Month: October 2022

Grozavu, Alexandru; Hepburn, Hamish B.; Smith, Philip J.; Potukuchi, Harish K.; Lindsay-Scott, Peter J.; Donohoe, Timothy J. published the artcile< The reductive C3 functionalization of pyridinium and quinolinium salts through iridium-catalysed interrupted transfer hydrogenation>, COA of Formula: C7H7NO2, the main research area is pyridinium salt formaldehyde iridium catalyst regioselective reductive hydroxymethylation; quinolinium salt formaldehyde iridium catalyst regioselective reductive hydroxymethylation; tetrahydropyridine preparation; tetrahydroquinoline preparation.

Aromatic rings are ubiquitous in organic chem. and form the basis of many com. products. Despite the numerous routes available for the preparation of aromatic compounds, there remain few methods that allow their conversion into synthetically useful partially saturated derivatives and even fewer that allow new C-C bonds to be formed at the same time. Here we set out to address this problem and uncover a unique catalytic partial reduction reaction that forms partially saturated azaheterocycles from aromatic precursors. In this reaction, methanol and formaldehyde are used for the reductive functionalization of pyridines and quinolines using catalytic iridium; thus, inexpensive and renewable feedstocks are utilized in the formation of complex N-heterocycles. By harnessing the formation of a nucleophilic enamine intermediate, the C-C bond-forming process reverses the normal pattern of reactivity and allows access to the C3 position of the arene. Mechanistic investigations using D-labeling experiments reveal the source of hydride added to the ring and show the reversible nature of the iridium-hydride addition

Nature Chemistry published new progress about C-C bond formation. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, COA of Formula: C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jevremovic, Anka; Bozinovic, Nevena; Arsenijevic, Dragana; Marmakov, Sanal; Nedic Vasiljevic, Bojana; Uskokovic-Markovic, Snezana; Bajuk-Bogdanovic, Danica; Milojevic-Rakic, Maja published the artcile< Modulation of cytotoxicity by consecutive adsorption of tannic acid and pesticides on surfactant functionalized zeolites>, Formula: C21H38ClN, the main research area is tannic acid pesticide zeolite adsorption cytotoxicity.

This study investigated the environmental application of FAU type zeolites modified with cationic surfactants (cetylpyridinium chloride, tetrapropylammonium chloride and benzalkonium chloride). Adsorbent characterization was conducted using Fourier-transform IR and Raman spectroscopy, thermogravimetry and DTA, at. force microscopy and X-ray powder diffraction. The efficiency for tannic acid adsorption from aqueous solution on the surface of prepared composites is studied and the adsorption process was modelled with different isotherm equations. Surfactant modifications of zeolites led to improved adsorption properties compared to FAU zeolites alone. The proposed mechanism controlling the adsorption of tannic acid onto surfactant modified zeolites mainly relies on π-π and hydrophobic interactions. The investigated materials are promising adsorbents for tannic acid and similar phenolics and may be important for environmental and dietary aspects of polyphenol persistence and usage. Further on, functionalized zeolites were studied for insecticide acetamiprid removal, prior to and after tannic acid retention. Promising findings of insecticide co-adsorption with tannic acid led to cytotoxicity evaluation. The cytotoxicity modulation effect of zeolites and tannic acid on acetamiprid points to the essential role of both components in insecticide toxicity reduction

Environmental Science: Processes & Impacts published new progress about Adsorption. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Formula: C21H38ClN.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bratt, Jack; Iddon, Brian; Mack, Arthur G.; Suschitzky, Hans; Taylor, Jack A.; Wakefield, Basil J. published the artcile< Polyhaloaromatic compounds. Part 41. Photochemical dehalogenation and arylation reactions of polyhaloaromatic and polyhaloheteroaromatic compounds>, Recommanded Product: 2,3,4,6-Tetrachloropyridine, the main research area is photochem dehalogenation arylation haloarom compound; photocyclization thiopyridine; halobenzene poly photochem dehalogenation arylation; pyridine halo dehalogenation arylation.

Photolysis of pentachloro- and pentabromopyridine in Et2O led to β-halogen loss and the formation of a product of attack by Et2O, I (R = Cl, Br, resp.). Both 4-bromo- and 4-iodotetrachloropyridines underwent exclusive loss of Br and iodine, resp. Perhalothiophenes, tetrachloropyrimidine and C6Cl6 underwent similar dehalogenation reactions. Photolysis of C6Cl5I (II), tetrachloroiodopyridines and trichloro-5-iodothiophene in C6H6 gave the corresponding polychloroaryl- or polychloroheteroarylbenzenes. E.g., II underwent photolysis in C6H6 to give 95% 2,3,4,5,6-pentachlorobiphenyl. Photolysis of the pyridines III (R1 = SPh, SC6Cl5) gave the corresponding photocyclization products IV (R2 = H, Cl) resp.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Photochemical arylation. 14121-36-9 belongs to class pyridine-derivatives, and the molecular formula is C5HCl4N, Recommanded Product: 2,3,4,6-Tetrachloropyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lee, Johnny Ching-Wei; Porcar, Lionel; Rogers, Simon A. published the artcile< Unveiling temporal nonlinear structure-rheology relationships under dynamic shearing>, COA of Formula: C21H38ClN, the main research area is micelle nonlinear rheol dynamic shearing; LAOS; nonlinear rheology; polymer rheology; rheo SANS; structure–rheology relationship; viscoelastic; worm-like micelles.

Understanding how microscopic rearrangements manifest in macroscopic flow responses is one of the central goals of nonlinear rheol. studies. Using the sequence-of-phys.-processes framework, we present a natural 3D structure-rheol. space that temporally correlates the structural and nonlinear viscoelastic parameters. Exploiting the rheo-small-angle neutron scattering (rheo-SANS) techniques, we demonstrate the use of the framework with a model system of polymer-like micelles (PLMs), where we unveil a sequence of microscopic events that micelles experience under dynamic shearing across a range of frequencies. The least-aligned state of the PLMs is observed to migrate from the total strain extreme toward zero strain with increasing frequency. Our proposed 3D space is generic, and can be equally applied to other soft materials under any sort of deformation, such as startup shear or uniaxial extension. This work therefore provides a natural approach for researchers to study complex out-of-equilibrium structure-rheol. relationships of soft materials.

Polymers (Basel, Switzerland) published new progress about Linear viscoelasticity. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, COA of Formula: C21H38ClN.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Grabner, Sabina; Modec, Barbara published the artcile< Zn(II) curcuminate complexes with 2,2′-bipyridine and carboxylates>, Recommanded Product: 2,2′-Bipyridine, the main research area is Zn(II) complexes; crystal structures; curcumin; stability.

Two novel zinc(II) compounds with curcuminate (abbreviated as cur-), [Zn(CH3COO)(cur)(bpy)] (1)·CH3OH·2H2O (bpy = 2,2′-bipyridine) and [Zn(PhCOO)(cur)(bpy)] (2)·CH3OH, have been synthesized and characterized. Their composition has been determined by single-crystal X-ray structure anal. Complexes 1 and 2 are similar: in both a five-fold coordination environment of zinc(II) consists of a monodentate carboxylate, a chelating bidentate 2,2′-bipyridine, and curcuminate, which is bound via a deprotonated 1,3-dione moiety. In 1, 2,2′-bipyridine nitrogen atoms and curcuminate oxygen atoms form the base of a square pyramid, whereas the acetate oxygen occupies its apex. The O3N2 donor set in 2 defines a polyhedron which more closely resembles a trigonal bipyramid. The packing in the crystal lattices of both compounds is governed by hydrogen-bonds. Complexes 1 and 2 display higher stability than curcumin in buffered media at pH = 7.0, however, the degradation of coordinated cur- is comparable to that of yellow pigment curcumin (curH) when the pH is raised to 7.2. Both complexes 1 and 2 in DMSO exhibit fluorescence with Stokes shifts of 5367 and 4634 cm-1, resp.

Molecules published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Recommanded Product: 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Jun-Xia; Du, Zhong-Xiang; Pan, Qiu-Yue; Zhang, Lu-Lu; Liu, Duo-Li published the artcile< The first 3,5,6-trichloropyridine-2-oxyacetate bridged manganese coordination polymer with features of π···π stacking and halogen···halogen interactions: Synthesis, crystal analysis and magnetic properties>, Electric Literature of 366-18-7, the main research area is trichloropyridineoxyacetate bridged manganese bipyridine coordination polymer preparation crystal structure; pi stacking halogen interaction crystal structure magnetic property manganese.

A new coordination polymer [Mn(3,5,6-tcpa)2(2,2′-bipy)]n (1) has been synthesized by the hydrothermal reaction of manganese sulfate hydrate with 3,5,6-trichloropyridine-2-oxyacetic acid (3,5,6-Htcpa) and 2,2′-bipyridine (2,2′-bipy) coligands. The x-ray single-crystal diffraction anal. shows that the MnII center is in deformed octahedral geometry bonded by two pyridyl nitrogen atoms of 2,2′-bipy mol. and four carboxy oxygen atoms of four different 3,5,6-tcpa- ligands. The 3,5,6-tcpa- anions play as bidentate bridging-μ2 linkers and connect neighboring MnII ions together to form the 1D double-stranded chain structure of 1, which displays interesting chair form [Mn2(COO)2] eight-membered rings. 1 Is further assembled into 3D network by the co-effects of π···π stacking and Cl···Cl halogen bonds interactions. In addition, the magnetic characterizations indicated weak antiferromagnetic coupling between MnII centers for 1.

Inorganica Chimica Acta published new progress about Antiferromagnetic exchange. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Electric Literature of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bairagi, Pallab Kumar; Goyal, Arpit; Verma, Nishith published the artcile< Methyl nicotinate biomarker of tuberculosis voltammetrically detected on cobalt nanoparticle-dispersed reduced graphene oxide-based carbon film in blood>, Quality Control of 93-60-7, the main research area is methyl nicotinate biomarker graphene oxide carbon cobalt nanoparticle tuberculosis.

Me nicotinate (MN), a metabolite of Mycobacterium tuberculosis, is an important biomarker of tuberculosis (TB). An effective measurement of MN can provide an early detection of TB, before it becomes life threatening. In this study, a cobalt (Co) and reduced graphene oxide (rGO) dispersed N-doped phenolic polymer precursor-based carbon film is used as the biosensor electrode to detect and measure MN in human blood for the first time. The Co nanoparticles are successfully used as the nonbiol. recognition element of MN. Doping of the carbon film with N-heteroatom using melamine increases the film electro-conductivity Using differential pulse voltammetry, the sensor electrode exhibits excellent linearity (0.9925) over 0.05-14 mg L-1MN concentrations (S/N ratio = 3), with high sensitivity (1735.2μA mM-1 cm-2) and low detection limit (0.0004 mM). The sensor also shows good selectivity and high recovery for MN. Most importantly, the sensor successfully confirms its clin. applicability when tested in the synthetic clin. MN solutions (RSD < 6.5%). The method and materials developed in this study have paved a new platform for developing similar biosensors using non-biol. components for chronic diseases such as typhoid and kidney-dysfunction. Sensors and Actuators, B: Chemical published new progress about Blood. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Quality Control of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pramanik, Bapan; Das, Saurav; Das, Debapratim published the artcile< Aggregation-directed High Fidelity Sensing of Picric Acid by a Perylenediimide-based Luminogen>, Related Products of 3731-53-1, the main research area is aggregation directed fluorescent sensor picric acid perylenediimide luminogen; aggregation caused quenching; chemosensor; explosive sensor; perylenediimide; picric acid.

Widespread use of picric acid (PA) in chem. industries and deadly explosives poses dreadful impact on all living creatures as well as the natural environment and has raised global concerns that necessitate the development of fast and efficient sensing platforms. To address this issue, herein, we report a perylenediimide-peptide conjugate, PDI-1 (I), for detection of PA in methanol. The probe displays typical aggregation caused quenching (ACQ) behavior and exhibits a fluorescence “”turn-off”” sensory response towards PA which is unaffected by the presence of other interfering nitroarom. compounds The sensing mechanism involves PA induced aggregation of the probe into higher order tape like structures which leads to quenching of emission. The probe possesses a low detection limit of 5.6 nM or 1.28 ppb and a significantly high Stern-Volmer constant of 6.87×104 M-1. It also exhibits conducting properties in the presence of PA vapors and thus represents a prospective candidate for vapor phase detection of PA. This is, to the best of our knowledge, the first example of a perylenediimide based probe that demonstrates extremely specific, selective and sensitive detection of PA and thus grasps the potential for application in practical scenarios.

Chemistry – An Asian Journal published new progress about Aggregation. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Related Products of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Su, Xuxian; Wang, Wen-Jin; Cao, Qian; Zhang, Hang; Liu, Bin; Ling, Yuyi; Zhou, Xiaotong; Mao, Zong-Wan published the artcile< A Carbonic Anhydrase IX (CAIX)-Anchored Rhenium(I) Photosensitizer Evokes Pyroptosis for Enhanced Anti-Tumor Immunity>, Formula: C6H8N2, the main research area is CAIX ruthenium photosensitizer preparation cancer PDT pyroptosis immunity; anti-tumor immunity; carbonic anhydrase IX targeting; metallodrugs; photodynamic therapy; pyroptosis.

An ideal cancer treatment should not only destroy primary tumors but also improve the immunogenicity of the tumor microenvironment to achieve a satisfactory anti-tumor immune effect. We designed a carbonic anhydrase IX (CAIX)-anchored rhenium(I) photosensitizer, named CA-Re, that not only performs type-I and type-II photodynamic therapy (PDT) with high efficiency under hypoxia (nanomolar-level phototoxicity), but also evokes gasdermin D (GSDMD) mediated pyroptotic cell death to effectively stimulate tumor immunogenicity. CA-Re could disrupt and self-report the loss of membrane integrity simultaneously. This promoted the maturation and antigen-presenting ability of dendritic cells (DCs), and fully activated T cells dependent adaptive immune response in vivo, eventually eliminating distant tumors at the same time as destroying primary tumors. To the best of our knowledge, CA-Re is the first metal complex-based pyroptosis inducer.

Angewandte Chemie, International Edition published new progress about Adaptive immunity. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Formula: C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dai, Qiang; Li, Wenbo; Li, Zhiming; Zhang, Junliang published the artcile< P-Chiral Phosphines Enabled by Palladium/Xiao-Phos-Catalyzed Asymmetric P-C Cross-Coupling of Secondary Phosphine Oxides and Aryl Bromides>, Recommanded Product: (S)-4-(tert-Butyl)-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole, the main research area is phosphine chiral palladium catalyzed arylation phosphine oxide aryl bromide; chiral aryldiphosphine oxide preparation crystal structure; mol structure chiral aryl diphosphine oxide palladium sulfinamidephosphine; palladium sulfinamidephosphine chiral complex preparation crystal structure.

The development of transition-metal-catalyzed methods for the synthesis of P-chiral phosphine derivatives poses a considerable challenge. Herein, the authors present a direct Pd/Xiao-Phos-catalyzed cross-coupling reaction of easily accessible secondary phosphine oxides and aryl bromides, which provides rapid access to P-chiral phosphine oxides. The reaction proceeds efficiently with a wide array of reaction partners to deliver various tertiary phosphine oxides in up to 96% yield and 97% ee. Also, the synthesis of DiPAMP ligand and its analogs was also realized, which demonstrates a suitable pathway to switching the branched chain of DiPAMP.

Journal of the American Chemical Society published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Recommanded Product: (S)-4-(tert-Butyl)-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem