Month: October 2022

Demakov, Pavel A.; Ryadun, Alexey A.; Dorovatovskii, Pavel V.; Lazarenko, Vladimir A.; Samsonenko, Denis G.; Brylev, Konstantin A.; Fedin, Vladimir P.; Dybtsev, Danil N. published the artcile< Intense multi-colored luminescence in a series of rare-earth metal-organic frameworks with aliphatic linkers>, Application of C10H8N2, the main research area is rare metal organic framework aliphatic linker multicolored luminescence.

Two series of highly luminescent yttrium(III), europium(III) and terbium(III) metal-organic frameworks containing diimine aromatic ligands and the dicarboxylate linker trans-1,4-cyclohexanedicarboxylate (chdc2-) which can be described by the general formulas [M2(bpy)2(chdc)3], where M = Y3+ (1), Eu3+ (2), and Tb3+ (3) and bpy = 2,2′-bipyridyl, and [M2(phen)2(chdc)3], where M = Y3+ (4), Eu3+ (5), and Tb3+ (6) and phen = 1,10-phenanthroline, were synthesized and characterized. All compounds are based on the same dinuclear {M2(L)2(OOCR)6} building blocks and possess a similar topol. of the 3D framework with narrow pores. The chelate aromatic ligands act as efficient light-harvesting antennas for subsequent energy transfer to the emitting metal center (M = Eu3+, Tb3+) or intraligand photoemission (M = Y3+). As a result, the reported compounds display intense emission in the red (Eu3+), green (Tb3+) or blue (Y3+) regions representing three basic colors (RGB) of visible light. The measured quantum yields (QYs) of the solid-state luminescence for individual compounds were found to be 63% (1), 46% (2), 59% (3), 2.3% (4), 55% (5) and 49% (6). The drastic reduction of the luminescence efficiency for 4 is explained by the strong disorder of phen ligands. The high thermal stability (up to 300 °C) and exceptional moisture resistance of the bpy-based frameworks 1-3 were confirmed by TG and PXRD measurements. Various bimetal or trimetal compositions were also prepared for the bpy-series. The luminescence properties of these mixed-metal compounds depend on both the chem. composition and excitation wavelength (λex). Remarkably, pure white emission with color temperature = 6126 K was achieved for [Y1.68Eu0.08Tb0.24(bpy)2(chdc)3] at λex = 360 nm with QY = 20%. The reported results suggest that the obtained coordination framework series is a convenient platform for the design of highly efficient light emitting materials with tunable properties.

Dalton Transactions published new progress about Crystal structure. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jiao, Chen; Obst, Franziska; Geisler, Martin; Che, Yunjiao; Richter, Andreas; Appelhans, Dietmar; Gaitzsch, Jens; Voit, Brigitte published the artcile< Reversible Protein Capture and Release by Redox-Responsive Hydrogel in Microfluidics>, Product Details of C10H8N2S2, the main research area is protein capture redox responsive hydrogel microfluidics; disulfide bonds; hydrogels; mechanical properties; microfluidics; protein capture and release; redox-responsive; swelling behaviors.

Stimuli-responsive hydrogels have a wide range of potential applications in microfluidics, which has drawn great attention. Double crosslinked hydrogels are very well suited for this application as they offer both stability and the required responsive behavior. Here, we report the integration of poly(N-isopropylacrylamide) (PNiPAAm) hydrogel with a permanent crosslinker (N,N′-methylenebisacrylamide, BIS) and a redox responsive reversible crosslinker (N,N′-bis(acryloyl)cystamine, BAC) into a microfluidic device through photopolymerization Cleavage and re-formation of disulfide bonds introduced by BAC changed the crosslinking densities of the hydrogel dots, making them swell or shrink. Rheol. measurements allowed for selecting hydrogels that withstand long-term shear forces present in microfluidic devices under continuous flow. Once implemented, the thiol-disulfide exchange allowed the hydrogel dots to successfully capture and release the protein bovine serum albumin (BSA). BSA was labeled with rhodamine B and functionalized with 2-(2-pyridyldithio)-ethylamine (PDA) to introduce disulfide bonds. The reversible capture and release of the protein reached an efficiency of 83.6% in release rate and could be repeated over 3 cycles within the microfluidic device. These results demonstrate that our redox-responsive hydrogel dots enable the dynamic capture and release of various different functionalized (macro)mols. (e.g., proteins and drugs) and have a great potential to be integrated into a lab-on-a-chip device for detection and/or delivery.

Polymers (Basel, Switzerland) published new progress about Bovine serum albumin Role: PEP (Physical, Engineering or Chemical Process), PUR (Purification or Recovery), PROC (Process), PREP (Preparation) (rhodamine B and PDA-labeled). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Product Details of C10H8N2S2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kizu, Tomohito; Uraguchi, Daisuke; Ooi, Takashi published the artcile< Independence from the Sequence of Single-Electron Transfer of Photoredox Process in Redox-Neutral Asymmetric Bond-Forming Reaction>, Name: Ir(p-F-ppy)3, the main research area is enantioselective coupling arylaminomethane methanesulfonylaldimine iridium photosensitizer.

A catalytic cycle initiated by the oxidative quenching of the excited photosensitizer (Ir*(ppy)3) is established for the enantioselective coupling between (N-arylamino)methanes and (N-methanesulfonyl)aldimines catalyzed by Ir-based photosensitizer and a chiral (arylamino)phosphonium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate under visible light irradiation This achievement clearly demonstrates the insensitivity of this redox-neutral asym. reaction to the sequence of the key redox events involved in the synergistic catalysis.

Journal of Organic Chemistry published new progress about Aldimines Role: RCT (Reactant), RACT (Reactant or Reagent). 370878-69-6 belongs to class pyridine-derivatives, and the molecular formula is C33H21F3IrN3, Name: Ir(p-F-ppy)3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bonardd, Sebastian; Angel, Alejandro; Norambuena, Angel; Coll, Deysma; Tundidor-Camba, Alain; Ortiz, Pablo A. published the artcile< Novel polyelectrolytes obtained by direct alkylation and ion replacement of a new aromatic polyamide copolymer bearing pyridinyl pendant groups>, SDS of cas: 3731-53-1, the main research area is aromatic polyamide copolymer pyridinyl pendant bearing polyelectrolyte alkylation; polyamide; polyelectrolyte; pyridinyl groups; quaternisation.

The following work shows, for the first time, the synthesis and characterization of a new family of polyelectrolytes, along with their preliminary assessments in terms of desalin water treatment. These materials fall into the category of aromatic co-polyamides, which are obtained by the direct condensation of monomers 4,4′-oxydianiline (ODA), isophthaloyl chloride, and 3,5-diamino-N-(pyridin-4-ylmethyl)benzamide (PyMDA). Thereby, the charged nature exhibited by these materials was achieved through the quaternization of PyMDA moieties using linear iodoalkanes of different lengths (CnI with n = 1, 2, 4, and 6). After completing the quaternization process, polyelectrolytes were subjected to a one-step anion substitution process, where iodide counterions were replaced by bis(trifluoromethane)sulfonamide entities. For all the obtained materials, solubility tests were carried out, showing that those alkylated with Me and Et chains exhibit high solubility in rutinary aprotic polar solvents, while those containing Bu and n-hexyl units resulted in the formation of insoluble gels. Due to the above, the latest were discarded from this study early on. The structural characterization of the initial neutral co-polyamide was carried out by means of IR spectroscopy (FT-IR), NMR (1H, 13C-NMR), and size-exclusion chromatog. (SEC), while the structure of methylated and ethylated polyelectrolytes was successfully confirmed through FT-IR, 1H, 13C, and 19F-NMR. Addnl., the thermal behavior of these materials was analyzed in terms of thermogravimetric anal. (TGA) and differential scanning calorimetry (DSC), showing thermal degradation temperatures above 300°C and glass transition temperatures (Tg) above 200°C, resulting in polymers with outstanding thermal properties for water treatment applications. On the other hand, through the solvent-casting method, both neutral and charged polymers were found to be easily prepared into films, exhibiting a remarkably flexibility. The mech. properties of the films were analyzed using the traction test, from which tensile strength values ranging between 83.5 and 87.9 Mpa, along with Young’s modulus values between 2.4 and 2.5 Gpa were obtained. Moreover, through contact angle measurements and absorption anal. by immersion, polyelectrolytes showed important changes in terms of affinity against polar and polar substances (water, n-heptane, and benzene), exhibiting a higher rejection regarding the neutral polymer. Finally, as a preliminary test against the seepage of saline waters, thin polymer films (from 11.4 to 17.1μm) were deposited on top of com. filter disks and tested as filters of saline solutions ([NaCl] = 1000 and 2000 ppm). These tests revealed a decrease of the salt concentration in the obtained filtrates, with retention values ranging between 6.2 and 20.3%, depending on the concentration of the former solution and the polymer used.

Polymers (Basel, Switzerland) published new progress about Absorption. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, SDS of cas: 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bregman, Howard; Simard, Jeffrey R.; Andrews, Kristin L.; Ayube, Shawn; Chen, Hao; Gunaydin, Hakan; Guzman-Perez, Angel; Hu, Jiali; Huang, Liyue; Huang, Xin; Krolikowski, Paul H.; Lehto, Sonya G.; Lewis, Richard T.; Michelsen, Klaus; Pegman, Pamela; Plant, Matthew H.; Shaffer, Paul L.; Teffera, Yohannes; Yi, Shuyan; Zhang, Maosheng; Gingras, Jacinthe; DiMauro, Erin F. published the artcile< The Discovery and Hit-to-Lead Optimization of Tricyclic Sulfonamides as Potent and Efficacious Potentiators of Glycine Receptors>, HPLC of Formula: 55279-29-3, the main research area is sulfonamide glycine receptor analgesic pain.

Current pain therapeutics suffer from undesirable psychotropic and sedative side-effects, as well as abuse potential. Glycine receptors (GlyRs) are inhibitory ligand-gated ion channels expressed in nerves of the spinal dorsal horn, where their activation is believed to reduce transmission of painful stimuli. Herein, the authors describe the identification and hit-to-lead optimization of a novel class of tricyclic sulfonamides as allosteric GlyR potentiators. Initial optimization of high-throughput screening (HTS) hit led to the identification of a compound, which demonstrated ex vivo potentiation of glycine-activated current in mouse dorsal horn neurons from spinal cord slices. Further improvement of potency and pharmacokinetics produced in vivo proof-of-concept tool mol. I (AM-1488) which reversed tactile allodynia in a mouse spared-nerve injury (SNI) model. Addnl. structural optimization provided highly potent potentiator II (AM-3607), which was cocrystd. with human GlyRα3cryst to afford the first described potentiator-bound x-ray cocrystal structure within this class of ligand-gated ion channels (LGICs).

Journal of Medicinal Chemistry published new progress about Analgesics. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, HPLC of Formula: 55279-29-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cheda, Aneta; Nowosielska, Ewa M.; Gebicki, Jerzy; Marcinek, Andrzej; Chlopicki, Stefan; Janiak, Marek K. published the artcile< A derivative of vitamin B3 applied several days after exposure reduces lethality of severely irradiated mice>, Reference of 350-03-8, the main research area is vitamin B3 lethality anti inflammatory agent.

Most, if not all, of the hitherto tested substances exert more or less pronounced pro-survival effects when applied before or immediately after the exposure to high doses of ionizing radiation. In the present study we demonstrate for the first time that 1-Me nicotinamide (MNA), a derivative of vitamin B3, significantly (1.6 to 1.9 times) prolonged survival of BALB/c mice irradiated at LD30/30 (6.5 Gy), LD50/30 (7.0 Gy) or LD80/30 (7.5 Gy) of γ-rays when the MNA administration started as late as 7 days post irradiation A slightly less efficient and only after the highest dose (7.5 Gy) of γ-rays was another vitamin B3 derivative, 1-methyl-3-acetylpyridine (1,3-MAP) (1.4-fold prolonged survival). These pro-survival effects did not seem to be mediated by stimulation of haematopoiesis, but might be related to anti-inflammatory and/or anti-thrombotic properties of the vitamin B3 derivatives Our results show that MNA may represent a prototype of a radioremedial agent capable of mitigating the severity and/or progression of radiation-induced injuries when applied several hours or days after exposure to high doses of ionizing radiation.

Scientific Reports published new progress about Anti-inflammatory agents. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Reference of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem