Month: October 2022

Formula: C12H12N2In 2021 ,《Thermochromic Color Switching to Temperature Controlled Volatile Memory and Counter Operations with Metal-Organic Complexes and Hybrid Gels》 was published in Angewandte Chemie, International Edition. The article was written by Nirmala, Anjali; Mukkatt, Indulekha; Shankar, Sreejith; Ajayaghosh, Ayyappanpillai. The article contains the following contents:

Temperature is often not considered as a precision stimulus for artificial chem. systems in contrast to the host-guest interactions related to many natural processes. Similarly, mimicking multi-state volatile memory operations using a single mol. system with temperature as a precision stimulus is highly laborious. A mixture of Fe(II) chloride and bipyridine can be used as a reversible color-to-colorless thermochromic switch and logic operators. The generality of the approach was illustrated using CoII and NiII salts that resulted in color-to-color transitions. DMSO gels of these systems exhibited reversible opaque-transparency switching. More importantly, optically readable multi-state volatile memory with temperature as a precision input was demonstrated. The stored data is volatile and is lost instantaneously upon withdrawal or change of temperature Simultaneous read-out at multiple wavelengths results in single-input/multi-output sequential logic operations such as data accumulators (counters) leading to volatile memory states. The present system provides access to thermoresponsive materials wherein temperature can be used as a precision stimulus. In the part of experimental materials, we found many familiar compounds, such as 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Formula: C12H12N2)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Formula: C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Rapid One-Pot Sequential Cyclization, Palladium Precatalyst Mediated Coupling Reactions of 6-Bromo-2-Chloroquinoline-3-Carboxaldehyde in Aqueous Medium》 was written by Thiyagamurthy, Pandurangan; Nawaz Khan, Fazlur-Rahman. Recommanded Product: 2510-22-7This research focused onxanthenedione quinolinyl preparation; bromo chloroquinoline carboxaldehyde Suzuki Sonogashira Stille coupling palladium catalyst. The article conveys some information:

Xanthene-1,8(2H)-diones I (R = Ph, 2-(pyridin-4-yl)ethynyl, ethenyl, etc.), were obtained from 6-bromo-2-chloro quinoline-3-carboxaldehyde, in water reflux and subsequently underwent Suzuki-Miyaura cross/Sonogashira/Stille coupling utilizing second generation XPhos Palladium preformed catalyst. Low catalyst loading, ambient temperature and wide scope of boronic acids, enantioselectivity are the advantages. In the part of experimental materials, we found many familiar compounds, such as 4-Ethynylpyridine(cas: 2510-22-7Recommanded Product: 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Recommanded Product: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Syntheses with aromatic nitramines. Part VIII. Rearrangements of isomeric nitraminopyridines with aroyl chlorides》 was published in Universitatis Iagellonicae Acta Chimica in 1991. These research results belong to Sepiol, Jadwiga; Tomasik, Piotr. Recommanded Product: 5-Chloro-3-methylpyridin-2-ol The article mentions the following:

2-Nitraminopyridine reacts with BzCl to give 5-chloro-1H-pyridin-2-one. 4-Nitraminopyridine with the same reagent produces both 3-chloro-1H-pyridin-4-one and unsubstituted 1H-pyridin-4-one, and 3-nitraminopyridine gives solely 3-hydroxypyridine. Any substituent in the 5-position of 2-nitraminopyridine or an electron-withdrawing substituent in the 3-position of that nitramine prohibit chlorination in the β-position. The reaction is accelerated by electron-donating substituents in the acyl moiety and (4-MeOC6H4COCl) and slowed down by electron-withdrawing substituents, e.g. 4-O2NC6H4COCl. In the experiment, the researchers used 5-Chloro-3-methylpyridin-2-ol(cas: 58498-61-6Recommanded Product: 5-Chloro-3-methylpyridin-2-ol)

5-Chloro-3-methylpyridin-2-ol(cas: 58498-61-6) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Recommanded Product: 5-Chloro-3-methylpyridin-2-ol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《The Effect of the Leaving Group in N-Heterocyclic Carbene-Catalyzed Nucleophilic Aromatic Substitution Reactions》 was published in Bulletin of the Chemical Society of Japan in 2020. These research results belong to Yasui, Kosuke; Kamitani, Miharu; Fujimoto, Hayato; Tobisu, Mamoru. Application In Synthesis of 2-Bromopyridin-3-amine The article mentions the following:

The reactivity order of the leaving group was F > Cl ≥ Br > I in N-heterocyclic carbene-catalyzed CSNAr reactions of aryl halides bearing an α,β-unsaturated amide was discussed. Based on a qual. Marcus anal., the nature of the transition state in this catalytic CSNAr was primarily determined by the potential energy of the Meisenheimer complex, even though it was not involved as a discrete intermediate in the reaction pathway. The results came from multiple reactions, including the reaction of 2-Bromopyridin-3-amine(cas: 39856-58-1Application In Synthesis of 2-Bromopyridin-3-amine)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Application In Synthesis of 2-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Computed Properties of C7H6BrNO2On November 6, 2013 ,《Picomolar Inhibitors of HIV Reverse Transcriptase Featuring Bicyclic Replacement of a Cyanovinylphenyl Group》 appeared in Journal of the American Chemical Society. The author of the article were Lee, Won-Gil; Gallardo-Macias, Ricardo; Frey, Kathleen M.; Spasov, Krasimir A.; Bollini, Mariela; Anderson, Karen S.; Jorgensen, William L.. The article conveys some information:

Members of the catechol diether class are highly potent non-nucleoside inhibitors of HIV-1 reverse transcriptase (NNRTIs). The most active compounds yield EC50 values below 0.5 nM in assays using human T-cells infected by wild-type HIV-1. However, these compounds such as rilpivirine, the most recently FDA-approved NNRTI, bear a cyanovinylphenyl (CVP) group. This is an uncommon substructure in drugs that gives reactivity concerns. In the present work, computer simulations were used to design bicyclic replacements for the CVP group. The predicted viability of a 2-cyanoindolizinyl alternative was confirmed exptl. and provided compounds with 0.4 nM activity against the wild-type virus. The compounds also performed well with EC50 values of 10 nM against the challenging HIV-1 variant that contains the Lys103Asn/Tyr181Cys double mutation in the RT enzyme. Indolyl and benzofuranyl analogs were also investigated; the most potent compounds in these cases have EC50 values toward wild-type HIV-1 near 10 nM and high-nanomolar activities toward the double-variant. The structural expectations from the modeling were much enhanced by obtaining an X-ray crystal structure at 2.88 Å resolution for the complex of the parent 2-cyanoindolizine I and HIV-1 RT. The aqueous solubilities of the most potent indolizine analogs were also measured to be ∼40 μg/mL, which is similar to that for the approved drug efavirenz and ∼1000-fold greater than for rilpivirine. In the experiment, the researchers used 3-Bromo-5-methylpicolinic acid(cas: 1211515-68-2Computed Properties of C7H6BrNO2)

3-Bromo-5-methylpicolinic acid(cas: 1211515-68-2) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Computed Properties of C7H6BrNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 4-Amino-2-picolineOn March 28, 2019, Rombouts, Frederik J. R.; Declercq, Lieven; Andres, Jose-Ignacio; Bottelbergs, Astrid; Chen, Lu; Iturrino, Laura; Leenaerts, Joseph E.; Marien, Jonas; Song, Fengbin; Wintmolders, Cindy; Wuyts, Stijn; Xia, Chunfang A.; te Riele, Paula; Bormans, Guy; Vandenberghe, Rik; Kolb, Hartmuth; Moechars, Diederik published an article in Journal of Medicinal Chemistry. The article was 《Discovery of N-(4-[18F]Fluoro-5-methylpyridin-2-yl)isoquinolin-6-amine (JNJ-64326067), a New Promising Tau Positron Emission Tomography Imaging Tracer》. The article mentions the following:

In Alzheimer’s disease, the d. and spread of aggregated tau protein track well with neurodegeneration and cognitive decline, making the imaging of aggregated tau a compelling biomarker. A structure-activity relationship exploration around an isoquinoline hit, followed by an exploration of tolerated fluorination positions, allowed us to identify 9 (JNJ-64326067), a potent and selective binder to aggregated tau with a favorable pharmacokinetic profile and no apparent off-target binding. This was confirmed in rat and monkey positron emission tomog. studies using [18F]9. In the part of experimental materials, we found many familiar compounds, such as 4-Amino-2-picoline(cas: 18437-58-6Recommanded Product: 4-Amino-2-picoline)

4-Amino-2-picoline(cas: 18437-58-6) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Recommanded Product: 4-Amino-2-picoline

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 18437-58-6On March 1, 2020, Morimoto, Nobuyuki; Oishi, Yoshifumi; Yamamoto, Masaya published an article in Macromolecular Chemistry and Physics. The article was 《The Design of Sulfobetaine Polymers with Thermoresponsiveness under Physiological Salt Conditions》. The article mentions the following:

Thermoresponsive polymers are attractive in terms of basics and applications because of the phase separation in aqueous solution Some sulfobetaine polymers are known for their antifouling biocompatibility and upper critical solution temperature (UCST) type thermoresponsiveness; however, thermoresponsiveness disappears in aliphatic sulfobetaine polymers in physiol. salt conditions. Aromatic cation-containing sulfobetaine polymers are not responded because of the strong intermol. interactions. In this study, new sulfobetaine methacrylamides with a pyridinium cation, 3-(4-(2-methacrylamido)alkyl pyridinio-1-yl)propane-1-sulfonates, (PySMAAm)s, are designed and then prepared the homopolymers using aqueous reversible addition-fragmentation chain transfer polymerization The P(PySMAAm)s exhibited UCST-type thermoresponsiveness that is induced by substitution of the dipole-dipole interaction between the interpolymer side chain to an ion-dipole interaction in physiol. salt conditions. The thermoresponsiveness is affected by the mol. weight and structure of the side chains. Such sulfobetaine polymers can be promising tools as biomaterials especially for drug delivery and regenerative medicine. In the part of experimental materials, we found many familiar compounds, such as 4-Amino-2-picoline(cas: 18437-58-6Related Products of 18437-58-6)

4-Amino-2-picoline(cas: 18437-58-6) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Related Products of 18437-58-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 2-Bromopyridin-3-amineOn March 9, 2022, Maust, Mark C.; Hendy, Cecilia M.; Jui, Nathan T.; Blakey, Simon B. published an article in Journal of the American Chemical Society. The article was 《Switchable Regioselective 6-endo or 5-exo Radical Cyclization via Photoredox Catalysis》. The article mentions the following:

Here a simple method for reagent controlled regioselective radical cyclization of halogenated N-heterocycles onto pendant olefins was developed. Radical generation occurs under mild photoredox conditions with control of the regioselectivity governed by the rate of hydrogen atom transfer (HAT). Utilizing a polarity-matched thiol-based HAT agent promoted the highly selective formation of the 5-exo cyclization product. Conversely, limiting the solubility of the HAT reagent Hantzsch ester (HEH) leads to selective formation of the thermodynamically favored 6-endo product. This occurs through an initial 5-exo cyclization, with the resulting alkyl radical intermediate undergoing neophyl rearrangement to form the 6-endo product. Development of this switchable catalysis strategy allows for two modes of divergent reactivity to form either the 6-endo or 5-exo product, generating fused N-heteroaromatic/saturated ring systems. In the experimental materials used by the author, we found 2-Bromopyridin-3-amine(cas: 39856-58-1Application In Synthesis of 2-Bromopyridin-3-amine)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Application In Synthesis of 2-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 39856-58-1On March 4, 2020, Deng, Tianning; Mazumdar, Wrickban; Ford, Russell L.; Jana, Navendu; Izar, Ragda; Wink, Donald J.; Driver, Tom G. published an article in Journal of the American Chemical Society. The article was 《Oxidation of Non-Activated Anilines to Generate N-Aryl Nitrenoids》. The article mentions the following:

A low temperature, protecting group-free oxidation of 2-substituted anilines was developed to generate an electrophilic N-aryl nitrenoid intermediate that can engage in C-NAr bond formation to constructed functionalized N-heterocycles. Exposure of 2-substituted anilines to PIFA and trifluoroacetic acid or 10 mol % of Sc(OTf)3 triggers nitrenoid formation, followed by productive and selective C-NAr and C-C bond formation to yield spirocyclic- or bicyclic 3H-indoles or benzazepinones. Our experiments demonstrated the breadth of these oxidative processes, uncover underlying fundamental elements that control selectivity and demonstrate how the distinct reactivity patterns embedded in N-aryl nitrenoid reactive intermediates can enable access to functionalized 3H-indoles or benzazepinones. The experimental part of the paper was very detailed, including the reaction process of 2-Bromopyridin-3-amine(cas: 39856-58-1SDS of cas: 39856-58-1)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.SDS of cas: 39856-58-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Towards Property Profiling: SYNTHESIS and SAR Probing of New Tetracyclic Diazaphenothiazine Analogues》 were Empel, Anna; Bak, Andrzej; Kozik, Violetta; Latocha, Malgorzata; Cizek, Alois; Jampilek, Josef; Suwinska, Kinga; Sochanik, Aleksander; Zieba, Andrzej. And the article was published in International Journal of Molecular Sciences in 2021. Category: pyridine-derivatives The author mentioned the following in the article:

A series of new tertiary phenothiazine derivatives containing a quinoline and a pyridine fragment was synthesized by the reaction of 1-methyl-3-benzoylthio-4-butylthioquinolinium chloride with 3-aminopyridine derivatives bearing various substituents on the pyridine ring. The direction and mechanism of the cyclization reaction of intermediates with the structure of 1-methyl-4-(3-pyridyl)aminoquinolinium-3-thiolate was related to the substituents in the 2- and 4-pyridine position. The structures of the compounds were analyzed using 1H, 13C NMR (COSY, HSQC, HMBC) and X-ray anal., resp. Moreover, the antiproliferative activity against tumor cells (A549, T47D, SNB-19) and a normal cell line (NHDF) was tested. The antibacterial screening of all the compounds was conducted against the reference and quality control strain Staphylococcus aureus ATCC 29213, three clin. isolates of methicillin-resistant S. aureus (MRSA). In silico computation of the intermol. similarity was performed using principal component anal. (PCA) and hierarchical clustering anal. (HCA) on the pool of structure/property-related descriptors calculated for the novel tetracyclic diazaphenothiazine derivatives The distance-oriented property evaluation was correlated with the exptl. anticancer activities and empirical lipophilicity as well. The quant. shape-based comparison was conducted using the CoMSA method in order to indicate the potentially valid steric, electronic and lipophilic properties. Finally, the numerical sampling of similarity-related activity landscape (SALI) provided a subtle picture of the SAR trends. In addition to this study using 2-Bromopyridin-3-amine, there are many other studies that have used 2-Bromopyridin-3-amine(cas: 39856-58-1Category: pyridine-derivatives) was used in this study.

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem