Month: October 2022

Ciriano, Miguel A.; Perez-Torrente, Jesus J.; Oro, Luis A. published the artcile< Synthesis and reactivity of binuclear 7-azaindolate complexes of iridium. II. Oxidative-addition reactions of halogens and halocarbons to [{Ir(μ-aza)(CO)2}2]>, COA of Formula: C7H5BrN2, the main research area is azaindolate iridium complex oxidative addition; halogen oxidative addition azaindolate iridium complex; halocarbon oxidative addition azaindolate iridium complex; pyrrolopyridinate iridium complex oxidative addition.

The compound [{Ir(μ-aza)(CO)2}2] (1, aza = 7-azaindolate) is oxidized by AgBF4 in a donor solvent to [{Ir(μ-aza)(CO)2(S)}2]2+ (S = Me2CO, MeCN) and to the neutral complex [{Ir(μ-aza)(CO)2(O2CMe)}2] (2) by silver acetate. The head-to-tail (HT) and the head-to-head (HH) isomers of 1 undergo trans-annular oxidative-addition reactions with a variety of substrates. Halogens (X2) add to 1 giving the diiridium(II) complexes [{Ir(μ-aza)X(CO)2}2] (X = Cl (3), Br, iodo). In addition, bromine selectively attacks position 3 of the five-membered ring in the aza bridges, affording [{Ir(μ-azaBr)Br(CO)2}2] as a single isomer. MeI and polyiodomethanes react with both isomers of 1 to give the iodomethyl complexes [{Ir(μ-aza)(CO)2}2(I)(R)] (R = Me, CH2I, CHI2, or (CH2)3I) as a mixture of isomers. The relative disposition, HH and HT, of the bridging ligands is maintained in these reactions. Complex 1 is a powerful photoreductor that reacts with CHCl3 and CCl4 giving [{Ir(μ-aza)(CO)2}2(Cl)(R)] (R = CHCl2 or CCl3), resp., whereas compound 3 results from reaction with 1,2-dichloroethane. Reactions of complex 1 with di-Et acetylenedicarboxylate and di-Me acetylenedicarboxylate (A) afford the tetranuclear complexes of the type [{Ir(μ-aza)(CO)2}4(A)2].

Journal of Organometallic Chemistry published new progress about Oxidative addition reaction. 23612-36-4 belongs to class pyridine-derivatives, and the molecular formula is C7H5BrN2, COA of Formula: C7H5BrN2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Matesanz, Encarna; Alcazar, Jesus; Andres, J. Ignacio; Bartolome, Jose M.; De Bruyn, Marcel; Fernandez, Javier; Van Emelen, Kristof published the artcile< Synthesis of novel aza analogues of 2-substituted-2,3-dihydro-1,4-benzodioxins as potential new scaffolds for drug discovery>, Application of C5H4ClNO, the main research area is benzodioxin aza analog preparation.

New synthesis approaches that have led to a series of novel aza analogs of the 2-substituted-2,3-dihydro-1,4-benzodioxin core, bearing versatile bromomethyl group on the non aromatic oxygenated ring, are described. According to their structures these novel scaffolds can be useful intermediates for the preparation of potential new therapeutic agents.

Tetrahedron Letters published new progress about Cyclization, regioselective. 96630-88-5 belongs to class pyridine-derivatives, and the molecular formula is C5H4ClNO, Application of C5H4ClNO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lepeltier, Marc; Dumur, Frederic; Marrot, Jerome; Contal, Emmanuel; Bertin, Denis; Gigmes, Didier; Mayer, Cedric R. published the artcile< Unprecedented combination of regioselective hydrodefluorination and ligand exchange reaction during the syntheses of tris-cyclometalated iridium(III) complexes>, Computed Properties of 370878-69-6, the main research area is fluoropyridine cyclometalated iridium complex preparation unprecedented regioselective hydrodefluorination ligand; crystal mol structure tris fluoropyridine cyclometalated iridium complex.

The first reported combination of regioselective hydro-defluorination and a ligand exchange reaction during the syntheses of neutral iridium(III) complexes is presented. Surprisingly, loss of one fluorine atom per ligand combined with a complete ligand exchange reaction on the transition metal were jointly observed during a bridge-splitting and substitution reaction of two different dimeric iridium(III) precursor complexes with two different ancillary ligands. The regioselectivity of defluorination was evidenced in both cases. The reaction time was identified as a factor strongly impacting the kinetics of the thermally induced reaction.

Dalton Transactions published new progress about Coordinative substitution reaction. 370878-69-6 belongs to class pyridine-derivatives, and the molecular formula is C33H21F3IrN3, Computed Properties of 370878-69-6.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

An, Yunfei; Dong, Yue; Liu, Min; Han, Jun; Zhao, Liyu; Sun, Bin published the artcile< Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation>, Application In Synthesis of 3731-53-1, the main research area is naphthylamide imidazole preparation antifungal activity mol docking SAR; squalene epoxidase cytochrome P450 enzyme inhibitor; Antifungal activity; Dual-target; Fungal infections; Inhibitors; Organic synthesis.

In the study, a series of active fragments were screened through the method of De Novo Link, and these active fragments with the higher Ludi_Scores were selected, which can show the obvious binding ability with the dual targets (SE, CYP51). Subsequently, three series of target compounds with naphthyl amide scaffolds were constructed by connecting these core fragments, and their structures were synthesized. Most of compounds showed the antifungal activity in the treatment of pathogenic fungi. It was worth noting that compoundsI [R = pyridin-4-ylmethyl] and II [R = methyl] with the excellent broad-spectrum antifungal properties also exhibited the obvious antifungal effects against drug-resistant fungi. Preliminary mechanism study has proved these target compounds can block the biosynthesis of ergosterol by inhibiting the activity of dual targets (SE, CYP51). Furthermore, target compounds I [R = pyridin-4-ylmethyl] and II [R = methyl] with low toxicity side effects also demonstrated the excellent pharmacol. effects in vivo. The mol. docking and ADMET prediction were performed, which can guide the optimization of subsequent lead compounds

European Journal of Medicinal Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Application In Synthesis of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Eremina, Julia A.; Lider, Elizaveta V.; Samsonenko, Denis G.; Sheludyakova, Liliya A.; Berezin, Alexey S.; Klyushova, Lyubov S.; Ostrovskii, Vladimir A.; Trifonov, Rostislav E. published the artcile< Mixed-ligand copper(II) complexes with tetrazole derivatives and 2,2'-bipyridine, 1,10-phenanthroline: Synthesis, structure and cytotoxic activity>, Category: pyridine-derivatives, the main research area is crystal structure copper phenanthroline bipyridine tetrazole; copper phenanthroline bipyridine phenyltetrazole tetrazole preparation cytotoxicity human.

The [Cu2(2,2′-bipy)2(L1)4] (1), [Cu2(1,10-phen)2(L1)4] (2), [Cu(2,2′-bipy)(L2)2]n (3) and [Cu2(1,10-phen)2(L2)4] (4) complexes, where HL1 – 5-phenyltetrazole, and HL2 – 1H-tetrazole, were synthesized. All complexes were characterized by elemental anal., IR, EPR spectroscopy and x-ray diffraction. The complexes possess distorted tetragonal-pyramidal coordination geometry. Compounds 1, 2, and 4 show μ-5-phenyl-tetrazole/tetrazole bridged dinuclear structures, while compound 3 reveals polymeric structure. The effect of the compounds on viability of the MCF-7 and Hep-2 cell lines was studied in vitro. Tetrazole ligands HL1 and HL2 are nontoxic at tested concentrations (1-50 μM), while 1,10-phen and 2,2′-bipy possess cytotoxicity. All of the complexes exhibit significant dose-dependent cytotoxic effect and have the potential to act as efficient cytotoxic drugs. [Cu(1,10-phen)Cl2] (5) and [Cu(2,2′-bipy)Cl2] (6) also were obtained to establish the influence of insertion of tetrazole ligands in compounds on their cytotoxic properties.

Inorganica Chimica Acta published new progress about Antitumor agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shirazi, Seyed Mohammad Hossein; Mokhtari, Javad; Mirjafary, Zohreh published the artcile< A new method for the synthesis of abiraterone drug catalyzed by Pd-NPs@Zn-MOF as efficient reusable catalyst>, Related Products of 329214-79-1, the main research area is abiraterone palladium nanoparticle heterogeneous catalyst Suzuki Miyaura.

The present work provides a novel process for the preparation of abiraterone drug in a Suzuki-Miyaura coupling approach by a new heterogeneous palladium catalyst, Pd-NPs@Zn-MOF, which has been synthesized by one-step encapsulation in nanoporous metal-organic framework Zn-MOF under a temperature control program for the first time. Pd-NPs@Zn-MOF were characterized by transmission electron microscopy (TEM), X-Ray powder diffraction (XRD), BET surface area anal., inductively coupled plasma (ICP)-optical emission spectrometry (OES), and XPS.

Applied Organometallic Chemistry published new progress about Emission spectroscopy. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Related Products of 329214-79-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xu, Si-Yu; Zhang, Rui; Zhang, Shu-Sheng; Feng, Chen-Guo published the artcile< Enantioselective synthesis of 3-aryl-phthalides through a nickel-catalyzed stereoconvergent cross-coupling reaction>, Recommanded Product: (S)-4-(tert-Butyl)-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole, the main research area is arylphthalide preparation enantioselective nickel catalyst; bromophthalide arylboronic acid Suzukimiiyaura crosscoupling reaction.

A nickel-catalyzed asym. Suzuki-Miyaura cross-coupling of racemic 3-bromo-phthalides and arylboronic acids was realized for the synthesis of diverse chiral 3-aryl-phthalides in moderate to excellent reaction yields. The reaction proceeded in a stereoconvergent manner and high enantioselectivities were observed for most examined examples. A number of functional groups like aldehyde, ester and bromide were well tolerated. Heteroaromatic boronic acids were also competent coupling partners in this reaction.

Organic & Biomolecular Chemistry published new progress about Arylboronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Recommanded Product: (S)-4-(tert-Butyl)-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Miller, Susanne L.; Chotana, Ghayoor A.; Fritz, Jonathan A.; Chattopadhyay, Buddhadeb; Maleczka, Robert E. Jr.; Smith, Milton R. III published the artcile< C-H Borylation Catalysts that Distinguish Between Similarly Sized Substituents Like Fluorine and Hydrogen>, Product Details of C7H9BrN2, the main research area is aromatic compound carbon hydrogen bond activation borylation iridium catalyst; borane heteroaryl derivative preparation.

By modifying ligand steric and electronic profiles it is possible to C-H borylate ortho or meta to substituents in aromatic and heteroaromatic compounds, where steric differences between accessible C-H sites are small. Dramatic effects on selectivities between reactions using B2pin2 or 4,4,5,5-tetramethyl-1,3,2-dioxaborolane (HBpin) are described for the 1st time. Judicious ligand and borane combinations give highly regioselective C-H borylations on substrates where typical borylation protocols afford poor selectivities.

Organic Letters published new progress about Boranes Role: SPN (Synthetic Preparation), PREP (Preparation) ((hetero)aromatic). 396092-82-3 belongs to class pyridine-derivatives, and the molecular formula is C7H9BrN2, Product Details of C7H9BrN2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Keller, P. A. published the artcile< Product class 2: pyridinones and related systems>, Category: pyridine-derivatives, the main research area is review pyridinone preparation; pyridinethione preparation review; pyridineselenone preparation review; pyridinetellurone preparation review.

A review of methods to prepare pyridinones and related systems is presented. Synthetic methods include cyclization, aromatization, ring transformation, and substituent modification. The parent pyridinones are generally stable and are easily handled under standard laboratory conditions. The corresponding pyridinethiones are generally more reactive but have the advantage of generally requiring only standard laboratory equipment for their handling. The pyridineselenones are more reactive and the pyridinetellurones have not been comprehensively studied and characterized due to their reactivity and associated difficulty in production

Science of Synthesis published new progress about Aromatization. 86129-63-7 belongs to class pyridine-derivatives, and the molecular formula is C9H9Cl2NO2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Timmer, Brian J. J.; Kravchenko, Oleksandr; Liu, Tianqi; Zhang, Biaobiao; Sun, Licheng published the artcile< Off-Set Interactions of Ruthenium-bda Type Catalysts for Promoting Water-Splitting Performance>, COA of Formula: C7H7NO2, the main research area is ruthenium catalyst water splitting performance catalytic activity; homogeneous catalysis; kinetics; noncovalent interactions; ruthenium; water splitting.

O-O bond formation with Ru(bda)L2-type catalysts is well-known to proceed through a bimol. reaction pathway, limiting the potential application of these catalysts at low concentrations Herein, we achieved high efficiencies with mononuclear catalysts, with TOFs of 460±32 s-1 at high catalyst loading and 31±3 s-1 at only 1 μM catalyst concentration, by simple structural considerations on the axial ligands. Kinetic and DFT studies show that introduction of an off-set in the interaction between the two catalytic units reduces the kinetic barrier of the second-order O-O bond formation, maintaining high catalytic activity even at low catalyst concentrations The results herein furthermore suggest that π-π interactions may only play a minor role in the observed catalytic activity, and that asymmetry can also rationalize high activity observed for Ru(bda)(isoq)2 type catalysts and offer inspiration to overcome the limitations of 2nd order catalysis.

Angewandte Chemie, International Edition published new progress about Bond formation. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, COA of Formula: C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem