Month: October 2022

Clarke, Coby J.; Morgan, Patrick J.; Hallett, Jason P.; Licence, Peter published an article in 2021. The article was titled 《Linking the the Thermal and Electronic Properties of Functional Dicationic Salts with their Molecular Structures》, and you may find the article in ACS Sustainable Chemistry & Engineering.HPLC of Formula: 626-05-1 The information in the text is summarized as follows:

The two major properties that underpin ionic liquids are tunability and the potential to create task-specific media. Together, these properties allow ionic liquids to surpass the roles long held by traditional mol. solvents. However, at elevated temperatures or under prolonged heating, the structural components that impart such properties decompose or degrade. Dicationic pyridine salts present new opportunities to extend functionality and tunability to high temperatures because they are coordinating and thermally robust. In this work, we present three structurally related series of dicationic pyridine salts, which have been characterized by a wide array of techniques to link thermal and electronic properties to structural variation. The phase transitions and thermal stabilities of the salts were significantly influenced by small structural changes, and several new candidates for high-temperature-based applications were identified. The electron d., and therefore the electron donating ability, of the pyridine functional group could also be controlled by structural variation of cations and anions. Therefore, dicationic pyridine salts are highly tunable choices for task-specific solvents at elevated temperatures Importantly, thermally robust solvents not only extend operational ranges but also reduce the need to replace or replenish solvents that degrade over time at temperatures commonly employed in industrial settings (i.e., 150-200°C); solvent lifetimes are extended, and production is reduced. This is a critical requirement for complex media such as ionic liquids, which have high economic and environmental production costs. The results came from multiple reactions, including the reaction of 2,6-Dibromopyridine(cas: 626-05-1HPLC of Formula: 626-05-1)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.HPLC of Formula: 626-05-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Matern, Jonas; Baeumer, Nils; Fernandez, Gustavo published an article in 2021. The article was titled 《Unraveling Halogen Effects in Supramolecular Polymerization》, and you may find the article in Journal of the American Chemical Society.SDS of cas: 2510-22-7 The information in the text is summarized as follows:

Halogens play a crucial role in numerous natural processes and synthetic materials due to their unique physicochem. properties and the diverse interactions they can engage in. In the field of supramol. polymerization, however, halogen effects remain poorly understood, and investigations were restricted to halogen bonding or the inclusion of polyfluorinated side groups. Recent contributions from our group revealed that chlorine ligands greatly influence mol. packing and pathway complexity phenomena of various metal complexes. These results prompted us to explore the role of the halogen nature on supramol. polymerization, a phenomenon that remained unexplored to date. To address this issue, the authors designed a series of archetypal bispyridyldihalogen PtII complexes bearing chlorine (1), bromine (2), or iodine (3) and systematically compared their supramol. polymerization in nonpolar media using various exptl. methods and theory. The studies reveal a remarkably different supramol. polymerization for the three compounds, which can undergo two competing pathways with either slipped (kinetic) or parallel (thermodn.) mol. packing. The halogen exerts an inverse effect on the energetic levels of the two self-assembled states, resulting in a single thermodn. pathway for 3, a transient kinetic species for 2, and a hidden thermodn. state for 1. This seesaw-like bias of the energy landscape can be traced back to the involvement of the halogens in weak N-H···X hydrogen-bonding interactions in the kinetic pathway, whereas in the thermodn. pathway the halogens are not engaged in the stabilizing interaction motif but rather amplify solvophobic effects. After reading the article, we found that the author used 4-Ethynylpyridine(cas: 2510-22-7SDS of cas: 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. SDS of cas: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Konda, Yesuraju; Ankireddy, Ashok Reddy; Velavalapalli, Vani Madhuri; Paidikondala, Kalyani; Pasula, Aparna; Gundla, Rambabu published an article in Russian Journal of General Chemistry. The title of the article was 《Synthesis, Alpha-Glucosidase Inhibition and Antibacterial Activities of the New Chiral (R)-3,3′-Disubstituted BINOL-Phosphates》.SDS of cas: 197958-29-5 The author mentioned the following in the article:

A new class of 3,3′-disubstituted chiral (R)-BINOL-derived phosphoric acid derivatives has been prepared The synthetic method has been optimized by involving Pd/C as a catalyst in the Suzuki-Miyaura cross coupling using a non-protected BINOL derivative The target compounds have been characterized and tested for their α-glucosidase inhibitory and antibacterial activities.2-Pyridinylboronic acid(cas: 197958-29-5SDS of cas: 197958-29-5) was used in this study.

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.SDS of cas: 197958-29-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Komaba, Kyoka; Nimori, Shigeki; Miyashita, Ryo; Kumai, Reiji; Goto, Hiromasa published an article in Polymer-Plastics Technology and Materials. The title of the article was 《Hydroxypropyl cellulose/poly(aniline-co-pyridine-oxyl) as a liquid crystal polymer/polyradical blend with helical magnetic structure》.Computed Properties of C5H7N3 The author mentioned the following in the article:

A helical magnetic polymer was synthesized by blending a polyradical and hydroxypropyl cellulose (HPC), which is a helical liquid crystal. First, achiral m-linked poly(aniline-co-pyridine) was synthesized via Buchwald-Hartwig coupling, and poly(aniline-co-pyridine-oxyl) as a linear polyradical was then prepared by Tokumaru method. Helicity was induced in the linear polyradical simply by blending with HPC as a helical cholesteric liquid crystal. The magnetic properties of the polyradical and the HPC/polyradical blend composite were evaluated by performing ESR, superconducting quantum interference device, and vibrating sample magnetometer measurements, which revealed that the linear polyradical shows diamagnetism up to 5 K and the polymer bend exhibits weak diamagnetism at high temperature and paramagnetism at low temperature2,6-Diaminopyridine(cas: 141-86-6Computed Properties of C5H7N3) was used in this study.

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Computed Properties of C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formula: C7H5NIn 2020 ,《Double Rotors with Fluxional Axles: Domino Rotation and Azide-Alkyne Huisgen Cycloaddition Catalysis》 appeared in Angewandte Chemie, International Edition. The author of the article were Goswami, Abir; Schmittel, Michael. The article conveys some information:

The simple preparation of the multicomponent devices [Cu4(A)2]4+ and [Cu2(A)(B)]2+, both rotors with fluxional axles undergoing domino rotation, highlights the potential of self-sorting. The concept of domino rotation requires the interconversion of axle and rotator, allowing the spatiotemporal decoupling of two degenerate exchange processes in [Cu4(A)2]4+ occurring at 142 kHz. Addition of two equiv of B to rotor [Cu4(A)2]4+ afforded the heteromeric two-axle rotor [Cu2(A)(B)]2+ with two distinct exchange processes (64.0 kHz and 0.55 Hz). The motion requiring a pyridine→zinc porphyrin bond cleavage is 1.2 × 105 times faster than that operating via a terpyridine→[Cu(phenAr2)]+ rupture. Finally, both rotors are catalysts due to their copper(I) content. The fast domino rotor (142 kHz) was shown to suppress product inhibition in the catalysis of the azide-alkyne Huisgen cycloaddition The experimental part of the paper was very detailed, including the reaction process of 4-Ethynylpyridine(cas: 2510-22-7Formula: C7H5N)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Formula: C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 4,4′-Dimethyl-2,2′-bipyridineIn 2019 ,《Dehydrogenative Synthesis of 2,2′-Bipyridyls through Regioselective Pyridine Dimerization》 appeared in Angewandte Chemie, International Edition. The author of the article were Yamada, Shuya; Kaneda, Takeshi; Steib, Philip; Murakami, Kei; Itami, Kenichiro. The article conveys some information:

2,2′-Bipyridyls have been utilized as indispensable ligands in metal-catalyzed reactions. The most streamlined approach for the synthesis of 2,2′-bipyridyls is the dehydrogenative dimerization of unfunctionalized pyridine. Herein, we report on the palladium-catalyzed dehydrogenative synthesis of 2,2′-bipyridyl derivatives The Pd catalysis effectively works with an AgI salt as the oxidant in the presence of pivalic acid. A variety of pyridines regioselectively react at the C2-positions. This dimerization method is applicable for challenging substrates such as sterically hindered 3-substituted pyridines, where the pyridines regioselectively react at the C2-position. This reaction enables the concise synthesis of twisted 3,3′-disubstituted-2,2′-bipyridyls as an underdeveloped class of ligands. In addition to this study using 4,4′-Dimethyl-2,2′-bipyridine, there are many other studies that have used 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Safety of 4,4′-Dimethyl-2,2′-bipyridine) was used in this study.

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Safety of 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Computed Properties of C6H6BrNIn 2022 ,《Anion-Directed Regulation of Structures and Luminescence of Heterometallic Clusters》 appeared in Angewandte Chemie, International Edition. The author of the article were Li, Jiao-Jiao; Liu, Chun-Yu; Guan, Zong-Jie; Lei, Zhen; Wang, Quan-Ming. The article conveys some information:

Anions have been used to regulate the structures and luminescence of heterometallic clusters. Introducing ClO4- into orange-emissive, butterfly-like [(C)(Au-PPhpy2)6Ag4](BF4)6 (1, PPhpy2 = bis(2-pyridyl)phenylphosphine) leads to the formation of red-emissive [(C)(Au-PPhpy2)6Ag5(ClO4)3](ClO4)4 (2) with a novel trigonal bipyramidal structure; employing PhCO2- gives yellow-emissive, hexagram-like [(C)(Au-PPhpy2)6Ag6(PhCO2)3](BF4)5 (3). Notably, 1 exhibits weak luminescence in CH2Cl2/CH3OH = 1 : 1 (v : v) with a quantum yield (QY) of 0.05, whereas it was dramatically increased to 0.49 and 0.83 for 2 and 3, resp. Theor. calculation confirms that the involvement of anions in the electronic structures is responsible for the shifts of emission. The high QYs of 2 and 3 are attributed to the protection provided by ligands and anions. This work demonstrates that anions may serve as an extra designable factor beyond just counterions for functional metal clusters. In the experiment, the researchers used many compounds, for example, 2-Bromo-5-methylpyridine(cas: 3510-66-5Computed Properties of C6H6BrN)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Computed Properties of C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 4-AcetylpyridineIn 2019 ,《Synthesis, molecular structure and multiple biological activities of N-(3-methoxyphenyl)-3-(pyridin-4-yl)-1H-pyrazole-5-carboxamide》 appeared in Journal of Molecular Structure. The author of the article were Nithyabalaji, Rajendran; Krishnan, Hariharasubramanian; Sribalan, Rajendran. The article conveys some information:

A new mol. of pyridylpyrazole amide (PPA) was successfully synthesized. The UV-Vis spectral absorption and IR frequencies were theor. calculated and compared with observed results. The in vitro biol. applications like anti-inflammatory, antioxidant and antidiabetic activities were performed. The synthesized compound exhibited admirable anti-inflammatory activity and antidiabetic, worthy antioxidant activities than standards The interactions between enzyme-ligand were identified with α-amylase (1HNY.pdb) using the autodock tool. Further potential energy scan, fukui function and mol. electrostatic potential (MEP) were performed using DFT methods. Finally, in silico pharmacol. studies like ADME were implemented for PPA. In addition to this study using 4-Acetylpyridine, there are many other studies that have used 4-Acetylpyridine(cas: 1122-54-9Recommanded Product: 4-Acetylpyridine) was used in this study.

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Recommanded Product: 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formula: C5H5BrN2In 2019 ,《Identification of novel quinazoline derivatives as potent antiplasmodial agents》 appeared in European Journal of Medicinal Chemistry. The author of the article were Bouchut, Anne; Rotili, Dante; Pierrot, Christine; Valente, Sergio; Lafitte, Sophia; Schultz, Johan; Hoglund, Urban; Mazzone, Roberta; Lucidi, Alessia; Fabrizi, Giancarlo; Pechalrieu, Dany; Arimondo, Paola B.; Skinner-Adams, Tina S.; Chua, Ming Jang; Andrews, Kathy T.; Mai, Antonello; Khalife, Jamal. The article conveys some information:

Despite the recent reductions in the global burden of malaria, this disease remains a devastating cause of death in tropical and subtropical regions. As there is no broadly effective vaccine for malaria, prevention and treatment still rely on chemotherapy. Unfortunately, emerging resistance to the gold standard artemisinin combination therapies means that new drugs with novel modes of action are urgently needed. In this context, Plasmodium histone modifying enzymes have emerged as potential drug targets, prompting us to develop and optimize compounds directed against such epigenetic targets. A panel of 51 compounds designed to target different epigenetic enzymes were screened for activity against Plasmodium falciparum parasites. Based on in vitro activity against drug susceptible and drug-resistant P. falciparum lines, selectivity index criterion and favorable pharmacokinetic properties, four compounds, one HDAC inhibitor (1) and three DNMT inhibitors (37, 43 and 45), were selected for preclin. studies in a mouse model of malaria. In vivo data showed that 37, 43 and 45 exhibited oral efficacy in the mouse model of Plasmodium berghei infection. These compounds represent promising starting points for the development of novel antimalarial drugs. In the part of experimental materials, we found many familiar compounds, such as 6-Bromopyridin-3-amine(cas: 13534-97-9Formula: C5H5BrN2)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Formula: C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 29682-15-3In 2018 ,《Selectivity in the Intermolecular Diels-Alder Reaction of Conjugated Trienes: Experimental and Theoretical Approaches》 appeared in European Journal of Organic Chemistry. The author of the article were Remeur, Camille; Desrat, Sandy; Gandon, Vincent; Roussi, Fanny. The article conveys some information:

Eleven analogs of the natural product meiogynin A, an inhibitor of proteins of the Bcl-2 family, have been elaborated by an intermol. Diels-Alder (DA) reaction of various conjugated chloro-trienes, in order to determine the influence of the modification of the south part of meiogynin A on its biol. activity. The chloro-trienes were obtained in two to five steps from com. compounds through a selective hydrochlorination of bromoalkyne intermediates to (Z)-1,2-dihalogenated alkenes followed by a chemoselective Suzuki-Miyaura cross-coupling. The intermol. DA reaction of these trienes with two α,β-unsaturated carboxylic acids as dienophiles occurred with a perfect regioselectivity and good to excellent diastereoselectivities [e.g., I + II → III (87%, endo/exo 85:15)]. These selectivities could be rationalized by DFT calculationsMethyl 5-bromopicolinate(cas: 29682-15-3HPLC of Formula: 29682-15-3) was used in this study.

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. HPLC of Formula: 29682-15-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem