Month: October 2022

Choi, Geun Su; Baek, Dong-Hyun; Park, Young Wook published an article in 2021. The article was titled 《Organic Thin-Film Characteristics Modulated by Deposition Substrate Rotation Speed and the Effect on Organic Light-Emitting Diodes》, and you may find the article in Journal of Nanoscience and Nanotechnology.SDS of cas: 94928-86-6 The information in the text is summarized as follows:

In this paper, we report on the effects of the substrate thermal evaporation process rotation speed on the electroluminescence (EL) characteristics of organic light-emitting diodes (OLEDs). In general OLED research, rotational and angle tilted deposition are widely used to maintain uniformity. However, there have been few reports on the effects of this deposition method on film characteristics. We analyzed these effects and found that the film d. and its refractive index showed remarkable changes as a function of substrate rotational speed during tilted deposition. The EL characteristics of the transport layer of fluorescent OLEDs were also significantly affected. We derived the OLED optimal thickness and refractive index from our calculations In the experimental materials used by the author, we found fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6SDS of cas: 94928-86-6)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.SDS of cas: 94928-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ovchenkova, Ekaterina N.; Tsaturyan, Arshak A.; Bichan, Nataliya G.; Lomova, Tatyana N. published an article in 2021. The article was titled 《N Basicity of Substituted Fullero[60]/[70]pyrrolidines According to DFT/TD-DFT Calculations and Chemical Thermodynamics》, and you may find the article in Journal of Physical Chemistry A.Related Products of 1539-42-0 The information in the text is summarized as follows:

The basicity thermodn. parameters of pyridyl/imidazole-substituted fullero[60]/[70]pyrrolidines with respect to N heteroatoms in dichloromethane, which are necessary both to deepen insight into aromaticity “”neque levia”” and to create supramol. chem. structures for application, are obtained and discussed in this work. Because of the presence of a chromophore in the mols., the acid-base reactions of three C60 derivatives functionalized in different ways and one C70 derivative are studied using spectrophotometric titration with trifluoroacetic acid. The dependence of the pK values determined using the data on Hammett′s acidity functions, H0, for a binary nonaqueous solvent on the mol.′s chem. structure is shown. D. functional theory (DFT) and time-dependent DFT (TD-DFT) at the B3LYP/6-311G(d,p) level were used for the optimization of the fullerene derivative structures and modeling of their UV-vis spectra. The pKBH+ values of substituted fullero[60]/[70]pyrrolidines are predicted by quantum-chem. calculations After reading the article, we found that the author used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Related Products of 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Related Products of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Manley, Paul W.; Huth, Felix; Moussaoui, Saliha; Schoepfer, Joseph published an article in Bioorganic & Medicinal Chemistry Letters. The title of the article was 《A kinase inhibitor which specifically targets the ABL myristate pocket (STAMP), but unlike asciminib crosses the blood-brain barrier》.Computed Properties of C5H6BNO2 The author mentioned the following in the article:

The ubiquitously expressed ABL1 and ABL2 protein kinases play many important roles in cell function. Although they have been implicated in neuron development, maintenance and signaling, there are no good tool compounds to evaluate the effects of ABL kinase inhibition in the brain. Asciminib is a recently approved drug that specifically and potently inhibits the tyrosine kinase activity of ABL1, ABL2 and that of the chimeric BCR-ABL1 oncoprotein which causes chronic myeloid leukemia. Herein we show that asciminib does not penetrate the intact blood-brain barrier (BBB) following administration to rats, which curtails its utility for assessing the in vivo effects of ABL kinase inhibition in the brain. However, we describe another specific ABL kinase inhibitor, possessing physicochem. characteristics suitable for BBB penetration, and which after administration (either i.v., i.p. or p.o.) to mice achieves substantial, pharmacol. relevant brain concentrations This bipyridine compound (4) therefore has potential for elucidating the role of ABL kinases in the brain in non-clin. studies. In the part of experimental materials, we found many familiar compounds, such as Pyridin-3-ylboronic acid(cas: 1692-25-7Computed Properties of C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Computed Properties of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Colgan, Avene C.; Proctor, Rupert S. J.; Gibson, David C.; Chuentragool, Padon; Lahdenpera, Antti S. K.; Ermanis, Kristaps; Phipps, Robert J. published an article in Angewandte Chemie, International Edition. The title of the article was 《Hydrogen Atom Transfer Driven Enantioselective Minisci Reaction of Alcohols》.Electric Literature of C7H9NO The author mentioned the following in the article:

Catalytic enantioselective Minisci reactions have recently been developed but all instances so far utilize α-amino radical coupling partners. Authors report a substantial evolution of the enantioselective Minisci reaction that enables α-hydroxy radicals to be used, providing valuable enantioenriched secondary alc. products. This is achieved through the direct oxidative coupling of two C-H bonds on simple alc. and pyridine partners through a hydrogen atom transfer (HAT)-driven approach: a challenging process to achieve due to the numerous side reactions that can occur. This approach is highly regioselective as well as highly enantioselective. Dicumyl peroxide, upon irradiation with 390 nm light, serves as both HAT reagent and oxidant while selectivity is controlled by use of a chiral phosphoric acid catalyst. Computational and exptl. evidence provide mechanistic insight as to the origin of selectivity, revealing a stereodetermining deprotonation step distinct from the analogous reaction of amide-containing substrates. The experimental part of the paper was very detailed, including the reaction process of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Electric Literature of C7H9NO)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Electric Literature of C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 141-86-6In 2020 ,《Poly(s-triazine) based porous carbon for CO2 sequestration》 appeared in Materials Chemistry and Physics. The author of the article were Senthilkumaran, Marimuthu; Saravanan, Chokalingam; Puthiaraj, Pillaiyar; Rameshkumar, Perumal; Kalaignan, Guruviah Paruthimal; Muthu Mareeswaran, Paulpandian. The article conveys some information:

Nitrogen containing microporous materials are promising candidates for the efficient and selective CO2 capture. Triazine containing polyaminals are the potential precursors for the preparation of porous carbons. The various nitrogen moieties present in the materials are examined by XPS anal. The FE-SEM and HR-TEM images of the materials and N2 sorption profile exhibit abundant microporous structure. Pore size distribution reveals the existence of narrow micropores in the materials. The prepared materials exhibit surface area up to 684 m2/g, microporous surface area up to 441 m2/g and CO2 capture up to 154 mg/g. CO2 isotherm data is well fitted with Langmuir and Freundlich isotherm models. Spontaneity of the CO2 adsorption process are demonstrated by thermodn. parameters. The high CO2/N2 selectivity and considerable CO2/CH4 selectivity of the materials are calculated by initial slope method (Henry′s law). The experimental part of the paper was very detailed, including the reaction process of 2,6-Diaminopyridine(cas: 141-86-6Recommanded Product: 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Recommanded Product: 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of 4,4′-Dimethyl-2,2′-bipyridineIn 2019 ,《Towards Long Wavelength Absorbing Photodynamic Therapy Photosensitizers via the Extension of a [Ru(bipy)3]2+ Core》 appeared in European Journal of Inorganic Chemistry. The author of the article were Karges, Johannes; Blacque, Olivier; Goldner, Philippe; Chao, Hui; Gasser, Gilles. The article conveys some information:

Complementary to classical treatment methods used against cancer, photodynamic therapy (PDT) has received increasing attention over the last years. PDT relies on the generation of reactive oxygen species (ROS) upon light irradiation to trigger cell death. As the wavelength employed during such treatments directly influences the light penetration depth and therefore the possibility to treat deep seated tumors or large tumors, research efforts have been made towards the development of photosensitizers (PSs) with an absorption in the phototherapeutic window (600-900 nm). To tackle this drawback, we report herein the preparation and characterization of new RuII-containing PDT PSs, that are based on a [Ru(bipy)3]2+ core (1; bipy: 2,2′-bipyridine) and that are extended with Me groups (2) or vinyl dimethylamino groups (3). As anticipated with our design, we found a red-shift of 65 nm of the maximum absorption of complex 3 in comparison to complex 1. In addition, we report on the in-depth photophys. properties as well as (photo-)cytotoxicity against cervical cancerous HeLa cells of the investigated compounds In addition to this study using 4,4′-Dimethyl-2,2′-bipyridine, there are many other studies that have used 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Quality Control of 4,4′-Dimethyl-2,2′-bipyridine) was used in this study.

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Quality Control of 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formula: C7H7NOIn 2020 ,《Design, Sonosynthesis, Quantum-Chemical Calculations, and Evaluation of New Mono- and Bis-pyridine Dicarbonitriles as Antiproliferative Agents》 appeared in Chinese Journal of Chemistry. The author of the article were Arafa, Wael Abdelgayd Ahmed; Hussein, Modather F.. The article conveys some information:

A highly efficient, simple, and clean single-step sonosynthetic procedure was sophisticated for assembling new series of mono- and bis-pyridine dicarbonitriles from ketones, HCl, and tetracyanoethylene. The presented protocol was applicable for the preparation of a broad range of uniquely substituted pyridine dicarbonitriles and were superior in comparison with other previously reported methods. The antiproliferative impact of the newly synthesized derivatives were screened towards three representative cancer cell lines (MCF-7, A549, and HCT116). Most of the evaluated derivatives showed a moderate to excellent anti-proliferative activity towards the selected cell lines. Of these, compounds I, II, III and IV [R = 2-pyridyl, 4-pyridyl] showed both potent anticancer activity (IC50 < 10μM) and lower cytotoxic effect (IC50 > 58μM) on non-tumorigenic cells (MCF-10A and NCM460), suggesting their promising potential to be lead mols. for future antitumor drug discovery. The structure-activity relationships was discussed. Moreover, quantum chem. studies based on d. functional theory (DFT) of the synthesized compounds were investigated and found to be consistent with the in-vitro inhibitory activities. In addition to this study using 4-Acetylpyridine, there are many other studies that have used 4-Acetylpyridine(cas: 1122-54-9Formula: C7H7NO) was used in this study.

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Formula: C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: 4-EthynylpyridineIn 2019 ,《Novel SAR for quinazoline inhibitors of EHMT1 and EHMT2》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Leenders, Ruben; Zijlmans, Remco; van Bree, Bart; van de Sande, Marc; Trivarelli, Federica; Damen, Eddy; Wegert, Anita; Mueller, Daniel; Ehlert, Jan Erik; Feger, Daniel; Heidemann-Dinger, Carolin; Kubbutat, Michael; Schaechtele, Christoph; Lenstra, Danny C.; Mecinovic, Jasmin; Mueller, Gerhard. The article conveys some information:

Detailed structure activity relationship of two series of quinazoline EHMT1/EHMT2 inhibitor compounds I [R = COOH, CONH2, (5-prop-2-ynylpyrrolidin-2-one)-3-yl etc.] and II [R1 = OMe, F, OCF3 ; R2 = aminopropynyl,(5-prop-2-ynylpyrrolidin-2-one)-3-yl etc.] were elaborated. New and active alternatives were presented for the ubiquitous substitution patterns found in literature for the linker to the lysine mimicking region and the lysine mimic itself. After reading the article, we found that the author used 4-Ethynylpyridine(cas: 2510-22-7Name: 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Name: 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 141-86-6In 2020 ,《Reinforcing Supramolecular Bonding with Magnetic Dipole Interactions to Assemble Dynamic Nanoparticle Superlattices》 was published in Journal of the American Chemical Society. The article was written by Santos, Peter J.; MacFarlane, Robert J.. The article contains the following contents:

Assembling superparamagnetic particles into ordered lattices is an attractive means of generating new magnetically responsive materials, and is commonly achieved by tailoring interparticle interactions as a function of the ligand coating. However, the inherent linkage between the collective magnetic behavior of particle arrays and the assembly processes used to generate them complicates efforts to understand and control material synthesis. Here, the authors use a synergistic combination of a chem. force (hydrogen bonding) and magnetic dipole coupling to assemble polymer-brush coated superparamagnetic Fe oxide nanoparticles, where the relative strengths of these interactions can be tuned to reinforce one another and stabilize the resulting superlattice phases. The authors can precisely control both the dipole-dipole coupling between nanoparticles and the strength of the ligand-ligand interactions by modifying the interparticle spacing through changes to the polymer spacer between the hydrogen bonding groups and the nanoparticles’ surface. This results in modulation of the materials’ blocking temperature, as well as the stabilization of a unique superlattice phase that only exists when magnetic coupling between particles is present. Using magnetic interactions to affect nanoparticle assembly in conjunction with ligand-mediated interparticle interactions expands the potential for synthesizing predictable and controllable nanoparticle-based magnetic composites. The experimental part of the paper was very detailed, including the reaction process of 2,6-Diaminopyridine(cas: 141-86-6Related Products of 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Related Products of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 1692-25-7In 2019 ,《Red/Near-Infrared Thermally Activated Delayed Fluorescence OLEDs with Near 100 % Internal Quantum Efficiency》 was published in Angewandte Chemie, International Edition. The article was written by Chen, Jia-Xiong; Tao, Wen-Wen; Chen, Wen-Cheng; Xiao, Ya-Fang; Wang, Kai; Cao, Chen; Yu, Jia; Li, Shengliang; Geng, Feng-Xia; Adachi, Chihaya; Lee, Chun-Sing; Zhang, Xiao-Hong. The article contains the following contents:

Developing red thermally activated delayed fluorescence (TADF) emitters, attainable for both high-efficient red organic light-emitting diodes (OLEDs) and non-doped deep red/near-IR (NIR) OLEDs, is challenging. Now, two red emitters, BPPZ-PXZ and mDPBPZ-PXZ, with twisted donor-acceptor structures were designed and synthesized to study mol. design strategies of high-efficiency red TADF emitters. BPPZ-PXZ employs the strictest mol. restrictions to suppress energy loss and realizes red emission with a photoluminescence quantum yield (ΦPL) of 100±0.8 % and external quantum efficiency (EQE) of 25.2 % in a doped OLED. Its non-doped OLED has an EQE of 2.5 % owing to unavoidable intermol. π-π interactions. MDPBPZ-PXZ releases two pyridine substituents from its fused acceptor moiety. Although mDPBPZ-PXZ realizes a lower EQE of 21.7 % in the doped OLED, its non-doped device shows a superior EQE of 5.2 % with a deep red/NIR emission at peak of 680 nm. The results came from multiple reactions, including the reaction of Pyridin-3-ylboronic acid(cas: 1692-25-7Product Details of 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Product Details of 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem