Month: October 2022

Jia, Meng-Ze; Cui, Jing-Wang; Rao, Cai-Hui; Chen, Yun-Rui; Yao, Xin-Rong; Zhang, Jie published an article in ACS Sustainable Chemistry & Engineering. The title of the article was 《Switchable ROS Species Regulation Facilitates the Selective Oxidation of Benzyl Alcohols Enabled by an Organic Photocatalyst》.Name: 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine The author mentioned the following in the article:

Benefiting from the regulation of ROS species through a simple and feasible strategy, an efficient and switchable photocatalytic protocol for the chemoselective synthesis of aldehydes and carboxylic acids via oxidation of primary alcs. under mild conditions was developed. Using the pyridinium derivative as a metal-free organic photocatalyst, a variety of benzyl alcs. can be converted into aldehydes or carboxylic acids under an air atm. at room temperature with high selectivity and yield via simple solvent regulation. A feasible tandem reaction combining the pyridinium-catalyzed alc.-to-aldehyde conversion and catalyst-free photoinduced oxidation of aromatic aldehydes provides a powerful and efficient approach for the one-pot oxidation of benzyl alcs. to carboxylic acids, while a small amount of water can effectively regulate the competition of electron transfer and energy transfer and inhibit the generation of carboxylic acids, facilitating highly efficient and selective oxidation of alcs. to aldehydes. In the experimental materials used by the author, we found 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3Name: 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine)

4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Name: 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kumar, Mopidevi Manikanta; Raj, C. Retna published an article on February 22 ,2019. The article was titled 《Carbothermal-Reduction-Assisted Phosphidation of Cobalt Affords Mesoporous Nitrogen-Doped Carbon-Embedded CoP Nanoelectrocatalysts for the Oxygen Reduction Reaction》, and you may find the article in ACS Applied Nano Materials.Computed Properties of C20H14N4 The information in the text is summarized as follows:

We demonstrate a new facile single-step synthesis of mesoporous nitrogen-doped carbon-embedded cobalt phosphide (NC-CoP) nanoparticles using a single-source precursor of the cobalt(II) bis(terpyridine)-based complex ([Co(pyterpy)2](PF6)2) by carbothermal reduction Phosphidation of cobalt is achieved with the hexafluorophosphate counteranion of the precursor complex for the first time. Polypyridyl complexes such as [Co(bpy)3](PF6)2 and [Co(terpy)2](PF6)2 do not yield the desired CoP. The at. percent of carbon in the precursor complex controls the growth of CoP. The as-synthesized NC-CoP has a large surface area of 120 m2/g and shows excellent electrocatalytic activity toward the oxygen reduction reaction (ORR). It is highly durable and favors the four-electron pathway for the reduction of oxygen to water at low overpotential. The synergistic effect between NC and CoP facilitates the electron-transfer kinetics for ORR. In addition to this study using 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine, there are many other studies that have used 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3Computed Properties of C20H14N4) was used in this study.

4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Computed Properties of C20H14N4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Luo, Dexia; Guo, Shengxin; He, Feng; Chen, Shunhong; Dai, Ali; Zhang, Renfeng; Wu, Jian published an article in Journal of Agricultural and Food Chemistry. The title of the article was 《Design, Synthesis, and Bioactivity of α-Ketoamide Derivatives Bearing a Vanillin Skeleton for Crop Diseases》.Safety of 4-Amino-2-picoline The author mentioned the following in the article:

A series of novel α-ketoamide derivatives bearing a vanillin skeleton were designed and synthesized. Bioactivity tests on virus and bacteria were performed. The results indicated that some compounds exhibited excellent antitobacco mosaic virus (TMV) activities, such as compound I exhibited an inactivation activity of 90.1% and curative activity of 51.8% and compound II exhibited a curative activity of 54.8% at 500μg mL-1, which is equivalent to that of the com. ningnanmycin (inactivation of 91.9% and curative of 51.9%). Moreover, the in vitro antibacterial activity test illustrated that compounds showed much higher activities than com. thiodiazole copper, which could be used as lead compounds or potential candidates. The findings of transmission electron microscopy and mol. docking indicated that the synthesized compounds exhibited strong and significant binding affinity to the TMV coat protein and could obstruct the self-assembly and increment of TMV particles. This study revealed that α-ketoamide derivatives bearing a vanillin skeleton could be used as a novel potential pesticide for controlling the plant diseases. In the part of experimental materials, we found many familiar compounds, such as 4-Amino-2-picoline(cas: 18437-58-6Safety of 4-Amino-2-picoline)

4-Amino-2-picoline(cas: 18437-58-6) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Safety of 4-Amino-2-picoline

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wu, Jing-wei; Yin, Ling; Liu, Yu-qiang; Zhang, Huan; Xie, Ya-fei; Wang, Run-ling; Zhao, Gui-long published an article on February 1 ,2019. The article was titled 《Synthesis, biological evaluation and 3D-QSAR studies of 1,2,4-triazole-5-substituted carboxylic acid bioisosteres as uric acid transporter 1 (URAT1) inhibitors for the treatment of hyperuricemia associated with gout》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.HPLC of Formula: 39856-58-1 The information in the text is summarized as follows:

Bromonaphthylmethyltriazolyl thioether lesinurad analogs and bioisosteres such as I were prepared as inhibitors of uric acid transporter 1 (URAT1) for potential use in treating hyperuricemia and gout. I inhibited URAT1 with an IC50 value of 32 nM, 225-fold lower than lesinurad. The pharmacophore for the lesinurad analogs was determined using a 3D-QSAR pharmacophore model; the hypothesis was validated by three methods (cost anal., Fisher’s randomization and leave-one-out). In addition to this study using 2-Bromopyridin-3-amine, there are many other studies that have used 2-Bromopyridin-3-amine(cas: 39856-58-1HPLC of Formula: 39856-58-1) was used in this study.

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).HPLC of Formula: 39856-58-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2011,Liu, Jingying; Zhu, Lin; Ploessl, Karl; Lieberman, Brian P.; Kung, Hank F. published 《Synthesis and evaluation of novel N-fluoropyridyl derivatives of tropane as potential PET imaging agents for the dopamine transporter》.Bioorganic & Medicinal Chemistry Letters published the findings.Product Details of 13534-97-9 The information in the text is summarized as follows:

A series of novel N-fluoropyridyl-containing tropane derivatives, e.g., I, were synthesized and their binding affinities for the dopamine transporter (DAT), serotonin transporter (SERT) and norepinephrine (NET) were determined via competitive radioligand binding assays. Among these derivatives, compound I showed the highest binding affinity to DAT (Ki = 4.1 nM), and selectivity for DAT over SERT (5-fold) and NET (16-fold). Compound I was radiolabeled with Fluorine-18 in two steps. Regional brain distribution and ex vivo autoradiog. studies of [18F]I demonstrated that the ligand was selectively localized in the striatum region, where DAT binding sites are highly expressed. [18F]I may be useful as a potential radioligand for imaging DATs with PET. The experimental part of the paper was very detailed, including the reaction process of 6-Bromopyridin-3-amine(cas: 13534-97-9Product Details of 13534-97-9)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Product Details of 13534-97-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2013,Dai, Jian-Jun; Fang, Chi; Xiao, Bin; Yi, Jun; Xu, Jun; Liu, Zhao-Jing; Lu, Xi; Liu, Lei; Fu, Yao published 《Copper-Promoted Sandmeyer Trifluoromethylation Reaction》.Journal of the American Chemical Society published the findings.Category: pyridine-derivatives The information in the text is summarized as follows:

A copper-promoted trifluoromethylation reaction of aromatic amines is described. This transformation proceeds smoothly under mild conditions and exhibits good tolerance of many synthetically relevant functional groups. It provides an alternative approach for the synthesis of trifluoromethylated arenes and heteroarenes. It also constitutes a new example of the Sandmeyer reaction. The experimental part of the paper was very detailed, including the reaction process of 6-Bromopyridin-3-amine(cas: 13534-97-9Category: pyridine-derivatives)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2015,Mou, Jianfeng; Park, Ann; Cai, Yu; Yuan, Junying; Yuan, Chengye published 《Structure-activity relationship study of E6 as a novel necroptosis inducer》.Bioorganic & Medicinal Chemistry Letters published the findings.Reference of 6-Bromopyridin-3-amine The information in the text is summarized as follows:

Necroptosis inducers represent a promising potential treatment for drug-resistant cancer. We herein describe the structure modification of E6, which was identified recently as a potent and selective necroptosis inducer. The studies described herein demonstrate for the first time that functionalized biphenyl derivatives possess necroptosis inducer activity. Furthermore, these studies have led to the identification of two promising compounds (I; R = 4-OMe, R = 4-OEt) that can be used for further optimization studies as well as mechanism of action investigations. The experimental process involved the reaction of 6-Bromopyridin-3-amine(cas: 13534-97-9Reference of 6-Bromopyridin-3-amine)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Reference of 6-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Garcia-Carceles, Javier; Decara, Juan M.; Vazquez-Villa, Henar; Rodriguez, Ramon; Codesido, Eva; Cruces, Jacobo; Brea, Jose; Loza, Maria I.; Alen, Francisco; Botta, Joaquin; McCormick, Peter J.; Ballesteros, Juan A.; Benhamu, Bellinda; Rodriguez de Fonseca, Fernando; Lopez-Rodriguez, Maria L. published 《A Positive Allosteric Modulator of the Serotonin 5-HT2C Receptor for Obesity》.Journal of Medicinal Chemistry published the findings.Formula: C6H7Br2N The information in the text is summarized as follows:

The 5-HT2CR agonist lorcaserin, clin. approved for the treatment of obesity, causes important side effects mainly related to subtype selectivity. In the search for 5-HT2CR allosteric modulators as safer antiobesity drugs, a chem. library from Vivia Biotech was screened using ExviTech platform. Structural modifications of identified hit VA240 in synthesized analogs 6-41 afforded compound 11 (N-[(1-benzyl-1H-indol-3-yl)methyl]pyridin-3-amine, VA012), which exhibited dose-dependent enhancement of serotonin efficacy, no significant off-target activities, and low binding competition with serotonin or other orthosteric ligands. PAM 11 was very active in feeding inhibition in rodents, an effect that was not related to the activation of 5-HT2AR. A combination of 11 with the SSRI sertraline increased the anorectic effect. Subchronic administration of 11 reduced food intake and body weight gain without causing CNS-related malaise. The behavior of compound 11 identified in this work supports the interest of a serotonin 5-HT2CR PAM as a promising therapeutic approach for obesity. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Formula: C6H7Br2N)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Formula: C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Silvi, Mattia; Sandford, Christopher; Aggarwal, Varinder K. published 《Merging Photoredox with 1,2-Metallate Rearrangements: The Photochemical Alkylation of Vinyl Boronate Complexes》.Journal of the American Chemical Society published the findings.Electric Literature of C5H3BrClN The information in the text is summarized as follows:

Vinyl boronates react with electron-deficient alkyl iodides in the presence of visible light to give boronic esters in which two new C-C bonds were created. The reaction occurs by radical addition of an electron-deficient alkyl radical to the vinyl boronate followed by electron transfer with another mol. of alkyl iodide, continuing the chain, and triggering a 1,2-metalate rearrangement. In a number of cases, the use of a photoredox catalyst enhances yields significantly. The scope of the radical precursor includes α-iodo ketones, esters, nitriles, primary amides, α-fluorinated halo-acetates and perfluoroalkyl iodides. In the experiment, the researchers used 5-Bromo-2-chloropyridine(cas: 53939-30-3Electric Literature of C5H3BrClN)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Electric Literature of C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Journal of the American Chemical Society included an article by Tanaka, Keita; Ewing, William R.; Yu, Jin-Quan. Synthetic Route of C6H7Br2N. The article was titled 《Hemilabile Benzyl Ether Enables γ-C(sp3)-H Carbonylation and Olefination of Alcohols》. The information in the text is summarized as follows:

Pd-catalyzed C(sp3)-H activation of alc. typically shows β-selectivity due to the required distance between the chelating atom in the attached directing group and the targeted C-H bonds. Herein the authors report the design of a hemilabile directing group which exploits the chelation of a readily removable benzyl ether moiety to direct γ- or δ-C-H carbonylation and olefination of alcs. The utility of this approach is also demonstrated in the late-stage C-H functionalization of β-estradiol to rapidly prepare desired analogs that required multi-step syntheses with classical methods. In addition to this study using 2-(Bromomethyl)pyridine hydrobromide, there are many other studies that have used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Synthetic Route of C6H7Br2N) was used in this study.

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Synthetic Route of C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem