Month: October 2022

In 2019,Photochemical & Photobiological Sciences included an article by Kumar, Girijesh; Guda, Ramu; Husain, Ahmad; Patra, Ranjan; Kirandeep; Kasula, Mamatha. Reference of 4-Cyanopyridine. The article was titled 《Synthesis and photophysical properties of pyridyl conjugated triazole appended naphthalenediimide derivatives》. The information in the text is summarized as follows:

A series of three substituted triazole appended naphthalenediimide (NDI)-derivatives, 2,7-bis(3,5-di(pyridin-X-yl)-4H-1,2,4-triazol-4-yl)benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetraones (where X = 2, NDI-PyTz-1; 3, NDI-PyTz-2; and 4, NDI-PyTz-3), were designed, synthesized and well characterized using various anal. and spectroscopic techniques. All the three NDI-PyTz derivatives exhibited decent electronic properties as suggested by DFT, cyclic voltammetry and fluorescence studies. In particular, NDI-PyTz-1 demonstrated the generation of a stable anion radical [NDI-PyTz-1].-. In the part of experimental materials, we found many familiar compounds, such as 4-Cyanopyridine(cas: 100-48-1Reference of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Reference of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,European Journal of Medicinal Chemistry included an article by Moir, Michael; Lane, Samuel; Lai, Felcia; Connor, Mark; Hibbs, David E.; Kassiou, Michael. Related Products of 128071-75-0. The article was titled 《Strategies to develop selective CB2 receptor agonists from indole carboxamide synthetic cannabinoids》. The information in the text is summarized as follows:

Activation of the CB2 receptor is an attractive therapeutic strategy for the treatment of a wide range of inflammatory diseases. However, receptor subtype selectivity is necessary in order to circumvent the psychoactive effects associated with activation of the CB1 receptor. We aimed to use potent, non-selective synthetic cannabinoids designer drugs to develop selective CB2 receptor agonists. Simple structural modifications such as moving the amide substituent of 3-amidoalkylindole synthetic cannabinoids to the 2-position and bioisosteric replacement of the indole core to the 7-azaindole scaffold are shown to be effective and general strategies to impart receptor subtype selectivity. 2-Amidoalkylindole 16 (EC50 CB1 > 10 μM, EC50 CB2 = 189 nM) and 3-amidoalkyl-7-azaindole 21 (EC50 CB1 > 10 μM, EC50 = 49 nM) were found to be potent and selective agonists with favorable physicochem. properties. Docking studies were used to elucidate the mol. basis for the observed receptor subtype selectivity for these compounds The experimental part of the paper was very detailed, including the reaction process of 2-Bromonicotinaldehyde(cas: 128071-75-0Related Products of 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Related Products of 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Angewandte Chemie, International Edition included an article by Yang, Zhongming; Zhao, Weijia; Liu, Wei; Wei, Xing; Chen, Meng; Zhang, Xiao; Zhang, Xiaolei; Liang, Yong; Lu, Changsheng; Yan, Hong. Computed Properties of C7H9NO. The article was titled 《Metal-Free Oxidative B-N Coupling of nido-Carborane with N-Heterocycles》. The information in the text is summarized as follows:

A general method for the oxidative substitution of nido-carborane (7,8-C2B9H12-) with N-heterocycles has been developed by using 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) as an oxidant, producing 9-Het-7,8-R2-7,8-dicarbaundecaboranes(11) [Het = pyridine, (iso)quinoline, (benz)imidazole, (benzo)thiazole, oxazole, pyrazole, pyrimidine 6-azaindole; R = Ph, H, Me, tBu, RR = CH2CH:CHCH2]. This metal-free B-N coupling strategy, in both inter- and intramol. fashions, gave rise to a wide array of charge-compensated, boron-substituted nido-carboranes in high yields (up to 97%) with excellent functional-group tolerance under mild reaction conditions. The reaction mechanism was investigated by d.-functional theory (DFT) calculations A successive single-electron transfer (SET), B-H hydrogen-atom transfer (HAT), and nucleophilic attack pathway is proposed. This method provides a new approach to nitrogen-containing carboranes with potential applications in medicine and materials. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Computed Properties of C7H9NO)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Computed Properties of C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Organic & Biomolecular Chemistry included an article by Satpathi, Bishnupada; Dutta, Lona; Ramasastry, S. S. V.. Recommanded Product: 2-Bromonicotinaldehyde. The article was titled 《Phosphine- and water-promoted pentannulative aldol reaction》. The information in the text is summarized as follows:

An efficient metal-free intramol. aldol reaction for the synthesis of an unusual class of cyclopentanoids was described. The reaction of α-substituted dienones tethered with ketones in the presence of tributylphosphine and water provided aldols. The role of water was realized to be crucial for this transformation. Furthermore, isotopic labeling experiments provided vital information about the reaction mechanism. In the experiment, the researchers used 2-Bromonicotinaldehyde(cas: 128071-75-0Recommanded Product: 2-Bromonicotinaldehyde)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Recommanded Product: 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Ultrafast photodynamics of an azopyridine-functionalized iron(II) complex: implications for the concept of ligand-driven light-induced spin change》 were Megow, Sebastian; Fitschen, Henrike-Leonie; Tuczek, Felix; Temps, Friedrich. And the article was published in Journal of Physical Chemistry Letters in 2019. Synthetic Route of C6H7Br2N The author mentioned the following in the article:

We report on the ultrafast photodynamics of an iron(II) complex with a photoisomerizable pentadentate azo-tetrapyridylamino ligand after irradiation with UV light. The results of femtosecond transient electronic absorption spectroscopy performed on the low-spin (LS) form of the title complex show that initial excitation of the ππ* state of the azopyridine unit in the ligand at λpump = 312 nm is followed by an ultrafast intersystem crossing (ISC) that leads to the formation of a metal-centered (MC) 5T state, in competition with the intended photoswitching of the azopyridine unit. Addnl. measurements carried out upon excitation of the singlet metal-to-ligand charge-transfer (1MLCT) transition at λpump = 455 nm suggest that this energy transfer occurs via an MLCT state. The resulting high-spin (HS) 5T state of the complex is metastable and recovers to the LS ground state with a time constant of ∼3 ns. The implications of these observations on the ligand-driven light-induced spin change concept are discussed. After reading the article, we found that the author used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Synthetic Route of C6H7Br2N)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Synthetic Route of C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Visible-Light-Induced Atom Transfer Radical Addition and Cyclization of Perfluoroalkyl Halides with 1,n-Enynes》 were Wang, Shuo-Wen; Yu, Jian; Zhou, Qin-Yi; Chen, Si-Yu; Xu, Zhen-Hua; Tang, Shi. And the article was published in ACS Sustainable Chemistry & Engineering in 2019. Application of 94928-86-6 The author mentioned the following in the article:

A mild and efficient visible-light-induced atom transfer radical addition and cyclization of 1,n-enynes (n = 6, 7) with perfluoroalkyl halides, leading to halo-perfluorinated N-heterocycles, was developed. This protocol offers a mild, completely atom-economic, and general access to perfluorinated 2,4-dihydronquinolin-2(1H)-ones and pyrrolidines from corresponding benzene and N-tethered 1,n-enynes (n = 6, 7) via 5-6-exo-dig cyclization, allowing for the expedient incorporation of a wide variety of perfluorinated groups, such as CF3, i/n-C3F7, n-C4F9, n-C6F13, n-C8F17, n-C10F21, CF2Br, CF2CO2Et, etc. In addition, the reactions using 1,7-enynes (n = 6, 7) bearing a tert-butyl-linked alkynyl moiety enable a divergent cyclization involving a hydrogen atom transfer (HAT) process, thereby leading to novel α,α-halo-perfluorinated 2,4-dihydronquinolin-2(1H)-ones. The experimental process involved the reaction of fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Application of 94928-86-6)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Application of 94928-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Self-Assembled Perylene Bisimide-Cored Trigonal Prism as an Electron-Deficient Host for C60 and C70 Driven by “”Like Dissolves Like””》 was written by Chang, Xingmao; Lin, Simin; Wang, Gang; Shang, Congdi; Wang, Zhaolong; Liu, Kaiqiang; Fang, Yu; Stang, Peter J.. Recommanded Product: 4-Ethynylpyridine And the article was included in Journal of the American Chemical Society in 2020. The article conveys some information:

Poor processability of fullerenes is a major remaining drawback for them to be studied monomolecularly and to find real-life applications. One of the strategies to tackle this problem is to encapsulate them within a host, which is however quite often, accompanied by significant alteration of their phys./chem. properties as encountered in chem. modification. To minimize the effect, an electron-deficient entities-based, dissolvable, and fluorescence active supramol. host was designed and constructed via coordination-driven self-assembly of o-tetrapyridyl perylene bisimide (PBI) with cis-(PEt3)2Pt(OTf)2. The trigonal prism 1 possesses a trigonal-prismatic inner cavity with 14.7 Å as the diameter of its inscribed circle. Host-guest chem. investigations revealed that both C60 and C70 could be quant. encapsulated by the host in a 1:1 ratio. Further studies demonstrated that the produced host-guest complex 1⊃C70 is significantly more stable than 1⊃C60, allowing complete transformation of the latter to the former and separation of C70 from its mixture with C60. The fullerenes in the inclusion state could rotate freely within the cavity. Electrochem. and spectroscopy studies disclosed that the encapsulation of the guests shows little effect upon the reduction of the host and its fluorescence properties. Thus, “”like dissolves like”” is believed to be the main driving force for the formation of the host-guest complexes. Moreover, the host and host-guest complexes can be fabricated into monomol. membranes using the conventional Langmuir-Blodgett technique. We propose that these unique host-guest complexes could be used as model ensembles for further studies of the phys./chem. properties of fullerenes in both single mol. and 2D membrane states. In addition, their reversible four-electron reduction property may allow them to find applications in photo/electrocatalysis, organic electronics, etc. In the experiment, the researchers used 4-Ethynylpyridine(cas: 2510-22-7Recommanded Product: 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Recommanded Product: 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Suzuki, Hirotsugu; Liao, Yumeng; Kawai, Yuya; Matsuda, Takanori published their research in European Journal of Organic Chemistry in 2021. The article was titled 《Rhodium-Catalyzed Additive-Free C-H Ethoxycarbonylation of (Hetero)Arenes with Diethyl Dicarbonate as a CO Surrogate》.Name: 2-Bromo-5-methylpyridine The article contains the following contents:

A rhodium-catalyzed C(sp2)-H ethoxycarbonylation of indoles and arylpyridines using di-Et dicarbonate to form indole-2-carboxylic acid esters such as I [X = CH, N; R1 = H, 4-Me, 5-Cl, etc.] and isophthalates II [R2 = H, 5-Me, 5-Ph, etc.; R3 = H, 5-Me, 4-Me] was developed. The catalytic process featured an additive-free ethoxycarbonylation reaction, in which only ethanol and CO2 were produced as byproducts, providing a CO-free and operationally simple protocol. The introduced ethoxycarbonyl group was easily transformed into other ester and amide functionalities in a single step. Moreover, the reaction could be successfully applied on gram scale, and allowed for the efficient synthesis of indole-2-carboxylic acid esters and isophthalates. The experimental part of the paper was very detailed, including the reaction process of 2-Bromo-5-methylpyridine(cas: 3510-66-5Name: 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Name: 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Chenhao; Gao, Anthony Z.; Nie, Xin; Ye, Chen-Xi; Ivlev, Sergei I.; Chen, Shuming; Meggers, Eric published their research in Journal of the American Chemical Society in 2021. The article was titled 《Catalytic α-Deracemization of Ketones Enabled by Photoredox Deprotonation and Enantioselective Protonation》.Category: pyridine-derivatives The article contains the following contents:

This study reports the catalytic deracemization of ketones bearing stereocenters in the α-position in a single reaction via deprotonation, followed by enantioselective protonation. The principle of microscopic reversibility, which has previously rendered this strategy elusive, is overcome by a photoredox deprotonation through single electron transfer and subsequent hydrogen atom transfer (HAT). Specifically, the irradiation of racemic pyridyl ketones in the presence of a single photocatalyst and a tertiary amine provides nonracemic carbonyl compounds with up to 97% enantiomeric excess. The photocatalyst harvests the visible light, induces the redox process, and is responsible for the asym. induction, while the amine serves as a single electron donor, HAT reagent, and proton source. This conceptually simple light-driven strategy of coupling a photoredox deprotonation with a stereocontrolled protonation, in conjunction with an enrichment process, serves as a blueprint for other deracemizations of ubiquitous carbonyl compounds In addition to this study using 2-Bromo-5-methylpyridine, there are many other studies that have used 2-Bromo-5-methylpyridine(cas: 3510-66-5Category: pyridine-derivatives) was used in this study.

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gujral, Gurjeet; Bhasin, K. K.; Gulati, Shivani published their research in Indian Journal of Heterocyclic Chemistry in 2021. The article was titled 《A new synthetic methodology for the preparation 2-Pyridyl anisyl/benzyl selenides: X-Ray Crystal Structure of 2-(4-Methyl pyridyl)tolyl selenide》.Synthetic Route of C5H3Br2N The article contains the following contents:

An effective methodol. for the synthesis of these selenides had been developed by reacting dianisyl/dibenzyl diselenide with substituted/unsubstituted 2-pyridyl halides in the presence of activated magnesium metal, Cu2O, and bipyridyl in DMF at 110°C for 18-20 h. The newly synthesized 2-pyridyl anisyl/benzyl selenides were either viscous liquids or crystalline solids that were stable at room temperature for several months without decomposition These were fully characterized by various spectroscopic techniques, namely, NMR (1H, 13C, and 77Se), IR, and mass spectroscopy. Single-crystal X-ray diffraction study of 2-(4-methylpyridyl) tolyl selenide was carried out to know the structural details of the mol. and well-defined diffraction quality crystals of 2-(4-Me pyridyl)tolyl selenide were obtained by slow evaporation of saturated solution of the compound in hexane-dichloromethane solvent mixture (4:1, volume/volume).2,5-Dibromopyridine(cas: 624-28-2Synthetic Route of C5H3Br2N) was used in this study.

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Synthetic Route of C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem