Month: October 2022

Lemaalem, M.; Ahfir, R.; Derouiche, A.; Filali, M. published the artcile< Static and dynamic properties of decane/water microemulsions stabilized by cetylpyridinium chloride cationic surfactant and octanol cosurfactant>, Electric Literature of 123-03-5, the main research area is decane water microemulsion stabilized cetylpyridinium chloride surfactant.

Mol. dynamics simulation (MD) is used to study the static and dynamic properties of pos. charged decane/water microemulsions, for various volume fractions φ (2.8%, 6.98%, 14%, and 26.5%). An effective hybrid potential combining three potentials, namely the hard-sphere repulsive potential, the van der Waals attractive potential, and the Yukawa repulsive potential, is used to describe the microemulsion interactions. The microemulsion shape is determined using the renormalized spectra in Porod representation. The appropriate potential parameters are tested using the Ornstein-Zernike integral equation approach with the Hypernetted Chain (HNC) closure relation by a comparison between the structure factor calculated from HNC and that obtained from Small Angle Neutron Scattering experiments (SANS). Thus, the micro arrangements of microemulsions have been analyzed using the pair correlation function g(r) and the structure factor S(q) obtained from HNC, SANS, and MD simulation using these parameters. The microemulsion dynamic properties were discussed using the mean-square displacement (MSD) and the diffusion coefficient Dc calculated from MD simulations.

RSC Advances published new progress about Biocompatible materials. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Electric Literature of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Klake, Raphael K.; Gargaro, Samantha L.; Gentry, Skyler L.; Elele, Sharon O.; Sieber, Joshua D. published the artcile< Development of a Strategy for Linear-Selective Cu-Catalyzed Reductive Coupling of Ketones and Allenes for the Synthesis of Chiral γ-Hydroxyaldehyde Equivalents>, HPLC of Formula: 350-03-8, the main research area is chirality hydroxyaldehyde linear preparation copper catalyst reductive coupling equivalent; ketone allene reductive coupling copper catalyst.

The authors report the development of a stereoselective method for the allylation of ketones using N-substituted allyl equivalent generated from a chiral allenamide. By choice of the appropriate ligand for the Cu-catalyst, high linear selectivity can be obtained with good diastereocontrol. This methodol. allows access to chiral γ-hydroxyaldehyde equivalent that were applied in the synthesis of chiral γ-lactones and 2,5-disubstitued tetrahydrofurans.

Organic Letters published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation) (γ-Hydroxyaldehyde). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, HPLC of Formula: 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sun, Manman; Wu, Haijian; Xia, Xiangyu; Chen, Weida; Wang, Zhiming; Yang, Jianguo published the artcile< Asymmetric Palladium-Catalyzed C-H Functionalization Cascade for Synthesis of Chiral 3,4-Dihydroisoquinolones>, Formula: C13H15F3N2O, the main research area is sulfonylbenzamide diene palladium bond activation enantioselective allylation cascade green; dihydroisoquinolone stereoselective preparation.

A palladium-catalyzed C-H functionalization/intramol. asym. allylation cascade of N-sulfonyl benzamides with 1,3-dienes has been developed. In the presence of a chiral pyridine-oxazoline ligand, this protocol enables the synthesis of chiral 3,4-dihydroisoquinolones, e.g., I, in yields of up to 83% with enantioselectivities of up to 96%, using environmentally friendly air as the terminal oxidant.

Journal of Organic Chemistry published new progress about 1,3-Alkadienes Role: RCT (Reactant), RACT (Reactant or Reagent). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Formula: C13H15F3N2O.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Echterhoff, Antje K. C.; Yogendra, Sivathmeehan; Koesters, Jutta; Fischer, Roland; Weigand, Jan J. published the artcile< A versatile protocol for the synthesis of pyrazolyl-substituted pyridinium and guanidinium salts from pyridone and urea derivatives>, HPLC of Formula: 73018-09-4, the main research area is pyridinium pyrazolyl guanidinium triflate preparation crystal structure; tripyridyl phosphite preparation crystal structure.

The trication I was used as a convenient pyrazolyl-transfer reactant to convert 2-pyridone, 4-pyridone and urea derivatives such as benzimidazol-2-one and theobromine to their pyrazolyl substituted triflate salts, e.g., II. The conversion represented a new, efficient and highly functional group-compatible approach that yielded the desired products conveniently and in high yields. Typically the reaction proceeded via exchange of carbonyl oxygen atom of the substrate for pyrazolyl moiety. However, for the structurally related 3-hydroxypyridines, a different reaction pathway occurred giving tripyridyl phosphites, e.g., III which was explained by the lactam-lactim tautomerism of the substrate. The structural arrangements of most of the products were confirmed by X-ray crystallog. anal.

European Journal of Organic Chemistry published new progress about Crystal structure. 73018-09-4 belongs to class pyridine-derivatives, and the molecular formula is C5H4ClNO, HPLC of Formula: 73018-09-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wythe, L. A.; Dittoe, D. K.; Feye, K. M.; Olson, E. G.; Perry, L. M.; Ricke, S. C. published the artcile< Reduction of Salmonella Infantis on skin-on, bone-in chicken thighs by cetylpyridinium chloride application and the impact on the skin microbiota>, Application of C21H38ClN, the main research area is cetylpyridinium chloride chicken thigh Salmonella infantis skin microbiota; 16S rDNA; Salmonella Infantis; cetylpyridinium chloride; peroxyacetic acid; poultry.

Salmonella Infantis has been the etiol. agent of numerous foodborne outbreaks of nontyphoidal Salmonella. Consequently, there is an emergent need to mitigate Salmonella Infantis among poultry. Thus, this study evaluated the efficacy of cetylpyridinium chloride (CPC) vs. peroxyacetic acid (PAA), on bone-in, skin-on chicken thighs for the reduction of Salmonella and changes in the microbiota. Exactly 100 skin-on, bone-in chicken thighs (2 trials, 0 and 24 h, k = 5, n = 5, N = 50) were inoculated with 108 CFU/mL of a nalidixic acid resistant strain of S. Infantis for an attachment of 106 CFU/g. Thighs were treated with 20 s part dips (350 mL): a no inoculum, no treatment control (NINTC); no treatment control (NTC); tap water (TW); TW+CPC; TW+PAA. Following treatment, thighs were rinsed in 150 mL of nBPW, and rinsates were collected. Rinsates were spot plated for Salmonella and aerobic bacteria (APC). Log10 transformed counts were analyzed using a mixed-effects model (random effect = trial) with means separated using Tukey’s HSD (P ≤ 0.05). The genomic DNA of rinsates was extracted, and the 16S rDNA was sequenced on an Illumina MiSeq. Microbiota data were analyzed using QIIME2, with data considered significant at P ≤0.05 (main effects) and Q≤0.05 (pairwise differences). Treatment x time interactions were observed for both Salmonella and APC (P < 0.05). The treatment of thighs with PAA and CPC reduced Salmonella and APC in respect to the controls. Numerically, thighs treated with CPC had less Salmonella (4.29 log10CFU/g) and less APC (4.56log10CFU/g) at 24 h than all other treatments (P > 0.05). Differences in diversity metrics were not consistently observed between treatments; however, in trial 2, the NTC treated thighs were different than those treated with CPC (P < 0.05; Q < 0.05). In both trials, ANCOM, the anal. of microbiome compositional profiles, revealed shifts at both the phylum and order levels with thighs being different in the relative abundances of Proteobacteria (P < 0.05). In conclusion, treatment of skin-on poultry parts with CPC may reduce the risk of foodborne outbreaks caused by Salmonella Infantis. Poultry Science published new progress about Acidobacteria. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Application of C21H38ClN.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Jun; Xu, Guan-Cheng; Zhang, Yan-Ping; Luo, Hua-Ying; Li, Jin-Yao; Zhang, Li; Jia, Dian-Zeng published the artcile< Copper(II) complexes with 4-acyl pyrazolone derivatives and diimine coligands: synthesis, structural characterization, DNA binding and antitumor activity>, Product Details of C10H8N2, the main research area is antitumor agent copper dipyridyl pyrazolone salicylidene derived complex; crystal structure copper dipyridyl pyrazolone salicylidene derived complex preparation; electrochem redox potential copper dipyridyl pyrazolone salicylidene derived complex.

Three mixed-ligand Cu(II) complexes [Cu(L)(bpy)] (1), [Cu(L)(phen)] (2) and [Cu(L)(dpq)]·CHCl3 (3) have been synthesized and fully characterized, where H2L = N-(1-phenyl-3-methyl-4-(4-fluorobenzoyl)-5-pyrazolone)-2-salicylidene hydrazide, bpy = 2,2′-bipyridine, phen = 1,10-phenanthroline and dpq = dipyrido[3,2-d:2′,3′-f]quinoxaline. Single crystal x-ray diffraction anal. revealed that complexes 1-3 have mononuclear structure and the Cu(II) ions are located in a five-coordinated distorted square pyramidal geometry. The interaction of the compounds with herring sperm DNA has been studied by absorption titration, ethidium bromide displacement experiments and electrochem. studies. All the compounds could interact intercalatively with DNA, and complex 3 shows the highest DNA binding ability, followed by 2, 1 and H2L. Complexes 1-3 exhibit excellent cytotoxicity against cervical cancer HeLa cells and human esophageal cancer Eca-109 cells. Complex 3 displays the best activity for both cancer cell lines, and the IC50 values are 4.37 ± 0.08 μM and 3.68 ± 0.14 μM for HeLa and Eca-109 cells, resp., which are ∼13 times lower than that of the com. antitumor drug cisplatin. Moreover, complex 3 dose-dependently induces Eca-109 cell apoptosis characterized by nuclear morphol. changes and increased Annexin V+ cells, suggesting that complex 3 inhibited the proliferation of Eca-109 cells by induction of apoptosis. In conclusion, the mixed-ligand complex 3 might be a potential antitumor drug.

New Journal of Chemistry published new progress about Antitumor agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Product Details of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pflegr, Vaclav; Stepankova, Sarka; Svrckova, Katarina; Svarcova, Marketa; Vinsova, Jarmila; Kratky, Martin published the artcile< 5-Aryl-1,3,4-oxadiazol-2-amines Decorated with Long Alkyl and Their Analogues: Synthesis, Acetyl- and Butyrylcholinesterase Inhibition and Docking Study>, Application In Synthesis of 93-60-7, the main research area is aryloyl dodecyl oxadiazol amine preparation cholinesterase inhibition docking SAR; dodecyl aryloyl thiadiazol amine preparation acetyl butyrylcholinesterase inhibition docking; hydrazine carboxamide cyclization; 1,3,4-oxadiazole; 1,3,4-thiadiazole; acetylcholinesterase; butyrylcholinesterase; enzyme inhibition; molecular docking.

The compounds 5-aryl-1,3,4-oxadiazoles/thiadiazols decorated with dodecyl linked via nitrogen, sulfur or directly to this heterocycle I [R = Ph, 4-MeC6H4, 4-tBuC6H4, etc.,; X = O, S; Y = NH, S] was designed as potential inhibitors of AChE and BChE. Oxadiazoles/thiadiazols derivatives I were prepared from hydrazides by reaction with dodecyl isocyanate to form hydrazine-1-carboxamides II (yields 67-98%) followed by cyclization using p-toluenesulfonyl chloride and triethylamine in 41-100% yields. The derivatives I were screened for inhibition of AChE and BChE using Ellman’s spectrophotometric method. The compounds I showed a moderate dual inhibition with IC50 values of 12.8-99.2 for AChE and from 53.1μM for BChE. All the heterocycles I were more efficient inhibitors of AChE. The most potent inhibitor, N-dodecyl-5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine I [R =4-pyridyl, X= S, Y = NH] was subjected to advanced reversibility and type of inhibition evaluation. Structure-activity relationships of heterocycles I were identified. Many oxadiazoles I showed lower IC50 values against AChE than established drug rivastigmine. According to mol. docking, the compounds I interact non-covalently with AChE and BChE and block entry into enzyme gorge and catalytic site, resp.

Pharmaceuticals published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Application In Synthesis of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Talik, Tadeusz; Talik, Zofia published the artcile< 2-Fluoronitro-derivatives of pyridine and picolines>, Name: 2-Fluoro-6-methyl-3-nitropyridine, the main research area is pyridine fluoro nitro; picoline fluoro nitro; diazotization aminopyridine.

6-Fluoro derivatives from 4-nitro- and 3,5- and 3,4-dinitropyridine, 3- and 5-nitro- and 3,5-dinitro-4-picoline, 3- and 5-nitro- and 3,5-dinitro-2-picoline, and 5-nitro-3-picoline as well as 2-fluoro-5-nitro-3-picoline were prepared in 52.5-85% yields by diazotization of the corresponding amino derivatives in 65% HF.

Roczniki Chemii published new progress about 19346-45-3. 19346-45-3 belongs to class pyridine-derivatives, and the molecular formula is C6H5FN2O2, Name: 2-Fluoro-6-methyl-3-nitropyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Barone, Antonella; Cristiano, Maria Chiara; Cilurzo, Felisa; Locatelli, Marcello; Iannotta, Dalila; Di Marzio, Luisa; Celia, Christian; Paolino, Donatella published the artcile< Ammonium glycyrrhizate skin delivery from ultradeformable liposomes: A novel use as an anti-inflammatory agent in topical drug delivery>, Safety of 3-(Methoxycarbonyl)pyridine, the main research area is ammonium glycyrrhizate skin drug delivery antiinflammatory activity; Ammonium glycyrrhizate; Anti-inflammatory activity; Colloidal nanocarriers; Topical administration; Ultradeformable liposomes.

Although several nanoformulations, such as ethosomes, are designed to provide a systemic effect through a topical application, there are different limitations to the distribution inside the blood stream. For this reason, ultradeformable liposomes, or transfersomes, are selected to improve the topical delivery of drugs and allow the distribution of payloads in the blood stream because they pass intact through the stratum corneum epidermis barrier, due to the presence of sodium cholate, aqueous cutaneous gradient, and the rapid penetration of transfersomes by cutaneous tight junctions, thus allowing the systemic delivery of different therapeutic cargo in non-occlusive conditions. The aim of this work was the synthesis and physicochem. characterization of the ammonium glycyrrhizinate-loaded ultradeformable liposomes, the evaluation of drug release and permeation through stratum corneum and epidermis barrier. The in vivo anti-inflammatory effect of ammonium glycyrrhizinate-loaded ultradeformable liposomes was tested on human healthy volunteers. The results demonstrated that the ammonium glycyrrhizinate-loaded ultradeformable liposomes decreased the skin inflammation on the human volunteers and the resulting nanoformulations can be used as a potential topical drug delivery system for anti-inflammatory therapy.Parts of these results were presented as a poster communication at the Recent Developments in Pharmaceutical Anal. 2019 (RDPA 2019), Chieti, Italy.

Colloids and Surfaces, B: Biointerfaces published new progress about Anti-inflammatory agents. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Safety of 3-(Methoxycarbonyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Oka, Naoki; Yamada, Tsuyoshi; Sajiki, Hironao; Akai, Shuji; Ikawa, Takashi published the artcile< Aryl Boronic Esters Are Stable on Silica Gel and Reactive under Suzuki-Miyaura Coupling Conditions>, Category: pyridine-derivatives, the main research area is aryl boronic ester bromoarene palladium Suzuki Miyaura coupling; biaryl preparation.

A wide range of aryl boronic 1,1,2,2-tetraethylethylene glycol esters [ArB(Epin)s] were readily synthesized. Purifying aryl boronic esters by conventional silica gel chromatog. is generally challenging; however, these introduced derivatives were easily purified on silica gel and isolated in excellent yields. The purified ArB(Epin) was subjected to Suzuki-Miyaura couplings, which provided higher yields of the desired biaryl products than those obtained using the corresponding aryl boronic acids or pinacol esters.

Organic Letters published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem