Month: October 2022

Parrot, Isabelle; Bisi, Helene; Folliard, Arnaud; Bonnard, Michel published the artcile< Volatile Compounds from Flowers of Elaeagnus x submacrophylla Servett.: Extraction, Identification of Flavonoids, and Antioxidant Capacity>, Product Details of C7H7NO2, the main research area is Elaeagnus submacrophylla flavonoid volatile compound extraction antioxidant capacity; Elaeagnus submacrophylla; antioxidants; flavonoids; phenolic content; volatile compounds.

Beneficial to the ecosystem and with significant potential in permaculture, Elaeagnus x submacrophylla Servett. was studied here mainly for the identification of its floral odorants. After olfactory evaluation and determination of the volatile profile of freshly picked flowers by headspace/solid phase microextraction coupled with gas chromatog./mass spectrometry, an ethanolic extract was prepared and investigated for its antioxidant capacity. Unusual mols. were identified in the floral headspace, such as isochavicol or chrysanthemum acetate. The evaluation of the in vitro free radical scavenging capacity (from 0.4 to 1.3 mmol TE/g) and total phenolic content (65.1 mg GAE/g) of the extract pointed out a promising antioxidant activity, potentially related to the identification of several flavonoid glycosides. These results have to be considered in the context of the ever-increasing need to produce innovative natural extracts with notably interesting claims for the cosmetic field.

ChemPlusChem published new progress about Alcohols Role: ANT (Analyte), FFD (Food or Feed Use), PAC (Pharmacological Activity), ANST (Analytical Study), BIOL (Biological Study), USES (Uses). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Product Details of C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bazyar, Zahra; Hosseini-Sarvari, Mona published the artcile< Au@ZnO Core-Shell: Scalable Photocatalytic Trifluoromethylation Using CF3CO2Na as an Inexpensive Reagent under Visible Light Irradiation>, Application In Synthesis of 3796-23-4, the main research area is trifluoromethylated compound preparation; photocatalytic trifluoromethylation gold nanoparticle modified zincoxide photocatalyst.

Trifluoromethylation is of significant importance for the synthesis of many small mols. vital for medicinal and agrochem. research. The importance of the CF3 group as well as the related synthetic challenges is so evident that many reagents have been reported for the synthesis of trifluoromethylated compounds, but these typical reagents are expensive and the methods for preparing them are difficult. Here, we report a new scalable and operationally simple trifluoromethylation reaction using sodium trifluoroacetate as a reagent and Au-modified ZnO as a photocatalyst under visible light irradiation The reaction proceeds via trifluoromethylation of a broad range of aryl halides, arylboronic acids, and arene and heteroarene substrates. Some pharmaceutical and agrochem. compounds have been trifluoromethylated directly to demonstrate the applicability of the method.

Organic Process Research & Development published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Application In Synthesis of 3796-23-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Song-Lin; Deng, Zhu-Qin published the artcile< Synthesis of quinolines and naphthyridines via catalytic retro-aldol reaction of β-hydroxyketones with ortho-aminobenzaldehydes or nicotinaldehydes>, Application In Synthesis of 55279-29-3, the main research area is quinoline naphthyridine preparation copper catalyst retro aldol hydroxyketone aldehyde.

A Cu(I)-catalyzed retro-aldol reaction of β-hydroxyketones with ortho-aminobenzaldehydes and nicotinaldehydes is reported that produces a range of quinolines and naphthyridines with high efficiency and selectivity. This reaction uses β-hydroxyketones as a regiospecific ketone-protected enolate source via copper-catalyzed retro-aldol Cα-Cβ bond cleavage. The in situ generated copper enolate undergoes kinetically favorable cyclization with ortho-amino aryl aldehydes to produce quinolines and naphthyridines in a chemo- and regioselective manner. The mild and weakly basic reaction conditions also suppress possible side reactions of benzaldehydes under strongly basic conditions, resulting in improved reaction yields.

Organic & Biomolecular Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent) (nicotine-). 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, Application In Synthesis of 55279-29-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Duklan, Neha; Chamoli, Pankaj; Raina, K. K.; Shukla, Ravi K. published the artcile< Dye dispersed lyotropic liquid crystals: Soft materials with high ionic conductivity and self-sustained adsorbents for dye sequestration>, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride, the main research area is cetylpyridinium chloride liquid crystal preparation dye sequestration adsorption.

Lyotropic liquid crystals phases are prepared from cationic surfactant (Cetylpyridinium chloride) in the aqueous medium. All the mixtures show well defined lamellar phases duly confirmed from X-ray diffraction and polarizing optical microscopy characterizations. Ionic conductivity of the lyotropic phases is ranging between 4.2 and 28.8 mS/cm and shows dependence on surfactant concentration Further, lamellar mesostructures are dispersed with cationic dye (methyl blue). We noticed that bilayer mesostructures act as an excellent adsorbent to sequester the cationic dye in the aqueous medium. Dye sequestration is confirmed visually and spectroscopically via UV-Visible characterization. Lyotropic adsorbents are found highly reactive as they sequester 0.01 wt% methyl blue dye within 30 min. Sequestration efficiency of lyotropic adsorbents is ranging from 98.9 to 87.5% (for 0.01 wt% dye). Considering electrostatic interactions, dye sequestration mechanisms are established and discussed. Our findings suggested that lyotropic adsorbents can be explored as a highly effective, reactive and cost-effective alternative for sequestration/adsorption of contaminations.

Inorganic Chemistry Communications published new progress about Adsorption. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jiao, Zhi-Feng; Zhao, Ji-Xiao; Guo, Xiao-Ning; Tong, Xi-Li; Zhang, Bin; Jin, Guo-Qiang; Qin, Yong; Guo, Xiang-Yun published the artcile< Turning the product selectivity of nitrile hydrogenation from primary to secondary amines by precise modification of Pd/SiC catalysts using NiO nanodots>, Recommanded Product: Pyridin-4-ylmethanamine, the main research area is nickel oxide palladium silicon carbide support preparation; nitrile nickel oxide palladium catalyst selective hydrogenation; amine preparation green chem.

The selectivity of Pd/SiC catalysts for the hydrogenation of nitriles with H2 can be turned from primary to secondary amines by modification of NiO nanodots. In the modified catalysts, the NiO nanodots act as reactive sites to consume hydrogen radicals on the Pd surface, and thus prolong the lifetime of an imine intermediate that determines the product selectivity. Under mild conditions (30 °C, atm. H2), Pd/SiC and NiO-Pd/SiC catalysts exhibit high selectivity to primary (94%) and secondary (99%) amines, resp.

Catalysis Science & Technology published new progress about Amines Role: SPN (Synthetic Preparation), PREP (Preparation). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Recommanded Product: Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hickey, David P.; Sandford, Christopher; Rhodes, Zayn; Gensch, Tobias; Fries, Lydia R.; Sigman, Matthew S.; Minteer, Shelley D. published the artcile< Investigating the Role of Ligand Electronics on Stabilizing Electrocatalytically Relevant Low-Valent Co(I) Intermediates>, Safety of (S)-4-(tert-Butyl)-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole, the main research area is bidentate ligand electronics cobalt complex electrochem low valence intermediate.

Cobalt complexes have shown great promise as electrocatalysts in applications ranging from hydrogen evolution to C-H functionalization. However, the use of such complexes often requires polydentate, bulky ligands to stabilize the catalytically active Co(I) oxidation state from deleterious disproportionation reactions to enable the desired reactivity. Herein, we describe the use of bidentate electronically asym. ligands as an alternative approach to stabilizing transient Co(I) species. Using disproportionation rates of electrochem. generated Co(I) complexes as a model for stability, we measured the relative stability of complexes prepared with a series of N,N-bidentate ligands. While the stability of Co(I)Cl complexes demonstrates a correlation with exptl. measured thermodn. properties, consistent with an outer-sphere electron transfer process, the set of ligated Co(I)Br complexes evaluated was found to be preferentially stabilized by electronically asym. ligands, demonstrating an alternative disproportionation mechanism. These results allow a greater understanding of the fundamental processes involved in the disproportionation of organometallic complexes and have allowed the identification of cobalt complexes that show promise for the development of novel electrocatalytic reactions.

Journal of the American Chemical Society published new progress about Activation energy. 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Safety of (S)-4-(tert-Butyl)-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Prabakaran, G.; Manivarman, S.; Bharanidharan, M. published the artcile< Catalytic synthesis, ADMET, QSAR and molecular modeling studies of novel chalcone derivatives as highly potent antioxidant agents>, Category: pyridine-derivatives, the main research area is chalcone derivative antioxidant agent.

A series of (E)-3-(3-(5-chlorothiophen-2-yl)-1-(furan-2-carbonyl)-2,3-dihydro-1H-pyrazol-4-yl)-1-(substituted)prop-2-en-1-one derivatives 5a-c was synthesized from the reaction of 3-(5-chlorothiophen-2-yl)-1-(furan-2-carbonyl)-2,3-dihydro-1H-pyrazole-4-carbaldehyde (2) with various substituted acetophenes by the use of TiO2-ZnS in ethanol under reflux conditions. All are structurally supported by IR spectrum and the basic testing and screening, and find that compounds 5a are potential antioxidants for their in vitro-antioxidant activity against DPPH. The results in vitro were compared with the results of the mol. docking, ADMET, QSAR and bioactivity study and it was found that the results were observed in good correlations with in vitro anti-oxidant results in silicon binding affinities. The anal. of mol. dockings revealed the interactions between the synthesized ligands and protein tyrosine kinase (2HCK) amino acid residues and has a strong hydrogen connexion to this enzyme.

Materials Today: Proceedings published new progress about Antioxidants. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mateos-Moreno, M. V.; Mira, A.; Ausina-Marquez, V.; Ferrer, M. D. published the artcile< Oral antiseptics against coronavirus: in-vitro and clinical evidence>, Quality Control of 123-03-5, the main research area is review povidone iodine cetylpyridinium chloride antiseptic mouthwash COVID19 SARSCoV2; COVID-19; Coronaviruses; Oral antiseptics; Oral rinse; SARS-CoV-2.

A review. Angiotensin converting enzyme 2 (ACE2) is the cellular receptor for SARS-CoV-2, so ACE2-expressing cells can act as target cells and are susceptible to infection. ACE2 receptors are highly expressed in the oral cavity, so this may be a potential high-risk route for SARS-CoV-2 infection. Furthermore, the virus can be detected in saliva, even before COVID-19 symptoms appear, with the consequent high risk of virus transmission in asymptomatic/presymptomatic patients. Reducing oral viral load could lead to a lower risk of transmission via salivary droplets or aerosols and therefore contribute to the control of the pandemic. Our aim was to evaluate the available evidence testing the in-vitro and in-vivo effects of oral antiseptics to inactivate or eradicate coronaviruses. The criteria used were those described in the PRISMA declaration for performing systematic reviews. An electronic search was conducted in Medline (via PubMed) and in Web of Sciences, using the MeSH terms: ‘mouthwash’ OR’oral rinse’ OR ‘mouth rinse’ OR ‘povidone iodine’ OR ‘hydrogen peroxide’ OR ‘cetylpyridinium chloride’ AND ‘COVID-19’ OR ‘SARS-CoV-2’ OR ‘coronavirus’ OR ‘SARS’ OR ‘MERS’. The initial search strategy identified 619 articles on two electronic databases. Seventeen articles were included assessing the virucidal efficacy of oral antiseptics against coronaviruses. In conclusion, there is sufficient in-vitro evidence to support the use of antiseptics to potentially reduce the viral load of SARS-CoV-2 and other coronaviruses. However, in-vivo evidence for most oral antiseptics is limited. Randomized clin. trials with a control group are needed to demonstrate its clin. efficacy.

Journal of Hospital Infection published new progress about Aerosols. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Quality Control of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pal, Sunirmal; Sommerfeldt, Andreas; Davidsen, Maiken B.; Hinge, Mogens; Pedersen, Steen U.; Daasbjerg, Kim published the artcile< Synthesis and Closed-Loop Recycling of Self-Immolative Poly(dithiothreitol)>, Category: pyridine-derivatives, the main research area is recycling self immolative polydithiothreitol.

Self-immolative polymers (SIPs) are promising members of the emerging class of recyclable polymers with the ability to end-to-end depolymerize to their monomers. Unfortunately, SIPs are often synthesized by cumbersome procedures at low temperatures in protected atm. In this study, a SIP with a novel poly(disulfide) backbone is introduced, using DL-dithiothreitol (DTT) as the monomer. Remarkably, poly(DTT) can be produced by solid-state polymerization in a robust and easily scalable process by mech. mixing DTT with 2,2′-dithiodipyridine as the end-capping agent. The new polymer possesses good thermal and chem. stabilities, but once its depolymerization is triggered, this proceeds smoothly within minutes to afford cyclic DTT because of a favorable intramol. back-biting thiol-disulfide exchange reaction in the polymer backbone. As a proof of concept, the cyclic DTT waste was recovered, reduced to DTT monomer, and repolymd. in a closed-loop approach.

Macromolecules (Washington, DC, United States) published new progress about Chemical stability. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Jian-Yuan; Miklossy, Gabriella; Modukuri, Ram K.; Bohren, Kurt M.; Yu, Zhifeng; Palaniappan, Murugesan; Faver, John C.; Riehle, Kevin; Matzuk, Martin M.; Simmons, Nicholas published the artcile< Palladium-Catalyzed Hydroxycarbonylation of (Hetero)aryl Halides for DNA-Encoded Chemical Library Synthesis>, Reference of 3796-23-4, the main research area is palladium catalyzed hydroxycarbonylation heteroaryl halide DNA encoded library synthesis.

A strategy for DNA-compatible, palladium-catalyzed hydroxycarbonylation of (hetero)aryl halides on DNA-chem. conjugates has been developed. This method generally provided the corresponding carboxylic acids in moderate to very good conversions for (hetero)aryl iodides and bromides, and in poor to moderate conversions for (hetero)aryl chlorides. These conditions were further validated by application within a DNA-encoded chem. library synthesis and subsequent discovery of enriched features from the library in selection experiments against two protein targets.

Bioconjugate Chemistry published new progress about Carbonylation. 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Reference of 3796-23-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem