Month: October 2022

Hao, Shu-Yi; Qi, Zhi-Yuan; Wang, Shuai; Wang, Xing-Rong; Chen, Shi-Wu published the artcile< Synthesis and bioevaluation of N-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-amines as tubulin polymerization inhibitors with anti-angiogenic effects>, Related Products of 777931-67-6, the main research area is pyridopyrazole trimethoxyaniline palladium acetate catalyst haloalkane Buchwald Hartwig coupling; trimethoxyphenyl pyrazolo pyridinamine preparation antitumor cytotoxicity SAR; Aniogenesis; Antitumor; Inhibitors; Pyrazolo[3,4-b]pyridine; Tubulin polymerization.

A new series of N-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-amine derivatives I [R1 = H, Me, cyclopentyl; R2 = Me, Et, Pr, etc.] as tubulin polymerization inhibitors were synthesized, and evaluated for the anti-proliferative activities. A structure-activity relationship study revealed that the free amino moiety of 1H-pyrazolo[3,4-b]pyridin-3-amine played an essential role in the anti-proliferative activities. Especially, compound I [R1 = H; R2 = methyl] displayed the strongest anti-proliferation against MCF-7 cells with IC50 value of 0.067 ± 0.003μM, and high selectivity over the normal human embryonic lung WI-38 cells with IC50 value of 23.41 ± 1.53μM. Further mechanistic studies revealed that I [R1 = H; R2 = methyl] showed strong anti-tubulin polymerization activity, changed the morphol. of tubulin, and arrested the cell cycle at the G2/M transition in MCF-7 cells. Mol. docking anal. suggested that I [R1 = H; R2 = methyl] well occupied the colchicine-binding pocket of tubulin. Addnl., I [R1 = H; R2 = methyl] demonstrated anti-angiogenic activities with blocking the migration, invasion and tube formation, disrupting the newly formed tube, and regulating both MMP-9 and TIMP-1 in HUVEC cells. In summary,results highlight that compound I [R1 = H; R2 = methyl] was a potential antitumor compound that was worthy of further development.

Bioorganic & Medicinal Chemistry published new progress about Antiangiogenic agents. 777931-67-6 belongs to class pyridine-derivatives, and the molecular formula is C6H5BrClNO, Related Products of 777931-67-6.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Herrera, Christian Leonardo; Santiago, Joao Victor; Pastre, Julio Cezar; Correia, Carlos Roque Duarte published the artcile< In Tandem Auto-Sustainable Enantioselective Heck-Matsuda Reactions Directly from Anilines>, Computed Properties of 1416819-91-4, the main research area is aniline cyclopentenol palladium catalyst enantioselective Heck Matsuda reaction green; phenyl cyclopentenol preparation; cyclopentenedicarboxylate aniline palladium catalyst enantioselective Heck Matsuda reaction green; dimethyl phenyl cyclopentenedicarboxylate preparation; butenediol aniline palladium catalyst enantioselective Heck Matsuda reaction green; aryl furanone preparation.

An in tandem enantioselective Heck-Matsuda (HM) reaction of cyclic and acyclic olefins directly from anilines was described. The method relied on a process involving the progressive in situ diazotization of the starting anilines followed by a palladium-catalyzed Heck-Matsuda arylation using chiral N,N-ligands. This intermol. enantioselective HM arylation strategy was applied to the desymmetrization of three distinct unactivated olefins as proof of concept. The method demonstrates broad substrate scope furnishing the Heck adducts in good to excellent enantiomeric ratios of up to 99:1, high diastereoselectivities (cyclopenten-3-ol with>20:1 dr), and good overall yields of up to 82% over 2 or 3 steps.

Advanced Synthesis & Catalysis published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Computed Properties of 1416819-91-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chhem-Kieth, Sorivan; Lametsch, Rene; Hansen, Erik Torngaard; Ruiz-Carrascal, Jorge published the artcile< Storage and thermal stability of novel heme-based pigments prepared from porcine hemoglobin>, Product Details of C7H7NO2, the main research area is porcine Hb heme pigment storage thermal stability.

The stability of novel meat pigments derived from heme-enriched extract obtained from porcine Hb was assessed. Four different ligands (sodium nitrite, 4-methylimidazole, Me nicotinate, and pyrazine) were used to produce spray-dried, microencapsulated heme-ligand complexes. The storage and thermal stabilities of the produced pigments were assessed, over a 6-mo storage period and across a temperature range of 25-75°C. Color measurements and evaluation were made on the dissolved pigments by UV-visible absorbance spectroscopy and CIELAB color space. All heme-ligand complexes exhibited a stable red color across the storage period, except for the heme-Me nicotinate adduct, which color faded to brown after 30 days of storage. For thermal stability, only the heme-4-methylimidazole complex did not retain its red color beyond 55°C. The redness of the heme-pyrazine complex showed improvement upon heating, which is proposed to be due to the degradation of polymeric heme-pyrazine structure formed during the ligation process. Due to the global effort to reduce nitrite addition in food product, there is an important interest to replace it in processed meat products, wholly or in part. Addnl., the perspective of optimizing the usage of an under-utilized blood fraction is attractive for the meat industry. The development of a heme pigment derived from porcine blood thus presents a good com. potential. Two important aspects of such product would be its stability upon storage, or during heat treatment to levels similar to what is used in processed, cooked meat products. This study presents the behavior for those two aspects of different heme-ligand complexes, and compares the results obtained with a heme pigment produced from the traditionally used nitrite.

Journal of Food Process Engineering published new progress about Blood. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Product Details of C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gonzalez, Alexandre; Benfodda, Zohra; Benimelis, David; Fontaine, Jean-Xavier; Molinie, Roland; Meffre, Patrick published the artcile< Extraction and Identification of Volatile Organic Compounds in Scentless Flowers of 14 Tillandsia Species Using HS-SPME/GC-MS>, Electric Literature of 93-60-7, the main research area is Tillandsia volatile organic compound flower mass spectrometry; PCA analysis; Tillandsia; faint-scented flowers; gas chromatography-mass spectrometry (GC-MS); headspace solid phase microextraction (HS-SPME); heatmap; scentless flowers; volatile organic compounds (VOCs).

VOCs emitted by flowers play an important role in plant ecol. In the past few years, the Tillandsia genus has been scarcely studied according to the VOCs emitted by flowers. Hence, we decided to enlarge the VOCs composition study already undergone in our laboratory on fragrant 3 Tillandsia species to 12 unscented and 2 faint-scented Tillandsia species and hybrids. The headspace solid phase microextraction (HS-SPME) coupled with gas chromatog. combined with the mass spectrometry (GC-MS) method was used to explore the chem. diversity of the VOCs. This study allowed the identification of 65 VOCs among the 14 species and between 6 to 25 compounds were identified in each of the species. The aromatic profile of 10 of the species and hybrids are similar to each other′s and show 8 predominant compounds: benzaldehyde, benzacetaldehyde, hexanol, hexanal, heptanal, octanal, nonanal, and furan-2-pentyl. Some specific compounds are present only in some unique species such as trans-calamenene, α-muurolene, and α-guaiene trans-β-bergamotene. The two faint-scented species studied present an original aromatic profile with a high number of monoterpenes or phenylpropanoids/benzenoids. Our studies allow a better understanding of the ecol. role and function of these VOCs in the interactions between these plants with their environment.

Metabolites published new progress about Aliphatic alcohols Role: ANT (Analyte), BSU (Biological Study, Unclassified), PAC (Pharmacological Activity), THU (Therapeutic Use), ANST (Analytical Study), BIOL (Biological Study), USES (Uses). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Electric Literature of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Ya-Nan; Hou, Jin-Le; Wang, Zhi; Gupta, Rakesh Kumar; Jaglicic, Zvonko; Jagodic, Marko; Wang, Wen-Guang; Tung, Chen-Ho; Sun, Di published the artcile< An Octanuclear Cobalt Cluster Protected by Macrocyclic Ligand: In Situ Ligand-Transformation-Assisted Assembly and Single-Molecule Magnet Behavior>, Quality Control of 366-18-7, the main research area is octanuclear cobalt silsesquioxane sandwich cluster preparation crystal mol structure; hexamethylcyclohexasiloxanolate cobalt octanuclear sandwich preparation single mol magnet; protected macrocyclic ligand transformation assisted mol magnet behavior.

Macrocyclic mols. with multiple coordination sites have been widely used as promising ligands to build polynuclear metal clusters; however, cyclic silsesquioxane-based metal clusters are still rare. Herein, authors report a new octanuclear Co-silsesquioxane cluster [Co8(OH)2{(MeSiO2)6}2(bpy)2(Obpy)2] (SD/Co8c; SD = SunDi), wherein the Co8 disk-like core is sandwiched by two hexamethylcyclohexasiloxanolate ligands (MeSiO2)6 at two poles and finally encircled by two bpy (bpy = 2,2′-bipyridine) and two Obpy (HObpy = 6-hydroxy-2,2′-bipyridine) ligands at the equatorial region. Interestingly, both MeSi(OMe)3 and bpy undergo in situ transformations to generate hexameric cyclic (MeSiO2)6 and Obpy, resp. The unusual hydroxylation of bpy and the OH- anion in the center of Co8 core provide addnl. binding sites to induce the formation of the larger cluster instead of the traditional hexanuclear cluster. The solution stability and fragmentation route in the gas phase were studied by cold-spray ionization and collision-induced dissociation mass spectrometry, resp. Both results reveal that the Co8 core is quite stable in solution as well as in the gas phase, even with increased collision voltage. Magnetic susceptibility studies of SD/Co8c show the slow magnetization relaxation indicative of single-mol. magnet (SMM) behavior. This work not only presents the multiple in situ ligand-transformation-assisted assembly of polynuclear cobalt cluster but also provides some new insights into the magnetism-structure relationship for SMMs.

Inorganic Chemistry published new progress about Crystal structure. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Quality Control of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Izzo, Francesco; Mercurio, Mariano; de Gennaro, Bruno; Aprea, Paolo; Cappelletti, Piergiulio; Dakovic, Aleksandra; Germinario, Chiara; Grifa, Celestino; Smiljanic, Danijela; Langella, Alessio published the artcile< Surface modified natural zeolites (SMNZs) as nanocomposite versatile materials for health and environment>, COA of Formula: C21H38ClN, the main research area is zeolite nanocomposite ibuprofen sodium salt drug release surface modification; Bayesian information criterion; Emerging contaminant; Ibuprofen; NSAID; Nižný hrabovec; Non-linear regression; Sips; Surfactant; Toth; Zeolite.

The present research deals with the evaluation of a clinoptilolite-rich rock, occurring in the Nizny ‘Hrabovec deposit (Slovakia), for high-value technol. applications based on sorption and in vitro release of nonsteroidal anti-inflammatory drugs (i.e., ibuprofen sodium salt). This georesource was surface modified (SMNZ) using four cationic surfactants. Results demonstrate that ibuprofen sorption is very fast and SMZNs can sorb up to ~26 mg/g of drug as a function of the type of counterion and morphol. of surfactant, as well as the hydrophobicity and mol. structure of the drug. Maximum sorption capacities observed for all SMNZs are fully comparable to other adsorbent carriers usually used for removal of contaminants in wastewaters. Sorption of ibuprofen is controlled by a dual mechanism: external anionic exchange and partition into the hydrophobic portion of the patchy bilayer. A prompt drug release in simulated intestinal fluid (SIF) was also observed, making this natural material also suitable to provide rapid soothing effects in potential pharmacol. applications. Comparing the results of this study with other recent investigations, a good technol. performance of clinoptilolite-rich rock can be inferred despite the relatively low zeolite content (~56 weight%).

Colloids and Surfaces, B: Biointerfaces published new progress about Adsorption. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, COA of Formula: C21H38ClN.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Halevas, E.; Papadopoulos, T. A.; Swanson, C. H.; Smith, G. C.; Hatzidimitriou, A.; Katsipis, G.; Pantazaki, A.; Sanakis, I.; Mitrikas, G.; Ypsilantis, K.; Litsardakis, G.; Salifoglou, A. published the artcile< In-depth synthetic, physicochemical and in vitro biological investigation of a new ternary V(IV) antioxidant material based on curcumin>, SDS of cas: 366-18-7, the main research area is ternary vanadium curcumin bipyridine complex preparation antioxidant crystal structure; Bioreactivity profile and antioxidant agent; Cell metabolism inhibition and DNA degradation; Crystal structure and DFT calculations; Hybrid metallopharmaceutical; ROS-suppression; Vanadium-curcumin complex.

Curcumin is a natural product with a broad spectrum of beneficial properties relating to pharmaceutical applications, extending from traditional remedies to modern cosmetics. The biol. activity of such pigments, however, is limited by their solubility and bioavailability, thereby necessitating new ways of achieving optimal tissue cellular response and efficacy as drugs. Metal ion complexation provides a significant route toward improvement of curcumin stability and biol. activity, with vanadium being a representative such metal ion, amply encountered in biol. systems and exhibiting exogenous bioactivity through potential pharmaceuticals. Driven by the need to optimally increase curcumin bioavailability and bioactivity through complexation, synthetic efforts were launched to seek out stable species, ultimately leading to the synthesis and isolation of a new ternary V(IV)-curcumin-(2,2′-bipyridine) complex. Physicochem. characterization (elemental anal., FT-IR, Thermogravimetry (TGA), UV-Visible, NMR, ESI-MS, Fluorescence, X-rays) portrayed the solid-state and solution properties of the ternary complex. Pulsed-EPR spectroscopy, in frozen solutions, suggested the presence of two species, cis- and trans-conformers. D. Functional Theory (DFT) calculations revealed the salient features and energetics of the two conformers, thereby complementing EPR spectroscopy. The well-described profile of the vanadium species led to its in vitro biol. investigation involving toxicity, cell metabolism inhibition in S. cerevisiae cultures, Reactive Oxygen Species (ROS)-suppressing capacity, lipid peroxidation, and plasmid DNA degradation A multitude of bio-assays and methodologies, in comparison to free curcumin, showed that it exhibits its antioxidant potential in a concentration-dependent fashion, thereby formulating a bioreactivity profile supporting development of new efficient vanado-pharmaceuticals, targeting (extra)intra-cellular processes under (patho)physiol. conditions.

Journal of Inorganic Biochemistry published new progress about Antioxidants. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, SDS of cas: 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bellini, Michela; Riva, Benedetta; Tinelli, Veronica; Rizzuto, Maria Antonietta; Salvioni, Lucia; Colombo, Miriam; Mingozzi, Francesca; Visioli, Alberto; Marongiu, Laura; Frascotti, Gianni; Christodoulou, Michael S.; Passarella, Daniele; Prosperi, Davide; Fiandra, Luisa published the artcile< Engineered Ferritin Nanoparticles for the Bioluminescence Tracking of Nanodrug Delivery in Cancer>, Synthetic Route of 2127-03-9, the main research area is ferritin nanoparticle bioluminescence imaging cancer; apoferritin nanoparticles; luciferase/luciferin; nanomedicine; self-immolative linkers; tumor targeting.

The identification of a highly sensitive method to check the delivery of administered nanodrugs into the tumor cells is a crucial step of preclin. studies aimed to develop new nanoformulated cures, since it allows the real therapeutic potential of these devices to be forecast. In the present work, the ability of an H-ferritin (HFn) nanocage, already investigated as a powerful tool for cancer therapy thanks to its ability to actively interact with the transferrin receptor 1, to act as an efficient probe for the monitoring of nanodrug delivery to tumors is demonstrated. The final formulation is a bioluminescent nanoparticle, where the luciferin probe is conjugated on nanoparticle surface by means of a disulfide containing linker (Luc-linker@HFn) which is subjected to glutathione-induced cyclization in tumor cell cytoplasm. The prolonged imaging of luciferase+ tumor models, demonstrated by an in vitro and an in vivo approach, associated with the prolonged release of luciferin into cancer cells by disulfide bridge reduction, clearly indicates the high efficiency of Luc-linker@HFn for drug delivery to the tumor tissues.

Small published new progress about Apoferritins Role: NAN (Nanomaterial), THU (Therapeutic Use), BIOL (Biological Study), USES (Uses). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Synthetic Route of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Alhatem, Aamer A. published the artcile< Tautomeric equilibria of substituted 2-pyridone/2-hydroxypyridine in the gas and aqueous phases>, Safety of 6-Chloropyridin-2-ol, the main research area is pyridone hydroxypyridine tautomer substituent effects formation enthalpy free energy.

Heats of formation, entropies and Gibbs free energies for the twenty structures of substituted 2-pyridone and 2-hydroxypyridine were studied using semiempirical Austin Model (AM1) and Parametric Method 3 (PM3) calculations at the SCF level, both in the gas and liquid phases, with full geometry optimization. It was revealed from the study that 2-hydroxypyridine is predominant in gas phase, while 2-pyridone in the liquid phase which agrees with the exptl. and theor. predictions. All substituents such as F, Cl, OH, CH3, NH2, NO2, CHO, CN, CF3 stabilize the 2-pyridone in the gas and liquid phases except F, Cl and NH2 in PM3 calculations in the gas phase. The substituents stabilization is more effective in liquid phase. This was also confirmed by thermodn. calculations and isodesmic reactions.

Chemical Science International Journal published new progress about Entropy. 73018-09-4 belongs to class pyridine-derivatives, and the molecular formula is C5H4ClNO, Safety of 6-Chloropyridin-2-ol.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Blumbergs, Peter; Ash, Arthur B.; Daniher, F. A.; Stevens, Calvin Lee; Michel, H. O.; Hackley, B. E. Jr.; Epstein, J. published the artcile< Alkylating agents containing a quaternary nitrogen group>, Category: pyridine-derivatives, the main research area is alkylating sulfonates; sulfonates alkylating; pyridinium sulfonates.

A series of 18 new, water-soluble alkylating agents was synthesized. The structures contain an alkylsulfonate group as the alkylating function and a quaternary ammonium salt group attached to a hydrocarbon backbone. Some pyridinium sulfonates perchlorates were also prepared

Journal of Organic Chemistry published new progress about 21876-43-7. 21876-43-7 belongs to class pyridine-derivatives, and the molecular formula is C9H13NO3S, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem