Month: October 2022

Luo, Yuncong; Jiang, Shengjie; Xu, Xin published the artcile< Yttrium-Catalyzed ortho-Selective C-H Borylation of Pyridines with Pinacolborane>, Related Products of 581-47-5, the main research area is yttrium catalyzed carbon hydrogen borylation pyridine pinacolborane; crystal mol structure pyridyl boronate; pentamethylcyclopentadienyl yttrium pyridyl boronate intermediate preparation crystal mol structure; Borylation; C−H Activation; Pyridines; Regioselectivity; Yttrium.

This work reports a site-selective C-H borylation of pyridines at the ortho-position with pinacolborane enabled by an yttrocene catalyst. The reaction provides a new family of 2-pyridyl boronates with a broad substrate scope and high atom efficiency. The resultant boronates were able to undergo a variety of transformations, e.g., oxidation, Suzuki-Miyaura coupling, Chan-Lam amination and etherification. Catalytic intermediates, including ortho-C-H metalated and borylated complexes, were isolated from stoichiometric experiments and confirmed by single-crystal x-ray diffraction.

Angewandte Chemie, International Edition published new progress about Amination. 581-47-5 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Related Products of 581-47-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhu, Hongmei; Wu, Shaohang; Yao, Jiaxu; Chen, Rui; Pan, Ming; Chen, Weitao; Zhou, Jing; Zhang, Wenjun; Wang, Tao; Chen, Wei published the artcile< An effective surface modification strategy with high reproducibility for simultaneously improving efficiency and stability of inverted MA-free perovskite solar cells>, Computed Properties of 350-03-8, the main research area is perovskite solar cell surface modification high reproducibility efficiency stability.

Perovskite solar cells (PSCs) have become the front-running photovoltaic technol. and have triggered enormous research interest worldwide owing to their ultra-high solar-to-elec. power conversion efficiency and low fabrication costs, but their poor intrinsic stability issues still constitute the main obstacles that hinder their rapid commercialization. Herein, we demonstrate that, by carefully designing the modifier’s mol. structure, a facile, highly reproducible and scalable surface modification strategy can effectively enhance both the stability and efficiency of inverted PSCs. The most efficient modifier (2-acetylpyridine) can not only passivate the surface traps of the perovskite film but also enhance its stability against moisture by forming a hydrophobic capping layer on top. Accordingly, the efficiency of the inverted PSC has been improved from 16.75% to 20.05% for the best-performing one, which is, to our knowledge, among the highest values for inverted MA-free PSCs. More encouragingly, the stability of the modified devices can also be largely enhanced: the devices retained 95%, 90%, and 91% of their initial efficiencies after storage in the dark in ambient air for 2000 h, 85°C thermal aging for 500 h in the dark, and light soaking at 45°C for 500 h, resp.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about Electric current-potential relationship. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Computed Properties of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zheng, Dongxiao; Li, Anze; Zhang, Man; Wang, Xiuli; Wu, Bin; Zhao, Pei; Jia, Xiaoyong; Ding, Jiandong; Zou, Qi; Zhu, Liangliang published the artcile< An excitation-dependent ratiometric dual-emission strategy for the large-scale enhancement of fluorescent tint control>, Application In Synthesis of 123-03-5, the main research area is carbon quantum dot surface state zeta potential photoexcitation fluorescence.

An alternative and convenient strategy for preparing carbon dots (CDs) with multicolor and dual-emission fluorescence is described. For this dual-emission characteristic, the short-wavelength emission reveals unique excitation-dependent fluorescence behavior, during which the long-wavelength emission remains unshifted regardless of the excitation. Consequently, such excitation-dependent ratiometric dual emission can be applied into a fluorescent tint control of this material between the cold and warm white-light regions. This unique property allows the CDs to be further translated into film sheets for visual detection of the irradiation source, and to also be conjugated with calf thymus DNA for multichannel bioimaging. These results offer new insights for the development of easy-to-handle techniques for material luminescent color tuning.

Nanoscale published new progress about Cytotoxicity. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Application In Synthesis of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Jing; Han, Fu-She published the artcile< Pd-Catalyzed Aerobic Oxidative Heck Cross-Coupling for the Straightforward Construction of Indole δ-Lactams>, Related Products of 93-60-7, the main research area is indolyl amide palladium catalyst oxidative Heck coupling regioselective hetereocyclization; fused indolyl lactam preparation; Catalysis; Chemistry; Organic Chemistry.

A co-ligand-prompted Pd-catalyzed 6-exo-trig intramol. cyclization of indolyl amides via the aerobic oxidative Heck cross-coupling. The method provided a general and efficient way for the construction of [6.5.6]-tricyclic indole δ-lactams. A mechanistic study suggests that a Pd(I)/Pd(III) catalytic cycle should be responsible for effective coupling, which represents a mechanistically alternative pathway when compared with the Pd(0)/Pd(II) cycle proposed for other related coupling reactions.

iScience published new progress about Alkenes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Related Products of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Darwish, Shaban; Sadeghiani, Neda; Fong, Shirley; Mozaffari, Saghar; Hamidi, Parinaz; Withana, Thimanthi; Yang, Sun; Tiwari, Rakesh Kumar; Parang, Keykavous published the artcile< Synthesis and antiproliferative activities of doxorubicin thiol conjugates and doxorubicin-SS-cyclic peptide>, Safety of 1,2-Di(pyridin-2-yl)disulfane, the main research area is human embryonic kidney ovarian fibrosarcoma leukemia; cyclopeptide preparation antitumor doxorubicin fluorescence cellular uptake chemotherapy antiproliferative; Anticancer; Cardiotoxicity; Cellular uptake; Cyclic peptide; Disulfide; Doxorubicin; Thiol.

Myocardial toxicity and drug resistance caused by drug efflux are major limitations of doxorubicin (Dox)-based chemotherapy. Dox structure modification could be used to develop conjugates with an improved biol. profile, such as antiproliferative activity and higher cellular retention. Thus, Dox thiol conjugates, Dox thiol (Dox-SH), thiol-reactive Dox-SS-pyridine (SS = disulfide), and a Dox-SS-cell-penetrating cyclic peptide, Dox-SS-[C(WR)4K], were synthesized. Dox was reacted with Traut’s reagent to generate Dox-SH. Cytotoxicity of the compounds was examined in human embryonic kidney (HEK-293), human ovarian cancer (SKOV-3), human fibrosarcoma (HT-1080), and human leukemia (CCRF-CEM) cells. These data indicate that Dox-SH, Dox-SS-Pyr, and Dox-SS-[C(WR)4K] have the potential to be further examined as Dox alternatives and anticancer agents.

European Journal of Medicinal Chemistry published new progress about Antiproliferative agents. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Safety of 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rani, S. Mahil; Brindha, J.; Reji, T. F. Abbs Fen published the artcile< Synthesis, computational studies and antioxidant activity of some 3-(2-alkylamino-4-aminothiazole-5-oyl)pyridines>, Name: 1-(Pyridin-3-yl)ethanone, the main research area is alkylamino aminothiazoloyl pyridine preparation antioxidant DFT HOMO LUMO.

A series of thiazoloylpyridine derivatives I (R = Et, n-Pr, i-Pr, n-Bu, allyl) has been synthesized and analyzed to confirm the structure of the product using IR, 1H and 13C NMR, mass spectra and anal. data. Optimized structural and electronic parameters of all the compounds I have been calculated by using B3LYP/ 6-31G basis set. The Mulliken charges of all atoms have been evaluated. All the synthesized compounds I have been examined for antioxidant activities. The antioxidant activity of 3-(2-alkylamino-4-aminothiazol -5-oyl)pyridines I have been analyzed using DPPH radical scavenging assay. The compounds I (R = Et, n-Pr) possess higher radical scavenging activity.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about Antioxidants. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Name: 1-(Pyridin-3-yl)ethanone.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lam, Hung Thanh; Le-Vinh, Bao; Phan, Thi Nhu Quynh; Bernkop-Schnuerch, Andreas published the artcile< Self-emulsifying drug delivery systems and cationic surfactants: do they potentiate each other in cytotoxicity>, Computed Properties of 123-03-5, the main research area is self emulsifying drug delivery system cationic surfactant; alkyltrimethylammonium bromide; benzalkonium chloride; cationic surfactant; cytotoxicity; self-emulsifying drug delivery systems.

The aim of this study was to evaluate the cytotoxicity of self-emulsifying drug delivery systems (SEDDS) containing five different cationic surfactants. Cationic surfactants were added in a concentration of 1% and 5% (m/m) to SEDDS comprising 30% Capmul MCM, 30% Captex 355, 30% Cremophor EL and 10% propylene glycol. The resulting formulations were characterized in terms of size, zeta potential, in-vitro haemolytic activity and toxicity on Caco-2 via MTT assay and lactate dehydrogenase release assay. The evaluated surfactants had in both concentrations a minor impact on the size of SEDDS ranging from 30.2 ± 0.6 to 55.4 ± 1.1 nm, whereas zeta potential changed significantly from -9.0 ± 0.3 to +28.8 ± 1.6 mV. The overall cytotoxicity of cationic surfactants followed the rank order: hexadecylpyridinium chloride > benzalkonium chloride > alkyltrimethylammonium bromide > octylamine > 1-decyl-3-methylimidazolium. The haemolytic activity of the combination of cationic surfactants and SEDDS on human red blood cells was synergistic. Furthermore, cationic SEDDS exhibited higher cytotoxicity of Caco-2 cells compared to SEDDS without cationic surfactants. According to these results, SEDDS and cationic surfactants seem to bear an additive up to synergistic toxic risk.

Journal of Pharmacy and Pharmacology published new progress about Castor oil, ethoxylated Role: MOA (Modifier or Additive Use), USES (Uses). 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Computed Properties of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ziolkowska, Dorota; Syrotynska, Iryna; Shyichuk, Alexander; Lamkiewicz, Jan published the artcile< Determination of SLES in personal care products by colloid titration with light reflection measurements>, Quality Control of 3811-73-2, the main research area is sodium laureth sulfate personal care product colloid titration; PDADMAC; PDDA; cationic polymer; polyDADMAC; quantitation of surfactants; turbidity.

The method of colloid titration with poly(diallyldimethylammonium) chloride has been improved to detect the endpoint with an off-vessel light reflectance sensor. The digital color sensor used measures light reflectance by means of light guides, with no immersion into the reaction solution In such a method, the optical signal is free of disturbances caused by sticky flocs in the solution The improved automatic titration set was applied for the determination of sodium laureth sulfate (SLES) in industrial batches and com. personal care products. The sample color and opacity do not disturb the SLES quantification. When the SLES content lies in the range from 5% to 9%, the optimal sample weight is from 6 g to 3 g.

Molecules published new progress about Almond. 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Quality Control of 3811-73-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sardaru, Monica-Cornelia; Craciun, Anda Mihaela; Al Matarneh, Cristina-Maria; Sandu, Isabela Andreea; Amarandi, Roxana Maria; Popovici, Lacramioara; Ciobanu, Catalina Ionica; Peptanariu, Dragos; Pinteala, Mariana; Mangalagiu, Ionel I.; Danac, Ramona published the artcile< Cytotoxic substituted indolizines as new colchicine site tubulin polymerisation inhibitors>, Product Details of C10H8N2, the main research area is indolizine derivative preparation colchicine tubulin polymerization inhibitor cancer; Indolizine; Phenstatin; anticancer; pyridyl; tubulin polymerisation inhibitors.

A potential microtubule destabilizing series of new indolizine derivatives was synthesized and tested for their anticancer activity against a panel of 60 human cancer cell lines. the compounds showed a broad spectrum of growth inhibitory activity against cancer cell lines representing leukemia, melanoma and cancer of lung, colon, central nervous system, ovary, kidney, breast, and prostate. Among them, compound was distinguishable by its excellent cytostatic activity, showing GI50 values in the range of 10-100 nM on 43 cell lines. The less potent compounds and in terms of GI50 values showed a high cytotoxic effect against tested colon cancer, CNS cancer, renal cancer and melanoma cell lines and only on few cell lines from other types of cancer. In vitro assaying revealed tubulin polymerization inhibition by all active compounds Mol. docking showed good complementarity of active compounds with the colchicine binding site of tubulin.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about Antitumor agents. 581-47-5 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Product Details of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

He, Yu-Ping; Cao, Jian; Wu, Hua; Wang, Qian; Zhu, Jieping published the artcile< Catalytic Enantioselective Aminopalladation-Heck Cascade>, Application In Synthesis of 1416819-91-4, the main research area is alkynylaniline cyclopentene diastereoselective enantioselective palladium pyrox aminopalladation Heck cascade; indole cyclopentene stereoselective preparation; asymmetric synthesis; domino reactions; homogeneous catalysis; nucleopalladation; oxidative Heck reactions.

Domino processes initiated by intramol. nucleopalladation of alkynes have been developed into powerful synthetic tools for the synthesis of functionalized heterocycles. However, a catalytic enantioselective version of this class of reactions remains scarce. We report herein that reaction of 2-alkynylanilines with prochiral cyclopentenes in the presence of a catalytic amount of Pd(OAc)2, a chiral bidentate pyrox ligand and O2 as terminal oxidant affords the structurally diverse indole-cyclopentene conjugates, e.g., I, bearing two stereocenters in a highly diastereo- and enantio-selective manner. One of the products is converted to a heavily functionalized tetracyclic indolinone derivative

Angewandte Chemie, International Edition published new progress about Addition reaction, aminopalladation. 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Application In Synthesis of 1416819-91-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem