Month: October 2022

In 2016,Wang, Hongyue; Wang, Ze; Li, Shaoheng; Qiu, Yuntao; Liu, Bowen; Song, Zhiguang; Liu, Zhihui published 《Synthesis of novel thiazoline catalysts and their application in Michael addition reaction》.Chemical Research in Chinese Universities published the findings.Recommanded Product: 31106-82-8 The information in the text is summarized as follows:

Several novel chiral thiazoline catalysts containing thiazoline, thiourea and proline were efficiently synthesized from com. available L-cysteine. These ligands were subsequently applied to the asym. Michael reaction between cyclohexanone and various β-nitrostyrene. The result showed that the optimal catalyst for this reaction was 2-methylpyridine containing chiral thiazoline ligand , the organocatalyst with thiazoline, thiourea and chiral proline motif, which efficiently promoted the enantioselective conjugate addition of cyclohexanone to various nitroalkenes to yield the corresponding addition products in high to excellent yields with enantiomeric excess(e.e.) up to 95% and diastereoselectivity ratio(dr.) up to 99:1. The results came from multiple reactions, including the reaction of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Recommanded Product: 31106-82-8)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Recommanded Product: 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Wappes, Ethan A.; Nakafuku, Kohki M.; Nagib, David A. published 《Directed β C-H Amination of Alcohols via Radical Relay Chaperones》.Journal of the American Chemical Society published the findings.Recommanded Product: 103-74-2 The information in the text is summarized as follows:

A radical-mediated strategy for β C-H amination of alcs. has been developed. This approach employs a radical relay chaperone, which serves as a traceless director that facilitates selective C-H functionalization via 1,5-hydrogen atom transfer (HAT) and enables net incorporation of ammonia at the β carbon of alcs. The chaperones presented herein enable direct access to imidate radicals, allowing their first use for H atom abstraction. A streamlined protocol enables rapid conversion of alcs. to their β-amino analogs (via in situ conversion of alcs. to imidates, directed C-H amination, and hydrolysis to NH2). Mechanistic experiments indicate HAT is rate-limiting, whereas intramol. amination is product- and stereo-determining In addition to this study using 2-(2-Hydroxyethyl)pyridine, there are many other studies that have used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Recommanded Product: 103-74-2) was used in this study.

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Zhao, Huai-Bo; Liu, Zhan-Jiang; Song, Jinshuai; Xu, Hai-Chao published 《Reagent-Free C-H/N-H Cross-Coupling: Regioselective Synthesis of N-Heteroaromatics from Biaryl Aldehydes and NH3》.Angewandte Chemie, International Edition published the findings.Quality Control of 2-Bromonicotinaldehyde The information in the text is summarized as follows:

An unprecedented synthesis of N-heteroaromatics from biaryl aldehydes and NH3 through reagent-free C-H/N-H cross-coupling has been developed. The electrosynthesis uses NH3 as an inexpensive and atom-economic nitrogen donor, requires no oxidizing agents, and allows efficient and regioselective access to a wide range of phenanthridines and structurally related polycyclic N-heteroaromatic products. Thus, e.g., oxidative condensation of aldehyde I with NH3 in an undivided cell using reticulated vitreous carbon anode and Pt cathode in an HFIP/MeOH solvent system afforded phenanthridine II (94%). In the experimental materials used by the author, we found 2-Bromonicotinaldehyde(cas: 128071-75-0Quality Control of 2-Bromonicotinaldehyde)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Quality Control of 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Kanishchev, Oleksandr S.; Dolbier, William R. Jr. published 《Ni/Ir-Catalyzed Photoredox Decarboxylative Coupling of S-Substituted Thiolactic Acids with Heteroaryl Bromides: Short Synthesis of Sulfoxaflor and Its SF5 Analog》.Chemistry – A European Journal published the findings.Reference of 5-Bromo-2-chloropyridine The information in the text is summarized as follows:

The Ni/Ir-catalyzed photoredox decarboxylative coupling of readily available S-substituted thiolactic acids such as S-Me thiolactic acid, S-Ph thiolactic acid, 2-(phenylsulfonyl)propanoic acid, etc. with electron-deficient heteroaryl bromides XBr (X = pyrimidin-2-yl, 5-cyanopyridin-2-yl, 4-F3CC6H4, etc.), resulted in the formation of simple but otherwise not easily accessible heteroarenes with alkylsulfide side chains XCH(CH3)SY (Y = Me, Ph). To demonstrate a practical use of this coupling reaction, its efficiency in the one-step synthesis of a key intermediate is shown in the synthesis of the recently marketed insecticide Sulfoxaflor, and for the short synthesis of SF5-Sulfoxaflor. The experimental process involved the reaction of 5-Bromo-2-chloropyridine(cas: 53939-30-3Reference of 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Reference of 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Zhao, Jiannan; Brosmer, Jonathan L.; Tang, Qingxuan; Yang, Zhongyue; Houk, K. N.; Diaconescu, Paula L.; Kwon, Ohyun published 《Intramolecular Crossed [2+2] Photocycloaddition through Visible Light-Induced Energy Transfer》.Journal of the American Chemical Society published the findings.Name: 2-Bromonicotinaldehyde The information in the text is summarized as follows:

Herein, we present the intramol. [2+2] cycloadditions of dienones promoted through sensitization, using a polypyridyl iridium(III) catalyst, to form bridged cyclobutanes [e.g., I → II (93%)]. In contrast to previous examples of straight [2+2] cycloadditions, these efficient crossed additions were achieved under irradiation with visible light. The reactions delivered desired bridged benzobicycloheptanone products with excellent regioselectivity in high yields (up to 96%). This process is superior to previous syntheses of benzobicyclo[3.1.1]heptanones, which are readily converted to B-norbenzomorphan analogs of biol. significance. Electrochem., computational, and spectroscopic studies substantiated the mechanism of triplet energy transfer and explained the unusual regiocontrol. In the part of experimental materials, we found many familiar compounds, such as 2-Bromonicotinaldehyde(cas: 128071-75-0Name: 2-Bromonicotinaldehyde)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Name: 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Chemical & Pharmaceutical Bulletin included an article by Sekimata, Katsuhiko; Sato, Tomohiro; Sakai, Naoki; Watanabe, Hisami; Mishima-Tsumagari, Chiemi; Taguri, Tomonori; Matsumoto, Takehisa; Fujii, Yoshifumi; Handa, Noriko; Honma, Teruki; Tanaka, Akiko; Shirouzu, Mikako; Yokoyama, Shigeyuki; Miyazono, Kohei; Hashizume, Yoshinobu; Koyama, Hiroo. Safety of 2-Pyridinylboronic acid. The article was titled 《Bis-heteroaryl pyrazoles: identification of orally bioavailable inhibitors of activin receptor-like kinase-2 (R206H)》. The information in the text is summarized as follows:

Mutant activin receptor-like kinase-2 (ALK2) was reported to be closely associated with the pathogenesis of fibrodysplasia ossificans progressiva (FOP) and diffuse intrinsic pontine glioma (DIPG), and therefore presents an attractive target for therapeutic intervention. Through in silico virtual screenings and structure-activity relationship studies assisted by X-ray crystallog. analyses, a novel series of bis-heteroaryl pyrazole was identified as potent inhibitors of ALK2 (R206H). Derived from in silico hit compound RK-59638 (6a), compound 18p was identified as a potent inhibitor of ALK2 (R206H) with good aqueous solubility, liver microsomal stability, and oral bioavailability. The experimental process involved the reaction of 2-Pyridinylboronic acid(cas: 197958-29-5Safety of 2-Pyridinylboronic acid)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Safety of 2-Pyridinylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,European Journal of Organic Chemistry included an article by Van Beek, Wim E.; Smets, Robert J.; Kushwaha, Khushbu; Herrebout, Wouter A.; Abbaspour Tehrani, Kourosch. COA of Formula: C5H6BNO2. The article was titled 《Synthesis of 3,3-Dichloropiperidines and Further Functionalization via Pd-Catalyzed Cross-Coupling Reactions of the Dichloromethylene Moiety》. The information in the text is summarized as follows:

A new synthetic methodol. for the functionalization of the dichloromethylene moiety in 3,3-dichloropiperidines via Pd-catalyzed cross-coupling reactions is reported. A range of 3,3-dichloropiperidines was synthesized via a hydride induced cyclization of α,α,δ-trichloroaldimines or an indium(III) triflate catalyzed alkynylation/cyclization procedure of α,α,δ-trichloroaldimines. Subsequently, a dehydrochlorination followed by a cross-coupling with the thus formed vinylic chloride was envisioned. The non-alkynylated 3,3-dichloropiperidines could be regioselectively eliminated and by careful choice of solvent and base both of the two regioisomeric vinyl chlorides could be exclusively formed. Palladium-catalyzed Suzuki cross-coupling of the thus formed 5-chloro-1,2,3,6-tetrahydropyridines led to C3-substituted 1,2,3,6-tetrahydropyridines, which could be easily reduced to 3-substituted piperidines, generating therapeutic agent (±)-Preclamol for example. The 2-alkynyl-3,3-dichloropiperidines were regioselectively eliminated giving the cyclic enamine, which was subsequently cross-coupled in one-pot. The presence of the alkynyl function, in this case, clearly directs elimination towards enamine structures. Hydrogenation of the resulting, unstable 2-alkynyl-3-substituted-1,2,3,4-tetrahydropyridines, yields stable 2,3-disubstituted piperidines. In addition to this study using 2-Pyridinylboronic acid, there are many other studies that have used 2-Pyridinylboronic acid(cas: 197958-29-5COA of Formula: C5H6BNO2) was used in this study.

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. COA of Formula: C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Journal of the American Chemical Society included an article by Santos, Peter J.; Cao, Zhen; Zhang, Jianyuan; Alexander-Katz, Alfredo; Macfarlane, Robert J.. Recommanded Product: 2,6-Diaminopyridine. The article was titled 《Dictating Nanoparticle Assembly via Systems-Level Control of Molecular Multivalency》. The information in the text is summarized as follows:

Nanoparticle assembly can be controlled by multivalent binding interactions between surface ligands, indicating that more precise control over these interactions is important to design complex nanoscale architectures. It has been well-established in natural materials that the arrangement of different mol. species in three dimensions can affect the ability of individual supramol. units to coordinate their binding, thereby regulating the strength and specificity of their collective mol. interactions. However, in artificial systems, limited examples exist that quant. demonstrate how changes in nanoscale geometry can be used to rationally modulate the thermodn. of individual mol. binding interactions. As a result, the use of nanoscale design features to regulate mol. bonding remains an underutilized design handle to control nanomaterials synthesis. Here we demonstrate a polymer-coated nanoparticle material where supramol. bonding and nanoscale structure are used in conjunction to dictate the thermodn. of their multivalent interactions, resulting in emergent bundling of supramol. binding groups that would not be expected on the basis of the mol. structures alone. Addnl., we show that these emergent phenomena can controllably alter the superlattice symmetry by using the mesoscale particle arrangement to alter the thermodn. of the supramol. bonding behavior. The ability to rationally program mol. multivalency via a systems-level approach therefore provides a major step forward in the assembly of complex artificial structures, with implications for future designs of both nanoparticle- and supramol.-based materials. In the part of experimental materials, we found many familiar compounds, such as 2,6-Diaminopyridine(cas: 141-86-6Recommanded Product: 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Recommanded Product: 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Green Light-Responsive CO-Releasing Polymeric Materials Derived from Ring-Opening Metathesis Polymerization》 were Gandra, Upendar Reddy; Sinopoli, Alessandro; Moncho, Salvador; NandaKumar, Manjula; Ninkovic, Dragan B.; Zaric, Snezana D.; Sohail, Muhammad; Al-Meer, Saeed; Brothers, Edward N.; Mazloum, Nayef A.; Al-Hashimi, Mohammed; Bazzi, Hassan S.. And the article was published in ACS Applied Materials & Interfaces in 2019. Application of 1539-42-0 The author mentioned the following in the article:

Carbon monoxide (CO) is an important biol. gasotransmitter in living cells. Precise spatial and temporal control over release of CO is a major requirement for clin. application. To date, the most reported carbon monoxide releasing materials use expensive fabrication methods and require harmful and poorly designed tissue-penetrating UV irradiation to initiate the CO release precisely at infected sites. Herein, we report the first example of utilizing a green light-responsive CO-releasing polymer P synthesized via ring-opening metathesis polymerization Both monomer M and polymer P were very stable under dark conditions and CO release was effectively triggered using minimal power and low energy wavelength irradiation (550 nm, ≤28 mW). Time-dependent d. functional theory (TD-DFT) calculations were carried out to simulate the electronic transition and insight into the nature of the excitations for both L and M. TD-DFT calculations indicate that the absorption peak of M is mainly due to the excitation of the seventh singlet excited state, S7. Furthermore, stretchable materials using polytetrafluoroethylene (PTFE) strips based on P were fabricated to afford P-PTFE, which can be used as a simple, inexpensive, and portable CO storage bandage. Insignificant cytotoxicity as well as cell permeability was found for M and P against human embryonic kidney cells. In addition to this study using Bis(pyridin-2-ylmethyl)amine, there are many other studies that have used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Application of 1539-42-0) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Application of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Halogen Bonding Helicates Encompassing Iodonium Cations》 were Vanderkooy, Alan; Gupta, Arvind Kumar; Foeldes, Tamas; Lindblad, Sofia; Orthaber, Andreas; Papai, Imre; Erdelyi, Mate. And the article was published in Angewandte Chemie, International Edition in 2019. SDS of cas: 626-05-1 The author mentioned the following in the article:

The first halonium-ion-based helixes were designed and synthesized using oligo-aryl/pyridylene-ethynylene backbones that fold around reactive iodonium ions. Halogen bonding interactions stabilize the iodonium ions within the helixes. Remarkably, the distance between two iodonium ions within a helix is shorter than the sum of their van der Waals radii. The helical conformations were characterized by X-ray crystallog. in the solid state, by NMR spectroscopy in solution and corroborated by DFT calculations The helical complexes possess potential synthetic utility, as demonstrated by their ability to induce iodocyclization of 4-penten-1-ol. In the experiment, the researchers used 2,6-Dibromopyridine(cas: 626-05-1SDS of cas: 626-05-1)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. SDS of cas: 626-05-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem