Month: October 2022

Rawat, Manish; Rawat, Diwan S. published the artcile< Cu2O-Decorated Marigold Hollow Alumina Microsphere Nanoparticles as a Robust and Efficient Catalyst for the Synthesis of Isoquinolones>, Electric Literature of 350-03-8, the main research area is copper oxide decorated marigold hollow alumina microsphere catalyst preparation; isoquinolone green preparation.

A novel Cu2O-decorated marigold hollow alumina microsphere nanocatalytic system for the synthesis of isoquinolones I [R1 = H, 7-Me, 6-F; R2 = Ph, 4-ClC6H4, 2-thienyl, etc.] using 2-bromobenzonitriles and ketones under neat condition was reported. The prepared nanocatalyst was well characterized by SEM, high-resolution transmission electron microscopy, powder X-ray diffraction, energy-dispersive X-ray anal., XPS and Brunauer-Emmett-Teller techniques. The present method was facile and showed better green chem. metrics such as low E-factor, high reaction mass efficiency, and high turnover number and could be reused for five cycles without any loss in its catalytic activity.

ACS Sustainable Chemistry & Engineering published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Electric Literature of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mandal, Rajorshi; Garai, Abhijit; Peli, Simone; Datta, Prasanta K.; Biradha, Kumar published the artcile< Photoinduced bending of single crystals of a linear bis-olefin via water-templated solid-state [2+2] photopolymerization reaction>, Recommanded Product: Pyridin-4-ylmethanamine, the main research area is photocycloaddition photopolymerization crystal bending; photoactuators; photochemistry; photoinduced bending; solid-state [2+2] photopolymerization.

The single crystals of two structural isomers of bis-olefinic mols. were shown to have contrasting properties in terms of their photoreactivity: one exhibits an excellent ability to form polymers, accompanied with bending of crystals upon irradiation, while the other is photostable. The photoreactive crystal is a first example in which [2+2] polymerization leads to bending of the crystals, with implications for the design of photoactuators. The hydrate formation ability of one of these mol. isomers promotes the solid-state reactivity in its crystal, as the H2O mols. act as a template to bring the olefin mols. into the required arrangement for [2+2] polymerization Further, the crystals of the polymer exhibited better flexibility and smoothed surfaces compared to those of the monomers. In addition, under UV-light the diene emits bluish violet light while the polymer emits green light, indicating that the luminescence property can be tuned through photoirradiation

Chemistry – A European Journal published new progress about [2+2] Photocycloaddition reaction. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Recommanded Product: Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kassem, Salma; Lee, Alan T. L.; Leigh, David A.; Markevicius, Augustinas; Tetlow, Daniel J.; Toriumi, Naoyuki published the artcile< Site-to-site peptide transport on a molecular platform using a small-molecule robotic arm>, Application of C10H8N2S2, the main research area is small mol robotic arm peptide transport.

Peptides attached to a cysteine hydrazide ‘transporter module’ are transported selectively in either direction between two chem. similar sites on a mol. platform, enabled by the discovery of new operating methods for a mol. transporter that functions through ratcheting. Substrate repositioning is achieved using a small-mol. robotic arm controlled by a protonation-mediated rotary switch and attachment/release dynamic covalent chem. A polar solvent mixtures were found to favor Z to E isomerization of the doubly-protonated switch, transporting cargo in one direction (arbitrarily defined as ‘forward’) in up to 85% yield, while polar solvent mixtures were unexpectedly found to favor E to Z isomerization enabling transport in the reverse (‘backward’) direction in >98% yield. Transport of the substrates proceeded in a matter of hours (compared to 6 days even for simple cargoes with the original system) without the peptides at any time dissociating from the machine nor exchanging with others in the bulk. Under the new operating conditions, key intermediates of the switch are sufficiently stabilized within the macrocycle formed between switch, arm, substrate and platform that they can be identified and structurally characterized by 1H NMR. The size of the peptide cargo has no significant effect on the rate or efficiency of transport in either direction. The new operating conditions allow detailed phys. organic chem. of the ratcheted transport mechanism to be uncovered, improve efficiency, and enable the transport of more complex cargoes than was previously possible.

Chemical Science published new progress about Peptides Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Application of C10H8N2S2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Troschuetz, Reinhard; Karger, Alexander published the artcile< Versatile synthesis of 6-substituted 8-deazapteridine-2,4-diamines. Formal total synthesis of 8,10-dideazaminopterin>, HPLC of Formula: 21901-29-1, the main research area is deazapteridinediamine preparation; dideazaaminopterin formal total synthesis.

A new synthesis of 4-amino-4-deoxy-8,10-dideazapteroic acid (I, R =CH2CH2C6H4CO2H-4, R1 = H) and 6-substituted and 5,6-anelated 8-deazapteridine-2,4-diamines I [R = Me, CH2CH2C6H4CO2Me-4, R1 = H; RR1 = (CH2)4] is described. Starting from (H2N)2C:CHNO2 or (H2N)2C:CHCO2Et and RCOCR1:CHNMe2, I can be prepared via functional group transformation of 2-aminopyridines yielding 3-amino-α-picolinonitriles which are cyclocondensed with guanidine.

Journal of Heterocyclic Chemistry published new progress about 21901-29-1. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, HPLC of Formula: 21901-29-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mohan, Midhun; Essalhi, Mohamed; Zaye, Sarah; Rana, Love Karan; Maris, Thierry; Duong, Adam published the artcile< Hydrogen Bond Patterns of Dipyridone and Bis(Hydroxypyridinium) Cations>, Recommanded Product: 2-(Benzyloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, the main research area is hydrogen bonding synthon Pyridone group; crystal structure Hydroxypyridinium Cation.

Dipyridonyl-substituted derivatives I,II,III ( 2,3,4, resp.) of benzene, pyridine, and pyrazine, resp., were synthesized to examine the ability of 2-pyridone and its protonated species to direct the self-assembly by hydrogen bonding. Structural anal. by single-crystal X-ray diffraction (SCXRD) of 2 and 4 in trifluoroacetic acid demonstrated that salts are formed as a result of the transfer of protons from the acid to the base (organic species) to generate a bis(hydroxypyridinium) dication. However, if no proton transfer takes place like in the case of crystals of 3 grown from DMSO/H2O, the self-assembly is mainly directed by the typical R22(8) hydrogen bond motif of 2-pyridone. These results indicate that the process of converting a neutral 2-pyridonyl group into a hydroxypyridinium cation makes structure prediction difficult. Consequently, examination of proton transfer and assembly of dipyridone and its protonated species are of interest. In combination with SCXRD, Hirshfeld surface anal. (HSA) was also used to have a better understanding on the nature of intermol. interactions within crystal structures of 2-4. The large number of F···H/H···F, H···O/O···H, H···H, and H···C/C···H contacts revealed by HSA indicates that hydrogen bonding and van der Waals interactions mainly contribute to crystal packing.

ACS Omega published new progress about Crystal engineering. 832735-54-3 belongs to class pyridine-derivatives, and the molecular formula is C18H22BNO3, Recommanded Product: 2-(Benzyloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Das, Jagadish; Vellakkaran, Mari; Banerjee, Debasis published the artcile< Nickel-Catalyzed Alkylation of Ketone Enolates: Synthesis of Monoselective Linear Ketones>, Product Details of C7H7NO, the main research area is ketone alc nickel monoselective alkylation catalyst; linear ketone preparation green chem.

Herein we have developed a Ni-catalyzed protocol for the synthesis of linear ketones. Aryl, alkyl, and heteroaryl ketones as well as alcs. yielded the monoselective ketones in up to 90% yield. The catalytic protocol was successfully applied in to a gram-scale synthesis. For a practical utility, applications of a steroid derivative, oleyl alc., and naproxen alc. were employed. Preliminary catalytic investigations involving the isolation of a Ni intermediate and defined Ni-H species as well as a series of deuterium-labeling experiments were performed.

Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Product Details of C7H7NO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mack, Arthur G.; Suschitzky, Hans; Wakefield, Basil J. published the artcile< Polyhaloaromatic compounds. Part 39. Synthesis of the bromo- and iodo-tetrachloropyridines>, Recommanded Product: 2,3,4,6-Tetrachloropyridine, the main research area is bromotetrachloropyridine; iodotetrachloropyridine; pyridine bromo tetrachloro.

The title compounds I (R = Br, iodo, R1 = R2 = Cl; R = R2 = Cl, R1 = Br, iodo; R = R1 = Cl, R2 = Br, iodo) were prepared via the corresponding pyridylhydrazines or pyridyllithium or -magnesium derivatives Thus, reaction of pentachloropyridine N-oxide with N2H4 in EtOH (reflux 2 h) gave 2,3,4,5-tetrachloro-6-hydrazinopyridine which with Br-HBr gave 60% I (R = Br, R1 = R2 = Cl). Metalation of 2,3,4,6-tetrachloropyridine with BuLi followed by reaction with Br and iodine gave 58% I (R = R2 = Cl, R1 = Br) and 60% I (R = R2 = Cl, R1 = iodo), resp. Reaction of pentachloropyridine in THF with Mg at -10° gave 2,3,5,6-tetrachloro-4-pyridylmagnesium chloride which reacted with Br (-75°) to give 61% I (R = R1 = Cl, R2 = Br).

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 14121-36-9. 14121-36-9 belongs to class pyridine-derivatives, and the molecular formula is C5HCl4N, Recommanded Product: 2,3,4,6-Tetrachloropyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Leer, Katharina; Cinar, Gizem; Solomun, Jana I.; Martin, Liam; Nischang, Ivo; Traeger, Anja published the artcile< Core-crosslinked, temperature- and pH-responsive micelles: design, physicochemical characterization, and gene delivery application>, Synthetic Route of 2127-03-9, the main research area is block copolymer micelles temperature pH gene delivery cytotoxicity.

Stimuli-responsive block copolymer micelles can provide tailored properties for the efficient delivery of genetic material. In particular, temperature- and pH-responsive materials are of interest, since their physicochem. properties can be easily tailored to meet the requirements for successful gene delivery. Within this study, a stimuli-responsive micelle system for gene delivery was designed based on a diblock copolymer consisting of poly(N,N-diethylacrylamide) (PDEAm) as a temperature-responsive segment combined with poly(aminoethyl acrylamide) (PAEAm) as a pH-responsive, cationic segment. Upon temperature increase, the PDEAm block becomes hydrophobic due to its lower critical solution temperature (LCST), leading to micelle formation. Furthermore, the monomer 2-(pyridin-2-yldisulfanyl)ethyl acrylate (PDSAc) was incorporated into the temperature-responsive PDEAm building block enabling disulfide crosslinking of the formed micelle core to stabilize its structure regardless of temperature and dilution The cloud points of the PDEAm block and the diblock copolymer were investigated by turbidimetry and fluorescence spectroscopy. The temperature-dependent formation of micelles was analyzed by dynamic light scattering (DLS) and elucidated in detail by an anal. ultracentrifuge (AUC), which provided detailed insights into the solution dynamics between polymers and assembled micelles as a function of temperature Finally, the micelles were investigated for their applicability as gene delivery vectors by evaluation of cytotoxicity, pDNA binding, and transfection efficiency using HEK293T cells. The investigations showed that core-crosslinking resulted in a 13-fold increase in observed transfection efficiency. Our study presents a comprehensive investigation from polymer synthesis to an in-depth physicochem. characterization and biol. application of a crosslinked micelle system including stimuli-responsive behavior.

Nanoscale published new progress about Cell viability. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Synthetic Route of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ma, Yulu; Tang, Huaijun; Dong, Xueyan; Wang, Kaimin; Liu, Manhong; Wang, Yuna published the artcile< A dual-functional 3D coordination polymer as a luminescent sensor for acetone in an aqueous medium and detecting the temperature>, Safety of 3-(Methoxycarbonyl)pyridine, the main research area is cadmium carboxybenzylcarboxypyridinium pyridinylethane preparation luminescent sensor acetone; crystal structure cadmium carboxybenzylcarboxypyridinium pyridinylethane coordination polymer.

A novel coordination polymer, {[Cd4(Ccbp)3(dpe)4·4H2O]·(ClO4)5·4H2O} (1) (Ccbp = 3-carboxy-1-(3-carboxybenzyl)pyridin-1-ium, dpe = 1,2-di(pyridin-4-yl)ethane), was synthesized under hydrothermal conditions by a zwitterionic organic ligand and dipyridine ligand, and was fully characterized. Coordination polymer 1 with a pyridine cation basic skeleton can be used as the 1st potential dual-function luminescence sensing material for the selective, sensitive and recyclable sensing of acetone mols. in aqueous phase and for the quant. detection of ultra-low temperatures of 10 to 70 K.

Inorganic Chemistry Communications published new progress about Crystal structure. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Safety of 3-(Methoxycarbonyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hamon, J. J.; Tabor, Rico F.; Striolo, Alberto; Grady, Brian P. published the artcile< Directly probing surfactant adsorption on nanoscopic trenches and pillars>, SDS of cas: 123-03-5, the main research area is surfactant adsorption silica nanostructure; Adsorption; Atomic force microscopy; Cationic surfactant; Cetylpyridinium chloride; Force curves; Silica; Surfactant; Tetradecyltrimethylammonium bromide.

Confinement causes a change in the amount of surfactant adsorbed and in the adsorption morphol. Two cationic surfactants, tetradecyltrimethylammonium bromide (TTAB) and cetylpyridinium chloride (CPC) were adsorbed at the silica-water interface. Atomic force microscopy (AFM) force curves were measured on 50 nm and 80 nm wide trenches. Force curves were also measured on silica pillars, and the results were quantified based on distance from the edge. Trenches: Adsorbed surfactants films in 50 nm and 80 nm trenches showed the same break-through values. However, compared to unconfined values, TTAB in trenches had decreased break-through and adhesion forces while CPC in trenches had increased break-through and adhesion forces, indicating that surfactant identity varies the confinement effect. Pillars: Near the edge, few surfactants adsorb, and those that do extend in the direction normal to the surface. While the exptl. data agree qual. with previous coarse-grained mol. dynamic simulations, the length scales at which the phenomena are detected differ by ∼ half-order of magnitude. Specifically, exptl. data show measurable effects on adsorbed surfactant morphol. at a distance from the edge 10-20 times the length of a surfactant mol. after accounting for the ∼8 nm size of the probe.

Journal of Colloid and Interface Science published new progress about Electron beam lithography. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, SDS of cas: 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem