Month: October 2022

Ferreira, Joana T.; Pina, Joao; Ribeiro, Carlos A. F.; Fernandes, Rosa; Tome, Joao P. C.; Torres, Tomas; Rodriguez-Morgade, M. Salome published the artcile< A ruthenium phthalocyanine functionalized with a folic acid unit as a photosensitizer for photodynamic therapy: Synthesis, characterization and in vitro evaluation>, Category: pyridine-derivatives, the main research area is ruthenium phthalocyanine functionalization folic acid photosensitizer photodynamic therapy.

A folate-targeted ruthenium(II) phthalocyanine (Ru(FA-Py)(DMSO)(PEG)8Pc), endowed with a pyridyl ligand functionalized with one folic acid unit (FA-Py) at one of the two axial coordination sites, and a dimethylsulfoxide (DMSO) ligand coordinated to the other axial position, resp., is described. In order to enhance its biocompatibility, the RuPc is donated with eight PEG chains attached at the peripheral positions. The observed singlet oxygen quantum yields of the PS measured in DMSO and in water are of 0.74 and 0.36, resp., in line with those observed for other RuPcs bearing comparable axial and peripheral substitution. In vitro PDT activity of the compound has been evaluated in HT-1376 human bladder cancer cell line. Ru(FA-Py)(DMSO)(PEG)8Pc revealed a slightly higher cellular uptake than those observed for the corresponding carbohydrate-substituted PSs and a better photodynamic activity compared to the glucose-functionalized RuPc.

Journal of Porphyrins and Phthalocyanines published new progress about Biocompatibility. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dubovoy, Viktor; Nawrocki, Shiri; Verma, Gaurav; Wojtas, Lukasz; Desai, Primit; Al-Tameemi, Hassan; Brinzari, Tatiana V.; Stranick, Michael; Chen, Dailin; Xu, Shaopeng; Ma, Shengqian; Boyd, Jeffrey M.; Asefa, Tewodros; Pan, Long published the artcile< Synthesis, Characterization, and Investigation of the Antimicrobial Activity of Cetylpyridinium Tetrachlorozincate>, Synthetic Route of 123-03-5, the main research area is zinc chloro complex preparation bactericide; silica amorphous preparation gas adsorption; crystal structure zinc chloro complex.

Cetylpyridinium tetrachlorozincate (referred to herein as (CP)2ZnCl4) was synthesized and its solid-state structure was elucidated via single-crystal X-ray diffraction (SC-XRD), revealing a stoichiometry of C42H76Cl4N2Zn with two cetylpyridinium (CP) cations per [ZnCl4]2- tetrahedra. Crystal structures at 100 and 298 K exhibited a zig-zag pattern with alternating alkyl chains and zinc units. The material showed potential for application as a broad-spectrum antimicrobial agent, to reduce volatile sulfur compounds (VSCs) generated by bacteria, and in the fabrication of advanced functional materials. Min. inhibitory concentration (MIC) of (CP)2ZnCl4 was 60, 6, and 6μg mL-1 for Salmonella enterica, Staphylococcus aureus, and Streptococcus mutans, resp. The MIC values of (CP)2ZnCl4 were comparable to that of pure cetylpyridinium chloride (CPC), despite the fact that approx. 16% of the bactericidal CPC is replaced with bacteriostatic ZnCl2 in the structure. A modified layer-by-layer deposition technique was implemented to synthesize mesoporous silica (i.e., SBA-15) loaded with approx. 9.0 weight % CPC and 8.9 weight % Zn.

ACS Omega published new progress about Antibacterial agents. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Synthetic Route of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Xiaotong; He, Yihui; Kepenekian, Mikael; Guo, Peijun; Ke, Weijun; Even, Jacky; Katan, Claudine; Stoumpos, Constantinos C.; Schaller, Richard D.; Kanatzidis, Mercouri G. published the artcile< Three-Dimensional Lead Iodide Perovskitoid Hybrids with High X-ray Photoresponse>, Formula: C6H8N2, the main research area is lead iodide perovskitoid hybrid 3D high X ray photoresponse; X ray detector lead iodide perovskitoid hybrid; crystal structure lead iodide perovskitoid hybrid.

Large organic A cations cannot stabilize the 3D perovskite AMX3 structure because they cannot be accommodated in the cubo-octahedral cage (do not follow the Goldschmidt tolerance factor rule), and they generally template low-dimensional structures. Here we report that the large dication aminomethylpyridinium (AMPY) can template novel 3D structures which resemble conventional perovskites. They have the formula (xAMPY)M2I6 (x = 3 or 4, M = Sn2+ or Pb2+) which is double of the AMX3 formula. However, because of the steric requirement of the Goldschmidt tolerance factor rule, it is impossible for (xAMPY)M2I6 to form proper perovskite structures. Instead, a combination of corner-sharing and edge-sharing connectivity is adopted in these compounds leading to the new 3D structures. DFT calculations reveal that the compounds are indirect band gap semiconductors with direct band gaps presenting at slightly higher energies and dispersive electronic bands. The indirect band gaps of the Sn and Pb compounds are ~1.7 and 2.0 eV, resp., which is slightly higher than the corresponding AMI3 3D perovskites. The Raman spectra for the compounds are diffuse, with a broad rising central peak at very low frequencies around 0 cm-1, a feature that is characteristic of dynamical lattices, high anharmonicity, and dissipative vibrations very similar to the 3D AMX3 perovskites. Devices of (3AMPY)Pb2I6 crystals exhibit clear photoresponse under ambient light without applied bias, reflecting a high carrier mobility (μ) and long carrier lifetime (τ). The devices also exhibit sizable X-ray generated photocurrent with a high μτ product of ~1.2 x 10-4 cm2 /V and an X-ray sensitivity of 207 μC·Gy-1·cm-2.

Journal of the American Chemical Society published new progress about Band structure. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Formula: C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mack, Arthur G.; Suschitzky, Hans; Wakefield, Basil J. published the artcile< Polyhaloaromatic compounds. Part 43. Inter- and intramolecular reactions of polychloroaromatic compounds with copper>, Name: 2,3,4,6-Tetrachloropyridine, the main research area is Ullmann reaction polychlorohalopyridine copper; chlorohalopyridine Ullmann intermol reaction; pyridine polychloro halo Ullmann reaction.

The Ullmann reaction of 4-bromotetrachloropyridine with Cu in DMF gave products arising from halogen exchange and reduction reaction in addition to the expected coupled products whereas pentachloropyridines gave tetrachloropyridines only. The Ullmann reaction of 4-(o-halophenoxy)- and 4-(o-halothiophenoxy)tetrahalopyridines gave products arising from cyclization, reduction, and halogen transfer. Some Cu reacts initially with the pyridyl rather than the o-haloaryl group. The results suggest the Ullmann reaction proceeds by a mechanism involving a pyridylcopper intermediate. Nucleophilic substitution products of pentahalopyridines with phenols, thiophenols, and aniline, were obtained.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 14121-36-9 belongs to class pyridine-derivatives, and the molecular formula is C5HCl4N, Name: 2,3,4,6-Tetrachloropyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Leibler, Isabelle Nathalie-Marie; Tekle-Smith, Makeda A.; Doyle, Abigail G. published the artcile< A general strategy for C(sp3)-H functionalization with nucleophiles using methyl radical as a hydrogen atom abstractor>, Recommanded Product: Ir(p-F-ppy)3, the main research area is hydrocarbon triethylamine hydrogen fluoride iridium catalyst photochem fluorination reaction; hydrofluorocarbon preparation; difluorodiphenylmethane nucleophile iridium catalyst photochem carbon hydrogen functionalization; carbon functionalized difluorodiphenylmethane preparation.

A strategy that transforms C(sp3)-H bonds into carbocations via sequential hydrogen atom transfer (HAT) and oxidative radical-polar crossover were discussed. The resulting carbocation was functionalized by a variety of nucleophiles-including halides, water, alcs., thiols, an electron-rich arene and an azide-to effect diverse bond formations. Mechanistic studies indicated that HAT was mediated by Me radical-a previously unexplored HAT agent with differing polarity to many of those used in photoredox catalysis-enabling new site-selectivity for late-stage C(sp3)-H functionalization.

Nature Communications published new progress about Bond activation catalysts. 370878-69-6 belongs to class pyridine-derivatives, and the molecular formula is C33H21F3IrN3, Recommanded Product: Ir(p-F-ppy)3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ju, Zhao-Yang; Song, Li-Na; Chong, Ming-Ben; Cheng, Dang-Guo; Hou, Yang; Zhang, Xi-Ming; Zhang, Qing-Hua; Ren, Lan-Hui published the artcile< Selective Aerobic Oxidation of Csp3-H Bonds Catalyzed by Yeast-Derived Nitrogen, Phosphorus, and Oxygen Codoped Carbon Materials>, HPLC of Formula: 350-03-8, the main research area is ketone ester preparation green chem regioselective; carbon hydrogen bond activation aerobic oxidation; yeast nitrogen phosphorus oxygen codoped carbon material catalyst.

Nitrogen, phosphorus and oxygen codoped carbon catalysts were successfully synthesized using dried yeast powder as pyrolysis precursor. The yeast-derived heteroatom-doped carbon (yeast@C) catalysts exhibited outstanding performance in the oxidation of Csp3-H bonds to ketones and esters giving excellent products yields (up to 98% yield) without organic solvents at low O2 pressure (0.1 MPa). The catalytic oxidation protocol exhibited broad range of substrates (38 examples) with good functional group tolerance, excellent regioselectivity and synthetic utility. The yeast-derived heteroatom-doped carbon catalysts showed good reusability and stability after recycle six times without any significant loss of activity. Exptl. results and DFT calculations proved the important role of N-oxide (N+-O-) on the surface of yeast@C and a reasonable carbon radical mechanism.

Journal of Organic Chemistry published new progress about C-H bond activation. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, HPLC of Formula: 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Saidalimu, Ibrayim; Liang, Yumeng; Niina, Kiyoteru; Tanagawa, Kazuhiro; Saito, Norimichi; Shibata, Norio published the artcile< Synthesis of aryl and heteroaryl tetrafluoro-λ6-sulfanyl chlorides from diaryl disulfides using trichloroisocyanuric acid and potassium fluoride>, Synthetic Route of 2127-03-9, the main research area is aryl heteroaryl tetrafluoro sulfanyl chloride preparation; diaryl disulfide trichloroisocyanuric acid potassium fluoride oxidative chlorotetrafluorination.

A catalyst-free method for the synthesis of aryl and heteroaryl tetrafluoro-λ6-sulfanyl chlorides (Ar-SF4Cl) by using trichloroisocyanuric acid and potassium fluoride in acetonitrile was presented. The method has wide substrate generality and proceeded well with high yields even in the absence of acid catalysts. The preparation of meta- and para-SF4Cl-substituted pyridines using TCCA was achieved for the first time.

Organic Chemistry Frontiers published new progress about Aromatic compounds, disulfides Role: RCT (Reactant), RACT (Reactant or Reagent). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Synthetic Route of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Song; Tian, Chengcheng published the artcile< Polyvinylpolypyrrolidone supported Bronsted acidic catalyst for esterification>, Electric Literature of 21876-43-7, the main research area is polyvinylpolypyrrolidone support Bronsted acidic catalyst esterification.

A polyvinylpolypyrrolidone (PVPP) supported Bronsted acidic catalyst ([PVPP-BS]HSO4) was prepared by coupling SO3H functionalized polyvinylpolypyrrolidone with H2SO4 in this work. After the characterization through FT-IR, FESEM, TG, BET, and elemental anal., it was found that 1,4-butane sultone (BS) and sulfuric acid reacted with PVPP and were immobilized on PVPP surface. The prepared [PVPP-BS]HSO4 catalyst shows high catalytic activity for a series of esterification reactions and could be separated from the reacted mixture easily. Moreover, this catalyst could be recycled and reused for six times without significant loss of catalytic performance.

International Journal of Polymer Science published new progress about Esterification. 21876-43-7 belongs to class pyridine-derivatives, and the molecular formula is C9H13NO3S, Electric Literature of 21876-43-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tierno, Anthony F.; Walters, Jennifer C.; Vazquez-Lopez, Andres; Xiao, Xiao; Wengryniuk, Sarah E. published the artcile< Heterocyclic group transfer reactions with I(III) N-HVI reagents: access to N-alkyl(heteroaryl)onium salts via olefin aminolactonization>, Formula: C11H16BNO2, the main research area is alkylheteroarylonium salt preparation; alkenoic acid heterocycle aminolactonization.

Herein, leverage (bis)cationic nitrogen-ligated I(III) hypervalent iodine reagents, or N-HVIs, as “”heterocyclic group transfer reagents”” to provide access to a broad scope of N-alkyl(heteroaryl)onium salts e.g., I via the aminolactonization of alkenoic acids e.g., 2,2-diphenylpent-4-enoic acid, the first example of engaging an olefin to directly generate these salts. The reactions proceed in excellent yields, under mild conditions, and are capable of incorporating a broad scope of sterically and electronically diverse aromatic heterocycles such as pyridine, 4-piperidinylpyridine, 1-methylimidazole, etc.. The N-HVI reagents can be generated in situ, the products are isolated via simple trituration, and subsequent derivatizations demonstrate the power of this platform for diversity-oriented synthesis of 6-membered nitrogen heterocycles e.g., I.

Chemical Science published new progress about Amination. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Formula: C11H16BNO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xu, Linan; Feng, Lili; Li, Xin; An, Qi published the artcile< Stable polymer/inorganic composite multilayers using covalent cross-linking assisted by a magnetic field>, HPLC of Formula: 123-03-5, the main research area is polymer composite multilayer covalent crosslinking magnetic field.

In this study, stable composite multilayers incorporating magnetic montmorillonite (MMT) and weak polyelectrolyte were prepared under the assistance of a magnetic field. We reported a facile method for fabrication of covalently crosslinked Layer-by-Layer (LbL) multilayers using a photosensitive crosslinking agent 4,4′-diazostilbene-2,2′-disulfonic acid disodium salt that carried double azido groups. The multilayers after crosslinking presented improved stability against extreme solution conditions (basic solution pH = 14), and over 78.15% of magnetic MMT remained on the substrate, in clear contrast with the non-crosslinked multilayers, for which less than 8% of the magnetic MMT remained. The results of UV-Vis spectroscopy and SEM measurements supported the improvement in the stability of the multilayers. Moreover, the assistance of the external magnetic field improved the LbL assembly efficiency and the crosslinking step achieved the mol. retarded release. When gauze was used as the substrate, the mass loading under the magnetic field was approx. 0.976 mg/cm2, which was 4.2 times the amount deposited on gauze without an external magnetic field. After interfacial modification of gauze using LbL multilayers, the static contact angle transformed from hydrophobic (111.25°) to perfect hydrophilic. When we employed aspirin as the target drug, it took 23 h for the crosslinked multilayers to achieve saturated release, as opposed to 9 h for the non-crosslinked multilayers.

Journal of Materials Science published new progress about Crosslinking. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, HPLC of Formula: 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem