitting layer (EML) red organic light emitting diodes (R-OLEDs).

Dyes and Pigments published new progress about Crystal structure. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, COA of Formula: C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Houlihan, Joanna C. C.; Moratti, Stephen C.; Hanton, Lyall R. published the artcile< Formation of a robust, double-walled LiMOF from an L-shaped di-substituted N-heterocyclic adamantane-based ligand>, Related Products of 93-60-7, the main research area is preparation lithium copper zinc heterocyclic adamantane complex; crystal structure lithium copper zinc heterocyclic adamantane complex; lithium copper zinc heterocyclic adamantane MOF.

The properties of adamantane render it an attractive building block towards the synthesis of robust frameworks. This work describes the synthesis of the L-shaped 1,3-bis(3′-carboxypyridine)adamantane (L1) ligand and the corresponding Li(I), Zn(II) and Cu(II) frameworks. Three topol. analogous Li(I) frameworks LiMOF12, LiMOF30 and LiMOF50 are reported, with calculated solvent accessible void volumes of 46, 43 and 36%, resp. The reaction between the carboxylate groups of L1 and the Li(I) cations gave Li-carboxylate rods. The Li-carboxylate rods contributed to the formation of a double-walled MOF with large, open one dimensional channels. The synergistic effect of the double wall, lithium-carboxylate rods and the adamantane core itself, gave a robust network stable up to temperatures of 300-350° and a min. of three months stability in air. Furthermore, complexation of L1 with Cu(BF4)2·H2O and Zn(CF3SO3)2 provided a 2D → 3D interpenetrated network containing a classic dimeric copper paddle-wheel SBU, and an infinite 1D chain which extended into a 3D structure facilitated by hydrogen-bonding interactions, resp.

Dalton Transactions published new progress about Crystal structure. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Related Products of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem