Month: October 2022

Kumar, Manoj; Pandey, Sushil K.; Chaudhary, Neha; Mishra, Anand; Gupta, Deepshikha published the artcile< Highly efficient method for the synthesis of substituted benzimidazoles using sodium metabisulfite adsorbed on silica gel>, Application In Synthesis of 212268-13-8, the main research area is benzimidazole preparation green chem; benzaldehyde heterocyclization phenylenediamine sodium metabisulfite silica.

A simple efficient and economical method is established to synthesize N-(un)substituted benzimidazoles from the corresponding benzaldehydes and N-(un)substituted o-phenylenediamines in moderate to excellent yields using sodium metabisulfite adsorbed on silica gel in ethanol. Most of the reactions are completed at ambient temperature with easy product isolation.

Results in Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 212268-13-8 belongs to class pyridine-derivatives, and the molecular formula is C5H6FN3, Application In Synthesis of 212268-13-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wei, Xiao-Jing; Abdiaj, Irini; Sambiagio, Carlo; Li, Chenfei; Zysman-Colman, Eli; Alcazar, Jesus; Noel, Timothy published the artcile< Visible-Light-Promoted Iron-Catalyzed C(sp2)-C(sp3) Kumada Cross-Coupling in Flow>, Related Products of 13472-84-9, the main research area is Kumada cross coupling aryl chloride Grignard reagent iron catalyst; visible light Kumada cross coupling iron catalyst mechanism flow; Kumada coupling; cross-coupling; flow chemistry; iron catalysis; photocatalysis.

A continuous-flow, visible-light-promoted method has been developed to overcome the limitations of iron-catalyzed Kumada-Corriu cross-coupling reactions. A variety of strongly electron rich aryl chlorides, previously hardly reactive, could be efficiently coupled with aliphatic Grignard reagents at room temperature in high yields and within a few minutes’ residence time, considerably enhancing the applicability of this iron-catalyzed reaction. The robustness of this protocol was demonstrated on a multigram scale, thus providing the potential for future pharmaceutical application. The mechanism was studied using radical clock experiments, kinetic measurements, DFT and other techniques.

Angewandte Chemie, International Edition published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, Related Products of 13472-84-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chowdhury, Suman; Rakshit, Atanu; Acharjee, Animesh; Ghosh, Aniruddha; Mahali, Kalachand; Saha, Bidyut published the artcile< Ru(III) catalysed oxidation of 2-propanol by Cr(VI) in micellar media>, Safety of 1-Hexadecylpyridin-1-ium chloride, the main research area is propanol ruthenium catalyst oxidation kinetics mechanism UV spectra.

Acetone, the simplest ketone of abundant useful is produced from 2-propanol by oxidation with hexavalent Cr(VI) sluggishly under pseudo 1st order reaction condition. The rate is enhanced considerably using Ru(III) metal salt solution at ppm level as a catalyst. Addnl. rate enhancement, is obtained in SDS micellar media, is reflected in rapid reduction of peak height of absorbance curve of the oxidant Cr(VI) at λmax = 440 nm. The product, acetone is confirmed by IR spectrum of 2, 4- DNP derivative and 1H NMR study of acetone.

Journal of Molecular Liquids published new progress about NMR (nuclear magnetic resonance), chemical shift. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Safety of 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yang, Gongming; Li, Zhipeng; Liu, Yuhan; Guo, Donghui; Sheng, Xijun; Wang, Jian published the artcile< Organocatalytic Higher-Order [8+2] Cycloaddition for the Assembly of Atropoenantiomeric 3-Arylindolizines>, Application of C6H4F3N, the main research area is arylindolizine preparation enantioselective; ylide ynal cycloaddition organocatalyst.

An unprecedented atroposelective [8+2] cycloaddition reaction between pyridinium/isoquinolinium ylides and ynals was presented. It was worth noting that this protocol represented a new example of the organocatalyzed atropoenantioselective higher-order cycloaddition reaction, providing various axial chiral 3-arylindolizines, e.g., I in good yields and high enantioselectivities. In addition, the obtained axially chiral 3-aryldolizines also provided many opportunities for structural transformations and potential drug discovery.

Organic Letters published new progress about Alkynes, internal Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Application of C6H4F3N.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hasanzadeh Esfahani, Maryam; Iranmanesh, Hasti; Beves, Jonathon E.; Kaur, Manpreet; Jasinski, Jerry P.; Behzad, Mahdi published the artcile< Crystal structures and antibacterial properties of Cu(II) complexes containing an unsymmetrical N2O Schiff base ligand and bidentate N-donor heterocyclic co-ligands>, Safety of 2,2′-Bipyridine, the main research area is copper Schiff propanediamine salicylaldehyde complex preparation; crystal structure copper Schiff propanediamine salicylaldehyde complex.

Three new Cu(II) Schiff base complexes with bidentate N-donor heterocyclic co-ligands, 2,2′-bipyridine (1), 1,10-phenanthroline (2), and 2,9-dimethyl-1,10-phenanthroline (3), were synthesized and characterized by FTIR and UV-visible spectroscopy. Mol. structures of [C20H21CuN4O](ClO4) (1) and [C24H25CuN4O](ClO4) (3) were characterized by single-crystal x-ray crystallog. The Schiff base ligand is an N2O-type ligand, which is the mono-condensed form of the reaction between 1,3-propanediamine and salicylaldehyde. The antibacterial activities of these complexes were studied against one gram pos. and four gram neg. bacteria. Considerable antibacterial activity was obtained against both gram type bacteria. Complexes 2 and 3 with 1,10-phenanthroline and 2,9-dimethyl-1,10-phenanthroline, resp., showed better antibacterial activity compared to which has the 2,2′-bipyridine co-ligand.

Journal of Coordination Chemistry published new progress about Antibacterial agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Safety of 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Manteau, Baptiste; Genix, Pierre; Brelot, Lydia; Vors, Jean-Pierre; Pazenok, Sergiy; Giornal, Florence; Leuenberger, Charlotte; Leroux, Frederic R. published the artcile< A General Approach to (Trifluoromethoxy)pyridines: first X-ray Structure Determinations and Quantum Chemistry Studies>, Reference of 73018-09-4, the main research area is general approach synthesis Trifluoromethoxy pyridines crystal structure; ab initio energy profiles rotation trifluoromethoxy methoxy pyridines.

The previously unknown 2-, 3-, and 4-(trifluoromethoxy)pyridines have now become readily accessible by means of an efficient and straightforward large-scale synthesis. Their regioselective functionalization by organometallic methods has been studied and has afforded new and highly important building blocks for life-sciences-oriented research. In addition, the first X-ray crystallog. structure determinations of (trifluoromethoxy)pyridines have been performed. Lowest-energy conformations of (trifluoromethoxy)pyridines and (trifluoromethoxy)pyridinium cations were determined by in silico studies.

European Journal of Organic Chemistry published new progress about Anomeric effect. 73018-09-4 belongs to class pyridine-derivatives, and the molecular formula is C5H4ClNO, Reference of 73018-09-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Schirrmacher, Ralf; Wangler, Bjorn; Schirrmacher, Esther; August, Thorsten; Rosch, Frank published the artcile< Dimethylpyridin-4-ylamine-catalysed alcoholysis of 2-amino-N,N,N-trimethyl-9H-purine-6-ylammonium chloride: An effective route to O6-substituted guanine derivatives from alcohols with poor nucleophilicity>, Name: 2-Fluoro-3-(hydroxymethyl)pyridine, the main research area is dimethylpyridinylamine catalyzed alcoholysis nucleophilicity aminotrimethylpurinylammonium chloride; guanine alc derivative preparation.

Dimethylpyridin-4-ylamine (DMAP)-catalyzed reactions of 2-amino-N,N,N-trimethyl-9H-purine-6-ylammonium chloride with fluoropyridine methoxides and various other alkoxides in DMSO at 60 °C gave the corresponding coupling products in moderate to good yields between 20-87%. Under these reaction conditions, fluorinated O6-substituted Guanine derivatives have been synthesized which could not be obtained via known analogous literature procedures. The resp. yields of known O6-substituted guanine derivatives could be significantly improved by using this method. The efficient use of DMAP as an excellent nucleophilic catalyst in the syntheses of O6-substituted Guanine derivatives has thus been demonstrated.

Synthesis published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 131747-55-2 belongs to class pyridine-derivatives, and the molecular formula is C6H6FNO, Name: 2-Fluoro-3-(hydroxymethyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chen, Zhi-Min; Liu, Jianbo; Guo, Jing-Yao; Loch, Maximillan; DeLuca, Ryan J.; Sigman, Matthew S. published the artcile< Palladium-catalyzed enantioselective alkenylation of alkenylbenzene derivatives>, Application of C13H15F3N2O, the main research area is alkenylarene alkenyl triflate palladium catalyst regioselective enantioselective Heck reaction.

A regioselective and enantioselective palladium-catalyzed relay Heck alkenylation of alkenylbenzene derivatives to construct remote stereocenters was disclosed. Various β-substituted styrenes were readily obtained in moderate yields with good to excellent levels of enantioselectivity. This strategy provided rapid access to enantioenriched δ, ε, ζ and η-alkenyl aryl compounds from simple starting materials. Mechanistic studies suggested that termination of the relay reaction was controlled by affinity of the arene for the Pd complex during migration.

Chemical Science published new progress about Alkenyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Application of C13H15F3N2O.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chakroun, Rami W.; Wang, Feihu; Lin, Ran; Wang, Yin; Su, Hao; Pompa, Danielle; Cui, Honggang published the artcile< Fine-Tuning the Linear Release Rate of Paclitaxel-Bearing Supramolecular Filament Hydrogels through Molecular Engineering>, Name: 1,2-Di(pyridin-2-yl)disulfane, the main research area is paclitaxel prodrug peptide hydrogel; chemotherapy; controlled release; drug delivery; hydrogels; molecular assembly; prodrug.

One key design feature in the development of any local drug delivery system is the controlled release of therapeutic agents over a certain period of time. In this context, we report the characteristic feature of a supramol. filament hydrogel system that enables a linear and sustainable drug release over the period of several months. Through covalent linkage with a short peptide sequence, we are able to convert an anticancer drug, paclitaxel (PTX), to a class of prodrug hydrogelators with varying critical gelation concentrations These self-assembling PTX prodrugs associate into filamentous nanostructures in aqueous conditions and consequently percolate into a supramol. filament network in the presence of appropriate counterions. The intriguing linear drug release profile is rooted in the supramol. nature of the self-assembling filaments which maintain a constant monomer concentration at the gelation conditions. We found that mol. engineering of the prodrug design, such as varying the number of oppositely charged amino acids or through the incorporation of hydrophobic segments, allows for the fine-tuning of the PTX linear release rate. In cell studies, these PTX prodrugs can exert effective cytotoxicity against glioblastoma cell lines and also primary brain cancer cells derived from patients and show enhanced tumor penetration in a cancer spheroid model. We believe this drug-bearing hydrogel platform offers an exciting opportunity for the local treatment of human diseases.

ACS Nano published new progress about Amphiphiles. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Name: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Vitali, Valerio; Nava, Giovanni; Zanchetta, Giuliano; Bragheri, Francesca; Crespi, Andrea; Osellame, Roberto; Bellini, Tommaso; Cristiani, Ilaria; Minzioni, Paolo published the artcile< Integrated Optofluidic Chip for Oscillatory Microrheology>, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride, the main research area is integrated optofluidic chip oscillatory microrheol interferometer waveguide.

Abstract: We propose and demonstrate an on-chip optofluidic device allowing active oscillatory microrheol. measurements with sub-μL sample volume, low cost and high flexibility. Thanks to the use of this optofluidic microrheometer it is possible to measure the viscoelastic properties of complex fluids in the frequency range 0.01-10 Hz at different temperatures The system is based on the optical forces exerted on a microbead by two counterpropagating IR laser beams. The core elements of the optical part, integrated waveguides and an optical modulator, are fabricated by fs-laser writing on a glass substrate. The system performance is validated by measuring viscoelastic solutions of aqueous worm-like micelles composed by Cetylpyridinium Chloride (CPyCl) and Sodium Salicylate (NaSal).

Scientific Reports published new progress about Electric potential. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem